Patents by Inventor Toshihiko Terao

Toshihiko Terao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6509445
    Abstract: A chimeric protein wherein HI-8 which is the C-terminal domain of human urinary trypsin inhibitor (UTI) having a cancer cell metastasis inhibitory effect, is linked to a peptide containing the G domain of urokinase binding specifically to urokinase receptor expressed in a large amount in cancer cells.
    Type: Grant
    Filed: July 8, 1998
    Date of Patent: January 21, 2003
    Assignee: Nissin Food Products Co., Ltd.
    Inventors: Hiroshi Kobayashi, Toshihiko Terao, Dan Sugino, Minoru Okushima
  • Patent number: 6197291
    Abstract: The inventors provide an agent for potentiating the effect of interleukin-8, which comprises dehydroepiandrosterone sulfate or a pharmaceutically acceptable salt thereof as an active ingredient. An agent for potentiating the effect of IL-8 of the present invention potentiates the effect of IL-8 by activating the receptor of IL-8 and increasing the number of receptors.
    Type: Grant
    Filed: October 14, 1998
    Date of Patent: March 6, 2001
    Assignees: Kanebo Limited, Akzo Nobel N.V.
    Inventors: Toshihiko Terao, Naohiro Kanayama
  • Patent number: 6013252
    Abstract: Leukocyte chemotactic factors such as interleukin-8 and MCAF, and inductive substances therefor were revealed to have proconceptive activities. These activities include promoting ovum growth and fertilized ovum implantation, and are exhibited by a sole substance. Accordingly, it has been shown that such substances can be used in drugs concerning medical treatment for infertility, and further, can be used in veterinary and livestock industry fields such as reproduction of industrial animals or species preservation of rare animals.
    Type: Grant
    Filed: June 5, 1997
    Date of Patent: January 11, 2000
    Assignee: Toray Industries, Inc.
    Inventors: Toshihiko Terao, Naohiro Kanayama, Masanobu Naruto, Tatsuya Kaneko
  • Patent number: 5650394
    Abstract: The present invention provides a method of diagnosing and treating a pregnant female at risk for impending preterm delivery. The method comprises the step of diagnosing imminent preterm delivery by testing with a method that has a sensitivity of at least 80% and a specificity of at least 80%, or by testing for fetal fibronectin in the female's vaginal or cervical secretions. If imminent preterm delivery is indicated by the test, the next step comprises administering to the female a combination of a tocolytic agent, at least one urinastatin-like compound, and at least one antibiotic. Also provided is a pharmaceutical composition of MGMTSRYFYNGTSMA (SEQ ID NO:1), RAFIQLWAFDAVKGK (SEQ ID NO:2) and an antibiotic.
    Type: Grant
    Filed: November 4, 1993
    Date of Patent: July 22, 1997
    Assignee: Adeza Biomedical
    Inventors: Toshihiko Terao, Naohiro Kanayama, David Casal
  • Patent number: 5290679
    Abstract: Even when the specimen contains human granulocyte elastase in the form of a mixture of free elastase with an elastase-inhibitor complex or complexes, the present invention enables the total quantity of elastase in that specimen to be precisely detected. The inhibitor is added to free elastase to convert it into an elastase-inhibitor complex, whereby the quantity of elastase can be measured by immunoassay as the total amount including the previously existing elastase-inhibitor complex. It is possible to precisely measure the total amount of elastase in mucus collected from the cervical canal of a pregnant woman, sputum or a rinsed solution of bronchovesicular lavage in which free elastase is mixed with an elastase-inhibitor complex.
    Type: Grant
    Filed: June 15, 1992
    Date of Patent: March 1, 1994
    Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.
    Inventors: Toshihiko Terao, Naohiro Kanayama, Akihiro Morioka, Yoshika Yasuda, Masami Kamiya, Juichi Awaya, Masayasu Kurono, Kiichi Sawai