Patents by Inventor Toshihiko Hibino

Toshihiko Hibino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Two novel genes from psoriatic epidermis: psoriastatin type I and psoriastatin type II
    Patent number: 6818214
    Abstract: A method of modulating cell proliferation or apoptosis comprising modulating psoriastatin activity.
    Type: Grant
    Filed: October 16, 1996
    Date of Patent: November 16, 2004
    Assignees: The General Hospital Corporation, Shiseido Co., Ltd.
    Inventors: Toshihiko Hibino, Tadahito Takahashi, Peter C. Baciu, Paul F. Goetinck
  • Hair tonics and method of screening the same
    Publication number: 20040022758
    Abstract: There is provided a hair tonic comprising at least two of an inhibitor against 5&agr; reductase type 2, an inhibitor against transforming growth factor &bgr;2, and an inhibitor against caspase-3; a method comprising screening for at least two of inhibition against 5&agr; reductase type 2, inhibition against transforming growth factor &bgr;2, and inhibition against caspase-3, or comprising screening for inhibition against caspase-3 and then for apoptosis inhibition, and a hair loss inhibitor having the effect of inhibiting caspase-3, and a hair loss inhibitor having the effect of inhibiting caspase-3 and of inhibiting apoptosis.
    Type: Application
    Filed: March 6, 2003
    Publication date: February 5, 2004
    Inventors: Toshihiko Hibino, Yumiko Tsuji, Tsutomu Soma, Sumiko Denda, Jotaro Nakanishi, Jotaro Nakanishi, Tadahito Takahashi, Kenichi Umishio, Koji Kobayashi
  • Human II type 5alpha-reductase promoter gene and uses thereof
    Publication number: 20030157536
    Abstract: A DNA molecule containing the promoter gene region of the human type II 5&agr;-reductase gene, its modifications, and a method for screening type II 5&agr;-reductase transcription controllers by using the same.
    Type: Application
    Filed: January 27, 2003
    Publication date: August 21, 2003
    Inventors: Jotaro Nakanishi, Toshihiko Hibino
  • TWO NOVEL GENES FROM PSORIATIC EPIDERMIS: PSORIASTATIN TYPE I AND PSORIASTATIN TYPE II
    Publication number: 20030072752
    Abstract: A method of modulating cell proliferation or apoptosis comprising modulating psoriastatin activity.
    Type: Application
    Filed: October 16, 1996
    Publication date: April 17, 2003
    Applicant: General Hospital Corporation, a Massachusetts corporation
    Inventors: TOSHIHIKO HIBINO, TADAHITO TAKAHASHI, PETER C. BACIU, PAUL F. GOETINCK
  • Urokinase plasminogen activator fragments
    Patent number: 6120765
    Abstract: Purified uPA peptides having, mitogenic activity and containing as few as six amino acids of the EGF-like domain of uPA.
    Type: Grant
    Filed: October 25, 1993
    Date of Patent: September 19, 2000
    Assignee: Shiseido Co. Ltd.
    Inventors: Toshihiko Hibino, Tadahito Takahashi, Izumi Horii, Paul F. Goetinck
  • Process for producing 5-carboxy-2-acetylthiophene
    Patent number: 4153610
    Abstract: 5-Carboxy-2-acetylthiophene, which is useful as an intermediate for the production of a therapeutic agent, can be prepared in a high yield by the selective oxidation of 5-acetyl-2-thienylacetic acid or its derivative with a particularly selected oxidizing agent, i.e. permanganate.
    Type: Grant
    Filed: November 1, 1977
    Date of Patent: May 8, 1979
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Toshihiko Hibino, Eiichi Murayama
  • Process for producing 5-carboxy-2-acetylthiophene
    Patent number: 4130566
    Abstract: 5-Carboxy-2-acetylthiophene, which is useful as an intermediate for the production of a therapeutic agent, can be prepared in a high yield by the selective oxidation of 5-acetyl-2-thienylacetic acid or its derivative with a particularly selected oxidizing agent, i.e. chromic anhydride complex, dichromate or hypohalite.
    Type: Grant
    Filed: October 28, 1977
    Date of Patent: December 19, 1978
    Assignee: Sumitomo Chemical Company, Limited
    Inventor: Toshihiko Hibino
  • Benzothiazole derivatives
    Patent number: 3951998
    Abstract: Novel benzothiazole derivatives of the formula ##SPC1##Wherein R.sub.1 and R.sub.2 are individually hydrogen, lower alkyl, nitro, halogen, optionally substituted amino, carboxyl, lower alkoxy-carbonyl or di-lower alkyl-carbamoyl; and R.sub.3 and R.sub.4 are individually hydrogen, lower alkyl or .alpha.-lower alkyl-benzyl or NR.sub.3 R.sub.4 is a saturated heterocyclic ring containing a nitrogen atom, and their salts. They are useful as antihypertensives.
    Type: Grant
    Filed: June 17, 1974
    Date of Patent: April 20, 1976
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Toshihiko Hibino, Yoshio Suzuki, Shigeru Okano, Yoichi Hara, Etsuro Sato
  • Thiazole derivatives
    Patent number: 3932400
    Abstract: This invention relates to thiazole derivatives of the formula (I): ##EQU1## wherein R.sub.1 and R.sub.2 are each hydrogen, lower alkyl, cycloalkyl, optionally substituted aryl or optionally substituted heteroaromatic rings containing oxygen, sulfur, nitrogen or combinations thereof, and R.sub.3 and R.sub.4 are each hydrogen or lower alkyl and salts thereof. The thiazole derivatives of the formula (I) have excellent pharmacological properties such as .beta.-adrenergic receptor blocking effects and are valuable compounds exerting preventive or therapeutic effects on heart diseases, for example, arrhythmia, coronary heart disease, etc.
    Type: Grant
    Filed: August 16, 1973
    Date of Patent: January 13, 1976
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Toshihiko Hibino, Yoshio Suzuki, Shigeru Okano, Yoichi Hara, Etsuro Sato