Patents by Inventor Tosapol Anukunwithaya

Tosapol Anukunwithaya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2,4-diamino-6-ethylpyrimidine derivatives with antimalarial activities against
    Patent number: 11028072
    Abstract: The present invention relates to 2,4-diamino-6-ethylpyrimidine derivatives that are inhibitors of wild type and quadruple mutant dihydrofolate reductase (DHFR) of Plasmodium falciparum. They also show in vitro antimalarial activities against Plasmodium falciparum for both wild type and mutant that are comparable to or better than pyrimethamine. In addition, the compounds of the present invention show a good selectivity to Plasmodium falciparum and exhibit lower cytotoxicity than pyrimethamine.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: June 8, 2021
    Assignee: National Science and Technology Development Agency
    Inventors: Sumalee Kamchonwongpaisan, Netnapa Charoensetakul, Krisana Peewasan, Jarunee Vanichtanankul, Roonglawan Rattanajak, Supannee Taweechai, Tosapol Anukunwithaya, Aphisit Yoomuang, Yongyuth Yuthavong, Tirayut Vilaivan
  • 2,4-DIAMINO-6-ETHYLPYRIMIDINE DERIVATIVES WITH ANTIMALARIAL ACTIVITIES AGAINST PLASMODIUM FALCIPARUM
    Publication number: 20200239445
    Abstract: The present invention relates to 2,4-diamino-6-ethylpyrimidine derivatives that are inhibitors of wild type and quadruple mutant dihydrofolate reductase (DHFR) of Plasmodium falciparum. They also show in vitro antimalarial activities against Plasmodium falciparum for both wild type and mutant that are comparable to or better than pyrimethamine. In addition, the compounds of the present invention show a good selectivity to Plasmodium falciparum and exhibit lower cytotoxicity than pyrimethamine.
    Type: Application
    Filed: September 16, 2016
    Publication date: July 30, 2020
    Applicant: National Science and Technology Development Agency
    Inventors: Sumalee KAMCHONWONGPAISAN, Netnapa CHAROENSETAKUL, Krisana PEEWASAN, Jarunee VANICHTANANKUL, Roonglawan RATTANAJAK, Supannee TAWEECHAI, Tosapol ANUKUNWITHAYA, Aphisit YOOMUANG, Yongyuth YUTHAVONG, Tirayut VILAIVAN
  • Anti-folate antimalarials with dual-binding modes and their preparation
    Patent number: 9000003
    Abstract: The present invention is anti-folate antimalarials with dual-binding modes of the general formula (I) [refer to structure in the abstract] wherein R1 and R2 which may be the same or different are independently selected from methyl or ethyl or alkylphenyl, R3 is independently hydrogen, halide, lower alkyl substituted with ester, carboxylic, amide, and ether. Linker is X(CH2)nY wherein X and Y which may be the same or different are independently selected from oxygen, carbon, nitrogen, substituted phenyl where n is an integer from 1 to 2-6, or pharmaceutically acceptable salts therefore. The anti-folate antimalarials with dual-binding modes act as novel inhibitors with good inhibition constants against wild-type, double (C59R+SIOSN), triple (N51+C59R+SIOSN, C59R+S 1 OSN+I164L), and quadruple (N51+C59R+S108N+I164L) mutant enzymes. The compounds are also effective against wild type (Tm4/S.2) and mutants (K1CB1, W2, Cs1-2 and V1/S) malaria parasites.
    Type: Grant
    Filed: February 9, 2012
    Date of Patent: April 7, 2015
    Assignee: National Science and Technology Development Agency
    Inventors: Bongkoch Tarnchompoo, Penchit Chitnumsub, Sumalee Kamchonwongpaisan, Philip James Shaw, Roonglawan Rattanajak, Sinothai Poen, Tosapol Anukunwithaya, Chayaphat Wongsombat, Yongyuth Yuthavong
  • ANTI-FOLATE ANTIMALARIALS WITH DUAL-BINDING MODES AND THEIR PREPARATION
    Publication number: 20130324727
    Abstract: The present invention is anti-folate antimalarials with dual-binding modes of the general formula (I) [refer to structure in the abstract] wherein R1 and R2 which may be the same or different are independently selected from methyl or ethyl or alkyl-phenyl, R3 is independently hydrogen, halide, lower alkyl substituted with ester, carboxylic, amide, and ether. Linker is X(CH2)nY wherein X and Y which may be the same or different are independently selected from oxygen, carbon, nitrogen, substituted phenyl where n is an integer from 1 to 2-6, or pharmaceutically acceptable salts therefore. The anti-folate antimalarials with dual-binding modes act as novel inhibitors with good inhibition constants against wild-type, double (C59R+SIOSN), triple (N51+C59R+SIOSN, C59R+S 1 OSN+I164L), and quadruple (N51+C59R+S108N+I164L) mutant enzymes. The compounds are also effective against wild type (Tm4/S.2) and mutants (K1CB1, W2, Cs1-2 and V1/S) malaria parasites.
    Type: Application
    Filed: February 9, 2012
    Publication date: December 5, 2013
    Applicant: National Science and Techology Development Agency
    Inventors: Bongkoch Tarnchompoo, Penchit Chitnumsub, Sumalee Kamchonwongpaisan, Philip James Shaw, Roonglawan Rattanajak, Sinothai Poen, Tosapol Anukunwithaya, Chayaphat Wongsombat, Yongyuth Yuthavong