Abstract: The invention relates to a powder inhaler with at least one specially sharpened needle, to ensure the precise piercing or cutting open of capsules and hence the optimum delivery of powdered medicament compositions, medicament formulations or medicament mixtures, as well as ensuring that little effort is needed to perforate or cut open the capsule.

Abstract: The present invention relates to capsules for housing pharmaceutical preparations for powder inhalers with increased medicinal product safety and capsules for pharmaceutical preparations for powder inhalers with improved adaption to use in powder inhalers. The capsules consist of non-water-soluble, hydrophobic plastics, which themselves do not substantially influence the pharmaceutical quality of the contents, but improve the usability of the filled capsules in respect of their operation, the period of use and/or the geographical location of their use and are advantageous in various steps from manufacture to use.

Abstract: An inhaler for inhaling powdered medicaments from capsules, having: a lower part which is cup-shaped, a plate latched to the lower part to close off the lower part, a capsule holder arranged on the underside of the plate, a mouthpiece that can be latched to the top of plate, and an actuating member for interacting with at least one pin for piercing a capsule in the capsule holder, where the actuating member includes a larger outer actuating member and a smaller inner actuating member, the outer actuating member forms a user-operated push-button, the inner actuating member contacts and holds the pin below a suspension element of the outer actuating member from the plate, and the point of application of force by the user onto push-button is lower than the inner actuating member.

Abstract: A package in the form of a bottle (1 to 1??) comprises damping and/or cushioning means (5) that act on packaged goods placeable in the fill volume (3) thereof and that are disposed between the packaged goods and the wall of the bottle, which are adapted to substantially automatically align and/or unfold or compress in accordance with the degree of filling of the volume (3) with packaged goods and to shrink or expand and/or unfold in accordance with the degree of removal of the packaged goods at least until a certain proportion has been removed.

Abstract: A process for producing a container comprising an outer container, an inner bag disposed therein and a pressure equalisation opening disposed in the outer container, and a container produced according to this process, is described, wherein a pre-moulding, comprising two coaxial tubes, is first produced by co-extrusion with the help of a blow mould and with an outwardly-projecting base seam being formed. The process forms a pressure equalisation opening in the outer container without endangering the integrity of the container, wherein a lower wastage rate and higher productivity are achieved. To do this, the base seam is partially cut off and a force which acts in the direction of the seam is introduced into the pre-moulding, which has a temperature of 40 degrees C. to 70 degrees C., which force breaks open and plastically deforms the base seam so that a pressure equalisation opening is formed in the base area.

Abstract: The invention relates to a method for filling a capsule with a pharmaceutical active-substance formulation, wherein the capsule consists of two capsule parts (a capsule body and a capsule cap) and the two capsule parts, without being previously interlocked when empty, are only fitted together in a telescopic manner once one capsule part has been filled with a pharmaceutical active-substance formulation, as well as a device for this purpose.

Abstract: The present invention relates to a method, a device, and a control program for the fluid-tight sealing of capsules containing medicaments, wherein the capsules consist of at least one capsule body and a capsule cap which are set one into the other telescopically and provided with a tight band in the abutment region on the exterior side of the capsule, wherein the capsule components are filled with gas which has a changed temperature and/or a changed pressure in relation to the environment, and wherein a reduction of the difference in pressure in the capsule occurs via gaps between capsule body and capsule cap after the capsule components have been placed one inside the other. The capsules produced via the method according to the invention are disposable capsules and preferably contain a single dose of an orally administered pharmaceutical formulation in the form of a powder or a liquid.

Abstract: A process for the production of a container (1) comprising an outer container (2), an inner bag (3) disposed therein and a pressure equalisation opening (10) disposed in the outer container (2), and also a container (1) produced according to this process, is described, wherein firstly a pre-moulding, comprising two coaxial tubes, is first produced by co-extrusion with the help of a blow mould and with an outwardly-projecting base seam (5) being formed. The process is to form a pressure equalisation opening (10) in the outer container (2) of the container (1) without endangering the integrity of the container (1), wherein a lower wastage rate and higher productivity are to be achieved. This is attained by a process wherein the base seam (5) is partially cut off and a force which acts in the direction of the seam is introduced into the pre-moulding, which still has a temperature of 40° C. to 70° C.

Abstract: A process for the production of a container comprising an outer container, an inner bag disposed therein and a pressure equalisation opening disposed in the outer container, and also a container produced according to this process, is described, wherein firstly a pre-moulding, comprising two coaxial tubes, is first produced by co-extrusion with the help of a blow mould and with an outwardly-projecting base seam being formed. The process is to form a pressure equalisation opening in the outer container of the container without endangering the integrity of the container, wherein a lower wastage rate and higher productivity are to be achieved. This is attained by a process wherein the base seam is partially cut off and a force which acts in the direction of the seam is introduced into the pre-moulding, which still has a temperature of 40 degrees C. to 70 degrees C., which force breaks open and plastically deforms the base seam so that a pressure equalisation opening is formed in the base area.

Abstract: The invention relates to a powder inhaler with at least one specially sharpened needle, to ensure the precise piercing or cutting open of capsules and hence the optimum delivery of powdered medicament compositions, medicament formulations or medicament mixtures, as well as ensuring that little effort is needed to perforate or cut open the capsule.

Abstract: A process is described, for preparing a container provided with a container opening, having a substantially inherently rigid outer layer and at least one inner layer, each of a different thermoplastic plastics material. First of all a preform of at least two coaxial molten polymer tubes (2,3) which are of a sufficient length to produce the container is produced in a blow-molding method between the closed individual parts of a blow-mold (4). The rigid inflating mandrel (5) with a balloon (6) mounted thereon is passed through the mold into the interior of the preform, after which the balloon (6) is inflated in the region of the container opening, such that the minimum of two layers are pressed against the blow-mold (4) and hardened there. Finally, pressure is introduced through the inflating mandrel (5) into the interior of the preform.

Abstract: The present invention relates to capsules for housing pharmaceutical preparations for powder inhalers with increased medicinal product safety and capsules for pharmaceutical preparations for powder inhalers with improved adaption to use in powder inhalers. The capsules consist of non-water-soluble, hydrophobic plastics, which themselves do not substantially influence the pharmaceutical quality of the contents, but improve the usability of the filled capsules in respect of their operation, the period of use and/or the geographical location of their use and are advantageous in various steps from manufacture to use.

Abstract: A system for testing systems which are in turn used to test the leaktightness of a hollow body is suggested. Instead of the hollow body, a test body (2) is placed in the system which generates a defined pressure increase in a measuring chamber (4) within a pre-determined time span. This defined pressure increase corresponds exactly to the pressure increase generated by a hollow body with a small amount of leakage, wherein the hollow body can still just be regarded as leaktight. The test body can be configured as a glass capillary which extends in a sealing manner between two chambers with different air pressure. Alternatively, the test body can comprise a material which can accept a defined amount of moisture from the ambient atmosphere during storage. A vacuum formed around the test body causes moisture to be withdrawn from the test body and at least partially evaporated in the vacuum, which again leads to an increase in pressure in the chamber.

Abstract: A process for the production of a container (1) comprising an outer container (2), an inner bag (3) disposed therein and a pressure equalisation opening (10) disposed in the outer container (2), and also a container (1) produced according to this process, is described, wherein firstly a pre-moulding, comprising two coaxial tubes, is first produced by co-extrusion with the help of a blow mould and with an outwardly-projecting base seam (5) being formed. The process is to form a pressure equalisation opening (10) in the outer container (2) of the container (1) without endangering the integrity of the container (1), wherein a lower wastage rate and higher productivity are to be achieved. This is attained by a process wherein the base seam (5) is partially cut off and a force which acts in the direction of the seam is introduced into the pre-moulding, which still has a temperature of 40° C. to 70° C.

Abstract: A process for the production of a container (1) comprising an outer container (2), an inner bag (3) disposed therein and a pressure equalisation opening (10) disposed in the outer container (2), and also a container (1) produced according to this process, is described, wherein firstly a pre-moulding, comprising two coaxial tubes, is first produced by co-extrusion with the help of a blow mould and with an outwardly-projecting base seam (5) being formed. The process is to form a pressure equalisation opening (10) in the outer container (2) of the container (1) without endangering the integrity of the container (1), wherein a lower wastage rate and higher productivity are to be achieved. This is attained by a process wherein the base seam (5) is partially cut off and a force which acts in the direction of the seam is introduced into the pre-moulding, which still has a temperature of 40° C. to 70° C.

Abstract: A system for testing systems which are in turn used to test the leaktightness of a hollow body is suggested.

Abstract: A system for testing systems which are in turn used to test the leaktightness of a hollow body is suggested.

Abstract: A process for the production of a container (1) comprising an outer container (2), an inner bag (3) disposed therein and a pressure equalisation opening (10) disposed in the outer container (2), and also a container (1) produced according to this process, is described, wherein firstly a pre-moulding, comprising two coaxial tubes, is first produced by co-extrusion with the help of a blow mould and with an outwardly-projecting base seam (5) being formed. The process is to form a pressure equalisation opening (10) in the outer container (2) of the container (1) without endangering the integrity of the container (1), wherein a lower wastage rate and higher productivity are to be achieved. This is attained by a process wherein the base seam (5) is partially cut off and a force which acts in the direction of the seam is introduced into the pre-moulding, which still has a temperature of 40° C. to 70°C.

Abstract: A process for the production of a container (1) comprising an outer container (2), an inner bag (3) disposed therein and a pressure equalization opening (10) disposed in the outer container (2), and also a container (1) produced according to this process, is described, wherein firstly a pre-molding, comprising two coaxial tubes, is first produced by co-extrusion with the help of a blow mold and with an outwardly-projecting base seam (5) being formed. The process is to form a pressure equalization opening (10) in the outer container (2) of the container (1) without endangering the integrity of the container (1), wherein a lower wastage rate and higher productivity are to be achieved. This is attained by a process wherein the base seam (5) is partially cut off and a force which acts in the direction of the seam is introduced into the pre-molding, which still has a temperature of 40° C. to 70° C.