Patents by Inventor Toru Hiruma

Toru Hiruma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ?1,3-N-acetyl-D-galactosamine transferase protein, nucleic acid encoding the same and method of examining canceration using the same
    Patent number: 8431365
    Abstract: The N-acetyl-D-galactosamine transferase protein of the present invention is characterized by transferring N-acetyl-D-galactosamine to N-acetyl-D-glucosamine with ?1,3 linkage, and it preferably has the amino acid sequence shown in SEQ ID NO: 2 or 4. The canceration assay according to the present invention uses a nucleic acid for measurement which hybridizes under stringent conditions to the nucleotide sequence shown in SEQ ID NO: 1 or 3 or a nucleotide sequence complementary to at least one of them.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: April 30, 2013
    Assignee: National Institute of Advanced Industrial Science and Technology
    Inventors: Hisashi Narimatsu, Akira Togayachi, Niro Inaba, Toru Hiruma, Yasuko Ishizuka
  • BETA 1,3-N-ACETYL-D-GALACTOSAMINE TRANSFERASE PROTEIN, NUCLEIC ACID ENCODING THE SAME AND METHOD OF EXAMINING CANCERATION USING THE SAME
    Publication number: 20130004995
    Abstract: The N-acetyl-D-galactosamine transferase protein of the present invention is characterized by transferring N-acetyl-D-galactosamine to N-acetyl-D-glucosamine with ?1,3 linkage, and it preferably has the amino acid sequence shown in SEQ ID NO: 2 or 4. The canceration assay according to the present invention uses a nucleic acid for measurement which hybridizes under stringent conditions to the nucleotide sequence shown in SEQ ID NO: 1 or 3 or a nucleotide sequence complementary to at least one of them.
    Type: Application
    Filed: June 29, 2012
    Publication date: January 3, 2013
    Applicant: National Institute of Advanced Science & Technology
    Inventors: Hisashi NARIMATSU, Akira Togayachi, Niro Inaba, Toru Hiruma, Yasuko Ishizuka
  • ?1,3-N-acetyl-D-galactosamine transferase protein, nucleic acid encoding the same and method of examining canceration using the same
    Patent number: 8227213
    Abstract: The N-acetyl-D-galactosamine transferase protein of the present invention is characterized by transferring N-acetyl-D-galactosamine to N-acetyl-D-glucosamine with ?1,3 linkage, and it preferably has the amino acid sequence shown in SEQ ID NO: 2 or 4. The canceration assay according to the present invention uses a nucleic acid for measurement which hybridizes under stringent conditions to the nucleotide sequence shown in SEQ ID NO: 1 or 3 or a nucleotide sequence complementary to at least one of them.
    Type: Grant
    Filed: April 30, 2010
    Date of Patent: July 24, 2012
    Assignee: National Institute of Advanced Science & Technology
    Inventors: Hisashi Narimatsu, Akira Togayachi, Niro Inaba, Toru Hiruma, Yasuko Ishizuka
  • BETA 1,3-N-ACETYL-D-GALACTOSAMINE TRANSFERASE PROTEIN, NUCLEIC ACID ENCODING THE SAME AND METHOD OF EXAMINING CANCERATION USING THE SAME
    Publication number: 20100279355
    Abstract: The N-acetyl-D-galactosamine transferase protein of the present invention is characterized by transferring N-acetyl-D-galactosamine to N-acetyl-D-glucosamine with ?1,3 linkage, and it preferably has the amino acid sequence shown in SEQ ID NO: 2 or 4. The canceration assay according to the present invention uses a nucleic acid for measurement which hybridizes under stringent conditions to the nucleotide sequence shown in SEQ ID NO: 1 or 3 or a nucleotide sequence complementary to at least one of them.
    Type: Application
    Filed: April 30, 2010
    Publication date: November 4, 2010
    Applicant: National Institute of Advanced Industrial Science and Technology
    Inventors: Hisashi NARIMATSU, Akira Togayachi, Niro Inaba, Toru Hiruma, Yasuko Ishizuka
  • Glycosyltransferase, nucleic acid encoding the glycosyltransferase and method of testing canceration using the nucleic acid
    Publication number: 20090081668
    Abstract: A tumor marker nucleic acid of the present invention is concerned with a nucleic acid hybridizing under stringent conditions to a nucleotide sequence described in SEQ ID NO: 1 or a complementary nucleotide sequence thereof. A method of testing canceration of the present invention is a method comprising diagnosing a biological sample as being cancerous when the transcription level of the nucleic acid in the biological sample significantly exceeds that in a normal biological sample as a control. The present invention also relates to a ?1,3-N-acetyl-D-glucosaminyltransferase protein having an activity of transferring N-acetyl-D-glucosamine from a donor substrate to an acceptor substrate through ?1,3-linkage.
    Type: Application
    Filed: June 2, 2008
    Publication date: March 26, 2009
    Applicant: National Institute of Advanced Industrial Science and Technology
    Inventors: Hisashi Narimatsu, Takashi Kudo, Akira Togayachi, Toru Hiruma
  • Beta1,3-N-acetyl-D-galactosamine transferase protein, nucleic acid encoding the same and method of examining canceration using the same
    Publication number: 20080299615
    Abstract: The N-acetyl-D-galactosamine transferase protein of the present invention is characterized by transferring N-acetyl-D-galactosamine to N-acetyl-D-glucosamine with ?1,3 linkage, and it preferably has the amino acid sequence shown in SEQ ID NO: 2 or 4. The canceration assay according to the present invention uses a nucleic acid for measurement which hybridizes under stringent conditions to the nucleotide sequence shown in SEQ ID NO: 1 or 3 or a nucleotide sequence complementary to at least one of them.
    Type: Application
    Filed: June 30, 2008
    Publication date: December 4, 2008
    Applicant: National Institute of Advanced Industrial Science and Technology
    Inventors: Hisashi Narimatsu, Akira Togayachi, Niro Inaba, Toru Hiruma, Yasuko Ishizuka
  • Glycosyltransferase, nucleic acid encoding the glycosyltransferase and method of testing canceration using the nucleic acid
    Patent number: 7396666
    Abstract: A tumor marker nucleic acid of the present invention is concerned with a nucleic acid hybridizing under stringent conditions to a nucleotide sequence described in SEQ ID NO: 1 or a complementary nucleotide sequence thereof. A method of testing canceration of the present invention is a method comprising diagnosing a biological sample as being cancerous when the transcription level of the nucleic acid in the biological sample significantly exceeds that in a normal biological sample as a control. The present invention also relates to a ?1,3-N-acetyl-D-glucosaminyltransferase protein having an activity of transferring N-acetyl-D-glucosamine from a donor substrate to an acceptor substrate through ?1,3-linkage.
    Type: Grant
    Filed: December 26, 2003
    Date of Patent: July 8, 2008
    Assignee: National Institute of Advanced Industrial Science and Technology
    Inventors: Hisashi Narimatsu, Takashi Kudo, Akira Togayachi, Toru Hiruma
  • Glycosyltransferase, nucleic acid encoding the glycosyltransferase and method of testing canceration using the nucleic acid
    Publication number: 20060177822
    Abstract: A tumor marker nucleic acid of the present invention is concerned with a nucleic acid hybridizing under stringent conditions to a nucleotide sequence described in SEQ ID NO: 1 or a complementary nucleotide sequence thereof. A method of testing canceration of the present invention is a method comprising diagnosing a biological sample as being cancerous when the transcription level of the nucleic acid in the biological sample significantly exceeds that in a normal biological sample as a control. The present invention also relates to a ?1,3-N-acetyl-D-glucosaminyltransferase protein having an activity of transferring N-acetyl-D-glucosamine from a donor substrate to an acceptor substrate through ?1,3-linkage.
    Type: Application
    Filed: December 26, 2003
    Publication date: August 10, 2006
    Inventors: Hisashi Narimatsu, Takashi Kudo, Akira Togayachi, Toru Hiruma
  • Ss 1,3-n-acetyl-d-galactosamine transferase protein, nucleic acid encoding the same and method of examining canceration using the same
    Publication number: 20060166211
    Abstract: The N-acetyl-D-galactosamine transferase protein of the present invention is characterized by transferring N-acetyl-D-galactosamine to N-acetyl-D-glucosamine with ?1,3 linkage, and it preferably has the amino acid sequence shown in SEQ ID NO: 2 or 4. The canceration assay according to the present invention uses a nucleic acid for measurement which hybridizes under stringent conditions to the nucleotide sequence shown in SEQ ID NO: 1 or 3 or a nucleotide sequence complementary to at least one of them.
    Type: Application
    Filed: January 23, 2004
    Publication date: July 27, 2006
    Inventors: Hisashi Narimatsu, Akira Togayachi, Niro Inaba, Toru Hiruma, Yasuko Ishizuka
  • Pyrimidine nucleus-containing compound and a medicament containing the same for a blood oxygen partial pressure amelioration, and a method for preparing the same
    Patent number: 6339089
    Abstract: A pyrimidine nucleus-containing compound represented by the formula (I): wherein ring A represents the ring of the formula (a): in which R1 is a nitro group, an amino group, a substituted amino group or a halogen atom, or the ring of the formula (b): in which R1′ is the group such as an alkyl group or an alkenyl group; R2 to R5 independently represent the group such as an alkyl group or an alkenyl group; with the proviso that at least one of R2 to R5 is an alkenyl group, or acid addition salts thereof.
    Type: Grant
    Filed: August 12, 1998
    Date of Patent: January 15, 2002
    Assignee: Fujirebio Inc.
    Inventors: Yoshiharu Nakashima, Takashi Fujita, Michiyo Hizuka, Hiroshi Ikawa, Toru Hiruma
  • PYRIMIDINE NUCLEUS-CONTAINING COMPOUND AND A MEDICAMENT CONTAINING THE SAME FOR A BLOOD OXYGEN PARTIAL PRESSURE AMELIORATION, AND A METHOD FOR PREPARING THE SAME
    Publication number: 20010006969
    Abstract: A pyrimidine nucleus-containing compound represented by the formula (I): 1
    Type: Application
    Filed: August 12, 1998
    Publication date: July 5, 2001
    Inventors: YOSHIHARU NAKASHIMA, TAKASHI FUJITA, MICHIYO HIZUKA, HIROSHI IKAWA, TORU HIRUMA