Patents by Inventor Toru Esaki
Toru Esaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220162208Abstract: The present invention provides compounds represented by formula (1) below and pharmacologically acceptable salts thereof: wherein R1, R2, R3, and R4 are as defined in the claims.Type: ApplicationFiled: May 25, 2021Publication date: May 26, 2022Applicant: Chugai Seiyaku Kabushiki KaishaInventors: Yoshikazu NISHIMURA, Toru ESAKI, Tatsuya TAMURA
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Publication number: 20210024524Abstract: The present invention provides compounds represented by formula (1) below and pharmacologically acceptable salts thereof: wherein R1, R2, R3, and R4 are as defined in the claims.Type: ApplicationFiled: February 28, 2020Publication date: January 28, 2021Applicant: Chugai Seiyaku Kabushiki KaishaInventors: Yoshikazu Nishimura, Toru Esaki, Tatsuya Tamura
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Publication number: 20180237436Abstract: The present invention provides compounds represented by formula (1) below and pharmacologically acceptable salts thereof: wherein R1, R2, R3, and R4 are as defined in the claims.Type: ApplicationFiled: December 20, 2017Publication date: August 23, 2018Applicant: Chugai Seiyaku Kabushiki KaishaInventors: Yoshikazu Nishimura, Toru Esaki, Tatsuya Tamura
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Publication number: 20160326175Abstract: The present invention provides compounds represented by formula (1) below and pharmacologically acceptable salts thereof:Type: ApplicationFiled: July 20, 2016Publication date: November 10, 2016Applicant: Chugai Seiyaku Kabushiki KaishaInventors: Yoshikazu Nishimura, Toru Esaki, Tatsuya Tamura
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Patent number: 9487517Abstract: The present invention relates to a compound represented by the following formula (1): wherein W, X, Y, R1, R2, R33, R34, m and n are as defined in the claims, or a pharmacologically acceptable salt thereof.Type: GrantFiled: September 17, 2015Date of Patent: November 8, 2016Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Toru Esaki, Yoshikazu Nishimura, Yoshiaki Isshiki, Naoki Okamoto, Yoshiyuki Furuta, Akemi Mizutani, Masateru Ohta, Wayne Wen Lai, Tomoya Kotake
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Patent number: 9428505Abstract: The present invention provides compounds represented by formula (1) below and pharmacologically acceptable salts thereof: wherein R1, R2, R3, and R4 are as defined in the claims.Type: GrantFiled: December 10, 2013Date of Patent: August 30, 2016Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Yoshikazu Nishimura, Toru Esaki, Tatsuya Tamura
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Publication number: 20160016956Abstract: The present invention relates to a compound represented by the following formula (1): wherein W, X, Y, R1, R2, R33, R34, m and n are as defined in the claims, or a pharmacologically acceptable salt thereof.Type: ApplicationFiled: September 17, 2015Publication date: January 21, 2016Applicant: Chugai Seiyaku Kabushiki KaishaInventors: Toru Esaki, Yoshikazu NISHIMURA, Yoshiaki ISSHIKI, Naoki OKAMOTO, Yoshiyuki FURUTA, Akemi MIZUTANI, Masateru OHTA, Wayne Wen LAI, Tomoya KOTAKE
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Patent number: 9169254Abstract: The present invention relates to a compound represented by the following formula (1): wherein W, X, Y, R1, R2, R33, R34, m and n are as defined in the claims, or a pharmacologically acceptable salt thereof.Type: GrantFiled: April 27, 2010Date of Patent: October 27, 2015Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Toru Esaki, Yoshikazu Nishimura, Yoshiaki Isshiki, Naoki Okamoto, Yoshiyuki Furuta, Akemi Mizutani, Masateru Ohta, Wayne Wen Lai, Tomoya Kotake
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Publication number: 20150274727Abstract: The present invention provides compounds represented by formula (1) below and pharmacologically acceptable salts thereof: wherein R1, R2, R3, and R4 are as defined in the claims.Type: ApplicationFiled: December 10, 2013Publication date: October 1, 2015Applicant: Chugai Seiyaku Kabushiki KaishaInventors: Yoshikazu Nishimura, Toru Esaki, Tatsuya Tamura
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Publication number: 20120270838Abstract: The present invention relates to a compound represented by the following formula (1): wherein W, X, Y, R1, R2, R33, R34, m and n are as defined in the claims, or a pharmacologically acceptable salt thereof.Type: ApplicationFiled: April 27, 2010Publication date: October 25, 2012Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHAInventors: Toru Esaki, Yoshikazu Nishimura, Yoshiaki Isshiki, Naoki Okamoto, Yoshiyuki Furuta, Akemi Mizutani, Masateru Ohta, Wayne Wen Lai, Tomoya Kotake
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Patent number: 6887890Abstract: The compounds of the invention are compounds represented by the following general formula (1): wherein E represents one selected from the group consisting of a methylidyne group and a nitrilo group, R1 represents one selected from the group consisting of optionally substituted aryl groups and optionally substituted heteroaryl groups, R2 represents one selected from the group consisting of a hydrogen atom and alkyl groups, W1 represents an amino acid residue, A represents one selected from the group consisting of a carbonyl group and a sulfonyl group, X1 represents one selected from the group consisting of optionally substituted alkylene groups and optionally substituted alkenylene groups, and p represents 0 or 1; and their pharmacologically acceptable salts, which exhibit thrombopoietin-like activity.Type: GrantFiled: May 30, 2001Date of Patent: May 3, 2005Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Shinya Fujiwara, Tomokazu Ozaki, Toshiro Kozono, Kunihiro Hattori, Toru Esaki
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Patent number: 6716628Abstract: A chondrogenesis promoter comprising as an active ingredient a compound represented by general formula (I) or a salt thereof: wherein R1 represents a halogen atom, a lower alkyl group, a lower alkoxy group, etc.; R2 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower alkoxy group, an acyl group, an aryl group, a heterocyclic group, etc.; R3 represents a lower alkyl group, a cycloalkyl group, an aryl group, a heterocyclic group, etc.; R4 represents a hydrogen atom, a lower alkyl group, an aryl group, a heterocyclic group, etc.; X and Y represent —CH2—, —NH— or —O—; and n represents an integer of 0-4.Type: GrantFiled: August 21, 2002Date of Patent: April 6, 2004Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Hidetomo Kitamura, Atsuhiko Kato, Toru Esaki
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Publication number: 20030162724Abstract: The compounds of the invention are compounds represented by the following general formula (1): 1Type: ApplicationFiled: November 27, 2002Publication date: August 28, 2003Inventors: Shinya Fujiwara, Tomokazu Ozaki, Toshiro Kozono, Kunihiro Hattori, Toru Esaki
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Publication number: 20030119896Abstract: A chondrogenesis promoter comprising as an active ingredient a compound represented by general formula (I) or a salt thereof: 1Type: ApplicationFiled: August 21, 2002Publication date: June 26, 2003Applicant: Chugai Seiyaku Kabushiki KaishaInventors: Hidetomo Kitamura, Atsuhiko Kato, Toru Esaki
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Patent number: 6500854Abstract: A chondrogenesis promoter comprising as an active ingredient a compound represented by general formula (I) or a salt thereof: wherein R1 represents a halogen atom, a lower alkyl group, a lower alkoxy group, etc.; R2 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower alkoxy group, an acyl group, an aryl group, a heterocyclic group, etc.; R1 represents a lower alkyl group, a cycloalkyl group, an aryl group, a heterocyclic group, etc.; R4 represents a hydrogen atom, a lower alkyl group, an aryl group, a heterocyclic group, etc.; X and Y represent —CH2—, —NH—or —O—; and n represents an integer of 0-4.Type: GrantFiled: September 21, 2001Date of Patent: December 31, 2002Assignee: Chugai Sei Yaku Kabushiki KaishaInventors: Hidetomo Kitamura, Atsuhiko Kato, Toru Esaki
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Patent number: 6331553Abstract: Compounds represented by the general formula (1): (where R1 and R2 are typically a hydrogen atom; R3 and R4 are typically a hydrogen atom or a lower alkyl group; R5 is typically a hydrogen atom; X1, X2, X3 and X4 are typically a hydrogen atom or a lower alkoxy group; A is typically an optionally substituted pyridine ring; m and n are each 0 or 1) have an NOS inhibiting activity and are useful as therapeutics of cerebrovascular diseases and other pharmaceuticals.Type: GrantFiled: June 24, 1999Date of Patent: December 18, 2001Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Toru Esaki, Toshihiko Makino, Yoshikazu Nishimura, Toshiaki Nagafuji
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Patent number: 6207836Abstract: A compound represented by formula (I): wherein R1 represents a halogen atom, a lower alkyl group, a lower alkoxy group, a hydroxyl group, a nitro group, a trifluoromethyl group, a lower alkylthio group, an acyl group, a carboxyl group, a mercapto group or an amino group; R2 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, an alkoxy group, an acyl group, an aryl group or a heterocyclic group; R3 represents a lower alkyl group, a cycloalkyl group, an aryl group, or a heterocyclic group; R4 represents a hydrogen atom, a lower alkyl group, an aryl group, a heterocyclic group, —OR5, —SR5 or —NR6R7 (wherein R5, R6, and R7 each represent a lower alkyl group, etc.); X and Y each represent —CH2—, —NH— or —O—; and n represents an integer of from 0 to 4, and an intermediate for synthesis thereof are disclosed.Type: GrantFiled: October 30, 1998Date of Patent: March 27, 2001Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Toru Esaki, Takashi Emura, Eiichi Hoshino
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Patent number: 6127544Abstract: A compound represented by formula (I): wherein R.sub.1 represents a halogen atom, a lower alkyl group, a lower alkoxy group, a hydroxyl group, a nitro group, a trifluoromethyl group, a lower alkylthio group, an acyl group, a carboxyl group, a mercapto group or an amino group; R.sub.2 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, an alkoxy group, an acyl group, an aryl group or a heterocyclic group; R.sub.3 represents a lower alkyl group, a cycloalkyl group, an aryl group, or a heterocyclic group; R.sub.4 represents a hydrogen atom, a lower alkyl group, an aryl group, a heterocyclic group, --OR.sub.5, --SR.sub.5 or --NR.sub.6 R.sub.7 (wherein R.sub.5, R.sub.6, and R.sub.7 each represent a lower alkyl group, etc.); X and Y each represent --CH.sub.2 --, --NH-- or --O--; and n represents an integer of from 0 to 4, and an intermediate for synthesis thereof are disclosed.Type: GrantFiled: October 30, 1998Date of Patent: October 3, 2000Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Toru Esaki, Takashi Emura, Eiichi Hoshino
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Patent number: 6114536Abstract: A compound represented by formula (I): ##STR1## wherein R.sub.1 represents a halogen atom, a lower alkyl group, a lower alkoxy group, a hydroxyl group, a nitro group, a trifluoromethyl group, a lower alkylthio group, an acyl group, a carboxyl group, a mercapto group or an amino group; R.sub.2 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, an alkoxy group, an acyl group, an aryl group or a heterocyclic group; R.sub.3 represents a lower alkyl group, a cycloalkyl group, an aryl group, or a heterocyclic group; R.sub.4 represents a hydrogen atom, a lower alkyl group, an aryl group, a heterocyclic group, --OR.sub.5, --SR.sub.5 or --NR.sub.6 R.sub.7 (wherein R.sub.5, R.sub.6, and R.sub.7 each represent a lower alkyl group, etc.); X and Y each represent --CH.sub.2 --, --NH-- or --O--; and n represents an integer of from 0 to 4, and an intermediate for synthesis thereof are disclosed.Type: GrantFiled: October 30, 1998Date of Patent: September 5, 2000Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Toru Esaki, Takashi Emura, Eiichi Hoshino
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Patent number: 6031111Abstract: A compound represented by formula (I): ##STR1## wherein R.sub.1 represents a halogen atom, a lower alkyl group, a lower alkoxy group, a hydroxyl group, a nitro group, a trifluoromethyl group, a lower alkylthio group, an acyl group, a carboxyl group, a mercapto group or an amino group; R.sub.2 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, an alkoxy group, an acyl group, an aryl group or a heterocyclic group; R.sub.3 represents a lower alkyl group, a cycloalkyl group, an aryl group, or a heterocyclic group; R.sub.4 represents a hydrogen atom, a lower alkyl group, an aryl group, a heterocyclic group, --OR.sub.5, --SR.sub.5 or --NR.sub.6 R.sub.7 (wherein R.sub.5, R.sub.6, and R.sub.7 each represent a lower alkyl group, etc.); X and Y each represent --CH.sub.2 --, --NH-- or --O--; and n represents an integer of from 0 to 4, and an intermediate for synthesis thereof are disclosed.Type: GrantFiled: October 30, 1998Date of Patent: February 29, 2000Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Toru Esaki, Takashi Emura, Eiichi Hoshino