Patents by Inventor Toshifumi Yamaki
Toshifumi Yamaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7595184Abstract: The amino acid sequence of a mutant which is obtained by introducing a novel mutation into a Pseudonocardia thermophila JCM3095-derived nitrile hydratase consisting of two types of heterogeneous subunits, and the base sequence of the gene are provided. The nitrile hydratase is modified by specifying the region to be modified in the stereostructure/amino acid sequence of the nitrile hydratase, and applying alteration such as substitution, insertion, deletion or the like, to the amino acids in the amino acid sequence which are corresponding to the amino acid residues forming the region. Also provided is a method for modifying an enzyme having a nitrile hydratase activity.Type: GrantFiled: December 15, 2003Date of Patent: September 29, 2009Assignee: Mitsui Chemicals, Inc.Inventors: Toshifumi Yamaki, Shinichi Banba, Kaori Matoishi, Kiyoshi Ito, Hideki Kobayashi, Eishi Tanaka, Toshihiro Oikawa
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Patent number: 7510861Abstract: A novel gluconate dehydratase derived from Achromobacter xylosoxidans and a gene encoding the gluconate dehydratase are provided. By reacting the gluconate dehydratase or a transformed cell containing the gene with an aldonic acid, the corresponding 2-keto-3-deoxyaldonic acid can be efficiently produced.Type: GrantFiled: September 20, 2006Date of Patent: March 31, 2009Assignee: Mitsui Chemicals, Inc.Inventors: Hitoki Miyake, Toshifumi Yamaki, Toshihiro Oikawa, Takeshi Nakamura, Hiroki Ishibashi, Yasushi Fukuiri, Atsushi Sakuma, Hironori Komatsu, Tomoyuki Ando, Kazuhiko Togashi, Hideki Umetani
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Publication number: 20070015265Abstract: A novel gluconate dehydratase derived from Achromobacter xylosoxidans and a gene encoding the gluconate dehydratase are provided. By reacting the gluconate dehydratase or a transformed cell containing the gene with an aldonic acid, the corresponding 2-keto-3-deoxyaldonic acid can be efficiently produced.Type: ApplicationFiled: September 20, 2006Publication date: January 18, 2007Applicant: Mitsui Chemicals, Inc.Inventors: Hitoki Miyake, Toshifumi Yamaki, Toshihiro Oikawa, Takeshi Nakamura, Hiroki Ishibashi, Yasushi Fukuiri, Atsushi Sakuma, Hironori Komatsu, Tomoyuki Ando, Kazuhiko Togashi, Hideki Umetani
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Publication number: 20070009985Abstract: The amino acid sequence of a mutant which is obtained by introducing a novel mutation into a Pseudonocardia thermophila JCM3095-derived nitrile hydratase consisting of two types of heterogeneous subunits, and the base sequence of the gene are provided. The nitrile hydratase is modified by specifying the region to be modified in the stereostructure/amino acid sequence of the nitrile hydratase, and applying alteration such as substitution, insertion, deletion or the like, to the amino acids in the amino acid sequence which are corresponding to the amino acid residues forming the region. Also provided is a method for modifying an enzyme having a nitrile hydratase activity.Type: ApplicationFiled: December 15, 2003Publication date: January 11, 2007Applicant: Mitsui Chemicals, Inc.Inventors: Toshifumi Yamaki, Shinichi Banba, Kaori Matoishi, Kiyoshi Ito, Hideki Kobayashi, Eishi Tanaka, Toshihiro Oikawa
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Patent number: 7125704Abstract: A novel gluconate dehydratase derived from Achromobacter xylosoxidans and a gene encoding the gluconate dehydratase are provided. By reacting the gluconate dehydratase or a transformed cell containing the gene with an aldonic acid, the corresponding 2-keto-3-deoxyaldonic acid can be efficiently produced.Type: GrantFiled: July 8, 2004Date of Patent: October 24, 2006Assignee: Mitsui Chemicals, Inc.Inventors: Hitoki Miyake, Toshifumi Yamaki, Toshihiro Oikawa, Takeshi Nakamura, Hiroki Ishibashi, Yasushi Fukuiri, Atsushi Sakuma, Hironori Komatsu, Tomoyuki Ando, Kazuhiko Togashi, Hideki Umetani
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Patent number: 6869788Abstract: This invention provides a novel D-aminoacylase obtained by cloning a DNA encoding the novel D-aminoacylase from Methylobacterium mesophilicum MT 10894, etc. and which shows sufficiently high activity at an industrially useful substrate concentration to allow a D-amino acid to be efficiently produced from an N-acyl-DL-amino acid; a DNA encoding the D-aminoacylase; a process for producing a D-amino acid from the corresponding N-acylamino acid using a transformant containing the DNA.Type: GrantFiled: February 1, 2002Date of Patent: March 22, 2005Assignee: Mitsui Chemicals, Inc.Inventors: Masami Osabe, Katsuyuki Takahashi, Toshifumi Yamaki, Teruo Arii, Toshihiro Oikawa
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Publication number: 20050054042Abstract: A novel gluconate dehydratase derived from Achromobacter xylosoxidans and a gene encoding the gluconate dehydratase are provided. By reacting the gluconate dehydratase or a transformed cell containing the gene with an aldonic acid, the corresponding 2-keto-3-deoxyaldonic acid can be efficiently produced.Type: ApplicationFiled: July 8, 2004Publication date: March 10, 2005Applicant: Mitsui Chemicals, Inc.Inventors: Hitoki Miyake, Toshifumi Yamaki, Toshihiro Oikawa, Takeshi Nakamura, Hiroki Ishibashi, Yasushi Fukuiri, Atsushi Sakuma, Hironori Komatsu, Tomoyuki Ando, Kazuhiko Togashi, Hideki Umetani
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Publication number: 20030212100Abstract: A quinoline derivative represented by the following formula (1): 1Type: ApplicationFiled: September 20, 2002Publication date: November 13, 2003Inventors: Hidetoshi Tsunoda, Nobuyuki Fukazawa, Hiroshi Nagase, Kyoko Chiba, Toshifumi Nakao, Noriaki Asada, Toshifumi Yamaki, Kenji Kibayashi, Hideyuki Migita, Maki Morikawa
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Publication number: 20030207436Abstract: This invention provides a novel D-aminoacylase obtained by cloning a DNA encoding the novel D-aminoacylase from Methylobacterium mesophilicum MT 10894, etc. and which shows sufficiently high activity at an industrially useful substrate concentration to allow a D-amino acid to be efficiently produced from an N-acyl-DL-amino acid; a DNA encoding the D-aminoacylase; a process for producing a D-amino acid from the corresponding N-acylamino acid using a transformant containing the DNA.Type: ApplicationFiled: September 30, 2002Publication date: November 6, 2003Inventors: Masami Osabe, Katsuyuki Takahashi, Toshifumi Yamaki, Teruo Arii, Toshihiro Oikawa
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Patent number: 5910432Abstract: The present invention provides the amino acid sequence and base sequence of a Pseudonocardia thermophila-derived nitrile hydratase, provides further a method for changing its amino acid sequence and base sequence without substantially changing the functions of said nitrile hydratase, and nitrile hydratases having a base sequence and an amino acid sequence as changed on the basis of said method, and provides furthermore a recombinant plasmid having the gene of said nitrile hydratase, a transformant containing said recombinant plasmid, a method of using said transformant for producing said enzyme, and a method of using said transformant for producing the corresponding amide compound from a nitrile compound.Type: GrantFiled: December 15, 1997Date of Patent: June 8, 1999Assignee: Mitsui Chemicals, Inc.Inventors: Kiyoshi Ito, Toshifumi Yamaki, Teruo Arii, Miyuki Tsuruoka, Takeshi Nakamura
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Patent number: 5807730Abstract: The present invention provides the amino acid sequence and base sequence of a Pseudonocardia thermophila-derived nitrile hydratase, provides further a method for changing its amino acid sequence and base sequence without substantially changing the functions of said nitrile hydratase, and nitrile hydratases having a base sequence and an amino acid sequence as changed on the basis of said method, and provides furthermore a recombinant plasmid having the gene of said nitrile hydratase, a transformant containing said recombinant plasmid, a method of using said transformant for producing said enzyme, and a method of using said transformant for producing the corresponding amide compound from a nitrile compound.Type: GrantFiled: February 14, 1997Date of Patent: September 15, 1998Assignee: Mitsui Chemicals, Inc.Inventors: Kiyoshi Ito, Toshifumi Yamaki, Teruo Arii, Miyuki Tsuruoka, Takeshi Nakamura