Patents by Inventor Toshifumi Yokota

Toshifumi Yokota has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antisense oligonucleotides that bind to exon 51 of human dystrophin pre-mRNA
    Patent number: 11891603
    Abstract: The present invention relates to a therapeutic antisense oligonucleotide which binds to exon 51 of the human dystrophin pre-mRNA to induce exon skipping, and conjugates and compositions thereof for the treatment of DMD.
    Type: Grant
    Filed: September 3, 2021
    Date of Patent: February 6, 2024
    Assignee: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: Toshifumi Yokota, Yusuke Echigoya
  • Gapmers and methods of using the same for the treatment of muscular dystrophy
    Patent number: 11518995
    Abstract: The disclosure relates to compositions comprising a nucleotide sequence having two domains: a locked nucleic acid (LNA) domain and a DNA gap domain, wherein nucleotide sequence binds to an endogenous DUX4 mRNA sequence disrupts DUX4 expression.
    Type: Grant
    Filed: September 19, 2018
    Date of Patent: December 6, 2022
    Assignees: Children's National Medical Center, The Governors of the University of Alberta
    Inventors: Yi-wen Chen, Toshifumi Yokota, Rika Yokota-Maruyama, Yusuke Echigoya
  • EXONS 45-55 SKIPPING USING MUTATION-TAILORED COCKTAILS OF ANTISENSE MORPHOLINOS IN THE DMD GENE
    Publication number: 20220288218
    Abstract: Described herein is/are a therapeutic antisense oligonucleotide(s) which binds to exons 45 to 55 of the human dystrophin pre-mRNA to induce exon skipping, and conjugates and compositions thereof for the treatment of DMD.
    Type: Application
    Filed: July 9, 2020
    Publication date: September 15, 2022
    Inventors: Toshifumi YOKOTA, Yusuke ECHIGOYA, Kenji Rowel Quintana LIM
  • ANTISENSE OLIGONUCLEOTIDES THAT BIND TO EXON 51 OF HUMAN DYSTROPHIN PRE-MRNA
    Publication number: 20210395741
    Abstract: The present invention relates to a therapeutic antisense oligonucleotide which binds to exon 51 of the human dystrophin pre-mRNA to induce exon skipping, and conjugates and compositions thereof for the treatment of DMD.
    Type: Application
    Filed: September 3, 2021
    Publication date: December 23, 2021
    Inventors: Toshifumi YOKOTA, Yusuke ECHIGOYA
  • Antisense oligonucleotides that bind to exon 51 of human dystrophin pre-mRNA
    Patent number: 11142767
    Abstract: The present invention relates to a therapeutic antisense oligonucleotide which binds to exon 51 of the human dystrophin pre-mRNA to induce exon skipping, and conjugates and compositions thereof for the treatment of DMD.
    Type: Grant
    Filed: July 20, 2018
    Date of Patent: October 12, 2021
    Assignee: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: Toshifumi Yokota, Yusuke Echigoya
  • ANTISENSE OLIGONUCLEOTIDES THAT BIND TO EXON 51 OF HUMAN DYSTROPHIN PRE-MRNA
    Publication number: 20200362336
    Abstract: The present invention relates to a therapeutic antisense oligonucleotide which binds to exon 51 of the human dystrophin pre-mRNA to induce exon skipping, and conjugates and compositions thereof for the treatment of DMD.
    Type: Application
    Filed: July 20, 2018
    Publication date: November 19, 2020
    Inventors: Toshifumi Yokota, Yusuke Echigoya
  • GAPMERS AND METHODS OF USING THE SAME FOR THE TREATMENT OF MUSCULAR DYSTROPHY
    Publication number: 20200291398
    Abstract: The disclosure relates to compositions comprising a nucleotide sequence having two domains: a locked nucleic acid domain and a DNA gap domain, wherein nucleotide sequence binds to an endogenous DUX4 mRNA sequence disrupts DUX4 expression.
    Type: Application
    Filed: September 19, 2018
    Publication date: September 17, 2020
    Inventors: Yi-wen CHEN, Toshifumi YOKOTA, Rika YOK0-TA-MARUYAMA, Yusuke ECHIGOYA
  • Information processing system
    Patent number: 5864335
    Abstract: The present invention relates to an information processing system using a coordinate detection device and displays, and more specifically to an input-display integrated information processing system which allows the displays to be carried like paper and to be freely laid out and stacked together on a desk (coordinate input device). The system includes a layout determining unit for determining a layout of the display on said coordinate detection device, wherein the layout determining unit further comprises a display position coordinate detector that detects where in the coordinate space of the coordinate detection device the display for displaying an information is located, and a coordinate converter that converts the information into display coordinates. The layout determination is done by using markers attached to three of the four corners of the display.
    Type: Grant
    Filed: August 28, 1997
    Date of Patent: January 26, 1999
    Assignee: Hitachi, Ltd.
    Inventors: Soshiro Kuzunuki, Hiroshi Shojima, Toshimi Yokota, Toshifumi Yokota, Masaki Miura, Keiko Gunji, Yasushi Fukunaga, Toshio Tanaka, Masaaki Kitajima