Patents by Inventor Toshihiko Kumazawa
Toshihiko Kumazawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230263841Abstract: A Bacillus bacterium that induces the production of interleukin-22 is provided. The Bacillus bacterium that induces the production of interleukin-22.Type: ApplicationFiled: March 16, 2023Publication date: August 24, 2023Applicants: ICHIBIKI CO., LTD., NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITYInventors: Toshihiko Kumazawa, Atsuhisa Nishimura, Noriyuki Asai, Takahiro Adachi
-
Patent number: 11260085Abstract: There is provided a salt-tolerant Lactobacillus having high foodstuff suitability, being easily produced, and having an immunostimulatory action. Salt-tolerant Lactobacillus having an immunostimulatory action with viability and activation potency of B cells.Type: GrantFiled: September 12, 2017Date of Patent: March 1, 2022Assignees: ICHIBIKI CO., LTD., NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITYInventors: Toshihiko Kumazawa, Atsuhisa Nishimura, Noriyuki Asai, Takahiro Adachi
-
Publication number: 20210283200Abstract: There is provided a salt-tolerant Lactobacillus having high foodstuff suitability, being easily produced, and having an immunostimulatory action. Salt-tolerant Lactobacillus having an immunostimulatory action with viability and activation potency of B cells.Type: ApplicationFiled: September 12, 2017Publication date: September 16, 2021Inventors: Toshihiko Kumazawa, Atsuhisa Nishimura, Noriyuki Asai, Takahiro Adachi
-
Publication number: 20210228651Abstract: A lactic acid bacterium is provided which has high foodstuff suitability, easy to manufacture, and can increase the blood iron concentration, thereby improving anemia. A lactic acid bacterium of salt-tolerant that increases the blood iron concentration.Type: ApplicationFiled: August 16, 2019Publication date: July 29, 2021Applicant: ICHIBIKI CO., LTD.Inventors: Atsuhisa Nishimura, Noriyuki Asai, Toshihiko Kumazawa
-
Publication number: 20210100851Abstract: A Bacillus bacterium that induces the production of interleukin-22 is provided. The Bacillus bacterium that induces the production of interleukin-22.Type: ApplicationFiled: February 15, 2019Publication date: April 8, 2021Inventors: Toshihiko Kumazawa, Atsuhisa Nishimura, Noriyuki Asai, Takahiro Adachi
-
Publication number: 20120244102Abstract: The present invention is to provide an agent for treating Crohn's disease that is of unknown cause and for which no radical therapeutic drug is present. Provided is an agent for preventing or treating Crohn's disease, comprising an organic acid polymer represented by the following formula: [(O1/2)3Ge-A-CO2H]n, wherein n is 100-1,000, and A is a lower alkyl group. Preferably, A is a C1-C3 lower alkyl group and the degree of polymerization n is 200-900. The organic acid polymer according to the present invention is effective as an agent for treating Crohn's disease.Type: ApplicationFiled: January 26, 2011Publication date: September 27, 2012Applicant: SANWA KAGAKU KENKYUSHO CO., LTD.Inventors: Hiroyuki Hashimoto, Toshihiko Kumazawa, Motohiro Takeda, Takahito Jomori, Chihiro Hibi, Kuniharu Mizuno
-
Patent number: 8105766Abstract: Provided is a novel and useful method of measuring pyrophosphate in a sample. There may be provided a novel and useful method of measuring pyrophosphate in a sample using pyruvate orthophosphate dikinase, nicotinamide-nucleotide adenylyltransferase, and dehydrogenase.Type: GrantFiled: February 27, 2009Date of Patent: January 31, 2012Assignees: Asahi Kasei Pharma Corporation, Ichibiki Co., Ltd.Inventors: Shinichi Sakasegawa, Yoshiaki Ikura, Atsuhisa Nishimura, Toshihiko Kumazawa, Shigeyuki Imamura
-
Publication number: 20090246783Abstract: Provided is a novel and useful method of measuring pyrophosphate in a sample. There may be provided a novel and useful method of measuring pyrophosphate in a sample using pyruvate orthophosphate dikinase, nicotinamide-nucleotide adenylyltransferase, and dehydrogenase.Type: ApplicationFiled: February 27, 2009Publication date: October 1, 2009Applicants: Asahi Kasei Pharma Corporation, Ichibiki Co., Ltd.Inventors: Shinichi SAKASEGAWA, Yoshiaki Ikura, Atsuhisa Nishimura, Toshihiko Kumazawa, Shigeyuki Imamura
-
Patent number: 7588910Abstract: There is provided a method for specifically determining a glycated ?-chain N-terminal of glycated hemoglobin using enzymes without a separation operation, and a determination reagent kit therefor. A protease that cleaves a glycated amino acid and/or a glycated peptide from a glycated ?-chain N-terminal without substantially cleaving a glycated amino acid or a glycated peptide from a glycated ?-chain N-terminal of glycated hemoglobin or a fragment thereof is screened. The method of specifically determining a glycated ?-chain N-terminal of glycated hemoglobin and the determination reagent kit are provided by using the protease obtained by the screening method. According to the present invention, a glycated ?-chain N-terminal of glycated hemoglobin can specifically be determined without a separation operation.Type: GrantFiled: May 21, 2004Date of Patent: September 15, 2009Assignees: Asahi Kasei Pharma Corporation, Ichibiki Co., Ltd.Inventors: Takeshi Matsuoka, Shinji Koga, Takuji Kouzuma, Issei Yoshioka, Atsuhisa Nishimura, Homare Itou, Toshihiko Kumazawa, Takashi Kuroyanagi
-
Publication number: 20080113381Abstract: There is provided a method for specifically determining a glycated ?-chain N-terminal of glycated hemoglobin using enzymes without a separation operation, and a determination reagent kit therefor. A protease that cleaves a glycated amino acid and/or a glycated peptide from a glycated ?-chain N-terminal without substantially cleaving a glycated amino acid or a glycated peptide from a glycated ?-chain N-terminal of glycated hemoglobin or a fragment thereof is screened. The method of specifically determining a glycated ?-chain N-terminal of glycated hemoglobin and the determination reagent kit are provided by using the protease obtained by the screening method. According to the present invention, a glycated ?-chain N-terminal of glycated hemoglobin can specifically be determined without a separation operation.Type: ApplicationFiled: May 21, 2004Publication date: May 15, 2008Inventors: Takeshi Matsuoka, Shinji Koga, Takuji Kouzuma, Issei Yoshioka, Atsuhisa Nishimura, Homare Itou, Toshihiko Kumazawa, Takashi Kuroyanagi
-
Patent number: 4415508Abstract: An apparatus for mixing a hydrocarbon-containing gas flow with a molecular oxygen-containing gas flow, wherein at least one aqueous medium sealing zone allowing the hydrocarbon-containing gas flow to pass therethrough is provided by sealing a side of said introduced gas flow with an aqueous medium, providing at least one shielding zone for flame propagration, said gas flow is allowed to pass therethrough on a discharge side of said gas flow, and providing means for introducing the molecular oxygen-containing gas flow into a gas mixing zone defined between both of the above zones there to be thoroughly mixed with the hydrocarbon-containing gas flow.Type: GrantFiled: October 14, 1980Date of Patent: November 15, 1983Assignee: Nippon Shokubai Kagaku Kogyo Co., Ltd.Inventors: Kenji Aida, Takeshi Yamamoto, Toshihiko Kumazawa
-
Patent number: 4389338Abstract: In a method for the manufacture of a silver catalyst having silver deposited on a porous inorganic carrier in conjunction with at least one reaction accelerator selected from the group consisting of alkali metals and thallium to be used for the production of ethylene oxide, the improvement comprising the steps of depositing silver on the porous inorganic carrier in conjunction with at least one reaction accelerator selected from the group consisting of alkali metals and thallium thereby preparing an activated silver catalyst and subsequently subjecting said silver catalyst to a high-temperature treatment at a temperature in the range of 550.degree. to 950.degree. C. in an inert gaseous atmosphere having an oxygen concentration of not more than 3 volume percent in the final step.Type: GrantFiled: December 17, 1981Date of Patent: June 21, 1983Assignee: Nippon Skokubai Kagaku Kogyo Co., Ltd.Inventors: Masashi Mitsuhata, Shin-ichi Nagase, Takahiko Nakai, Toshihiko Kumazawa
-
Patent number: 4376209Abstract: A process for the production of ethylene oxide by the vapor-phase catalytic oxidation of ethylene with molecular oxygen, which process comprises passing a mixed gas containing ethylene and molecular oxygen through a catalyst bed filled with a silver catalyst and subsequently passing the resultant reaction product gas through a cooling zone filled with a particulate material containing a substance capable of inhibiting the isomerization of ethylene oxide to acetaldehyde carrying at least one metal selected from the group consisting of sodium, potassium, rubidium, cesium, calcium, strontium, barium and thallium or a compound of said metal to be carried on an inert refractory particulate material.Type: GrantFiled: September 18, 1980Date of Patent: March 8, 1983Assignee: Nippon Shokubai Kagaku Kogyo Co., Ltd.Inventors: Fumio Watanabe, Masashi Mitsuhata, Toshihiko Kumazawa
-
Patent number: 4368144Abstract: A silver catalyst for the production of ethylene oxide, comprising a granular .alpha.-alumina carrier having a sodium content of not more than 0.07% by weight and a specific surface area within the range of from 0.5 to 5 m.sup.2 /g, a finely divided metallic silver deposited on said carrier in an amount within the range of from 5 to 25% by weight based on the total catalyst, and at least one member selected from the group consisting of alkali metals of Atomic Numbers 19 to 55 and alkali metal compounds said at least one member being in an amount within the range of from 0.001 to 0.05 gram equivalent weight per kilogram of the complete catalyst.Type: GrantFiled: December 22, 1980Date of Patent: January 11, 1983Assignee: Nippon Shokubai Kagaku Kogyo Co., Ltd.Inventors: Masashi Mitsuhata, Fumio Watanabe, Toshihiko Kumazawa
-
Patent number: 4283580Abstract: A process for the production of alkylene glycols, which comprises causing a corresponding alkylene carbonate to react with water in the presence of a catalyst of at least one member selected from the group consisting of molybdenum and tungsten.Type: GrantFiled: September 19, 1979Date of Patent: August 11, 1981Assignee: Nippon Shokubai Kagaku Kogyo Co., Ltd.Inventors: Hiroshi Odanaka, Minoru Saotome, Toshihiko Kumazawa
-
Patent number: 4277632Abstract: A process for the production of alkylene glycols, which comprises causing a corresponding alkylene oxide to react with water in the presence of a catalyst of at least one member selected from the group consisting of molybdenum and tungsten.Type: GrantFiled: September 19, 1979Date of Patent: July 7, 1981Assignee: Nippon Shokubai Kaguku Kogyo Co., Ltd.Inventors: Toshihiko Kumazawa, Takeshi Yamamoto, Hiroshi Odanaka
-
Patent number: 4256604Abstract: A method for mixing a hydrocarbon-containing gas flow with a molecular oxygen-containing gas flow, wherein at least one aqueous medium sealing zone allowing the hydrocarbon-containing gas flow to pass therethrough is provided by sealing a side of introducing said gas flow with an aqueous medium and at least one shielding zone for flame propagation allowing said gas flow to pass therethrough is provided on a side of discharging said gas flow, and the molecular oxygen-containing gas flow is introduced in a gas mixing zone defined between both of the above zones to be thoroughly mixed with the hydrocarbon-containing gas flow.Type: GrantFiled: October 23, 1978Date of Patent: March 17, 1981Assignee: Nippon Shokubai Kagaku Kogyo Co., Ltd.Inventors: Kenji Aida, Takeshi Yamamoto, Toshihiko Kumazawa
-
Patent number: 4248740Abstract: An improved process for preparing a silver-supported catalyst for use in the production of ethylene oxide by catalytic vapor phase oxidation of ethylene with molecular oxygen, which comprises impregnating a porous inorganic carrier with a solution of a silver compound containing a reducing compound, subjecting the impregnated product to a reducing treatment at 50.degree. to 200.degree. C. to disperse and deposit metallic silver on the external surface of the carrier and the internal surfaces of its pores, washing the silver-supported carrier with water, a lower alcohol or both, drying the washed product at a temperature of 50.degree. to 150.degree. C., impregnating the dried product with a solution containing a promoter, and evaporating the liquid ingredients.Type: GrantFiled: June 28, 1978Date of Patent: February 3, 1981Assignee: Nippon Shokubai Kagaku Kogyo Co. Ltd.Inventors: Masashi Mitsuhata, Toshihiko Kumazawa, Isamu Kiguchi
-
Patent number: 4039561Abstract: A process for preparing ethylene oxide by the catalytic vapor phase oxidation of ethylene with molecular oxygen in the presence of a catalytic composition whose constituent metallic elements and atomic ratio are represented by the general formulaAg.sub.a Ba.sub.b X.sub.c Tl.sub.d K.sub.e Cs.sub.f O.sub.gwherein X represents at least one metallic element of the group consisting of tin and antimony, a, b, d, e, f and g are number of atoms of silver, barium, thallium, potassium, cesium and oxygen, respectively, and c is the sum of the number of atoms of at least one metallic element of the group consisting of tin and antimony; and when a is 100, b is a number from 0 to 100, c is a number from 0.001 to 0.15, d is a number from 0 to 0.1, e is a number from 0 to 0.1, f is a number from 0 to 0.1, with the proviso that the relationship 0<d + e + f.ltoreq.0.3 is satisfied, and g is a number determined by the valence requirements of the other elements present.Type: GrantFiled: September 3, 1974Date of Patent: August 2, 1977Assignee: Nippon Shokubai Kagaku KogyoInventors: Masashi Mitsuhata, Toshihiko Kumazawa, Isamu Kiguchi