Patents by Inventor Toru Sugaya

Toru Sugaya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for producing tetrahydroisoquinoline-3-carboxylic acid compounds
    Patent number: 5602255
    Abstract: The present invention relates to a process for producing 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid compounds or salts thereof represented by the following formula (II): ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 independently represent hydrogen, hydroxy or lower alkoxy, and R.sup.4 represent hydrogen, lower alkyl, aryl or aralkyl, the process comprising, allowing phenylalanine compounds to react with formaldehyde or paraformaldehyde in the presence of sulfuric acid or hydrobromic acid, the phenylalanine compounds being represented by the following formula (I): ##STR2## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the same meaning as defined above.
    Type: Grant
    Filed: April 4, 1995
    Date of Patent: February 11, 1997
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Yukihiro Kuge, Toru Sugaya, Shinji Tomioka
  • 6H-pyrazolo-[4,5,1-d,e]acridin-6-one derivatives having anit-tumor activity
    Patent number: 5079358
    Abstract: Novel pyrazoloacridone compounds represented by the following formula: ##STR1## and pharmaceutically acceptable salts thereof have an excellent anti-tumor activity.
    Type: Grant
    Filed: June 14, 1989
    Date of Patent: January 7, 1992
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Toru Sugaya, Yukiteru Mimura, Yasushi Shida, Yutaka Osawa, Ikuo Matsukuma, Shiro Akinaga, Makoto Morimoto
  • 1-benzyl-3,5-dimethyl-4-piperdyl ester of a Hantzsch dihydropyridine
    Patent number: 4639522
    Abstract: The compound of the formula ##STR1## is disclosed to have a less rapid decrease in blood pressure in its use as an antihypertensive.
    Type: Grant
    Filed: February 14, 1986
    Date of Patent: January 27, 1987
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Kenji Muto, Toru Sugaya, Tokuyuki Kuroda, Tamotsu Hashimoto, Koji Yamada, Nobuhiro Nakamizo, Minoru Watanabe
  • 1,4-Dihydropyridine derivatives
    Patent number: 4448964
    Abstract: Compounds having coronary and vasodilator effects, a hypotensive effect, and useful as antianginal drugs and drugs for treating hypertension are represented by the following general formula: ##STR1## wherein R.sub.1 and R.sub.2 are the same or different groups and each represents a lower alkyl group, one of R.sub.3 and R.sub.4 represents a lower alkyl group and the other represents a group of the general formula: ##STR2## wherein R.sub.5 represents an aralkyl group or an acyl group and n represents 0 or an integer of 1-3; the pharmaceutically acceptable acid addition salts thereof are also effective therapeutic compounds.
    Type: Grant
    Filed: April 13, 1982
    Date of Patent: May 15, 1984
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Kenji Muto, Minoru Watanabe, Takao Hatta, Toru Sugaya, Yoshinori Takemoto, Nobuhiro Nakamizo