Patents by Inventor Toshiaki Nihoshi

Toshiaki Nihoshi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8098279
    Abstract: Providing an imaging apparatus and a microscope capable of taking two-dimensional images of a sample at a plurality of observation positions different in the optical axis direction at the same time. The apparatus includes an image-forming lens 15 that forms images of a sample 4 on a plurality of image-forming places; an optical-path-dividing member 17, 18, 19 that divides an optical path from the same area in a plane perpendicular to an optical axis of the sample 4 so as to form the plurality of image-forming places; and an optical-path-length-changing member 27, 28, 29 that is provided on at least one optical path between the plurality of image-forming places and the imaging lens 15.
    Type: Grant
    Filed: April 23, 2009
    Date of Patent: January 17, 2012
    Assignee: Nikon Corporation
    Inventors: Ichiro Sase, Toshiaki Nihoshi
  • Patent number: 8014065
    Abstract: A microscope apparatus has an illumination optical system illuminating a sample with laser light from laser light sources. A fluorescence detection optical system detects fluorescence from the sample. Fluorescence cubes are interchangeably provided in an optical path of the illumination optical system and lead the laser light to the sample. An objective lens is also provided. At least one of the fluorescence cubes includes an optical member that makes a principal ray of the laser light substantially parallel to an optical axis of the illumination optical system and concentrates the laser light on a given position that is on a pupil position of the objective lens and separated from the optical axis, thereby providing a microscope apparatus capable of changing from a confocal microscope to a total-internal-reflection fluorescence microscope by exchanging a fluorescence cube used in the fluorescence microscope.
    Type: Grant
    Filed: September 20, 2009
    Date of Patent: September 6, 2011
    Assignee: Nikon Corporation
    Inventor: Toshiaki Nihoshi
  • Publication number: 20100014158
    Abstract: A microscope apparatus 1 comprises: an illumination optical system illuminating a sample with laser light from laser light sources 32, 42; a fluorescence detection optical system that detects fluorescence from the sample; a plurality of fluorescence cubes 61 that are provided on an optical path of the illumination optical system and leads the laser light to the sample; and an objective lens 16. At least one of the fluorescence cube includes an optical member 60 that makes a principal ray of the laser light substantially parallel to an optical axis of the illumination optical system and concentrates the laser light on a given position that is on a pupil position P of the objective lens and separates from the optical axis, thereby providing a microscope apparatus capable of changing from a confocal microscope to a total-internal-reflection fluorescence microscope by exchanging a fluorescence cube used in the fluorescence microscope.
    Type: Application
    Filed: September 20, 2009
    Publication date: January 21, 2010
    Inventor: Toshiaki Nihoshi
  • Publication number: 20090201366
    Abstract: Providing an imaging apparatus and a microscope capable of taking two-dimensional images of a sample at a plurality of observation positions different in the optical axis direction at the same time. The apparatus includes an image-forming lens 15 that forms images of a sample 4 on a plurality of image-forming places; an optical-path-dividing member 17, 18, 19 that divides an optical path from the same area in a plane perpendicular to an optical axis of the sample 4 so as to form the plurality of image-forming places; and an optical-path-length-changing member 27, 28, 29 that is provided on at least one optical path between the plurality of image-forming places and the imaging lens 15.
    Type: Application
    Filed: April 23, 2009
    Publication date: August 13, 2009
    Inventors: Ichiro Sase, Toshiaki Nihoshi
  • Patent number: 7071451
    Abstract: An autofocus system according to the present invention comprises: a light source; a focusing illumination optical system that forms an optical image generated with light from the light source on a target object through an objective lens; a focusing image forming optical system that receives through the objective lens reflected light generated as the optical image is reflected off the target object and forms a reflected image of the optical image; a photoelectric converter that is provided at an image forming position at which the reflected image is formed by the focusing image forming optical system to detect the reflected image; a signal output device that outputs a signal for controlling a focus actuator based upon a signal corresponding to the reflected image obtained at the photoelectric converter; and an image forming position adjustment device that adjusts an offset quantity between a focus position of the objective lens and an image forming position of the optical image by moving at least one of the im
    Type: Grant
    Filed: June 16, 2003
    Date of Patent: July 4, 2006
    Assignee: Nikon Corporation
    Inventors: Aiichi Ishikawa, Toshiaki Nihoshi
  • Patent number: 6963446
    Abstract: An epi-illumination apparatus has, in the following order from an light source device side, a first imaging lens which forms an image of the light source and a field lens which projects the image of the light source to an object to be illuminated. Either one of a first magnification varying unit or a second magnification varying unit is selectively disposed between the first imaging lens and the field lens in order to vary a magnification of the image of the light source. The first magnification varying unit has a first aperture stop and a second imaging lens that is disposed in the field lens side of the first aperture stop, while the second magnification varying unit has a second aperture stop and a third imaging lens that is disposed in the first imaging lens side of the second aperture stop.
    Type: Grant
    Filed: December 10, 2002
    Date of Patent: November 8, 2005
    Assignee: Nikon Corporation
    Inventor: Toshiaki Nihoshi
  • Patent number: 6906859
    Abstract: An epi-illumination apparatus for fluorescent observation, adjusting light intensities of a plurality of illuminations on a sample over a wide wavelength band continuously and being configured inexpensively, and a fluorescence microscope having the same are provided. A light source, extracting means, an aperture stop, and a filter are arranged on a predetermined optical axis. The aperture stop is arranged on a plane generally conjugated with a pupil plane of an objective. The filter is placed near the aperture stop. The extracting means extracts a plurality of narrow wavelength bands from the wavelength band of the illumination emitted from the light source. The filter has regions of different spectral transmission characteristics to the narrow wavelength bands. The adjusting means for adjusting light intensities of transmitted light from the filter in the narrow wavelength bands independently by moving the filter in a direction orthogonal to the optical axis is provided.
    Type: Grant
    Filed: June 4, 2003
    Date of Patent: June 14, 2005
    Assignee: Nikon Corporation
    Inventors: Toshiaki Nihoshi, Hisashi Okugawa
  • Publication number: 20040113043
    Abstract: An autofocus system according to the present invention comprises: a light source; a focusing illumination optical system that forms an optical image generated with light from the light source on a target object through an objective lens; a focusing image forming optical system that receives through the objective lens reflected light generated as the optical image is reflected off the target object and forms a reflected image of the optical image; a photoelectric converter that is provided at an image forming position at which the reflected image is formed by the focusing image forming optical system to detect the reflected image; a signal output device that outputs a signal for controlling a focus actuator based upon a signal corresponding to the reflected image obtained at the photoelectric converter; and an image forming position adjustment device that adjusts an offset quantity between a focus position of the objective lens and an image forming position of the optical image by moving at least one of the im
    Type: Application
    Filed: June 16, 2003
    Publication date: June 17, 2004
    Applicant: Nikon Corporation
    Inventors: Aiichi Ishikawa, Toshiaki Nihoshi
  • Publication number: 20030227674
    Abstract: An epi-illumination apparatus for fluorescent observation, adjusting light intensities of a plurality of illuminations on a sample over a wide wavelength band continuously and being configured inexpensively, and a fluorescence microscope having the same are provided. A light source, extracting means, an aperture stop, and a filter are arranged on a predetermined optical axis. The aperture stop is arranged on a plane generally conjugated with a pupil plane of an objective. The filter is placed near the aperture stop. The extracting means extracts a plurality of narrow wavelength bands from the wavelength band of the illumination emitted from the light source. The filter has regions of different spectral transmission characteristics to the narrow wavelength bands. The adjusting means for adjusting light intensities of transmitted light from the filter in the narrow wavelength bands independently by moving the filter in a direction orthogonal to the optical axis is provided.
    Type: Application
    Filed: June 4, 2003
    Publication date: December 11, 2003
    Applicant: NIKON CORPORATION
    Inventors: Toshiaki Nihoshi, Hisashi Okugawa
  • Publication number: 20030112505
    Abstract: An epi-illumination apparatus has, in the following order from an light source device side, a first imaging lens which forms an image of the light source and a field lens which projects the image of the light source to an object to be illuminated. Either one of a first magnification varying unit or a second magnification varying unit is selectively disposed between the first imaging lens and the field lens in order to vary a magnification of the image of the light source. The first magnification varying unit has a first aperture stop and a second imaging lens that is disposed in the field lens side of the first aperture stop, while the second magnification varying unit has a second aperture stop and a third imaging lens that is disposed in the first imaging lens side of the second aperture stop.
    Type: Application
    Filed: December 10, 2002
    Publication date: June 19, 2003
    Applicant: Nikon Corporation
    Inventor: Toshiaki Nihoshi
  • Patent number: 6188515
    Abstract: A lens system for a microscope having a variable angle lens-barrel. The lens-barrel includes an afocal optical system lying along an optical path extending from an infinite correction type objective lens to an ocular lens and comprises a first lens group which has positive refractive power, a second lens group which has negative refractive power, and a third lens group which has positive refractive power. The lens system includes a reflective mirror positioned between the second lens group and the third lens group which is mounted for rotation a out a pendular axis. Light through the infinite correction type objective lens becomes a parallel light beam which is passed to the third lens group from the reflective mirror.
    Type: Grant
    Filed: August 20, 1999
    Date of Patent: February 13, 2001
    Assignee: Nikon Corporation
    Inventor: Toshiaki Nihoshi
  • Patent number: 6128128
    Abstract: A microscope system for observing an image of a sample at desired magnifications includes a first objective lens having an objective side surface which is telecentric, a focusing lens, disposed in an optical path along which optical rays emitted from the first objective lens travel, for focusing the optical rays and forming a sample image and a second objective lens having a magnification factor different from that of the first objective lens. An interchanging member holds the first objective lens and the second objective lens and is used for placing one of the first and second objective lenses in an observational optical path between the sample and the focusing lens. The inequality 0.29<D/fI<0.40 is satisfied, assuming D to be a parfocal length which equals a distance between a surface of the sample and an attachment plane of the objective lens and fI to be a focal length of the focusing lens.
    Type: Grant
    Filed: May 12, 1997
    Date of Patent: October 3, 2000
    Assignee: Nikon Corporation
    Inventors: Tatsuro Otaki, Toshiaki Nihoshi, Manabu Sato, Hitoshi Kaizu, Yumiko Ouchi
  • Patent number: 5552928
    Abstract: A microscope has an objective optical system coupled to an observation optical system with parallel optical axes. A stage, which holds a sample, rectilinearly moves in a direction toward and away from the observation optical axis, which is perpendicular to the plane of the stage. The objective optical system rectilinearly moves in a direction perpendicular to the movement of the stage. The microscope thus permits viewing of a large sample with a small stroke of the stage, whereby a compact and lightweight structure may be achieved.
    Type: Grant
    Filed: December 16, 1993
    Date of Patent: September 3, 1996
    Assignee: Nikon Corporation
    Inventors: Hidehiko Furuhashi, Toshiaki Nihoshi
  • Patent number: 4527869
    Abstract: A microscope provided with a photographing device comprises an objective lens, prism means having a first surface opposed to the objective lens, a second surface parallel to the first surface, and a third and a fourth surface inclined by a predetermined angle with respect to the first and second surfaces and parallel to each other, the prism means introducing thereinto the emergent light from the objective lens through said first surface and causing the light to emerge from said second surface, light guide means for causing the emergent light from the second surface of the prism means to enter the third surface thereof, change-over means operated to change an optical path determined by the light guide means and direct the emergent light from said second surface to the photographing device, and an eyepiece system for receiving the emergent light from the fourth surface of the prism means.
    Type: Grant
    Filed: May 31, 1983
    Date of Patent: July 9, 1985
    Assignee: Nippon Kogaku K.K.
    Inventor: Toshiaki Nihoshi
  • Patent number: 4512640
    Abstract: A polarizing microscope comprises an orthoscopic system having an objective lens for forming the image of a sample, and a conoscopic system including polarizer means, analyzer means and an image forming lens disposed between the objective lens and the image plane of the image of the sample. The image forming lens is disposed at a position whereat the exit pupil of the objective lens and said image plane are conjugate with respect to the image forming lens and has a sufficiently small diameter relative to the width of the optical path of the orthoscopic system in said position. Thus, the conoscopic system forms the image of the exit pupil of the objective lens on the image plane and the observation light beam by the orthoscopic system passes through the outside of the image forming lens and forms the image of the sample around the image of the exit pupil on said image plane.
    Type: Grant
    Filed: May 20, 1983
    Date of Patent: April 23, 1985
    Assignee: Nippon Kogaku K.K.
    Inventor: Toshiaki Nihoshi