Abstract: The invention relates to a reaction vessel, a device and a method for detecting specific interactions between molecular target and probe molecules. The present invention especially relates to a reaction vessel which has a shape and size typical of a laboratory reaction vessel and in which a supporting element with probe molecules immobilised thereon on predetermined regions is arranged on its base surfaces.

Abstract: Disclosed are devices for holding a substance library carrier, and which are useful in conducting reactions in which binding between complementary molecules is measured qualitatively or quantitatively. Also disclosed are methods for conducting such reactions in the device.

Abstract: A sensor chip having at least upstream from the sensor region, at least one potential surface that, by electrical interaction with the contaminants in the flowing medium, prevents precipitation in the sensor region.

Abstract: A sensor chip exposed to a flowing medium is provided with an additional heater situated upstream and at a definite distance from the sensor area, resulting in the impurities in the flowing medium being deposited in the area of the additional heater, and in the impurities being unable to reach the sensor area.

Abstract: The present invention relates to novel thin layers for microsystem techniques and microstructuring. It is an object of the invention to provide thin layers which can be manufactured under less problems and more economically than the previous conventional layers, and which permit the use of existing technologies for microstructuring. The object is realized in that the thin layer is formed of an enzymatically degradable biopolymer in a range of layer thicknesses of from 30 nm to 3 &mgr;m. Biopolymeric thin layers manufactured according to the invention permit their application, after a respective structurizing, as test assays or in setting up substance libraries.

Abstract: Disclosed is a method for qualitative and/or quantitative detection of nucleic acid molecules amplified in an amplification reaction such as PCR. The change of the mass of oligonucleotides in an amplification solution, comprising the mass of target DNA and optionally, the mass of oligonucleotide primers, is determined during the amplification reaction. Also disclosed is a device for conducting the method.

Abstract: A system and method for standardizing data on a plurality of electronic devices. The system comprises: an intermediate server on which is stored a plurality of characterizations, wherein the plurality of characterizations includes a separate characterization for each of the plurality of electronic devices. The intermediate server comprises: a service provider that forwards a request from one of the plurality of electronic devices to one or more back-end software modules and for receiving data from the one or more back-end software modules; an auxiliary data management module that combines the data with an auxiliary data source in order to form a combined data feed; and a data transformation module for transforming the combined data feed in accordance with one of the characterizations.

Abstract: A method for cleaning of a measuring element (1) passed over by a gas flow is arranged on a thin-walled membranous material (5). The measuring element (1) includes at least one heatable element (6, 7, 8; 10, 11), which is arranged on the membranous material, the membranous material being capable of vibrating. By means of a control apparatus (20) or a switching (22) associated with the measuring element, a periodic delivery of current (41, 42) in intervals takes place in this manner to at least one heatable element (6, 7, 8; 10, 11) of the measuring element (1) and thereby produces vibrations. Alternatively, vibrations of the membranous material (5) can be produced by special vibration exciters or by means of ultrasonic coupling.

Abstract: The invention relates to a method for qualitatively and/or quantitatively detecting certain molecular targets using probe arrays. The inventive detection method comprises a reaction which delivers a product with a particular solubility product, this solubility product causing the precipitation or the formation of a precipitate of the product on an array element of the probe array on which an interaction has taken place between the probe and the target.

Abstract: A bath for generating microstructures which is required in numerous fields of application of the microsystem technique and in microstructuring offers a less expensive alternative to known conventional approaches and disposal of the used bath may be carried out in a manner more environmentally friendly manner than in the previous methods for manufacture of microstructures. The bath includes at least one biogenic agent (in particular, an enzyme) which acts upon a preselectable thin layer.

Abstract: Method for identifying a novel biologically active substance, which is based on defining the targeted property of the substance and selecting a reference organism, naturally displaying the targeted property.

Abstract: A system and method for standardizing data on a plurality of electronic devices. The system comprises: an intermediate server on which is stored a plurality of characterizations, wherein the plurality of characterizations includes a separate characterization for each of the plurality of electronic devices. The intermediate server comprises: a service provider that forwards a request from one of the plurality of electronic devices to one or more back-end software modules and for receiving data from the one or more back-end software modules; an auxiliary data management module that combines the data with an auxiliary data source in order to form a combined data feed; and a data transformation module for transforming the combined data feed in accordance with one of the characterizations.

Abstract: In a sensor chip according to the existing art, contaminants in the medium flowing past the sensor chip result in deposits in the sensor region.

Abstract: A bath for generating microstructures which is required in numerous fields of application of the microsystem technique and in microstructuring offers a less expensive alternative to known conventional approaches and disposal of the used bath may be carried out in a manner more environmentally friendly manner than in the previous methods for manufacture of microstructures. The bath includes at least one biogenic agent (in particular, an enzyme) which acts upon a preselectable thin layer.

Abstract: In the case of a sensor chip according to the related art, impurities in a flowing medium may be deposited in the area of a sensor area and may permanently soil it, resulting in a negative effect on the measurement response of the membrane.

Abstract: The invention relates to a method for producing structured, self-organized molecular monolayers of individual molecular species. The invention is preferably used to create solid-phase bonded substance libraries. To this end, a) a substrate (2) suitable for the first monolayer is provided; b) a microstructured polymer mask (1) having openings is applied to the subtrate (2) at least once in a defined direction.

Abstract: The invention relates to a miniaturized fluid flow switch which enables a directed deflection or deviation of a fluidic test current injected into a fluidic carrier current. The aim of the invention it to provide a fluid flow switch which does not require any moveable parts and with which no restricting preconditions exist with regard to the fluid media to be used. To this end, the inventive switch is comprised of at least two carrier current channels (11, 12) and of a test current channel (2) which, together, open into a distribution chamber (3) to which at least two discharge channels (41, 42) connect. The carrier current channels (11, 12) are connected to a common inlet (10), and at least the carrier current channels (11, 12) are respectively placed, in particle sections, in close thermal contact with controllable heating devices (5).

Abstract: The aim of the invention is to provide a device for duplicating and characterizing nucleic acids almost simultaneously and with a high sample throughput rate. The device consists of a chamber body with a recess whose edge sealingly holds an optically transparent chip. Said chip holds nucleic acids in individual spots on a detection surface. The chamber body is placed on an optically transparent chamber support with a bearing surface, in such a way that a capillary gap, which can be filled with a liquid sample, is formed between the detection surface of the chip facing towards the chamber support and said chamber support. The chamber body is provided with an inlet and an outlet, which are spatially separate from each other, and has a space, which laterally encompasses the chip and which has a gas reservoir. The chamber support is provided with heating elements.

Abstract: The present invention relates to novel baths for generating microstructures which are required in numerous fields of application of the microsystem technique and in microstructuring. It is an object of the invention to provide novel baths for generating microstructures which offer a less expensive and, above all, a solution for their disposal which is more friendly to environment than the previous methods for manufacture of microstructures. The object is realized in that the respective baths are added at least one biogenic catalyst (in particular, an enzyme) which acts upon a preselectable thin layer.

Abstract: The invention relates to a method for producing structured, self-organized molecular monolayers of individual molecular species. The invention is preferably used to create solid-phase bonded substance libraries. To this end, a) a substrate (2) suitable for the first monolayer is provided; b) a microstructured polymer mask (1) having openings is applied to the subtrate (2) at least once in a defined direction.