Abstract: This invention relates to crystals of compounds of formula (I), wherein TBS represents t-butyldimethylsilyl, and Ph represents phenyl, or its salt or solvate. Compounds of formula (I) are synthesis intermediates of 2-substituted-1?-methyl carbapenem compounds useful as antimicrobial agents. The crystals of the present invention have excellent handleability and can realize the production of carbapenem compounds having excellent antimicrobial activity in a simpler manner with improved yield and purity.

Abstract: This invention relates to crystals of compounds of formula (I), wherein TBS represents t-butyldimethylsilyl, and Ph represents phenyl, or its salt or solvate. Compounds of formula (I) are synthesis intermediates of 2-substituted-1?-methyl carbapenem compounds useful as antimicrobial agents. The crystals of the present invention have excellent handleability and can realize the production of carbapenem compounds having excellent antimicrobial actibity in a simpler manner with improved yield and purity.

Abstract: Disclosed are compounds represented by general formula (I) or pharmacologically acceptable salts or solvates thereof having excellent antimicrobial activity against bacteria causative of severe infections such as pneumonia and septicemia, particularly against MRSA, and also antimicrobial agents comprising these compounds, and pharmaceutical compositions comprising these compounds as an active component.

Abstract: Disclosed is a novel compound, designated BU-4514N, which is produced by cultivation of a novel strain of Microtetraspora, designated species T689-92. The novel compound possesses antibacterial and neuritogenic properties.

Abstract: A tool transfer mechanism for transferring a tool between a gateway position of a tool storage magazine and an exchange position adjacent a spindle which includes a base mounted on a frame, an actuator for rectilinearly moving the base, and a holding arm mounted on the base resiliently biased toward the tool to hold the same. The holding arm is moved outwardly to release the tool when the base is at the gateway position. The base is rotated in accordance with its rectilinear movement to change the posture of the tool between a first posture where the tool is parallel with remaining tools stored in the magazine and a second posture where the tool is parallel with the spindle.

Abstract: A spindle head for a machine tool rotatably carries a tool spindle, which is drivingly connected with an output shaft of a drive motor provided in axial alignment therewith. A drawing bar received in an axial through hole of the tool spindle is urged by means of springs for clamping on the tool spindle a tool being inserted into a front tapered bore of the tool spindle. In order to move the drawing bar against the springs and thereby to unclamp the tool from the tool spindle, an annular cylinder device is provided around the tool spindle. This cylinder device, when supplied with pressurized fluid, moves first and second operating members toward and away from each other in the axial direction of the tool spindle.

Abstract: A machine tool is provided with a double actuation hydraulic cylinder incorporated into a pallet clamp member, which is vertically movable for clamping and unclamping a work pallet onto and releasing it from a work table of the machine tool. The cylinder, in an extension operation, outwardly extends a first hollow rod and further extends a second rod telescopically from the first rod so as to present a first engaging member secured to the outer end of the second rod under a second engaging member of a work pallet on a pallet support. The pallet clamp member, when upwardly moved, establishes engagement of the first engaging member with the second engaging member, so that the subsequent retraction operation of the cylinder causes the work pallet to be transferred from the pallet support onto the work table.

Abstract: A machine tool with an automatic tool change function wherein a rotatable tool spindle carries a movable key engageable with either of a pair of key-ways formed on a tool. A tool changing arm, serving as a tool support device, friction-rotatably supports at least one tool for being selectively inserted within and removed from the tool spindle. When tool changing operation is to be performed, rotation of the spindle is changed to a predetermined speed permitting key-engagement. A first confirming device is provided for confirming the fact that the spindle has reached a first predetermined position during rotation thereof. The tool change arm is then operated to remove the tool from the spindle in response to the first confirming device. A second confirming device is provided for confirming that the spindle has reached a second predetermined position during rotation thereof.

Abstract: In a machine tool with an automatic tool change function, a rotatable tool spindle carries a movable key engageable with a key-way formed on a tool. A tool changing arm, serving as a tool support device, friction-rotatably supports at least one tool for selectively inserting and removing same into and from the tool spindle. When a tool change operation is to be performed, rotation of the spindle is changed into a predetermined speed permitting key-engagement. A detecting device is provided for detecting movement of the movable key to confirm engagement of the movable key with the key-way of the tool. A clamp device clamps the tool inserted into the spindle in response to the detecting device. After the tool is clamped on the spindle, rotation of the spindle is changed into a machining speed. A confirming device is provided for confirming that the spindle is reached at a predetermined angular position during rotation thereof.

Abstract: A tool storage magazine of the type wherein a plurality of tool sockets each for removably storing a cutting tool therein are pivotably carried on an indexable element is provided with an engaging member moved by a hydraulic cylinder for pivoting each tool socket at a tool taking out position from a horizontal position to a vertical position through engagement with a pair of engaging rollers which are rotatably supported by each tool socket and located outside the side faces of each tool socket. The magazine is further provided with a locking mechanism which prevents a holding plunger of any tool socket indexed to the tool taking out position from being disengaged from a tool received in the tool socket until the tool socket is pivoted to its vertical position.

Abstract: A vertical support shaft supporting a tool support is slidably and rotatably supported in a base. A gear member is rotatably but non-slidably mounted on the support shaft and is provided with a threaded portion threadedly engaged with the base. A sleeve member having a rack engaging with the gear member is moved axially to lift the tool support to an upper position for an index operation. The sleeve member is provided with a notch to receive a resiliently urged lock shaft for restraining the axial movement of the sleeve member when the tool support is moved to the upper position.