Abstract: The present invention provides an antisense oligonucleotide that is formed of 15-22 nucleotides and that is complementary to a nucleic acid including at least 15 consecutive bases in a specific target region of a base sequence of SEQ ID NO: 471, or a pharmaceutically acceptable salt thereof, or hydrates of those.

Abstract: A non-transitory computer-readable recording medium having instructions stored therein causes at least one processor of a game apparatus to: communicate with a distribution system configured to distribute videos to a plurality of terminal apparatuses; progress a computer game; generate, based on a progress of the computer game, video information that is used to play a video of the computer game indicating a state of a virtual space of the computer game; supply the video information to the distribution system; acquire spectator apparatus information from the distribution system, the spectator apparatus information relating to at least one spectator apparatus that is a part of the plurality of terminal apparatus, and receives a video based on the video information from the distribution system; and control display of an advertisement in the virtual space, based on the spectator apparatus information.

Abstract: A multi-stage screw compressor includes a plurality of stages of compressor bodies that compress a gas in sequence. Each of the stages of compressor bodies has both male and female rotors that are housed revolvably in a casing in a mutually meshing state. The male and female rotors each include a rotor lobe section having a suction-side end face and a discharge-side end face on one end and the other end thereof in the axial direction and having a twisted lobe extending from the suction-side end face to the discharge-side end face. The male and female rotors in a downstream-stage compressor body of at least one certain stage, excluding an upstream-stage compressor body as the first stage, among the plurality of stages of compressor bodies are each configured such that their lead increases from the suction side in the axial direction of the rotor lobe section toward the discharge side.

Abstract: A seal member and outer cylinder needle (OCN) tip part for blocking, in a fluid-tight state, both external peripheral space (EPS) end parts formed between the external-peripheral-surface of an inner needle (IN) and internal peripheral surface of an OCN, for slidably holding the IN in close contact; an opening part formed on the OCN external-peripheral-surface and for intravascular communication with the EPS; an OCN connection part for communicating between the EPS and blood circuit end; an IN connection part for communicating between the IN internal space and other blood circuit end. The movable IN positioned between the projecting position where the tip part protrudes from the OCN tip and the housed position housing the tip inside the OCN. The IN punctures the blood vessel interior while holding the projecting position, and moved to the housed position after puncture allowing blood to extracorporeally circulate via the OCN and IN connection part.

Abstract: A fluid sterilization device includes: a housing that defines a flow passage extending in a longitudinal direction; a filter provided in the housing and extending in the longitudinal direction; and a light source including a light emitting device that emits ultraviolet light and irradiating a fluid passing through the filter and flowing in a laminar flow state with the ultraviolet light. The filter may be a hollow fiber filter. The light source may be provided to radiate ultraviolet light in the longitudinal direction.

Abstract: In a water purification apparatus, a light source irradiates the water, passing through the flow passage, with ultraviolet light. The light source has a light emitting diode that emits the ultraviolet light whose wavelength is contained in a bandwidth of 220 nm or above to less than 300 nm, and the optical output in this wavelength bandwidth is in a range of 1 W to 50 W. The flow passage passes the water at a flow rate of 5 mL/second to 250 mL/second. The flow passage is formed by a wall surface having a tubular shape. A window through which the ultraviolet light is passed is provided in at least part of the wall surface.

Abstract: A seal member and outer cylinder needle (OCN) tip part for blocking, in a fluid-tight state, both external peripheral space (EPS) end parts formed between the external-peripheral-surface of an inner needle (IN) and internal peripheral surface of an OCN, for slidably holding the IN in close contact; an opening part formed on the OCN external-peripheral-surface and for intravascular communication with the EPS; an OCN connection part for communicating between the EPS and blood circuit end; an IN connection part for communicating between the IN internal space and other blood circuit end. The movable IN positioned between the projecting position where the tip part protrudes from the OCN tip and the housed position housing the tip inside the OCN. The IN punctures the blood vessel interior while holding the projecting position, and moved to the housed position after puncture allowing blood to extracorporeally circulate via the OCN and IN connection part.

Abstract: A method for producing a light-modulating film in which a light-modulating layer is sandwiched between two transparent resin substrates, the light-modulating layer being formed by use of a light-modulating material containing: a polymeric medium for forming a resin matrix; and a light-modulating suspension, includes the following steps: step (a) of applying the light-modulating material to one (a first transparent resin substrate: of the transparent resin substrates; step (b) of bonding the other transparent resin substrate (a second transparent resin substrate) onto the light-modulating material applied to the first transparent resin substrate; and step (c) of irradiating the light-modulating material sandwiched between the first transparent resin substrate and the second transparent resin substrate with an energy ray to cure the polymeric medium for forming the resin matrix contained in the light-modulating material, thereby forming the light-modulating layer to yield the light-modulating film.

Abstract: A blood cells removal module including a casing having an inlet into which a blood flow before blood cells removal flows, and an outlet in which a blood flow after blood cells removal is discharged, an adsorbent for blood cells removal of short fiber shape accommodated in the casing, a mesh being provided inside the inlet and the outlet, respectively, and holding the adsorbent for blood cells removal in the casing, wherein a length of the adsorbent for blood cells removal is within a range from 1 to 60% of the internal diameter of the casing.

Abstract: A blood cells removal module including a casing having an inlet into which a blood flow before blood cells removal flows, and an outlet in which a blood flow after blood cells removal is discharged, an adsorbent for blood cells removal of short fiber shape accommodated in the casing, a mesh being provided inside the inlet and the outlet, respectively, and holding the adsorbent for blood cells removal in the casing, wherein a length of the adsorbent for blood cells removal is within a range from 1 to 60% of the internal diameter of the casing.

Abstract: An adsorbent for the removal of blood cells, which is formed from a hydrophobic polymer resin and has a surface center line average roughness of 5 to 100 nm. The hydrophobic polymer resin is preferably a polyarylate resin (PAR), polyethersulfone resin (PES), polysulfone resin (PSF), or a polymer alloy consisting of two or more of these resins. The adsorbent for the removal of blood cells can take the form of beads, hollow fibers, or solid fibers.

Abstract: Disclosed is a method for producing a light-modulating film in which a light-modulating layer is sandwiched between two transparent resin substrates, the light-modulating layer being formed by use of a light-modulating material containing: a polymeric medium for forming a resin matrix; and a light-modulating suspension, the method comprising the following steps. Using this method, a light-modulating film can be obtained which has a wholly uniform external appearance and an excellent adhesiveness between its light-modulating layer and transparent resin substrate.

Abstract: A electromagnetic relay includes a spool, a coil, a U-shaped yoke, an armature, a movable contact, a pair of stationary contacts, and a taper. The spool has an inner hole and first and second flange portions formed at its two ends. The coil is wound on the spool. The yoke is locked at the flange portions of the spool by press fitting to stride over the coil. The armature is movably connected to one end of the yoke and positioned to extend through the inner hole of the spool. The movable contact is attached to move in an interlocked manner with the armature. The pair of stationary contacts are arranged to sandwich the movable contact. The taper is formed on at least one of press-fit locking surfaces of one end of the yoke and the first flange portion, and has a locking force that increases as being closer to a vicinity of the inner hole of the spool. A method of adjusting an electromagnetic relay, and a method of assembling an electromagnetic relay are also disclosed.