Patents by Inventor Toshihiko Kumazawa

Toshihiko Kumazawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230263841
    Abstract: A Bacillus bacterium that induces the production of interleukin-22 is provided. The Bacillus bacterium that induces the production of interleukin-22.
    Type: Application
    Filed: March 16, 2023
    Publication date: August 24, 2023
    Applicants: ICHIBIKI CO., LTD., NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY
    Inventors: Toshihiko Kumazawa, Atsuhisa Nishimura, Noriyuki Asai, Takahiro Adachi
  • Patent number: 11260085
    Abstract: There is provided a salt-tolerant Lactobacillus having high foodstuff suitability, being easily produced, and having an immunostimulatory action. Salt-tolerant Lactobacillus having an immunostimulatory action with viability and activation potency of B cells.
    Type: Grant
    Filed: September 12, 2017
    Date of Patent: March 1, 2022
    Assignees: ICHIBIKI CO., LTD., NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY
    Inventors: Toshihiko Kumazawa, Atsuhisa Nishimura, Noriyuki Asai, Takahiro Adachi
  • Publication number: 20210283200
    Abstract: There is provided a salt-tolerant Lactobacillus having high foodstuff suitability, being easily produced, and having an immunostimulatory action. Salt-tolerant Lactobacillus having an immunostimulatory action with viability and activation potency of B cells.
    Type: Application
    Filed: September 12, 2017
    Publication date: September 16, 2021
    Inventors: Toshihiko Kumazawa, Atsuhisa Nishimura, Noriyuki Asai, Takahiro Adachi
  • Publication number: 20210228651
    Abstract: A lactic acid bacterium is provided which has high foodstuff suitability, easy to manufacture, and can increase the blood iron concentration, thereby improving anemia. A lactic acid bacterium of salt-tolerant that increases the blood iron concentration.
    Type: Application
    Filed: August 16, 2019
    Publication date: July 29, 2021
    Applicant: ICHIBIKI CO., LTD.
    Inventors: Atsuhisa Nishimura, Noriyuki Asai, Toshihiko Kumazawa
  • Publication number: 20210100851
    Abstract: A Bacillus bacterium that induces the production of interleukin-22 is provided. The Bacillus bacterium that induces the production of interleukin-22.
    Type: Application
    Filed: February 15, 2019
    Publication date: April 8, 2021
    Inventors: Toshihiko Kumazawa, Atsuhisa Nishimura, Noriyuki Asai, Takahiro Adachi
  • Publication number: 20120244102
    Abstract: The present invention is to provide an agent for treating Crohn's disease that is of unknown cause and for which no radical therapeutic drug is present. Provided is an agent for preventing or treating Crohn's disease, comprising an organic acid polymer represented by the following formula: [(O1/2)3Ge-A-CO2H]n, wherein n is 100-1,000, and A is a lower alkyl group. Preferably, A is a C1-C3 lower alkyl group and the degree of polymerization n is 200-900. The organic acid polymer according to the present invention is effective as an agent for treating Crohn's disease.
    Type: Application
    Filed: January 26, 2011
    Publication date: September 27, 2012
    Applicant: SANWA KAGAKU KENKYUSHO CO., LTD.
    Inventors: Hiroyuki Hashimoto, Toshihiko Kumazawa, Motohiro Takeda, Takahito Jomori, Chihiro Hibi, Kuniharu Mizuno
  • Patent number: 8105766
    Abstract: Provided is a novel and useful method of measuring pyrophosphate in a sample. There may be provided a novel and useful method of measuring pyrophosphate in a sample using pyruvate orthophosphate dikinase, nicotinamide-nucleotide adenylyltransferase, and dehydrogenase.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: January 31, 2012
    Assignees: Asahi Kasei Pharma Corporation, Ichibiki Co., Ltd.
    Inventors: Shinichi Sakasegawa, Yoshiaki Ikura, Atsuhisa Nishimura, Toshihiko Kumazawa, Shigeyuki Imamura
  • Publication number: 20090246783
    Abstract: Provided is a novel and useful method of measuring pyrophosphate in a sample. There may be provided a novel and useful method of measuring pyrophosphate in a sample using pyruvate orthophosphate dikinase, nicotinamide-nucleotide adenylyltransferase, and dehydrogenase.
    Type: Application
    Filed: February 27, 2009
    Publication date: October 1, 2009
    Applicants: Asahi Kasei Pharma Corporation, Ichibiki Co., Ltd.
    Inventors: Shinichi SAKASEGAWA, Yoshiaki Ikura, Atsuhisa Nishimura, Toshihiko Kumazawa, Shigeyuki Imamura
  • Patent number: 7588910
    Abstract: There is provided a method for specifically determining a glycated ?-chain N-terminal of glycated hemoglobin using enzymes without a separation operation, and a determination reagent kit therefor. A protease that cleaves a glycated amino acid and/or a glycated peptide from a glycated ?-chain N-terminal without substantially cleaving a glycated amino acid or a glycated peptide from a glycated ?-chain N-terminal of glycated hemoglobin or a fragment thereof is screened. The method of specifically determining a glycated ?-chain N-terminal of glycated hemoglobin and the determination reagent kit are provided by using the protease obtained by the screening method. According to the present invention, a glycated ?-chain N-terminal of glycated hemoglobin can specifically be determined without a separation operation.
    Type: Grant
    Filed: May 21, 2004
    Date of Patent: September 15, 2009
    Assignees: Asahi Kasei Pharma Corporation, Ichibiki Co., Ltd.
    Inventors: Takeshi Matsuoka, Shinji Koga, Takuji Kouzuma, Issei Yoshioka, Atsuhisa Nishimura, Homare Itou, Toshihiko Kumazawa, Takashi Kuroyanagi
  • Publication number: 20080113381
    Abstract: There is provided a method for specifically determining a glycated ?-chain N-terminal of glycated hemoglobin using enzymes without a separation operation, and a determination reagent kit therefor. A protease that cleaves a glycated amino acid and/or a glycated peptide from a glycated ?-chain N-terminal without substantially cleaving a glycated amino acid or a glycated peptide from a glycated ?-chain N-terminal of glycated hemoglobin or a fragment thereof is screened. The method of specifically determining a glycated ?-chain N-terminal of glycated hemoglobin and the determination reagent kit are provided by using the protease obtained by the screening method. According to the present invention, a glycated ?-chain N-terminal of glycated hemoglobin can specifically be determined without a separation operation.
    Type: Application
    Filed: May 21, 2004
    Publication date: May 15, 2008
    Inventors: Takeshi Matsuoka, Shinji Koga, Takuji Kouzuma, Issei Yoshioka, Atsuhisa Nishimura, Homare Itou, Toshihiko Kumazawa, Takashi Kuroyanagi
  • Patent number: 4415508
    Abstract: An apparatus for mixing a hydrocarbon-containing gas flow with a molecular oxygen-containing gas flow, wherein at least one aqueous medium sealing zone allowing the hydrocarbon-containing gas flow to pass therethrough is provided by sealing a side of said introduced gas flow with an aqueous medium, providing at least one shielding zone for flame propagration, said gas flow is allowed to pass therethrough on a discharge side of said gas flow, and providing means for introducing the molecular oxygen-containing gas flow into a gas mixing zone defined between both of the above zones there to be thoroughly mixed with the hydrocarbon-containing gas flow.
    Type: Grant
    Filed: October 14, 1980
    Date of Patent: November 15, 1983
    Assignee: Nippon Shokubai Kagaku Kogyo Co., Ltd.
    Inventors: Kenji Aida, Takeshi Yamamoto, Toshihiko Kumazawa
  • Patent number: 4389338
    Abstract: In a method for the manufacture of a silver catalyst having silver deposited on a porous inorganic carrier in conjunction with at least one reaction accelerator selected from the group consisting of alkali metals and thallium to be used for the production of ethylene oxide, the improvement comprising the steps of depositing silver on the porous inorganic carrier in conjunction with at least one reaction accelerator selected from the group consisting of alkali metals and thallium thereby preparing an activated silver catalyst and subsequently subjecting said silver catalyst to a high-temperature treatment at a temperature in the range of 550.degree. to 950.degree. C. in an inert gaseous atmosphere having an oxygen concentration of not more than 3 volume percent in the final step.
    Type: Grant
    Filed: December 17, 1981
    Date of Patent: June 21, 1983
    Assignee: Nippon Skokubai Kagaku Kogyo Co., Ltd.
    Inventors: Masashi Mitsuhata, Shin-ichi Nagase, Takahiko Nakai, Toshihiko Kumazawa
  • Patent number: 4376209
    Abstract: A process for the production of ethylene oxide by the vapor-phase catalytic oxidation of ethylene with molecular oxygen, which process comprises passing a mixed gas containing ethylene and molecular oxygen through a catalyst bed filled with a silver catalyst and subsequently passing the resultant reaction product gas through a cooling zone filled with a particulate material containing a substance capable of inhibiting the isomerization of ethylene oxide to acetaldehyde carrying at least one metal selected from the group consisting of sodium, potassium, rubidium, cesium, calcium, strontium, barium and thallium or a compound of said metal to be carried on an inert refractory particulate material.
    Type: Grant
    Filed: September 18, 1980
    Date of Patent: March 8, 1983
    Assignee: Nippon Shokubai Kagaku Kogyo Co., Ltd.
    Inventors: Fumio Watanabe, Masashi Mitsuhata, Toshihiko Kumazawa
  • Patent number: 4368144
    Abstract: A silver catalyst for the production of ethylene oxide, comprising a granular .alpha.-alumina carrier having a sodium content of not more than 0.07% by weight and a specific surface area within the range of from 0.5 to 5 m.sup.2 /g, a finely divided metallic silver deposited on said carrier in an amount within the range of from 5 to 25% by weight based on the total catalyst, and at least one member selected from the group consisting of alkali metals of Atomic Numbers 19 to 55 and alkali metal compounds said at least one member being in an amount within the range of from 0.001 to 0.05 gram equivalent weight per kilogram of the complete catalyst.
    Type: Grant
    Filed: December 22, 1980
    Date of Patent: January 11, 1983
    Assignee: Nippon Shokubai Kagaku Kogyo Co., Ltd.
    Inventors: Masashi Mitsuhata, Fumio Watanabe, Toshihiko Kumazawa
  • Patent number: 4283580
    Abstract: A process for the production of alkylene glycols, which comprises causing a corresponding alkylene carbonate to react with water in the presence of a catalyst of at least one member selected from the group consisting of molybdenum and tungsten.
    Type: Grant
    Filed: September 19, 1979
    Date of Patent: August 11, 1981
    Assignee: Nippon Shokubai Kagaku Kogyo Co., Ltd.
    Inventors: Hiroshi Odanaka, Minoru Saotome, Toshihiko Kumazawa
  • Patent number: 4277632
    Abstract: A process for the production of alkylene glycols, which comprises causing a corresponding alkylene oxide to react with water in the presence of a catalyst of at least one member selected from the group consisting of molybdenum and tungsten.
    Type: Grant
    Filed: September 19, 1979
    Date of Patent: July 7, 1981
    Assignee: Nippon Shokubai Kaguku Kogyo Co., Ltd.
    Inventors: Toshihiko Kumazawa, Takeshi Yamamoto, Hiroshi Odanaka
  • Patent number: 4256604
    Abstract: A method for mixing a hydrocarbon-containing gas flow with a molecular oxygen-containing gas flow, wherein at least one aqueous medium sealing zone allowing the hydrocarbon-containing gas flow to pass therethrough is provided by sealing a side of introducing said gas flow with an aqueous medium and at least one shielding zone for flame propagation allowing said gas flow to pass therethrough is provided on a side of discharging said gas flow, and the molecular oxygen-containing gas flow is introduced in a gas mixing zone defined between both of the above zones to be thoroughly mixed with the hydrocarbon-containing gas flow.
    Type: Grant
    Filed: October 23, 1978
    Date of Patent: March 17, 1981
    Assignee: Nippon Shokubai Kagaku Kogyo Co., Ltd.
    Inventors: Kenji Aida, Takeshi Yamamoto, Toshihiko Kumazawa
  • Patent number: 4248740
    Abstract: An improved process for preparing a silver-supported catalyst for use in the production of ethylene oxide by catalytic vapor phase oxidation of ethylene with molecular oxygen, which comprises impregnating a porous inorganic carrier with a solution of a silver compound containing a reducing compound, subjecting the impregnated product to a reducing treatment at 50.degree. to 200.degree. C. to disperse and deposit metallic silver on the external surface of the carrier and the internal surfaces of its pores, washing the silver-supported carrier with water, a lower alcohol or both, drying the washed product at a temperature of 50.degree. to 150.degree. C., impregnating the dried product with a solution containing a promoter, and evaporating the liquid ingredients.
    Type: Grant
    Filed: June 28, 1978
    Date of Patent: February 3, 1981
    Assignee: Nippon Shokubai Kagaku Kogyo Co. Ltd.
    Inventors: Masashi Mitsuhata, Toshihiko Kumazawa, Isamu Kiguchi
  • Patent number: 4039561
    Abstract: A process for preparing ethylene oxide by the catalytic vapor phase oxidation of ethylene with molecular oxygen in the presence of a catalytic composition whose constituent metallic elements and atomic ratio are represented by the general formulaAg.sub.a Ba.sub.b X.sub.c Tl.sub.d K.sub.e Cs.sub.f O.sub.gwherein X represents at least one metallic element of the group consisting of tin and antimony, a, b, d, e, f and g are number of atoms of silver, barium, thallium, potassium, cesium and oxygen, respectively, and c is the sum of the number of atoms of at least one metallic element of the group consisting of tin and antimony; and when a is 100, b is a number from 0 to 100, c is a number from 0.001 to 0.15, d is a number from 0 to 0.1, e is a number from 0 to 0.1, f is a number from 0 to 0.1, with the proviso that the relationship 0<d + e + f.ltoreq.0.3 is satisfied, and g is a number determined by the valence requirements of the other elements present.
    Type: Grant
    Filed: September 3, 1974
    Date of Patent: August 2, 1977
    Assignee: Nippon Shokubai Kagaku Kogyo
    Inventors: Masashi Mitsuhata, Toshihiko Kumazawa, Isamu Kiguchi