Patents by Inventor Torsten O. Nielsen
Torsten O. Nielsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230272476Abstract: The present invention provides methods for classifying and for evaluating the prognosis of a subject having breast cancer are provided. The methods include prediction of breast cancer subtype using a supervised algorithm trained to stratify subjects on the basis of breast cancer intrinsic subtype. The prediction model is based on the gene expression profile of the intrinsic genes listed in Table 1. Further provided are compositions and methods for predicting outcome or response to therapy of a subject diagnosed with or suspected of having breast cancer. These methods are useful for guiding or determining treatment options for a subject afflicted with breast cancer. Methods of the invention further include means for evaluating gene expression profiles, including microarrays and quantitative polymerase chain reaction assays, as well as kits comprising reagents for practicing the methods of the invention.Type: ApplicationFiled: September 29, 2022Publication date: August 31, 2023Inventors: Sean M. Ferree, James J. Storhoff, Joel S. Parker, Charles M. Perou, Matthew J. Ellis, Philip S. Bernard, Torsten O. Nielsen
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Publication number: 20200332368Abstract: The present invention provides methods for classifying and for evaluating the prognosis of a subject having breast cancer are provided. The methods include prediction of breast cancer subtype using a supervised algorithm trained to stratify subjects on the basis of breast cancer intrinsic subtype. The prediction model is based on the gene expression profile of the intrinsic genes listed in Table 1. Further provided are compositions and methods for predicting outcome or response to therapy of a subject diagnosed with or suspected of having breast cancer. These methods are useful for guiding or determining treatment options for a subject afflicted with breast cancer. Methods of the invention further include means for evaluating gene expression profiles, including microarrays and quantitative polymerase chain reaction assays, as well as kits comprising reagents for practicing the methods of the invention.Type: ApplicationFiled: February 14, 2020Publication date: October 22, 2020Inventors: Sean M. Ferree, James J. Storhoff, Joel S. Parker, Charles M. Perou, Matthew J. Ellis, Phillip S. Bernard, Torsten O. Nielsen
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Publication number: 20200040407Abstract: Methods for classifying and for evaluating the prognosis of a subject having breast cancer are provided. The methods include prediction of breast cancer subtype using a supervised algorithm trained to stratify subjects on the basis of breast cancer intrinsic subtype. The prediction model is based on the gene expression profile of the intrinsic genes listed in Table 1. This prediction model can be used to accurately predict the intrinsic subtype of a subject diagnosed with or suspected of having breast cancer. Further provided are compositions and methods for predicting outcome or response to therapy of a subject diagnosed with or suspected of having breast cancer. These methods are useful for guiding or determining treatment options for a subject afflicted with breast cancer.Type: ApplicationFiled: October 18, 2019Publication date: February 6, 2020Inventors: Charles M. PEROU, Joel S. PARKER, James Stephen MARRON, Andrew NOBEL, Philip S. BERNARD, Matthew J. ELLIS, Elaine MARDIS, Torsten O. NIELSEN, Maggie Chon U. CHEANG
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Publication number: 20190264290Abstract: Methods for classifying and for evaluating the prognosis of a subject having breast cancer are provided. The methods include prediction of breast cancer subtype using a supervised algorithm trained to stratify subjects on the basis of breast cancer intrinsic subtype. The prediction model is based on the gene expression profile of the intrinsic genes listed in Table 1. This prediction model can be used to accurately predict the intrinsic subtype of a subject diagnosed with or suspected of having breast cancer. Further provided are compositions and methods for predicting outcome or response to therapy of a subject diagnosed with or suspected of having breast cancer. These methods are useful for guiding or determining treatment options for a subject afflicted with breast cancer.Type: ApplicationFiled: March 14, 2019Publication date: August 29, 2019Inventors: Charles M. PEROU, Joel S. PARKER, James Stephen MARRON, Andrew NOBEL, Philip S. BERNARD, Matthew J. ELLIS, Elaine MARDIS, Torsten O. NIELSEN, Maggie Chon U. CHEANG, Robert A. PALAIS
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Patent number: 9631239Abstract: Methods for classifying and for evaluating the prognosis of a subject having breast cancer are provided. The methods include prediction of breast cancer subtype using a supervised algorithm trained to stratify subjects on the basis of breast cancer intrinsic subtype. The prediction model is based on the gene expression profile of the intrinsic genes listed in Table 1. This prediction model can be used to accurately predict the intrinsic subtype of a subject diagnosed with or suspected of having breast cancer. Further provided are compositions and methods for predicting outcome or response to therapy of a subject diagnosed with or suspected of having breast cancer. These methods are useful for guiding or determining treatment options for a subject afflicted with breast cancer.Type: GrantFiled: June 1, 2009Date of Patent: April 25, 2017Assignees: University of Utah Research Foundation, British Columbia Cancer Agency Branch, Washington University, University of North Carolina at Chapel HillInventors: Charles M. Perou, Joel S. Parker, James Stephen Marron, Andrew Nobel, Philip S. Bernard, Matthew Ellis, Elaine Mardis, Torsten O. Nielsen, Maggie Cheang
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Publication number: 20160168645Abstract: Methods for classifying and for evaluating the prognosis of a subject having breast cancer are provided. The methods include prediction of breast cancer subtype using a supervised algorithm trained to stratify subjects on the basis of breast cancer intrinsic subtype. The prediction model is based on the gene expression profile of the intrinsic genes listed in Table 1. This prediction model can be used to accurately predict the intrinsic subtype of a subject diagnosed with or suspected of having breast cancer. Further provided are compositions and methods for predicting outcome or response to therapy of a subject diagnosed with or suspected of having breast cancer. These methods are useful for guiding or determining treatment options for a subject afflicted with breast cancer.Type: ApplicationFiled: November 3, 2015Publication date: June 16, 2016Inventors: Charles M. PEROU, Joel S. Parker, James S. Marron, Andrew Nobel, Philip S. Bernard, Matthew Ellis, Elaine Mardis, Torsten O. Nielsen, Maggie Cheang
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Publication number: 20160153051Abstract: Methods for classifying and for evaluating the prognosis of a subject having breast cancer are provided. The methods include prediction of breast cancer subtype using a supervised algorithm trained to stratify subjects on the basis of breast cancer intrinsic subtype. The prediction model is based on the gene expression profile of the intrinsic genes listed in Table 1. This prediction model can be used to accurately predict the intrinsic subtype of a subject diagnosed with or suspected of having breast cancer. Further provided are compositions and methods for predicting outcome or response to therapy of a subject diagnosed with or suspected of having breast cancer. These methods are useful for guiding or determining treatment options for a subject afflicted with breast cancer.Type: ApplicationFiled: November 3, 2015Publication date: June 2, 2016Inventors: Charles M. PEROU, Joel S. Parker, James S. Marron, Andrew Nobel, Philip S. Bernard, Matthew Ellis, Elaine Mardis, Torsten O. Nielsen, Maggie Cheang
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Publication number: 20160017438Abstract: The application describes methods for screening subjects with breast cancer to determine if the breast cancer will be responsive to a breast cancer therapy including a taxane or a taxane derivative. The application also describes methods for treating subjects with breast cancer by screening them for the likelihood of the effectiveness of treating the cancer with a therapy including a taxane or a taxane derivative and administering the therapy in subjects when it is found that a taxane or a taxane derivative is likely to be effective.Type: ApplicationFiled: August 17, 2015Publication date: January 21, 2016Inventors: Charles M. Perou, Philip S. Bernard, Torsten O. Nielsen, Matthew J. Ellis, Joel S. Parker, Miguel Martin, Eva Carrasco, Rosalia Caballero
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Patent number: 9181588Abstract: The application describes methods for screening subjects with breast cancer to determine if the breast cancer will be responsive to a breast cancer therapy including a taxane or a taxane derivative. The application also describes methods for treating subjects with breast cancer by screening them for the likelihood of the effectiveness of treating the cancer with a therapy including a taxane or a taxane derivative and administering the therapy in subjects when it is found that a taxane or a taxane derivative is likely to be effective.Type: GrantFiled: November 30, 2012Date of Patent: November 10, 2015Assignees: The University of Utah Research Foundation, British Columbia Cancer Agency Branch, Washington University, The University of North Carolina at Chapel Hill, Bioclassifier, LLCInventors: Charles M. Perou, Philip S. Bernard, Torsten O. Nielsen, Matthew J. Ellis, Joel S. Parker, Miguel Martin, Eva Carrasco, Rosalia Caballero
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Publication number: 20150252440Abstract: The application describes methods for screening subjects with breast cancer to determine if the breast cancer will be responsive to a breast cancer therapy including an anthracycline. The application also describes methods for treating subjects with breast cancer by screening them for the likelihood of the effectiveness of treating the cancer with a therapy including anthracycline and administering the therapy in subjects when it is found that anthracycline is likely to be effective.Type: ApplicationFiled: May 20, 2015Publication date: September 10, 2015Inventors: Charles M. Perou, Matthew J. Ellis, Philip S. Bernard, Torsten O. Nielsen
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Patent number: 9066963Abstract: The application describes methods for screening subjects with breast cancer to determine if the breast cancer will be responsive to a breast cancer therapy including an anthracycline. The application also describes methods for treating subjects with breast cancer by screening them for the likelihood of the effectiveness of treating the cancer with a therapy including anthracycline and administering the therapy in subjects when it is found that anthracycline is likely to be effective.Type: GrantFiled: March 15, 2012Date of Patent: June 30, 2015Assignees: The University of North Carolina at Chapel Hill, Washington University, University of Utah Research Foundation, British Columbia Cancer Agency BranchInventors: Charles M. Perou, Matthew J. Ellis, Philip S. Bernard, Torsten O. Nielsen
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Publication number: 20150072021Abstract: The application describes methods and kits for screening subjects with breast cancer to determine if the breast cancer will be responsive to a post-mastectomy breast cancer therapy including radiation. The application further describes methods and kits for treating subjects with post-mastectomy breast cancer by screening them for the likelihood of the effectiveness of treating the cancer with a therapy including radiation and administering the therapy in subjects when it is found that radiation is likely to be effective.Type: ApplicationFiled: September 9, 2014Publication date: March 12, 2015Inventors: Maggie Chon U. Cheang, Torsten O. Nielsen, Charles M. Perou, Matthew J. Ellis, Philip S. Bernard
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Publication number: 20140037620Abstract: The application describes methods for predicting overall survival in subjects with breast cancer. The application also describes for screening subjects with breast cancer to determine if the breast cancer will be responsive to a breast cancer therapy including gemcitabine. The application further describes methods for treating subjects with breast cancer by screening them for the likelihood of the effectiveness of treating the cancer with a therapy including gemcitabine and administering the therapy in subjects when it is found that gemcitabine is likely to be effective.Type: ApplicationFiled: June 28, 2013Publication date: February 6, 2014Inventors: Sean M. Ferree, J. Wayne Cowens, Charlotte Levin Tykjaer Jorgensen, Torsten O. Nielsen, Bent Ejlertsen
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Publication number: 20130345161Abstract: The application describes methods for screening subjects with breast cancer to determine if the breast cancer will be responsive to a breast cancer therapy including a taxane or a taxane derivative. The application also describes methods for treating subjects with breast cancer by screening them for the likelihood of the effectiveness of treating the cancer with a therapy including a taxane or a taxane derivative and administering the therapy in subjects when it is found that a taxane or a taxane derivative is likely to be effective.Type: ApplicationFiled: November 30, 2012Publication date: December 26, 2013Inventors: Charles M. Perou, Philip S. Bernard, Torsten O. Nielsen, Matthew J. Ellis, Joel S. Parker, Miguel Martin, Eva Carrasco, Rosalia Caballero
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Publication number: 20130004482Abstract: The application describes methods for screening subjects with breast cancer to determine if the breast cancer will be responsive to a breast cancer therapy including an anthracycline. The application also describes methods for treating subjects with breast cancer by screening them for the likelihood of the effectiveness of treating the cancer with a therapy including anthracycline and administering the therapy in subjects when it is found that anthracycline is likely to be effective.Type: ApplicationFiled: March 15, 2012Publication date: January 3, 2013Applicants: The University of North Carolina at Chapel Hill, British Columbia Cancer Agency Branch, University of Utah Research Foundation, Washington UniversityInventors: Charles M. Perou, Matthew J. Ellis, Philip S. Bernard, Torsten O. Nielsen
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Publication number: 20110145176Abstract: Methods for classifying and for evaluating the prognosis of a subject having breast cancer are provided. The methods include prediction of breast cancer subtype using a supervised algorithm trained to stratify subjects on the basis of breast cancer intrinsic subtype. The prediction model is based on the gene expression profile of the intrinsic genes listed in Table 1. This prediction model can be used to accurately predict the intrinsic subtype of a subject diagnosed with or suspected of having breast cancer. Further provided are compositions and methods for predicting outcome or response to therapy of a subject diagnosed with or suspected of having breast cancer. These methods are useful for guiding or determining treatment options for a subject afflicted with breast cancer.Type: ApplicationFiled: June 1, 2009Publication date: June 16, 2011Inventors: Charles M. Perou, Joel S. Parker, James Stephen Marron, Andrew Nobel, Philip S. Bernard, Matthew Ellis, Elaine Mardis, Torsten O. Nielsen, Maggie Cheang
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Publication number: 20020164801Abstract: The present invention relates to a human or mammalian DNA replication origin consensus sequence which consists of a sequence selected from the group consisting of CCTMDAWKSGBYTSMAAWYWBCMYTTRSCAAATTCC (SEQ ID NO: 1); and AWMTWAAKRAWRWWKKDAVWWGAKRWWKWVWHRASSACMDWKAAKTWKGGWTWARRYWKGRKMWWTWKAWSDATAKWWWKDAKWKMWRKTT (SEQ ID NO: 4). A method for the control of initiation of mammalian DNA replication which comprises the steps of: a) inserting a consensus sequence coding for a sequence of the present invention together with a DNA fragment to form a vector capable of expression of the DNA fragment; b) introducing the vector of step a) into mammalian cells in vitro.Type: ApplicationFiled: March 6, 2002Publication date: November 7, 2002Inventors: Gerald B. Price, Maria Zannis-Hadjopoulos, Torsten O. Nielsen, Nandini H. Cossons
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Patent number: 6410722Abstract: The present invention relates to a human or mammalian DNA replication origin consensus sequence which consists of a sequence selected from the group consisting of CCTMDAWKSGBYTSMAAWYWBCMYTTRSCAAATTCC (SEQ ID NO:1); and AWMTWAAKRAWRWWKKDAVWWGAKRWWKWVWHRASSACMDWKAAKTWKGGWTWARRYWKGRKMWWTWKAWSDATAKWWWKDAKWKMWRKTT (SEQ ID NO:4). A method for the control of initiation of mammalian DNA replication which comprises the steps of: a) inserting a consensus sequence coding for a sequence of the present invention together with a DNA fragment to form a vector capable of expression of the DNA fragment; b) introducing the vector of step a) into mammalian cells in vitro.Type: GrantFiled: June 9, 1999Date of Patent: June 25, 2002Assignee: McGill UniversityInventors: Gerald B. Price, Maria Zannis-Hadjopoulos, Torsten O. Nielsen, Nandini H. Cossons