Abstract: Described is a cannula (110 to 1110, CA1500, CA1600) for detection of the volume (V) of a cavity within a body (100), comprising: —a lumen portion (LP) comprising and inner surface (ISF) and an outer surface (OSF), —a first opening (OP1) on a first end (FE) of the lumen portion (LP), —a second opening (OP2) on a second end (SE) of the lumen portion (LP), wherein the first opening (OP1) and the second opening (OP2) have an inner diameter that allows endovascular blood circuit support of the blood circuit of a subject (Pat), —a lumen (LU) extending from the first end (FE) to the second end (SE) within the lumen portion (LP), and —at least one series (SER1) of electrodes (EE1 to EE2) comprising at least two electrodes (EE1 to EE2), wherein the series of electrodes (EE1 to EE2) is arranged along at least a part of the lumen portion (LP) at the outer surface (OSF), wherein the at least one series (SER1) of electrodes (EE1 to EE2) is configured to be used for the detection of the amount of a volume (V) of a cavity

Abstract: Described is an endovascular cannula (L1b, L2b) for defining a border of a transport volume (TrV) for an in-vivo fluid transport, the cannula (L1b, L2b) comprising:—a lumen portion (LP) that extends between a proximal end of the cannula (L1b, L2b) and a distal end of the cannula (L1b, L2b), the lumen portion (LP) defining an inner lumen, and—an expandable arrangement that has a non-expanded state and an expanded state, wherein the expandable arrangement can be switched from the non-expanded state to the expanded state, wherein in the expanded state the expandable arrangement is adapted to define at least one border of the transport volume (TrV), and wherein the border is configured to separate the transport volume from a body fluid circuit (BC).

Abstract: Described is a cannula (110, O1 to O3, I1 to I3) comprising: —a lumen portion (LP) that extends axially between a proximal part of the cannula (110, O1 to O3, I1 to I3) and at least one distal part of the cannula (110, O1 to O3, I1 to I3), and —an expandable arrangement (114) at the at least one distal part of the lumen portion, wherein the expandable arrangement (114) is adapted to have an expanded state and a non-expanded state, wherein in the expanded state a volume defined by the expandable arrangement (114) is greater than the volume defined by the expandable arrangement (114) in the non-expanded state.

Abstract: Disclosed is a Cannula system (CS1 to CS3, 210, 310, 1010, 1040, 1110) comprising: a first cannula (O1 to O3) having a minimum inner diameter or width, a second cannula (I1 to I3) having a maximum outer diameter or width, wherein the minimum inner diameter or width is greater than the maximum outer diameter or width, wherein the second cannula (I1 to I3) is adapted to be guided into the first cannula (O1 to O3) such that a first lumen of the first cannula (O1 to O3) remains in the first cannula (O1 to O3) between an outer surface the second cannula (I1 to I3) and an inner surface of the first cannula (O1 to O3), and wherein the first lumen of the first cannula (O1 to O3) defines a first fluid conduit and a first lumen of the second cannula (I1 to I3) defines a second fluid conduit.

Abstract: Disclosed is a cannula (CA1 to CA7) for endovascular and/or jugular blood circuit support, comprising: —a proximal portion (PP1 to PP6), —a distal portion (DP1 to DP7) that comprises at least one distal opening (DO1 to DO7), —a lumen portion (LP) that extends from the proximal portion (PP1 to PP6) to the at least one distal opening (DO1 to DO7), and—at least one intermediate portion (IP1 to IP7) that is arranged between the proximal portion (PP1 to PP6) and the distal portion (DP1 to DP7), wherein the intermediate portion (IP1 to IP7) comprises at least one intermediate opening (IO1 to IO7), and wherein the intermediate portion (IP1 to IP7) is configured such that more than 90 volume percent of the fluid flow are drained from the intermediate opening (IO1 to IO7) if a fluid flow within the proximal portion (PP1 to PP6) is directed proximally and such that more than 90 volume percent of the fluid flow are delivered through the at least one distal opening (DO1 to DO7) if a fluid flow within the proximal portion

Abstract: An arrangement (200 to 1200) is provided for transporting a liquid (B) through a cannula system (CS), comprising: a liquid guiding system (LGS) comprising at least three separated portions (SP2a, SP2b, SP3c) which define separate liquid guiding portions of the liquid guiding system (LGS), and a connecting portion (CP2 to CP12) which fluidically connects the at least three separated portions (SP2a, SP2b, SP3c) and which comprises a lumen that branches out into at least two lumens, wherein the liquid guiding system (LGS) is configured to be connected to a pump arrangement (Arr2 to An12) which drives a flow of the liquid (B), and wherein the liquid guiding system (LGS) is configured to be connected to a cannula system (CS) which is adapted to be inserted into a body of a human or of an animal and which comprises an inflow opening and an outflow opening of the liquid guiding system (LGS).

Abstract: A pulmonary artery (PA) via trans-septal to left atrial (LA) percutaneous dual lumen cannulation system which reduce the pressure of the right ventricle provides drainage of pulmonary artery blood with bypassing the lung while return the blood to the Left Atrium (LA) without the need for thoracotomy for a wearable pump less extra corporeal lung assist (pECLA) to remove CO2, pump less extra corporeal membrane oxygenation (ECMO), para-corporeal pump driven CO2 removal, extra corporeal CO2 removal (ECCO2R) pump driven, para-corporeal pump driven membrane oxygenation, or extra corporeal membrane oxygenation (ECMO) with extra-corporeal pump. By establishing percutaneously a shunt with a dual lumen cannula between PA and LA using the PA-LA pressure gradient as the driving force for the blood flow through the drainage lumen, CO2 removal device, or oxygenator and return cannula lumen in the vascular system.

Abstract: A pulmonary artery (PA) via trans-septal to left atrial (LA) percutaneous dual lumen cannulation system which reduce the pressure of the right ventricle provides drainage of pulmonary artery blood with bypassing the lung while return the blood to the Left Atrium (LA) without the need for thoracotomy for a wearable pump less extra corporeal lung assist (pECLA) to remove CO2, pump less extra corporeal membrane oxygenation (ECMO), para-corporeal pump driven CO2 removal, extra corporeal CO2 removal (ECCO2R) pump driven, para-corporeal pump driven membrane oxygenation, or extra corporeal membrane oxygenation (ECMO) with extra-corporeal pump. By establishing percutaneously a shunt with a dual lumen cannula between PA and LA using the PA-LA pressure gradient as the driving force for the blood flow through the drainage lumen, CO2 removal device, or oxygenator and return cannula lumen in the vascular system.

Abstract: The present invention relates a pharmaceutical composition comprising a taxane and an inhibitory compound capable of inhibiting the enzyme acetaldehyde dehydrogenase e.g. disulfiram. The pharmaceutical compositions of the invention can be used to coat medical devices such as implants. Such implant can be an expansible hollow part, having at least one opening, which consists of an elastic biocompatible material that comprises elongated micro-cavities in its surface. Medical devices coated with a pharmaceutical composition of the invention exhibit an enhanced transfer of taxane from the surface of said medical device into the target tissue.

Abstract: The present invention relates to an expansible hollow part, having at least one opening, which consists of an elastic biocompatible material and which comprises at least one biologically active substance and, optionally at least one matrix compound. The invention also provides a method of producing said expansible hollow part, a medical device covered at least partially with said hollow part, a kit-of-parts comprising said hollow part of the invention and the use of said hollow part as a therapeutic device and for protecting a medical device.