Patents by Inventor Torsten Schultz-Fademrecht
Torsten Schultz-Fademrecht has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11572385Abstract: It is disclosed an improved multi-step process for the preparation of a highly concentrated liquid formulation containing biomolecules comprising the steps of (a) a first ultrafiltration UF1; (b) a first diafiltration DF1; (c) a second diafiltration DF2; and (d) a second ultrafiltration UF2; wherein an aqueous solution of one or more salts, as liquid medium B, is used for step (b) and water or an aqueous solution of one or more salts, as liquid medium C, is used for step (c), wherein the one or more salts used for step (b) are the same or different from the one or more salts used for step (c) and wherein the liquid medium B has an ionic strength which is higher than the ionic strength of the liquid medium C. The process according to the present invention allows the preparation of well-defined highly concentrated formulations containing biomolecules, particularly proteins, intended for pharmaceutical or non-pharmaceutical use.Type: GrantFiled: August 11, 2017Date of Patent: February 7, 2023Assignee: Boehringer Ingelheim International GmbHInventors: Patrick Garidel, Sven Bahrenburg, Torsten Schultz-Fademrecht, Andrea Eiperle
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Publication number: 20210317201Abstract: The present invention relates to anti-IL-23p19 binding compounds, in particular new humanized anti-IL-23p19 antibodies, pharmaceutical compositions and therapeutic and diagnostic methods and compositions for using the same.Type: ApplicationFiled: June 23, 2021Publication date: October 14, 2021Applicant: Boehringer Ingelheim International GmbHInventors: Gerald Henry NABOZNY, Annette Bettina GALLER, Patrick GARIDEL, William Troy LOGING, Steven John PADULA, Torsten SCHULTZ-FADEMRECHT, Elaine Ee-Ling WANG
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Patent number: 11078265Abstract: The present invention relates to anti-IL-23p19 binding compounds, in particular new humanized anti-IL-23p19 antibodies, pharmaceutical compositions and therapeutic and diagnostic methods and compositions for using the same.Type: GrantFiled: April 25, 2013Date of Patent: August 3, 2021Assignee: Boehringer Ingelheim International GmbHInventors: Gerald Henry Nabozny, Annette Bettina Galler, Patrick Garidel, William Troy Loging, Steven John Padula, Torsten Schultz-Fademrecht, Elaine Ee-Ling Wang
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Publication number: 20210070852Abstract: The present disclosure inter alia provides a liquid pharmaceutical formulation comprising a) 150 mg/ml of an anti-IL-23p19 antibody, wherein the antibody comprises a light chain amino acid sequence according to SEQ ID NO: 1 and a heavy chain amino acid sequence according to SEQ ID NO: 2; b) a polyol; and c) a surfactant. The disclosed high concentration formulations are advantageously storage stable and suitable for subcutaneous administration.Type: ApplicationFiled: September 8, 2020Publication date: March 11, 2021Applicant: Boehringer Ingelheim International GmbHInventors: Patrick Garidel, Torsten SCHULTZ-FADEMRECHT
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Publication number: 20190309016Abstract: It is disclosed an improved multi-step process for the preparation of a highly concentrated liquid formulation containing biomolecules comprising the steps of (a) a first ultrafiltration UF1; (b) a first diafiltration DF1; (c) a second diafiltration DF2; and (d) a second ultrafiltration UF2; wherein an aqueous solution of one or more salts, as liquid medium B, is used for step (b) and water or an aqueous solution of one or more salts, as liquid medium C, is used for step (c), wherein the one or more salts used for step (b) are the same or different from the one or more salts used for step (c) and wherein the liquid medium B has an ionic strength which is higher than the ionic strength of the liquid medium C. The process according to the present invention allows the preparation of well-defined highly concentrated formulations containing biomolecules, particularly proteins, intended for pharmaceutical or non-pharmaceutical use.Type: ApplicationFiled: August 11, 2017Publication date: October 10, 2019Inventors: Patrick GARIDEL, Sven BAHRENBURG, Torsten SCHULTZ-FADEMRECHT, Andrea EIPERLE
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Patent number: 9753021Abstract: The invention concerns the field of biomolecule formulation screening and stability testing. It concerns a method for the evaluation of the colloidal stability of liquid biopolymer solutions. The present invention describes a method for determining the stability of a liquid pharmaceutical composition comprising: a) providing a liquid pharmaceutical composition in a container, b) shaking said container on a shaker, whereby the shaker performs an oloid movement, c) determining the stability of said liquid pharmaceutical composition.Type: GrantFiled: February 27, 2013Date of Patent: September 5, 2017Assignee: Boehringer Ingelheim International GmbHInventors: Patrick Garidel, Thomas Hennes, Torsten Schultz-Fademrecht
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Publication number: 20150015886Abstract: The invention concerns the field of biomolecule formulation screening and stability testing. It concerns a method for the evaluation of the colloidal stability of liquid biopolymer solutions. The present invention describes a method for determining the stability of a liquid pharmaceutical composition comprising: a) providing a liquid pharmaceutical composition in a container, b) shaking said container on a shaker, whereby the shaker performs an oloid movement, c) determining the stability of said liquid pharmaceutical composition.Type: ApplicationFiled: February 27, 2013Publication date: January 15, 2015Applicant: Boehringer Ingelheim International GMBHInventors: Patrick Garidel, Thomas Hennes, Torsten Schultz-Fademrecht
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Publication number: 20140178401Abstract: The present invention relates to anti-IL-23p19 binding compounds, in particular new humanized anti-IL-23p19 antibodies, pharmaceutical compositions and therapeutic and diagnostic methods and compositions for using the same.Type: ApplicationFiled: April 25, 2013Publication date: June 26, 2014Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventors: Gerald Henry NABOZNY, Annette Bettina GALLER, Patrick GARIDEL, William Troy LOGING, Steven John PADULA, Torsten SCHULTZ-FADEMRECHT, Elaine Ee-Ling WANG
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Publication number: 20130199734Abstract: The invention relates to a method for preparing highly concentrated liquid protein formulations. They are prepared by concentrating a protein solution by carrier gas drying at a reduced process pressure.Type: ApplicationFiled: August 2, 2012Publication date: August 8, 2013Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventors: Torsten SCHULTZ-FADEMRECHT, Stefan BASSARAB, Patrick GARIDEL
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Patent number: 8226982Abstract: The invention therefore relates to protein-containing powders, wherein the proportion of phenylalanine is at least 30% (w/w), or at least 40% (w/w). It has been shown that phenylalanine-containing powders, particularly after spray drying, are very suitable in terms of their aerodynamic characteristics and protein stabilization for preparing powders or protein compositions with improved aerodynamic properties. The main component is phenylalanine and the optional further component is an excipient which has good water-solubility compared with phenylalanine, preferably a sugar or a polyol.Type: GrantFiled: June 22, 2007Date of Patent: July 24, 2012Assignee: Boehringer Ingelheim Pharma GmbH & Co. KGInventors: Torsten Schultz-Fademrecht, Patrick Garidel, Beate Fischer, Karoline Bechtold-Peters
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Publication number: 20100143331Abstract: The invention relates to a method for preparing powder mixtures, one component consisting of spray-dried powder. The invention also relates to a method for coating spray-dried particles with nanoscale particles, a method for mixing spray-dried powder with microscale particles and a method for covering carrier substances with spray-dried particles.Type: ApplicationFiled: November 8, 2007Publication date: June 10, 2010Applicant: BOEHRINGER INGELHEIM PHARMA GMBH & CO. KGInventors: Torsten Schultz-Fademrecht, Sandra Zimontkowski, Patrick Garidel, Hans-Joachim Kern, Klaus-Juergen Steffens
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Patent number: 7727962Abstract: The present invention concerns powders containing a pharmaceutical active substance and a combination of excipients comprising at least one 1,4 O-linked saccharose derivative selected from the compounds: 1,4 O-linked D-Gal-saccharose (lactosucrose), 1,4 O-linked D-Glu-saccharose (glucosyl sucrose), or 1,4 O-linked Glu-Glu-saccharose (maltosyl sucrose) in combination with at least one further excipient. The other excipient is preferably an amino acid, a peptide and/or a mono-, di- and/or oligosaccharide, wherein the oligosaccharide may be a second 1,4 O-linked saccharose derivative, provided that this is different from the first.Type: GrantFiled: May 2, 2005Date of Patent: June 1, 2010Assignee: Boehringer Ingelheim Pharma GmbH & Co. KGInventors: Stefan Bassarab, Karoline Bechtold-Peters, Richard Fuhrherr, Wolfgang Friess, Patrick Garidel, Torsten Schultz-Fademrecht
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Patent number: 7723306Abstract: The present invention relates to a spray-dried powder and method for its manufacture. A spray dried powder containing a pharmaceutical active substance and one or more 1,4 O-linked saccharose derivatives chosen from the compounds: 1,4 O-linked D-gal-saccharose (lactosucrose), 1,4 O-linked D-glu-saccharose (glucosyl sucrose) or 1,4 O-linked glu-glu-saccharose (maltosyl sucrose). Preferred combinations are such that they contain glucosyl and maltosyl sucrose.Type: GrantFiled: May 2, 2005Date of Patent: May 25, 2010Assignee: Boehringer Ingelheim Pharma GmbH & Co. KGInventors: Stefan Bassarab, Karoline Bechtold-Peters, Richard Fuhrherr, Wolfgang Friess, Patrick Garidel, Torsten Schultz-Fademrecht
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Patent number: 7611709Abstract: Disclosed are applications of oligosaccharides/oligosaccharide mixtures for the production and stabilization of pharmaceutical compositions, chiefly powders, that contain antibodies or antibody derivatives as pharmaceutical active substance. The production of powders is accomplished through spray drying or freeze drying. Also disclosed are the corresponding antibody-containing powders as well as processes for their production.Type: GrantFiled: May 2, 2005Date of Patent: November 3, 2009Assignee: Boehringer Ingelheim Pharma GmbH and Co. KGInventors: Stefan Bassarab, Karoline Bechtold-Peters, Richard Fuhrherr, Wolfgang Friess, Patrick Garidel, Torsten Schultz-Fademrecht
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Publication number: 20080089849Abstract: The invention therefore relates to protein-containing powders, wherein the proportion of phenylalanine is at least 30% (w/w), or at least 40% (w/w). It has been shown that phenylalanine-containing powders, particularly after spray drying, are very suitable in terms of their aerodynamic characteristics and protein stabilisation for preparing powders or protein compositions with improved aerodynamic properties. The main component is phenylalanine and the optional further component is an excipient which has good water-solubility compared with phenylalanine, preferably a sugar or a polyol.Type: ApplicationFiled: June 22, 2007Publication date: April 17, 2008Inventors: Torsten SCHULTZ-FADEMRECHT, Patrick Garidel, Beate Fischer, Karoline Bechtold-Peters
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Publication number: 20080071064Abstract: The invention relates to the controlled crystallisation of powders, particularly spray-dried powders, for improving the flowability and the aerodynamic characteristics thereof and a method of reducing the electrostatics of a powder.Type: ApplicationFiled: June 22, 2007Publication date: March 20, 2008Inventors: Torsten SCHULTZ-FADEMRECHT, Patrick GARIDEL, Beate FISCHER, Karoline BECHTOLD-PETERS
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Publication number: 20070298116Abstract: The present invention relates to spray-dried amorphous powders which contain a pharmaceutical active substance and a matrix-forming agent, preferably a polymer, sugar or sugar alcohol in an amount of ?20-60% (w/w). The powders have a moisture content which is less than 1.2% (w/w), preferably less than 1% (w/w). The present invention also relates to special methods of preparing such powders and methods of administering them by inhalation.Type: ApplicationFiled: August 10, 2004Publication date: December 27, 2007Applicant: Boehringer Ingelheim Pharma GmbH & Co. KGInventors: Karoline Bechtold-Peters, Wolfgang Friess, Stefanie Schuele, Stefan Bassarab, Patrick Garidel, Torsten Schultz-Fademrecht
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Publication number: 20050255119Abstract: The present invention relates to compositions, preferably powdered compositions such as spray-dried or freeze-dried powders, containing an antibody or and antibody derivative and one or more 1,4 O-linked saccharose derivatives chosen from the compounds: 1,4 O-linked D-gal-saccharose (lactosucrose), 1,4 O-linked D-glu-saccharose (glucosyl sucrose) or 1,4 O-linked glu-glu-saccharose (maltosyl sucrose). Preferred combinations are those which contain lactosucrose or a combination of glucosyl and maltosyl sucrose.Type: ApplicationFiled: May 2, 2005Publication date: November 17, 2005Applicant: Boehringer Ingelheim Pharma GmbH & Co. KGInventors: Stefan Bassarab, Karoline Bechtold-Peters, Richard Fuhrherr, Wolfgang Friess, Patrick Garidel, Torsten Schultz-Fademrecht
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Publication number: 20050250704Abstract: The present invention concerns powders containing a pharmaceutical active substance and a combination of excipients comprising at least one 1,4 O-linked saccharose derivative selected from the compounds: 1,4 O-linked D-Gal-saccharose (lactosucrose), 1,4 O-linked D-Glu-saccharose (glucosyl sucrose), or 1,4 O-linked Glu-Glu-saccharose (maltosyl sucrose) in combination with at least one further excipient. The other excipient is preferably an amino acid, a peptide and/or a mono-, di- and/or oligosaccharide, wherein the oligosaccharide may be a second 1,4 O-linked saccharose derivative, provided that this is different from the first.Type: ApplicationFiled: May 2, 2005Publication date: November 10, 2005Applicant: Boehringer Ingelheim Pharma GmbH & Co. KGInventors: Stefan Bassarab, Karoline Bechtold-Peters, Richard Fuhrherr, Wolfgang Friess, Patrick Garidel, Torsten Schultz-Fademrecht
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Publication number: 20050250705Abstract: The present invention relates to a spray-dried powder and method for its manufacture. A spray dried powder containing a pharmaceutical active substance and one or more 1,4 O-linked saccharose derivatives chosen from the compounds: 1,4 O-linked D-gal-saccharose (lactosucrose), 1,4 O-linked D-glu-saccharose (glucosyl sucrose) or 1,4 O-linked glu-glu-saccharose (maltosyl sucrose). Preferred combinations are such that they contain glucosyl and maltosyl sucrose.Type: ApplicationFiled: May 2, 2005Publication date: November 10, 2005Applicant: Boehringer Ingelheim Pharma GmbH Co. KGInventors: Stefan Bassarab, Karoline Bechtold-Peters, Richard Fuhrherr, Wolfgang Friess, Patrick Garidel, Torsten Schultz-Fademrecht