Patents by Inventor Toshiaki Kudo
Toshiaki Kudo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20160151322Abstract: A new metallo-?-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of ?-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-?-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of ?-lactam antibiotics against metallo-?-lactamase producing bacteria by combining the compound of the general formula (I) with ?-lactam antibiotics.Type: ApplicationFiled: December 29, 2015Publication date: June 2, 2016Inventors: Ken Chikauchi, Mizuyo Ida, Takao Abe, Yukiko Hiraiwa, Akihiro Morinaka, Toshiaki Kudo
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Patent number: 9260375Abstract: A new metallo-?-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of ?-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-?-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of ?-lactam antibiotics against metallo-?-lactamase producing bacteria by combining the compound of the general formula (I) with ?-lactam antibiotics.Type: GrantFiled: November 29, 2011Date of Patent: February 16, 2016Assignee: Meiji Seika Kaisha, Ltd.Inventors: Ken Chikauchi, Mizuyo Ida, Takao Abe, Yukiko Hiraiwa, Akihiro Morinaka, Toshiaki Kudo
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Patent number: 8728459Abstract: An object of the present invention is to provide a means for imparting resistance against pathogenic fungal, pathogenic bacterial, or pathogenic viral disease to agriculturally useful plants. The present invention relates to a bacterium belonging to the genus Azospirillum or the genus Herbaspirillum capable of imparting resistance against pathogenic fungal, pathogenic bacterial, or pathogenic viral disease to a host plant by living symbiotically within the plant, a method for controlling plant disease using the bacteria, and plants produced by such method.Type: GrantFiled: March 2, 2007Date of Patent: May 20, 2014Assignees: Mayekawa Mfg. Co., Ltd., RikenInventors: Tsuyoshi Isawa, Michiko Yasuda, Satoshi Shinozaki, Hideo Nakashita, Toshiaki Kudo
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Patent number: 8383798Abstract: This invention provides: DNA encoding cellulase enzymes from intestinal symbiotic protists of the insects of Reticulitermes speratus, Hodotermopsis sjostedti, Neotermes koshunensis, Mastotermes darwiniensis, and Cryptocercidae, comprising the nucleotide sequences as shown in SEQ ID NOS:1 to 140; an expression system for the DNA; and a method for producing the cellulase enzymes using the expression system.Type: GrantFiled: January 18, 2008Date of Patent: February 26, 2013Assignees: Riken, The University of TokyoInventors: Shigeharu Moriya, Toshiaki Kudo, Tetsushi Inoue, Nemuri Todaka, Katsuhiko Kitamoto, Manabu Arioka, Junichi Maruyama
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Publication number: 20120071457Abstract: A new metallo-?-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of ?-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-?-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of ?-lactam antibiotics against metallo-?-lactamase producing bacteria by combining the compound of the general formula (I) with ?-lactam antibiotics.Type: ApplicationFiled: November 29, 2011Publication date: March 22, 2012Inventors: Ken Chikauchi, Mizuyo Ida, Takao Abe, Yukiko Hiraiwa, Akihiro Morinaka, Toshiaki Kudo
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Patent number: 8093294Abstract: A new metallo-?-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of ?-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-?-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of ?-lactam antibiotics against metallo-?-lactamase producing bacteria by combining the compound of the general formula (I) with ?-lactam antibiotics.Type: GrantFiled: August 10, 2007Date of Patent: January 10, 2012Assignee: Meiji Seika Kaisha, Ltd.Inventors: Ken Chikauchi, Mizuyo Ida, Takao Abe, Yukiko Hiraiwa, Akihiro Morinaka, Toshiaki Kudo
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Publication number: 20100221807Abstract: This invention provides a cellulase enzyme derived from intestinal symbiotic protists of insects selected from the group consisting of Reticulitermes speratus, Hodotermopsis sjostedti, Neotermes koshunensis, Mastotermes darwiniensis, and Cryptocercidae and comprising an amino acid sequence encoded by a nucleotide sequence selected from the group consisting of the nucleotide sequences as shown in SEQ ID NOS:1 to 140 and nucleotide sequences having 90% or higher identity therewith, a mixture of two or more said enzymes, a processed matter of said enzyme or mixture, DNA encoding said enzyme and an expression system thereof, and a method for producing said enzyme.Type: ApplicationFiled: January 18, 2008Publication date: September 2, 2010Applicants: RIKEN, The University of TokyoInventors: Shigeharu Moriya, Toshiaki Kudo, Tetsushi Inoue, Nemuri Todaka, Katsuhiko Kitamoto, Manabu Arioka, Manabu Arioka, Junichi Maruyama
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Publication number: 20090155214Abstract: An object of the present invention is to provide a means for imparting resistance against pathogenic fungal, pathogenic bacterial, or pathogenic viral disease to agriculturally useful plants. The present invention relates to a bacterium belonging to the genus Azospirillum or the genus Herbaspirillum capable of imparting resistance against pathogenic fungal, pathogenic bacterial, or pathogenic viral disease to a host plant by living symbiotically within the plant, a method for controlling plant disease using the bacteria, and plants produced by such method.Type: ApplicationFiled: March 2, 2007Publication date: June 18, 2009Applicants: Mayekawa MFG. Co. Ltd, RIKENInventors: Tsuyoshi Isawa, Michiko Yasuda, Satoshi Shinozaki, Hideo Nakashita, Toshiaki Kudo
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Publication number: 20080090825Abstract: A new metallo-?-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of ?-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-?-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of ?-lactam antibiotics against metallo-?-lactamase producing bacteria by combining the compound of the general formula (I) with ?-lactam antibiotics.Type: ApplicationFiled: August 10, 2007Publication date: April 17, 2008Inventors: Ken Chikauchi, Mizuyo Ida, Takao Abe, Yukiko Hiraiwa, Akihiro Morinaka, Toshiaki Kudo
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Publication number: 20070249011Abstract: An object of the present invention is to provide a method for effectively screening a agricultural chemical candidate or drug candidate. Specifically, an object of the present invention as to a agricultural chemical is to effectively screen, without the use of plants, a agricultural chemical candidate compound that does not exert a harmful effect on other organisms such as plants.Type: ApplicationFiled: March 4, 2005Publication date: October 25, 2007Applicant: RIKENInventors: Toshiaki Kudo, Takayuki Motoyama
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Patent number: 6916822Abstract: A medicament useful for preventive and/or therapeutic treatment of nerve system diseases which comprises, as an active ingredient, a compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof: wherein, X represents a group represented by the following general formula (II), (III), (IV), (V), or (VI), “A” represents a saturated or unsaturated 3- to 6-membered carbocyclic group and the like, “B” represents CH2 and the like, “n” represents 0 to 2, R1 represents a hydrogen atom, a halogen atom and the like, R2, R3, and R7 to R14 represent a hydrogen atom, a lower alkyl group which may be substituted and the like, R4 represents a hydrogen atom, a lower alkyl group which may be substituted and the like, R5 represents a hydrogen atom, a halogen atom and the like, R6 represents a saturated or unsaturated monocyclic or bicyclic carbocyclic group and the like, and R5 and R6, R7 and R8, R9 and R10, or R11 and R12 may bind to each other to form a cyclic structure.Type: GrantFiled: February 16, 2001Date of Patent: July 12, 2005Assignee: Meiji Seika Kaisha, Ltd.Inventors: Masaki Tsushima, Kaori Tadauchi, Kenji Asai, Naoko Miike, Masako Imai, Toshiaki Kudo
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Publication number: 20050148583Abstract: A medicament useful for preventive and/or therapeutic treatment of nerve system diseases which comprises, as an active ingredient, a compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof: wherein, X represents a group represented by the following general formula (II), (III), (IV), (V), or (VI), “A” represents a saturated or unsaturated 3- to 6-membered carbocyclic group and the like, “B” represents CH2 and the like, “n” represents 0 to 2, R1 represents a hydrogen atom, a halogen atom and the like, R2, R3, and R7 to R14 represent a hydrogen atom, a lower alkyl group which may be substituted and the like, R4 represents a hydrogen atom, a lower alkyl group which may be substituted and the like, R5 represents a hydrogen atom, a halogen atom and the like, R6 represents a saturated or unsaturated monocyclic or bicyclic carbocyclic group and the like, and R5 and R6, R7 and R8, R9 and R10, or R11 and R12 may bind to each other to form a cyclic structure.Type: ApplicationFiled: March 2, 2005Publication date: July 7, 2005Applicant: Meiji Seika Kaisha, Ltd.Inventors: Masaki Tsushima, Kaori Tadauchi, Kenji Asai, Naoko Miike, Masako Imai, Toshiaki Kudo
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Patent number: 6790854Abstract: A substance having affinity for an opioid &dgr; receptor, which is represented by the following general formula (I): wherein, X represents a group of the general formula: —CO—N(R5)(R6) (II) and the like, n represents 1 to 3, R1 and R2 represent a hydrogen atom, a halogen atom, a lower alkyl group and the like, R3 represents a hydrogen atom, a halogen atom, a lower alkyl group and the like, R4 represents a saturated or unsaturated monocyclic or bicyclic carbocyclic group and the like, R5 to R12 represent a hydrogen atom, a lower alkyl group and the like, and R3 and R4, R5 and R6, R7 or R8 and R9 and R10 may bind to each other to form a cyclic structure, and a medicament useful for preventive and/or therapeutic treatment of central nervous system diseases and peripheral nervous system diseases comprising the substance as an active ingredient.Type: GrantFiled: March 13, 2003Date of Patent: September 14, 2004Assignee: Meiji Seika Kaisha, Ltd.Inventors: Masaki Tsushima, Kaori Tadauchi, Kenji Asai, Naoko Miike, Toshiaki Kudo
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Publication number: 20030176693Abstract: A substance having affinity for an opioid &dgr; receptor, which is represented by the following general formula (I): 1Type: ApplicationFiled: March 13, 2003Publication date: September 18, 2003Inventors: Masaki Tsushima, Kaori Tadauchi, Kenji Asai, Naoko Miike, Toshiaki Kudo
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Publication number: 20030171370Abstract: A medicament useful for preventive and/or therapeutic treatment of nerve system diseases which comprises, as an active ingredient, a compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof: 1Type: ApplicationFiled: December 3, 2002Publication date: September 11, 2003Inventors: Masaki Tsushima, Kaori Tadauchi, Kenji Asai, Naoko Miike, Masako Imai, Toshiaki Kudo
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Patent number: 5663162Abstract: Compounds represented by the following formula (I), that is, cephem derivatives having substituted or unsubstituted imidazo[5,1-b]thiazolium-6-yl as a substituent at the 3-position of the cephem ring: ##STR1## wherein X represents CH or N, R.sup.1 represents H, alkyl, alkenyl or the like, and R.sup.2, R.sup.3, R.sup.4 and R.sup.5 represent H, alkyl, carbamoyl, amino or the like. The above compounds have excellent antibacterial activity, and useful as medicines for the treatment of various infectious diseases caused by bacteria.Type: GrantFiled: July 25, 1995Date of Patent: September 2, 1997Assignee: Meiji Seika Kabushiki KaishaInventors: Kunio Atsumi, Eijiro Umemura, Yuko Kano, Sohjiro Shiokawa, Toshiaki Kudo, Masaki Tsushima, Katsuyoshi Iwamatsu, Atsushi Tamura, Seiji Shibahara
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Patent number: 5618795Abstract: As new dibekacin derivatives and new arbekacin derivatives are now provided 2"-amino-2"-deoxydibekacin, 2"-amino-5,2"-dideoxydibekacin, 2"-amino-2"-deoxyarbekacin, 2"-amino-5,2"-dideoxyarbekacin, 2"-amino-5,2"-dideoxy-5-epi-fluoroarbekacin and 2"-amino-5,2"-dideoxy-5-epi-aminoarbekacin which all exhibit high antibacterial activity against a wide variety of gram-positive and gram-negative bacteria, including resistant bacteria such as methicillin-resistant Staphylococcus aureus and which are of low toxicity to mammals and are useful as antibacterial agent for treatment of bacterial infections.Type: GrantFiled: September 8, 1995Date of Patent: April 8, 1997Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Shinichi Kondo, Seiji Shibahara, Takayuki Usui, Toshiaki Kudo, Shuichi Gomi, Atsushi Tamura, Yoko Ikeda, Daishiro Ikeda, Tomio Takeuchi
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Patent number: 5488038Abstract: As new dibekacin derivatives and new arbekacin derivatives are now provided 2"-amino-2"-deoxydibekacin, 2"-amino-5,2"-dideoxydibekacin, 2"-amino-2"-deoxyarbekacin, 2"-amino-5,2"-dideoxyarbekacin, 2"-amino-5,2"-dideoxy-5-epi-fluoroarbekacin and 2"-amino-5,2"-dideoxy-5-epi-aminoarbekacin which all exhibit high antibacterial activity against a wide variety of gram-positive and gram-negative bacteria, including resistant bacteria such as methicillin-resistant Staphylococcus aureus and which are of low toxicity to mammals and are useful as antibacterial agent for treatment of bacterial infections.Type: GrantFiled: November 18, 1993Date of Patent: January 30, 1996Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Shinichi Kondo, Seiji Shibahara, Takayuki Usui, Toshiaki Kudo, Shuichi Gomi, Atsushi Tamura, Yoko Ikeda, Daishiro Ikeda, Tomio Takeuchi
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Patent number: 5246839Abstract: The present invention provides for a plasmid, pEAP7.DELTA.P, containing a DNA region capable of inducing extracellular secretion of a useful, physiologically active substance in transformed host and a promoter DNA region regulating expression of the first DNA region. The present invention further provides for a microorganism transformed with the plasmid and a process for the production of the substances by culturing the microorganism.Type: GrantFiled: September 15, 1992Date of Patent: September 21, 1993Assignee: Rikagaku KenkyushoInventors: Koki Horikoshi, Toshiaki Kudo, Tetsuo Kobayashi, Chiaki Kato
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Patent number: 4962055Abstract: A novel plasmid pEAP2, which was constructed from Bacillus sp. 170 chromosomal DNA carrying the gene for extracellular production of penicillinase and a vector plasmid pMB9. A novel microorganism, Escherichia coli HB101(pEAP2) carrying the plasmid pEAP2 and being capable of extracellular production of penicillinase. The method for cultivation of the microorganism is characterized by culturing it in the medium containing NaCl (or KCl) for 16-48 hours. According to this invention, useful high-molecular substances can be produced in a high yield.Type: GrantFiled: March 30, 1987Date of Patent: October 9, 1990Assignee: Rikagaku KenkyushoInventors: Koki Horikoshi, Toshiaki Kudo, Chiaki Kato