Abstract: To provide a superior anti-human NGF antibody Fab fragment that maintains a high neutralizing activity, and that reduces systemic side-effects arising from systemic exposure while expressing a local drug effect, and means for treating postoperative pain by using such antibody fragment. An anti-human NGF antibody Fab fragment comprising a heavy-chain fragment consisting of the amino acid sequence shown by SEQ ID NO:5 and a light-chain consisting of the amino acid sequence shown by SEQ ID NO: 8.

Abstract: A shoe includes a sole, an upper and a strap. The upper is attached to the sole. The strap extends in a width direction of the shoe. The strap includes a proximal end fixed to the upper and a distal end located on an opposite side of the proximal end in the width direction of the shoe. One of the upper and the strap includes at least one first engaging portion, whereas the other of the upper and the strap includes at least one second engaging portion that is engaged with the at least one first engaging portion while extending in a direction intersecting with a longitudinal direction of the shoe where the distal end is held against the upper.

Abstract: A heat exchanger tube for transferring a heat of an exhaust gas to a fluid to be heated includes a turn-back portion formed in an intermediate portion of the heat exchanger tube and a reciprocating conduit portion. The reciprocating conduit portion includes a conduit portion leading from a starting end of the heat exchanger tube to the turn-back portion, and a conduit portion leading from the turn-back portion to a terminal end of the heat exchanger tube. A space equal to or greater than the outer diameter of the conduit portions is provided between these conduit portions.

Abstract: The filter device includes a supply air introducing part, a filter main body part and a discharge part. The supply air introducing part takes in an outside air. The filter main body part includes a ventilation pipe connected to the supply air introducing part to allow the outside air to flow through the ventilation pipe and a filter housing part being equipped with an outflow hole allowing the outside air to flow outside at a position higher than a position of the opening part of the ventilation pipe to separate, from the outside air, a liquid in a liquid state or a state close thereto. The liquid is taken in together with the outside air. The discharge part discharges at least the separated liquid from the filter main body part.

Abstract: To provide a method of toppling a tower structure more safely, simply and quickly than in the conventional manner.

Abstract: A piping connection unit of a combustion apparatus supplying and discharging air through a duct includes an apparatus-side connecting part, a connecting part and a spacer. The apparatus-side connecting part is to be connected to an air supply part or an exhaust part of the combustion apparatus. The connecting part has a diameter larger than a diameter of the apparatus-side connecting part, and communicates with the apparatus-side connecting part to be connected to a duct to be inserted from an opening part. The spacer is detachably disposed in the connecting part. The spacer is disposed between an inner wall of the connecting part and the duct to be inserted when the duct has a pipe diameter smaller than an inner diameter of the connecting part. The spacer is removed from the connecting part when the duct has a pipe diameter equivalent to the inner diameter of the connecting part.

Abstract: A novel pharmaceutical composition for suppressing atrial fibrillation that has an action mechanism that does not affect the normal heart function is provided. A pharmaceutical composition including an anti-human NGF antibody or antigen binding fragment thereof as an active ingredient is provided.

Abstract: A shoe sole comprises a bottom surface including a plurality of grooves arranged in a longitudinal direction of the shoe sole for engaging the engagement parts 6a, 6b that are formed parallel to the pedal shaft 8 of the bicycle pedal, and a protrusion having a ground contact surface between the grooves adjacent in the longitudinal direction, the sole characterized in that the protrusion has a width W2 in the longitudinal direction on an inner side in the left-right direction with respect to both feet of a wearer that is wider than a width W1 on an outer side in the left-right direction with respect to both feet of a wearer.

Abstract: A mobile terminal testing device includes a layer processing unit 3 that communicates with a mobile terminal 10 by performing processing of each layer of a layer-configured communication protocol with a plurality of layers, in which the layer processing unit 3 includes a PHY processing unit 31 that performs multiplexing, channel coding, or the like in order to transmit and receive communication data transmitted to and received from the mobile terminal 10, in which the PHY processing unit 31 transmits a dummy signal, by omitting higher processing from predetermined processing, for an interference signal in multi user-multi input multi output (MU-MIMO) multiplex signals, in a case of testing MU-MIMO terminal-to-terminal interference.

Abstract: A heat exchanging unit exchanges heat between a fluid to be heated and exhaust gas. The heat exchanging unit includes a heat exchange portion, a header portion, and a flow changing portion. The heat exchange portion includes a heat exchange pipe in the interior of which the fluid to be heated flows. The header portion is connected to the heat exchange pipe, the header portion allowing the fluid to be heated to flow from the header portion to the heat exchange pipe or from the heat exchange pipe to the header portion. The flow changing portion changes the state of flow of the exhaust gas introduced into the heat exchange portion.

Abstract: A bicycle shoe includes a sole. The sole includes a recess, which is recessed from a bottom surface of the sole. The recess is defined by a bottom portion and lateral surfaces. The bottom portion has a lateral dimension, which is greater than or equal to 20 millimeters and less than or equal to 45 millimeters.

Abstract: A wiring substrate includes a coil wiring and a magnetic layer that is in contact with a lower surface of the coil wiring and includes an opening extending through in a thickness-wise direction. The wiring substrate further includes a first insulation layer covering the coil wiring, an upper surface of the magnetic layer, and a wall surface of the opening and a signal wiring structure formed so that a signal of a semiconductor element, when mounted on the wiring substrate, travels through the opening of the magnetic layer. The signal wiring structure includes a first wiring portion located on an upper surface of the first insulation layer and a first via wiring located inward from the opening of the magnetic layer and connected to the first wiring portion. The magnetic layer is not in contact with the signal wiring structure.

Abstract: The filter device includes a supply air introducing part, a filter main body part and a discharge part. The supply air introducing part takes in an outside air. The filter main body part includes a ventilation pipe connected to the supply air introducing part to allow the outside air to flow through the ventilation pipe and a filter housing part being equipped with an outflow hole allowing the outside air to flow outside at a position higher than a position of the opening part of the ventilation pipe to separate, from the outside air, a liquid in a liquid state or a state close thereto. The liquid is taken in together with the outside air. The discharge part discharges at least the separated liquid from the filter main body part.

Abstract: A piping connection unit of a combustion apparatus supplying and discharging air through a duct includes an apparatus-side connecting part, a connecting part and a spacer. The apparatus-side connecting part is to be connected to an air supply part or an exhaust part of the combustion apparatus. The connecting part has a diameter larger than a diameter of the apparatus-side connecting part, and communicates with the apparatus-side connecting part to be connected to a duct to be inserted from an opening part. The spacer is detachably disposed in the connecting part. The spacer is disposed between an inner wall of the connecting part and the duct to be inserted when the duct has a pipe diameter smaller than an inner diameter of the connecting part. The spacer is removed from the connecting part when the duct has a pipe diameter equivalent to the inner diameter of the connecting part.

Abstract: The compounds of the subject invention are related to 2-substituted cephem compounds, which have a wide antimicrobial spectrum, in particular exhibit potent antimicrobial activity against beta-lactamase producing Gram negative bacteria, and pharmaceutical compositions comprising the same.

Abstract: A heat exchanger tube for transferring a heat of an exhaust gas to a fluid to be heated includes a turn-back portion formed in an intermediate portion of the heat exchanger tube and a reciprocating conduit portion. The reciprocating conduit portion includes a conduit portion leading from a starting end of the heat exchanger tube to the turn-back portion, and a conduit portion leading from the turn-back portion to a terminal end of the heat exchanger tube. A space equal to or greater than the outer diameter of the conduit portions is provided between these conduit portions.

Abstract: A wiring substrate includes a coil wiring and a magnetic layer that is in contact with a lower surface of the coil wiring and includes an opening extending through in a thickness-wise direction. The wiring substrate further includes a first insulation layer covering the coil wiring, an upper surface of the magnetic layer, and a wall surface of the opening and a signal wiring structure formed so that a signal of a semiconductor element, when mounted on the wiring substrate, travels through the opening of the magnetic layer. The signal wiring structure includes a first wiring portion located on an upper surface of the first insulation layer and a first via wiring located inward from the opening of the magnetic layer and connected to the first wiring portion. The magnetic layer is not in contact with the signal wiring structure.

Abstract: To provide a superior anti-human NGF antibody Fab fragment that maintains a high neutralizing activity, and that reduces systemic side-effects arising from systemic exposure while expressing a local drug effect, and means for treating postoperative pain by using such antibody fragment. An anti-human NGF antibody Fab fragment comprising a heavy-chain fragment consisting of the amino acid sequence shown by SEQ ID NO:5 and a light-chain consisting of the amino acid sequence shown by SEQ ID NO: 8.

Abstract: A shoe positioning plate has a shoe facing side surface, a sole surface and a shoe positioning member. The sole surface is configured to be a part of a shoe sole when the shoe facing side surface is attached the shoe sole. The shoe positioning member includes at least one abutment disposed on an opposite side of the shoe positioning plate from the shoe facing side surface and extending in an elongated direction of a shoe when the shoe positioning plate is attached the shoe sole.

Abstract: The compounds of the subject invention are related to 2-substituted cephem compounds, which have a wide antimicrobial spectrum, in particular exhibit potent antimicrobial activity against beta-lactamase producing Gram negative bacteria, and pharmaceutical compositions comprising the same.