Patents by Inventor Toshiharu Iwama

Toshiharu Iwama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aminopyridine derivatives having Aurora A selective inhibitory action
    Patent number: 8492397
    Abstract: The present invention relates to a compound of Formula (I): wherein R1 is H or C1-2 alkyl; R2 is H or C1-3 alkyl; R3 and R4 are each independently H or C1-2 alkyl, where the alkyl may be substituted with one to three of the same or different substituents selected from R10; R5 is H, hydroxy, C1-2 alkyl, or OCH3; and R10 is F or Cl, or a pharmaceutically acceptable salt or ester thereof.
    Type: Grant
    Filed: March 12, 2010
    Date of Patent: July 23, 2013
    Assignees: Vertex Pharmaceuticals Incorporated, MSD K.K.
    Inventors: Hayley Binch, Masaya Hashimoto, Toshiharu Iwama, Nobuhiko Kawanishi, Michael Mortimore, Mitsuru Ohkubo, Tomoko Sunami
  • Aminopyridine derivatives having Aurora A selective inhibitory action
    Patent number: 8263632
    Abstract: The present invention relates to a compound of Formula (I): wherein: n is 0 or 1; X is 0 or CH2; R1 is H or C1-2 alkyl; R2 is H or C1-3 alkyl; R3 and R4 are each independently H or C1-2 alkyl, where the alkyl may be substituted with one to three of the same or different substituents selected from R10; R5 is H or OCH3; R10 is F or Cl; or a pharmaceutically acceptable salt or ester thereof
    Type: Grant
    Filed: March 15, 2010
    Date of Patent: September 11, 2012
    Assignees: Vertex Pharmaceuticals Incoporated, MSD K.K.
    Inventors: Toshiharu Iwama, Nobuhiko Kawanishi, Michael Mortimore, Mitsuru Ohkubo, Tomoko Sunami
  • NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION
    Publication number: 20120029004
    Abstract: The present invention relates to a compound of Formula (I): wherein: R1 is H or C1-2 alkyl; R2 is H or C1-3 alkyl; R3 and R4 are each independently H or C1-2 alkyl, where the alkyl may be substituted with one to three of the same or different substituents selected from R10; R5 is H, hydroxy, C1-2 alkyl, or OCH3; and R10 is F or Cl, or a pharmaceutically acceptable salt or ester thereof.
    Type: Application
    Filed: March 12, 2010
    Publication date: February 2, 2012
    Inventors: Hayley Binch, Masaya Hashimoto, Toshiharu Iwama, Nobuhiko Kawanishi, Michael Mortimore, Mitsuru Ohkubo, Tomoko Sunami
  • NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION
    Publication number: 20120015940
    Abstract: The present invention relates to a compound of Formula (I): wherein: n is 0 or 1; X is O or CH2; R1 is H or C1-2 alkyl; R2 is H or C1-3 alkyl; R3 and R4 are each independently H or C1-2 alkyl, where the alkyl may be substituted with one to three of the same or different substituents selected from R10 R5 is H or OCH3; R10 is F or Cl; or a pharmaceutically acceptable salt or ester thereof.
    Type: Application
    Filed: March 15, 2010
    Publication date: January 19, 2012
    Inventors: Toshiharu Iwama, Nobuhiko Kawanishi, Michael Mortimore, Mitsuru Ohkubo, Tomoko Sunami
  • Crystal of glucokinase protein, and method for drug design using the crystal
    Publication number: 20070231874
    Abstract: Glucokinase is crystallized, the three-dimensional structure thereof is analyzed, and then a compound to be bonded to glucokinase is designed on the basis of the coordinate for the resulting three-dimensional structure. Specifically, glucokinase is freed of a part of amino acid residues being on the N-terminal side thereof, to thereby crystallize it, and the three-dimensional structure of the resulting crystal is elucidated through the X-ray crystallographic analysis thereof.
    Type: Application
    Filed: May 15, 2003
    Publication date: October 4, 2007
    Inventors: Kenji Kamata, Yasufumi Nagata, Toshiharu Iwama