Patents by Inventor Toshiaki Isobe
Toshiaki Isobe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9904877Abstract: A printing apparatus includes: a transport unit that arranges and is able to transport a plurality of continuous paper pieces in parallel; a printing unit of which a print head reciprocates in a direction intersecting with a transport direction of the plurality of continuous paper pieces and which is configured to be able to perform printing on the plurality of continuous paper pieces separately; a reception unit that is able to receive a plurality of print jobs; and a control unit that controls operations of the transport unit and the printing unit based on the plurality of print jobs received by the reception unit.Type: GrantFiled: March 24, 2015Date of Patent: February 27, 2018Assignee: Seiko Epson CorporationInventors: Hirofumi Yoshiwaka, Toshiaki Isobe, Mamiko Ishida, Mamoru Akatsu
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Publication number: 20150278649Abstract: A printing apparatus includes: a transport unit that arranges and is able to transport a plurality of continuous paper pieces in parallel; a printing unit of which a print head reciprocates in a direction intersecting with a transport direction of the plurality of continuous paper pieces and which is configured to be able to perform printing on the plurality of continuous paper pieces separately; a reception unit that is able to receive a plurality of print jobs; and a control unit that controls operations of the transport unit and the printing unit based on the plurality of print jobs received by the reception unit.Type: ApplicationFiled: March 24, 2015Publication date: October 1, 2015Inventors: Hirofumi YOSHIWAKA, Toshiaki ISOBE, Mamiko ISHIDA, Mamoru AKATSU
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Publication number: 20150045248Abstract: The present invention aims to develop and provide a method for identifying a disease associated with the abundance of TDP-43 in cells and a method for producing a TDP-43 binding inhibitor. By measuring the abundance of a measurement substance, the amount of binding between a measurement substance and TDP-43, etc. in cells obtained from a subject, it is identified whether or not the subject is suffering from a disease associated with the abundance of TDP-43 in cells. Also, a drug which can significantly reduce the binding between a measurement substance and TDP-43 is produced by adding a drug candidate substance.Type: ApplicationFiled: February 28, 2013Publication date: February 12, 2015Inventors: Nobuhiro Takahashi, Keiichi Izumikawa, Hideaki Ishikawa, Harunori Yoshikawa, Toshiaki Isobe, Masato Taoka, Hiroshi Nakayama
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Patent number: 8880353Abstract: Disclosed are an apparatus for the identification of a ribonucleic acid, whereby not only the molecular weights of digestion products, from which nothing but the nucleic acid residue composition can be understood, but also nucleic acid residue sequence data is obtained from a product ion mass set and thus the identification reliability for the individual digestion products can be remarkably improved; a method for the identification of a ribonucleic acid; and a program and system for the identification of a ribonucleic acid.Type: GrantFiled: April 17, 2009Date of Patent: November 4, 2014Assignees: Riken, Tokyo Metropolitan University, National University Corporation Tokyo University of Agriculture and TechnologyInventors: Hiroshi Nakayama, Misaki Akiyama, Toshiaki Isobe, Masato Taoka, Yoshio Yamauchi, Nobuhiro Takahashi, Hideaki Ishikawa
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Patent number: 8507851Abstract: Nano-electrospray ionization techniques include the introduction of a separation solvent containing a sample to a column-integrated needle having a column filled with a resin for liquid chromatography. The separated sample components are sprayed from the tip of the column-integrated needle toward a sample introduction orifice of a mass spectrometer. An organic solvent is simultaneously introduced to a solvent-supplying needle. The organic solvent is supplied from the tip of the solvent-supplying needle to the tip of the column-integrated needle.Type: GrantFiled: August 20, 2012Date of Patent: August 13, 2013Assignee: Tokyo Metropolitan UniversityInventors: Toshiaki Isobe, Yoshio Yamauchi
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Patent number: 8401320Abstract: An image forming apparatus for compressing image data, includes: a compression unit that reduces data into a predetermined bit number per band of image data so as to satisfy a condition related to a predetermined compression and compresses the reduced data; a specifying unit that specifies a minimum bit number among the predetermined bit numbers applied to the bands and specifies bands which are not compressed by the minimum bit number; and a re-compression unit that performs re-compression on the specified bands so that the data is compressed by the minimum bit number.Type: GrantFiled: January 15, 2010Date of Patent: March 19, 2013Assignee: Seiko Epson CorporationInventors: Mariko Watanabe, Toshiaki Isobe
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Publication number: 20120312983Abstract: Nano-electrospray ionization techniques include the introduction of a separation solvent containing a sample to a column-integrated needle having a column filled with a resin for liquid chromatography. The separated sample components are sprayed from the tip of the column-integrated needle toward a sample introduction orifice of a mass spectrometer. An organic solvent is simultaneously introduced to a solvent-supplying needle. The organic solvent is supplied from the tip of the solvent-supplying needle to the tip of the column-integrated needle.Type: ApplicationFiled: August 20, 2012Publication date: December 13, 2012Applicant: TOKYO METROPOLITAN UNIVERSITYInventors: Toshiaki ISOBE, Yoshio YAMAUCHI
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Patent number: 8295616Abstract: An image processing device configured to compress image data to be used for printing with a plurality of compression levels having different compression rates includes a former stage compression unit, a storing unit and a latter stage compression unit. The latter stage compression unit is configured, after the former stage compression unit finishes compressing all of the areas, to recompress each of areas of a latest compression level at the moment being different from a compression level stored in the storing unit with the latest compression level.Type: GrantFiled: January 27, 2009Date of Patent: October 23, 2012Assignee: Seiko Epson CorporationInventors: Mariko Watanabe, Toshiaki Isobe
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Patent number: 8269165Abstract: Nano-electrospray ionization techniques include the introduction of a separation solvent containing a sample to a column-integrated needle having a column filled with a resin for liquid chromatography. The separated sample components are sprayed from the tip of the column-integrated needle toward a sample introduction orifice of a mass spectrometer. An organic solvent is simultaneously introduced to a solvent-supplying needle. The organic solvent is supplied from the tip of the solvent-supplying needle to the tip of the column-integrated needle.Type: GrantFiled: June 2, 2010Date of Patent: September 18, 2012Assignee: Tokyo Metropolitan UniversityInventors: Toshiaki Isobe, Yoshio Yamauchi
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Publication number: 20110161273Abstract: Disclosed are an apparatus for the identification of a ribonucleic acid, whereby not only the molecular weights of digestion products, from which nothing but the nucleic acid residue composition can be understood, but also nucleic acid residue sequence data is obtained from a product ion mass set and thus the identification reliability for the individual digestion products can be remarkably improved; a method for the identification of a ribonucleic acid; and a program and system for the identification of a ribonucleic acid.Type: ApplicationFiled: April 17, 2009Publication date: June 30, 2011Inventors: Hiroshi Nakayama, Misaki Akiyama, Toshiaki Isobe, Masato Taoka, Yoshio Yamauchi, Nobuhiro Takahashi, Hideaki Ishikawa
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Publication number: 20110089319Abstract: Nano-electrospray ionization techniques include the introduction of a separation solvent containing a sample to a column-integrated needle having a column filled with a resin for liquid chromatography. The separated sample components are sprayed from the tip of the column-integrated needle toward a sample introduction orifice of a mass spectrometer. An organic solvent is simultaneously introduced to a solvent-supplying needle. The organic solvent is supplied from the tip of the solvent-supplying needle to the tip of the column-integrated needle.Type: ApplicationFiled: June 2, 2010Publication date: April 21, 2011Applicant: TOKYO METROPOLITAN UNIVERSITYInventors: Toshiaki Isobe, Yoshio Yamauchi
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Publication number: 20100182644Abstract: An image forming apparatus for compressing image data, includes: a compression unit that reduces data into a predetermined bit number per band of image data so as to satisfy a condition related to a predetermined compression and compresses the reduced data; a specifying unit that specifies a minimum bit number among the predetermined bit numbers applied to the bands and specifies bands which are not compressed by the minimum bit number; and a re-compression unit that performs re-compression on the specified bands so that the data is compressed by the minimum bit number.Type: ApplicationFiled: January 15, 2010Publication date: July 22, 2010Applicant: SEIKO EPSON CORPORATIONInventors: Mariko Watanabe, Toshiaki Isobe
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Publication number: 20090190848Abstract: An image processing device configured to compress image data to be used for printing with a plurality of compression levels having different compression rates includes a former stage compression unit, a storing unit and a latter stage compression unit. The latter stage compression unit is configured, after the former stage compression unit finishes compressing all of the areas, to recompress each of areas of a latest compression level at the moment being different from a compression level stored in the storing unit with the latest compression level.Type: ApplicationFiled: January 27, 2009Publication date: July 30, 2009Applicant: SEIKO EPSON CORPORATIONInventors: Mariko WATANABE, Toshiaki ISOBE
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Publication number: 20080166696Abstract: A method for analyzing proteins according to which two types of samples containing proteins are compared using a mass spectrometer, so that the proteins which are included in respective samples are identified and the mass ratio of a protein of the same type that is included in the respective samples is analyzed, wherein the method for analyzing proteins is characterized by including the steps of: respectively digestting said two types of samples containing proteins at portions of a certain amino acid using a restriction enzyme so as to prepare samples containing peptides; modifying peptides which are included in said respective samples containing peptides with labeling compounds having different masses due to isotopes, so that peptides of the same type that are included in the respective samples containing peptides have different masses; mixing the samples containing peptides that have been respectively labeled with isotopes, separating and quantifying the mixed sample for each peptide and measuring the MS spType: ApplicationFiled: December 17, 2004Publication date: July 10, 2008Inventors: Yoshio Yamauchi, Takashi Shinkawa, Toshiaki Isobe
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Patent number: 7066011Abstract: The present invention aims to provide a liquid chromatograph, an analysis system, and a gradient elution method, which are designed to permit a gradient change of eluent with higher precision and also permit a high sensitive detection or analysis.Type: GrantFiled: April 8, 2001Date of Patent: June 27, 2006Assignee: Nano Solution, Inc.Inventors: Yoshi Yamauchi, Tohru Natsume, Toshiaki Isobe
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Patent number: 6979817Abstract: A problem is to provide a microspray column capable of increasing the ionization efficiency, and a high sensitive mass spectrometer and a mass spectrometric method using such a microspray column. For solving this problem, we provide a column for introducing a sample in an ionization source of a mass spectrometer (ESI/MS) being designed to ionize a sample molecule with electrospray and introduce it into an analyzer, has structural features of: (1) 0.5 ?m or less in an inner diameter of a tip opening of the column; (2) 0.5 ?m or more and 5 ?m or less in a particle size of a column filler; and (3) fritless, a microspray column having the above (1) to (3), a mass spectrometer having such a microspray column in an ionization source, and a mass spectrometric method capable of performing a nonoflow electrospray with the microspray column.Type: GrantFiled: April 8, 2002Date of Patent: December 27, 2005Assignee: Nano Solution, Inc.Inventors: Yoshio Yamauchi, Tohru Natsume, Toshiaki Isobe
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Publication number: 20050121608Abstract: A problem is to provide a microspray column capable of increasing the ionization efficiency, and a high sensitive mass spectrometer and a mass spectrometric method using such a microspray column. For solving this problem, we provide a column for introducing a sample in an ionization source of a mass spectrometer (ESI/MS) being designed to ionize a sample molecule with electrospray and introduce it into an analyzer, has structural features of: (1) 0.5 ?m or less in an inner diameter of a tip opening of the column; (2) 0.5 ?m or more and 5 ?m or less in a particle size of a column filler; and (3) fritless, a microspray column having the above (1) to (3), a mass spectrometer having such a microspray column in an ionization source, and a mass spectrometric method capable of performing a nonoflow electrospray with the microspray column.Type: ApplicationFiled: April 8, 2002Publication date: June 9, 2005Applicant: Nano Solution, IncInventors: Yoshio Yamauchi, Tohru Natsume, Toshiaki Isobe
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Publication number: 20050016263Abstract: The present invention aims to provide a liquid chromatograph, an analysis system, and a gradient elution method, which are designed to permit a gradient change of eluent with higher precision and also permit a high sensitive detection or analysis.Type: ApplicationFiled: April 8, 2001Publication date: January 27, 2005Inventors: Yoshio Yamauchi, Tohru Natsume, Toshiaki Isobe
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Patent number: 6052203Abstract: To convert gray-scale data of each pixel of image data into pulse-width data for each pixel, a RAM is provided. The RAM has nine pixel memory regions corresponding to nine pixels a to i for forming, for example, a 3.times.3 pixel matrix on the output image. In each of the pixel memory regions, there are stored pulse-width data items corresponding to values which are permitted for gray-scale data to have. Pulse-width data items in the pixel memory regions are slightly different from one another among pixel memory regions. Gray-scale data of each pixel of image data and address word composed of gray-scale data of each pixel of image data and coordinates of each pixel in the 3.times.3 matrix is supplied to the RAM. Thus, pulse-width data corresponding to gray-scale data is read from the pixel memory region so that a laser drive pulse having a pulse width corresponding to the read pulse-width data is generated.Type: GrantFiled: August 6, 1998Date of Patent: April 18, 2000Assignee: Seiko Epson CorporationInventors: Tetsuya Suzuki, Sunao Murata, Toshiaki Isobe, Takeshi Miyashita, Shinji Nozawa, Toshiyuki Hattori
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Patent number: 5408227Abstract: A multiplex transmission system for a vehicle is constructed such that signals are given and received via a communication line between a plurality of peripheral stations and a central station. The plurality of peripheral stations are arranged at various places such as a door system, an engine system and the like. Each of the peripheral stations is constructed such that an input signal from the plurality of working members (a door lock, a power window and the like) is sent to the central station via the communication line. A control signal from the central station is input via the communication line 5 by the peripheral stations to output to the plurality of working members. Depending on the bit unit form of the control signal working members are actuated. The central station processes data sent by the peripheral stations to generate the control signal.Type: GrantFiled: June 10, 1994Date of Patent: April 18, 1995Assignee: Nippondenso Co., Ltd.Inventors: Yuuzi Hirabayashi, Kenji Kobayashi, Toshiaki Isobe, Shigeru Uehara