Patents by Inventor Toshihiko Ohtomo
Toshihiko Ohtomo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8034903Abstract: The invention relates to a modified antibody which contains two or more H chain V regions and two or more L chain V regions of monoclonal antibody and can transduce a signal into cells by crosslinking TPO receptor to thereby exert TPO agonist action. The modified antibody can be used as a TPO signal transduction agonist and, therefore, useful as a remedy for various diseases such as platelet-reduction-related blood diseases, thrombopenia following chemotherapy for cancer or leukemia, etc.Type: GrantFiled: October 22, 2001Date of Patent: October 11, 2011Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Masayuki Tsuchiya, Toshihiko Ohtomo, Naohiro Yabuta, Hiroyuki Tsunoda, Tetsuro Orita
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Publication number: 20110082284Abstract: Disclosed are a protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a fragment thereof, an antibody recognizing the protein or antigen-binding fragment thereof, and a polynucleotide having a sequence comprising at least 12 consecutive nucleotides of a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a nucleotide sequence complementary thereto. The gene and the protein of the invention is useful for diagnosing and treating cancer.Type: ApplicationFiled: August 31, 2010Publication date: April 7, 2011Applicants: ABURANTAI, Hiroyuki, Perseus Proteomics Inc., Chugai Seiyaku Kabushiki KaishaInventors: Hiroyuki Aburatani, Yoshitaka Hippo, Hirokazu Taniguchi, Yong xin Chen, Shumpei Ishikawa, Shin-ichi Fukumoto, Takahiro Shimamura, Naoko Kamimura, Ying qiu Guo, Shogo Yamamoto, Yukio Ito, Hirotaka Ito, Toshihiko Ohtomo
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Patent number: 7892543Abstract: The invention provides a reshaped human anti-HM 1.24 antibody having: (A) an L chain having (1) the C region of a human L chain, and (2) the V region of an L chain having the FR of a human L chain and the CDR of the L chain of a mouse anti-HM 1.24 monoclonal antibody; and (B) an H chain having (1) the C region of a human H chain, and (2) the V region of an H chain having the FR of a human H chain and the CDR of the H chain of a mouse anti-HM 1.24 monoclonal antibody. This reshaped human antibody is derived from human antibody and the CDR has a low antigenicity, and the reshaped human antibody of the present invention has a low antigenicity and can be used for medical treatment.Type: GrantFiled: August 13, 2002Date of Patent: February 22, 2011Assignee: Chugai Seiyako Kabushiki KaishaInventors: Koichiro Ono, Toshihiko Ohtomo, Masayuki Tsuchiya, Yasushi Yoshimura, Yasuo Koishihara, Masaaki Kosaka
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Patent number: 7812128Abstract: Disclosed are a protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a fragment thereof, an antibody recognizing the protein or antigen-binding fragment thereof, and a polynucleotide having a sequence comprising at least 12 consecutive nucleotides of a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a nucleotide sequence complementary thereto. The gene and the protein of the invention is useful for diagnosing and treating cancer.Type: GrantFiled: August 26, 2008Date of Patent: October 12, 2010Inventors: Hiroyuki Aburatani, Yoshitaka Hippo, Hirokazu Taniguchi, Yong xin Chen, Shumpei Ishikawa, Shin-ichi Fukumoto, Takahiro Shimamura, Naoko Kamimura, Ying qiu Guo, Shogo Yamamoto, Yukio Ito, Hirotaka Ito, Toshihiko Ohtomo
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Patent number: 7666610Abstract: Methods for measuring transporter activity using budding baculoviruses that do not express endogenous transporters on their envelope have a low background level and can measure the target activity with a high sensitivity. Such methods can be used to measure functional changes due to transporter SNPs over a more extensive range of substrates, and can be applied to tailor-made therapies.Type: GrantFiled: March 28, 2003Date of Patent: February 23, 2010Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Ryoichi Saitoh, Toshihiko Ohtomo, Masayuki Tsuchiya
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Publication number: 20090311718Abstract: The invention relates to a modified antibody which contains two or more H chain V regions and two or more L chain V regions of monoclonal antibody and can transduce a signal into cells by crosslinking a cell surface molecule(s) to thereby serve as an agonist. The modified antibody can be used as a signal transduction agonist and, therefore, useful as a preventive and/or remedy for various diseases such as cancer, inflammation, hormone disorders and blood diseases.Type: ApplicationFiled: July 2, 2009Publication date: December 17, 2009Inventors: Naoshi Fukushima, Masayuki Tsuchiya, Shinsuke Uno, Toshihiko Ohtomo, Naohiro Yabuta, Hiroyuki Tsunod
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Publication number: 20090226918Abstract: Disclosed are a protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a fragment thereof, an antibody recognizing the protein or antigen-binding fragment thereof, and a polynucleotide having a sequence comprising at least 12 consecutive nucleotides of a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a nucleotide sequence complementary thereto. The gene and the protein of the invention is useful for diagnosing and treating cancer.Type: ApplicationFiled: April 1, 2009Publication date: September 10, 2009Applicants: Perseus Proteomics Inc, Chugai Seiyaku Kabushiki KaishaInventors: Hiroyuki Aburatani, Yoshitaka Hippo, Hirokazu Taniguchi, Yong xin Chen, Shumpei Ishikawa, Shin-ichi Fukumoto, Takahiro Shimamura, Naoka Kamimura, Ying qiu Guo, Shogo Yamamoto, Yukio Ito, Hirotaka Ito, Toshihiko Ohtomo
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Publication number: 20090192108Abstract: Disclosed are a protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a fragment thereof, an antibody recognizing the protein or antigen-binding fragment thereof, and a polynucleotide having a sequence comprising at least 12 consecutive nucleotides of a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a nucleotide sequence complementary thereto. The gene and the protein of the invention is useful for diagnosing and treating cancer.Type: ApplicationFiled: August 26, 2008Publication date: July 30, 2009Applicants: Perseus Proteomics Inc., Chugai Seiyaku Kabushiki KaishaInventors: Hiroyuki Aburatani, Yoshitaka Hippo, Hirokazu Taniguchi, Yong xin Chen, Shumpei Ishikawa, Shin-ichi Fukumoto, Takahiro Shimamura, Naoko Kamimura, Ying qiu Guo, Shogo Yamamoto, Yukio Ito, Hirotaka Ito, Toshihiko Ohtomo
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Patent number: 7563599Abstract: The present invention discloses reshaped antibody to human medulloblastoma cells comprising: (A) an L chain comprising: (1) a human L chain C region, and (2) an L chain V region comprising human L chain FRs and L chain CDRs of mouse monoclonal antibody ONS-M21 to human medulloblastoma cells; and, (B) an H chain containing: (1) a human H chain C region, and (2) an H chain V region comprising human H chain FRs and H chain CDRs of mouse monoclonal antibody ONS-M21 to human medulloblastoma cells. Since the majority of this reshaped human antibody is derived from a human antibody and mouse CDRs have a low level of antigenicity, the reshaped human antibody of the present invention has a low level of antigenicity in humans, and is therefore expected to be useful as a therapeutic agent and diagnostic tool for brain tumors such as medulloblastoma which strongly express antigen that is recognized by this antibody.Type: GrantFiled: May 6, 2004Date of Patent: July 21, 2009Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Toshihiko Ohtomo, Koh Sato, Masayuki Tsuchiya
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Publication number: 20080160541Abstract: Revealed are that the actions of inflammatory cytokine and the production of inflammatory cytokines such as IL-1 and TNF induced by an inflammatory stimulus as well as the production of other inflammatory cytokines such as IL-6 induced by the former class of inflammatory cytokines are all suppressed by inhibiting the signal transduction through TAK1.Type: ApplicationFiled: February 6, 2008Publication date: July 3, 2008Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHAInventors: Masayuki Tsuchiya, Toshihiko Ohtomo, Yasuhiro Sugamata, Kunihiro Matsumoto
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Publication number: 20080153104Abstract: Disclosed are a protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a fragment thereof, an antibody recognizing the protein or antigen-binding fragment thereof, and a polynucleotide having a sequence comprising at least 12 consecutive nucleotides of a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a nucleotide sequence complementary thereto. The gene and the protein of the invention is useful for diagnosing and treating cancer.Type: ApplicationFiled: August 6, 2004Publication date: June 26, 2008Applicants: HIROYUKI ABURANTAI, PERSEUS PROTEOMICS INC, CHUGAI SEIYAKU KABUSHIKI KAISHAInventors: Hiroyuki Aburatani, Yoshitaka Hippo, Hirokazu Taniguchi, Yong xin Chen, Shumpei Ishikawa, Shin-ichi Fukumoto, Takahiro Shimamura, Naoko Kamimura, Ying qiu Guo, Shogo Yamamoto, Yukio Ito, Hirotaka Ito, Toshihiko Ohtomo
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Patent number: 7338797Abstract: A method, vector, and kit are provided for selectively isolating genes encoding membrane-bound proteins by fusing proteins to a secretable protein having a binding affinity to an antigen (e.g., an antibody), expressing these fusions in host cells, and selectively isolating individual host cells by their ability to bind the antigen via the fusion protein. Host cells expressing fusion proteins that do not contain a membrane binding domain will be relatively unable to bind the antigen, since the fusion proteins in those cells are secreted and unattached to their host cells. The method, vector, and kit disclosed herein are particularly useful for identifying genes for membrane-bound proteins represented in cDNA libraries.Type: GrantFiled: April 29, 2003Date of Patent: March 4, 2008Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Masayuki Tsuchiya, Mikiyoshi Saito, Toshihiko Ohtomo
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Publication number: 20080009038Abstract: Anti-human Mp1 antibodies were isolated and purified, and then single-chain anti-human Mp1 antibodies were prepared using genetic engineering techniques. The antibodies were found to exhibit a high agonistic activity. This shows that the activity of an antibody can be enhanced by making the antibody into a single-chain polypeptide that comprises two or more heavy chain variable regions and two or more light chain variable regions linked via linkers.Type: ApplicationFiled: December 10, 2004Publication date: January 10, 2008Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHAInventors: Toshihiko Ohtomo, Naohiro Yabuta, Hiroyuki Tsunoda, Masayuki Tsuchiya
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Publication number: 20070212359Abstract: A method for diagnosing cancer comprising detecting ROBO1 protein is disclosed. In addition, a method for treating a disease caused by abnormal cell growth comprising administrating an antibody that binds to ROBO1, as well as a pharmaceutical composition, a cell growth inhibitor and an anticancer agent comprising an antibody that binds to ROBO1 as an active ingredient are disclosed. Further, a method for inducing cell damages in a ROBO1 expressing cell and a method for inhibiting the growth of a ROBO1 expressing cell by bringing a ROBO1 expressing cell into contact with an antibody that binds to ROBO1, are disclosed. Furthermore, a method for monitoring progression of hepatitis by detecting ROBO1 protein is disclosed.Type: ApplicationFiled: March 31, 2005Publication date: September 13, 2007Applicant: Chugai Seiyaku Kabushiki KaishaInventors: Hiroyuki Aburatani, Yoshitaka Hippo, Akira Watanabe, Yukio Ito, Hirotaka Ito, Shin-ichi Funahashi, Masashi Fukayama, Masahiro Arai, Toshihiko Ohtomo, Yasuko Kinoshita
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Publication number: 20070037204Abstract: Disclosed are a protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a fragment thereof, an antibody recognizing the protein or antigen-binding fragment thereof, and a polynucleotide having a sequence comprising at least 12 consecutive nucleotides of a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a nucleotide sequence complementary thereto. The gene and the protein of the invention is useful for diagnosing and treating cancer.Type: ApplicationFiled: October 20, 2006Publication date: February 15, 2007Applicants: Perseus Proteomics Inc., Chugai Seiyaku Kabushiki KaishaInventors: Hiroyuki Aburatani, Yoshitaka Hippo, Hirokazu Taniguchi, Yong Chen, Shumpei Ishikawa, Shin-ichi Fukumoto, Takahiro Shimamura, Naoko Kamimura, Ying Gou, Shogo Yamamoto, Yukio Ito, Hirotaka Ito, Toshihiko Ohtomo
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Patent number: 7067297Abstract: A DNA encoding a novel protein SMAP-1 having a signal sequence was successfully isolated by screening a cDNA library derived from human fetal hepatocyte using the TMT method developed originally by the inventors. Based on the expression pattern and structural properties, SMAP-1 was suggested to be a molecule playing an important role in living cells.Type: GrantFiled: February 15, 2001Date of Patent: June 27, 2006Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Masayuki Tsuchiya, Mikiyoshi Saito, Hirotaka Ito, Motooki Ashihara, Toshihiko Ohtomo
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Publication number: 20060084119Abstract: Methods for measuring transporter activity using budding baculoviruses that do not express endogenous transporters on their envelope have a low background level and can measure the target activity with a high sensitivity. Such methods can be used to measure functional changes due to transporter SNPs over a more extensive range of substrates, and can be applied to tailor-made therapies.Type: ApplicationFiled: March 28, 2003Publication date: April 20, 2006Inventors: Ryoichi Saitoh, Toshihiko Ohtomo, Masayuki Tsuchiya
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Publication number: 20060040316Abstract: Revealed are that the actions of inflammatory cytokine and the production of inflammatory cytokines such as IL-1 and TNF induced by an inflammatory stimulus as well as the production of other inflammatory cytokines such as IL-6 induced by the former class of inflammatory cytokines are all suppressed by inhibiting the signal transduction through TAK1.Type: ApplicationFiled: October 27, 2005Publication date: February 23, 2006Applicant: Chugai Seiyaku Kabushiki Kaisha,Inventors: Masayuki Tsuchiya, Toshihiko Ohtomo, Yasuhiro Sugamata, Kunihiro Matsumoto
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Patent number: 6989244Abstract: The present invention relates to methods of screening for compounds that inhibit signal transduction by inflammatory cytokines. The methods include providing a sample that contains a TAK1 and a TAB1; contacting the sample with a compound; detecting binding between the TAK1 and the TAB1; and selecting the compound if binding between the TAK1 and TAB1 is inhibited in the sample compared to a control.Type: GrantFiled: October 21, 1999Date of Patent: January 24, 2006Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Masayuki Tsuchiya, Toshihiko Ohtomo, Yasuhiro Sugamata, Kunihiro Matsumoto
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Publication number: 20050249726Abstract: The present invention discloses reshaped antibody to human medulloblastoma cells comprising: (A) an L chain comprising: (1) a human L chain C region, and (2) an L chain V region comprising human L chain FRs and L chain CDRs of mouse monoclonal antibody ONS-M21 to human medulloblastoma cells; and, (B) an H chain containing: (1) a human H chain C region, and (2) an H chain V region comprising human H chain FRs and H chain CDRs of mouse monoclonal antibody ONS-M21 to human medulloblastoma cells. Since the majority of this reshaped human antibody is derived from a human antibody and mouse CDRs have a low level of antigenicity, the reshaped human antibody of the present invention has a low level of antigenicity in humans, and is therefore expected to be useful as a therapeutic agent and diagnostic tool for brain tumors such as medulloblastoma which strongly express antigen that is recognized by this antibody.Type: ApplicationFiled: May 6, 2004Publication date: November 10, 2005Inventors: Toshihiko Ohtomo, Koh Sato, Masayuki Tsuchiya