Patents by Inventor Toshihide KURIHARA
Toshihide KURIHARA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11932679Abstract: The purpose of the present invention is to provide an agent for restoring a visual function or an agent for preventing the deterioration in a visual function, which has an excellent visual function restoring ability. The agent for regenerating a visual function or the agent for preventing the deterioration in a visual function according to the present invention contains, as an active ingredient, a chimeric protein having both an amino acid sequence for a microorganism-origin ion-transporting receptor rhodopsin and an amino acid sequence for an animal-origin G-protein-coupled receptor rhodopsin. The chimeric protein is preferably one in which an amino acid sequence for a cytoplasm-side second loop and/or a cytoplasm-side third loop in the amino acid sequence for the microorganism-origin ion-transporting receptor rhodopsin is substituted by an amino acid sequence for a cytoplasm-side second loop and/or a cytoplasm-side third loop in the G-protein-coupled receptor rhodopsin.Type: GrantFiled: September 1, 2017Date of Patent: March 19, 2024Assignees: Keio University, Nagoya Institute of TechnologyInventors: Toshihide Kurihara, Yusaku Katada, Hiromitsu Kunimi, Kazuo Tsubota, Hideki Kandori
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Publication number: 20240041806Abstract: The present invention provides a screening method for searching a component inhibiting the PERK pathway and/or the ATF6 pathway, and by obtaining, by the screening method, an active ingredient inhibiting myopia progression without impairing normal growth of the eyeballs (emmetropization) in children, provides eyedrops and a composition containing the active ingredient. The problems are solved by eyedrops for inhibiting myopia progression in children containing, as an active ingredient, an inhibitor of the PERK (PKR-like endoplasmic reticulum kinase) pathway and/or the ATF6 (activating transcription factor 6) pathway. The problems are solved by a screening method for an inhibitor of myopia progression in children, including a step of contacting a candidate substance with an eye-derived cell, and a step of selecting the candidate substance using, as an index, change in a protein and/or a gene of the signal transduction system of PERK and/or ATF6.Type: ApplicationFiled: September 1, 2021Publication date: February 8, 2024Applicant: Tsubota Laboratory, Inc.Inventors: Kazuo Tsubota, Toshihide Kurihara, Shinichi Ikeda, Kiwako Mori, Xiaoyan Jiang
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Patent number: 11890309Abstract: An object of the present invention is to provide a composition for preventing visual dysfunction caused by exposure to light, such as so-called blue light. The present invention provides a composition comprising a lactic acid bacterium as an active ingredient for use in suppressing or improving conditions caused by retinal inflammation resulting from light damage. Eye discomfort is an exemplary condition caused by retinal inflammation resulting from light damage.Type: GrantFiled: June 13, 2022Date of Patent: February 6, 2024Assignee: Kirin Holdings Kabushiki KaishaInventors: Toshihide Kurihara, Yuji Morita, Kenta Jonai, Daisuke Fujiwara
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Publication number: 20240033311Abstract: The ophthalmic composition effective for the prevention or treatment of myopia or ocular diseases are provided. In particular, the present invention provides an ophthalmic composition effective in a growing child or a young person in whom myopia develops and progresses, as well as a middle-aged and elderly person in whom age-related ocular diseases such as cataract, glaucoma, retinal detachment, retinopathy, maculopathy, choroidal neovascularization, posterior staphyloma, and optic neuropathy develop, a functional food containing the ophthalmic composition, and a screening method capable of searching for the same. [Solution] The above problem is solved by an ophthalmic composition or functional food product containing at least one component selected from the group consisting of crocetin and its pharmaceutically acceptable salts and ginkgo leaf extract.Type: ApplicationFiled: October 9, 2023Publication date: February 1, 2024Inventors: Kazuo TSUBOTA, Toshihide KURIHARA
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Publication number: 20230364441Abstract: A device and a method for inhibiting thinning of a choroid. A choroidal thinning inhibiting device including a light source that emits violet light having a wavelength within a range from 360 nm to 400 nm, the choroidal thinning inhibiting device inhibiting thinning of a choroid by irradiation with the violet light. This device may further include a control mechanism that controls an irradiance and an irradiation time of the violet light, can be applied to ocular diseases selected from age-related macular degeneration, glaucoma, diabetic retinopathy, macular edema, eye strain, retinal vascular occlusion, triangle syndrome, central serous chorioretinopathy, retinitis pigmentosa, presbyopia, cataracts, and the like that are based on inadequate blood flow or reduced blood flow, and can be expected to prevent and treat such ocular diseases.Type: ApplicationFiled: September 16, 2021Publication date: November 16, 2023Applicant: TSUBOTA LABORATORY, INC.Inventors: Xiaoyan JIANG, Kiwako MORI, Toshihide KURIHARA, Kazuo TSUBOTA
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Patent number: 11813299Abstract: The ophthalmic composition effective for the prevention or treatment of myopia or ocular diseases are provided. In particular, the present invention provides an ophthalmic composition effective in a growing child or a young person in whom myopia develops and progresses, as well as a middle-aged and elderly person in whom age-related ocular diseases such as cataract, glaucoma, retinal detachment, retinopathy, maculopathy, choroidal neovascularization, posterior staphyloma, and optic neuropathy develop, a functional food containing the ophthalmic composition, and a screening method capable of searching for the same. [Solution] The above problem is solved by an ophthalmic composition or functional food product containing at least one component selected from the group consisting of crocetin and its pharmaceutically acceptable salts and ginkgo leaf extract.Type: GrantFiled: May 15, 2018Date of Patent: November 14, 2023Assignees: TSUBOTA LABORATORY, INC., ROHTO PHARMACEUTICAL CO., LTD.Inventors: Kazuo Tsubota, Toshihide Kurihara
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Patent number: 11771741Abstract: Provided are: a nucleic acid including a nucleic acid sequence encoding a chimeric protein including at least part of an ion-transporting receptor rhodopsin and at least part of a G protein-coupled receptor rhodopsin and a nucleic acid sequence encoding a signal sequence; and a nucleic acid including a nucleic acid sequence encoding a chimeric protein including at least part of an ion channeling receptor rhodopsin and at least part of a G protein-coupled receptor rhodopsin; and a nucleic acid construct including the nucleic acid sequences. The use of the nucleic acids or nucleic acid constructs prevents and suppresses the progress of retinal diseases, and enhances the visual cognitive behavioral function and visual function.Type: GrantFiled: April 28, 2022Date of Patent: October 3, 2023Assignee: Restore Vision Inc.Inventors: Toshihide Kurihara, Yusaku Katada, Kazuo Tsubota, Hideki Kandori
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Publication number: 20230248804Abstract: Provided are: a nucleic acid including a nucleic acid sequence encoding a chimeric protein including at least part of an ion-transporting receptor rhodopsin and at least part of a G protein-coupled receptor rhodopsin and a nucleic acid sequence encoding a signal sequence; and a nucleic acid including a nucleic acid sequence encoding a chimeric protein including at least part of an ion channeling receptor rhodopsin and at least part of a G protein-coupled receptor rhodopsin; and a nucleic acid construct including the nucleic acid sequences. The use of the nucleic acids or nucleic acid constructs prevents and suppresses the progress of retinal diseases, and enhances the visual cognitive behavioral function and visual function.Type: ApplicationFiled: April 28, 2022Publication date: August 10, 2023Inventors: Toshihide Kurihara, Yusaku Katada, Kazuo Tsubota, Hideki Kandori
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Publication number: 20220402994Abstract: Provided are: a nucleic acid including a nucleic acid sequence encoding a chimeric protein including at least part of an ion-transporting receptor rhodopsin and at least part of a G protein-coupled receptor rhodopsin and a nucleic acid sequence encoding a signal sequence; and a nucleic acid including a nucleic acid sequence encoding a chimeric protein including at least part of an ion channeling receptor rhodopsin and at least part of a G protein-coupled receptor rhodopsin; and a nucleic acid construct including the nucleic acid sequences. The use of the nucleic acids or nucleic acid constructs prevents and suppresses the progress of retinal diseases, and enhances the visual cognitive behavioral function and visual function.Type: ApplicationFiled: September 11, 2020Publication date: December 22, 2022Inventors: Toshihide Kurihara, Yusaku Katada, Kazuo Tsubota, Hideki Kandori
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Publication number: 20220323516Abstract: An object of the present invention is to provide a composition for preventing visual dysfunction caused by exposure to light, such as so-called blue light. The present invention provides a composition comprising a lactic acid bacterium as an active ingredient for use in suppressing or improving conditions caused by retinal inflammation resulting from light damage. Eye discomfort is an exemplary condition caused by retinal inflammation resulting from light damage.Type: ApplicationFiled: June 13, 2022Publication date: October 13, 2022Applicant: Kirin Holdings Kabushiki KaishaInventors: Toshihide KURIHARA, Yuji MORITA, Kenta JONAI, Daisuke FUJIWARA
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Publication number: 20220273761Abstract: Provided are: a nucleic acid including a nucleic acid sequence encoding a chimeric protein including at least part of an ion-transporting receptor rhodopsin and at least part of a G protein-coupled receptor rhodopsin and a nucleic acid sequence encoding a signal sequence; and a nucleic acid including a nucleic acid sequence encoding a chimeric protein including at least part of an ion channeling receptor rhodopsin and at least part of a G protein-coupled receptor rhodopsin; and a nucleic acid construct including the nucleic acid sequences. The use of the nucleic acids or nucleic acid constructs prevents and suppresses the progress of retinal diseases, and enhances the visual cognitive behavioral function and visual function.Type: ApplicationFiled: April 28, 2022Publication date: September 1, 2022Inventors: Toshihide Kurihara, Yusaku Katada, Kazuo Tsubota, Hideki Kandori
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Patent number: 11389494Abstract: An object of the present invention is to provide a composition for preventing visual dysfunction caused by exposure to light, such as so-called blue light. The present invention provides a composition comprising a lactic acid bacterium as an active ingredient for use in suppressing or improving conditions caused by retinal inflammation resulting from light damage. Eye discomfort is an exemplary condition caused by retinal inflammation resulting from light damage.Type: GrantFiled: September 8, 2017Date of Patent: July 19, 2022Assignee: Kirin Holdings Kabushiki KaishaInventors: Toshihide Kurihara, Yuji Morita, Kenta Jonai, Daisuke Fujiwara
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Publication number: 20220025018Abstract: Provided are a chimeric protein of two types of rhodopsins, an ion-transporting rhodopsin and a G protein-coupled receptor rhodopsin, and a nucleic acid encoding the same, for the prevention and suppression of progression of retinal diseases, the improvement in visual cognitive behavioral functions (e.g., improvement in light-dark determination functions, improvement in bright spot evading functions, and/or crisis avoidance functions), and the enhancement of visual functions (e.g., improvement in visual acuity). The present invention also provides a method for preventing or suppressing the progression of a disease, disorder or symptom of the retina, for improving a visual cognitive behavioral function (e.g., improvement in light-dark determination functions, improvement in bright spot evading functions, and/or crisis avoidance functions), or for enhancing visual functions (e.g.Type: ApplicationFiled: January 18, 2019Publication date: January 27, 2022Inventors: Toshihide Kurihara, Yusaku Katada, Kazuo Tsubota
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Publication number: 20210228901Abstract: A light source for myopia prevention article includes a light emitter to emit light having an emission spectrum continuing from a first wavelength of not less than 360 nm nor more than 400 nm to a second wavelength of more than 400 nm.Type: ApplicationFiled: April 16, 2021Publication date: July 29, 2021Applicants: TOSHIBA MATERIALS CO., LTD., TSUBOTA LABORATORY, INC.Inventors: Masahiko YAMAKAWA, Hidemasa TORII, Toshihide KURIHARA, Kazuo TSUBOTA
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Patent number: 11007375Abstract: A light source for myopia prevention article includes a light emitter to emit light having an emission spectrum continuing from a first wavelength of not less than 360 nm nor more than 400 nm to a second wavelength of more than 400 nm.Type: GrantFiled: July 25, 2018Date of Patent: May 18, 2021Assignees: Toshiba Materials Co., Ltd., Tsubota Laboratory, Inc.Inventors: Masahiko Yamakawa, Hidemasa Torii, Toshihide Kurihara, Kazuo Tsubota
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Publication number: 20210000343Abstract: A device for supporting diagnosis has: a reception unit that is configured to receive a fundus image of a subject eye; an identification unit provided with a trained model that is configured to recognize, in the fundus image of the subject eye, an area of abnormality in blood circulation, wherein the model has been trained based upon an image of a fundus and an area of abnormality in blood circulation specified in a fluorescent angiography image of the fundus; and an output unit that is configured to output information relating to the area of abnormality in blood circulation recognized in the fundus image of the subject eye.Type: ApplicationFiled: July 16, 2020Publication date: January 7, 2021Applicant: NIKON CORPORATIONInventors: Toshihide KURIHARA, Yusaku KATADA, Kazuo TSUBOTA, Kanato MASAYOSHI
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Patent number: 10865134Abstract: A wavelength-selective transmissive glass has a light transmittance Tmore than 315 nm and 400 nm or less at a wavelength of more than 315 nm and 400 nm or less represented by the formula shown below of 1% or more in terms of a plate thickness of 6 mm and a light transmittance T315 nm or less at a wavelength of 315 nm or less represented by the formula shown below of 60% or less in terms of a plate thickness of 6 mm. Ak is a weighting factor at a wavelength k (nm) for calculating T (light transmittance) defined in ISO-9050:2003, and Tk is a transmittance at the wavelength k (nm) in terms of a plate thickness of 6 mm: Tmore than 315 nm and 400 nm or less=(?k=more than 315400Ak×Tk)/(?k=more than 315400Ak) T315 nm or less=(?k=300315Ak×Tk)/(?k=300315Ak).Type: GrantFiled: June 1, 2018Date of Patent: December 15, 2020Assignees: AGC Inc., TSUBOTA LABORATORY, INC.Inventors: Kensuke Nagai, Tetsuya Nakashima, Yutaka Kuroiwa, Hiroyuki Hijiya, Masamichi Tanida, Akio Koike, Manabu Nishizawa, Kazuo Tsubota, Toshihide Kurihara, Hidemasa Torii
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Patent number: 10866433Abstract: An optical element has a transmission spectrum characterized in that a local maximum falls within a wavelength region longer than 315 nm but shorter than or equal to 400 nm, a local minimum falls within a wavelength region longer than or equal to 380 nm but shorter than or equal to 500 nm, and the wavelength at the local maximum is shorter than the wavelength at the local minimum.Type: GrantFiled: November 25, 2015Date of Patent: December 15, 2020Assignees: JINS HOLDINGS Inc., Tsubota Laboratory, Inc.Inventors: Shunsuke Shioya, Kazuo Tsubota, Toshihide Kurihara, Hidemasa Torii
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Patent number: 10823982Abstract: The purpose of the present invention is to provide a myopia treatment device. A myopia treatment device of the present invention comprises a light transmission part selected from a group consisting of an eyesight correcting tool, an eye protection tool, a face protection tool, a sunshade, a display device, a window, a wall, a light source covering, and a coating material. The light transmission part of the device transmits violet light having a wavelength within a range of 360 nm to 400 nm inclusive and thus treats myopia. Or, the myopia treatment device comprises a light emission part selected from a group consisting of lighting equipment, a display device, and a light irradiation device. The light emission part of the device emits violet light having a wavelength within a range of 360 nm to 400 nm inclusive and thus treats myopia.Type: GrantFiled: October 9, 2018Date of Patent: November 3, 2020Assignee: TSUBOTA LABORATORY, INC.Inventors: Kazuo Tsubota, Kazuno Negishi, Hidemasa Torii, Toshihide Kurihara
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Publication number: 20200171112Abstract: The ophthalmic composition effective for the prevention or treatment of myopia or ocular diseases are provided. In particular, the present invention provides an ophthalmic composition effective in a growing child or a young person in whom myopia develops and progresses, as well as a middle-aged and elderly person in whom age-related ocular diseases such as cataract, glaucoma, retinal detachment, retinopathy, maculopathy, choroidal neovascularization, posterior staphyloma, and optic neuropathy develop, a functional food containing the ophthalmic composition, and a screening method capable of searching for the same. [Solution] The above problem is solved by an ophthalmic composition or functional food product containing at least one component selected from the group consisting of crocetin and its pharmaceutically acceptable salts and ginkgo leaf extract.Type: ApplicationFiled: May 15, 2018Publication date: June 4, 2020Inventors: Kazuo TSUBOTA, Toshihide KURIHARA