Abstract: A pair of thick steel plates are set up side by side such that an I groove with a narrow gap is formed between the facing edges of the plates, and a welding wire projecting from a welding torch of an arc welding unit with a constant voltage characteristic is inserted into the I groove obliquely from above with respect to the thickness direction of the plates. The welding torch is moved vertically while the distal end of the welding wire is caused to reciprocate inside the I groove in the thickness direction. At this time, the wire feed rate Vf is varied and also the extension L of the welding wire is increased or decreased so as to keep welding current Iw at a target value. Further, the wire feed rate Vf is subjected to incremental/decremental correction according to the moving direction of the torch.

Abstract: Fused bicyclic compound having an affinity to mineral corticoid receptor (MR), of formula [I]: wherein ring A is benzene having a substituent R1, fused to an adjacent 6-membered heterocyclic ring and further optionally having a substituent(s) other than R1, R1 is alkylsulfonylamino, etc., R2 and R3 are (a) the same of different and are hydrogen, alkyl, or optionally substituted aryl, or (b) combined with each other to form an oxo group or (c) combined with each other at its terminal together with the adjacent carbon atom to form cycloalkyl, X is ?N—, ?C(R4)— or —CH(R4)—, R4 is (a) hydrogen, (b) cyano, (c) halogen, (d) alkyl, (e) alkenyl, (f) cycloalkyl, (g) alkanoyl, (h) carbamoyl, or (i) cycloalkenyl, Ar is an optionally substituted aromatic cyclic group and a dotted line means presence or absence of a double bond, or a pharmaceutically acceptable salt thereof, useful e.g. as an antihypertensive agent.

Abstract: Fused bicyclic compound having an affinity to mineral corticoid receptor (MR), of formula [I]: wherein ring A is benzene having a substituent R1, fused to an adjacent 6-membered heterocyclic ring and further optionally having a substituent(s) other than R1, R1 is alkylsulfonylamino, etc., R2 and R3 are (a) the same of different and are hydrogen, alkyl, or optionally substituted aryl, or (b) combined with each other to form an oxo group or (c) combined with each other at its terminal together with the adjacent carbon atom to form cycloalkyl, X is ?N—, ?C(R4)— or —CH(R4)—, R4 is (a) hydrogen, (b) cyano, (c) halogen, (d) alkyl, (e) alkenyl, (f) cycloalkyl, (g) alkanoyl, (h) carbamoyl, or (i) cycloalkenyl, Ar is an optionally substituted aromatic cyclic group and a dotted line means presence or absence of a double bond, or a pharmaceutically acceptable salt thereof, useful e.g. as an antihypertensive agent.

Abstract: A pair of thick steel plates are set up side by side such that an I groove with a narrow gap is formed between the facing edges of the plates, and a welding wire projecting from a welding torch of an arc welding unit with a constant voltage characteristic is inserted into the I groove obliquely from above with respect to the thickness direction of the plates. The welding torch is moved vertically while the distal end of the welding wire is caused to reciprocate inside the I groove in the thickness direction. At this time, the wire feed rate Vf is varied and also the extension L of the welding wire is increased or decreased so as to keep welding current Iw at a target value. Further, the wire feed rate Vf is subjected to incremental/decremental correction according to the moving direction of the torch.