Patents by Inventor Toshihiko Yoshimura

Toshihiko Yoshimura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180274569
    Abstract: Provided are a method for generating mechanical and electrochemical cavitation, a method for changing the geometric shape and the electrochemical properties of a surface of a substance, a method for peeling off a rare metal using the generated mechanical and electrochemical cavitation, a mechanical and electrochemical cavitation generator, and a method for generating a nuclear fusion reaction of deuterium. In the method for generating mechanical and electrochemical cavitation, a water jet is jetted from a jetting nozzle immersed in water, and flow cavitation generated by the jetting of the water jet is irradiated with an ultrasonic wave to generate cavitation MFC having both a functional effect and an electrochemical effect.
    Type: Application
    Filed: February 22, 2016
    Publication date: September 27, 2018
    Inventor: Toshihiko Yoshimura
  • Patent number: 8426588
    Abstract: Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to ?4 integrin. They are used as therapeutic agents for various diseases concerning ?4 integrin.
    Type: Grant
    Filed: June 15, 2012
    Date of Patent: April 23, 2013
    Assignee: Ajinomoto Co, Inc.
    Inventors: Shingo Makino, Tatsuya Okuzumi, Toshihiko Yoshimura, Yuko Satake, Nobuyasu Suzuki, Hiroyuki Izawa, Kazuyuki Sagi, Akira Chiba, Eiji Nakanishi, Masahiro Murata, Takashi Tsuji
  • Publication number: 20120253041
    Abstract: Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to ?4 integrin. They are used as therapeutic agents for various diseases concerning ?4 integrin.
    Type: Application
    Filed: June 15, 2012
    Publication date: October 4, 2012
    Applicant: Ajinomoto Co., Inc.
    Inventors: Shingo MAKINO, Tatsuya Okuzumi, Toshihiko Yoshimura, Yuko Satake, Nobuyasu Suzuki, Hiroyuki Izawa, Kazuyuki Sagi, Akira Chiba, Eiji Nakanishi, Masahiro Murata, Takashi Tsuji
  • Patent number: 8222405
    Abstract: Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to ?4 integrin. They are used as therapeutic agents for various diseases concerning ?4 integrin.
    Type: Grant
    Filed: November 22, 2010
    Date of Patent: July 17, 2012
    Assignee: Ajinomoto Co., Inc.
    Inventors: Shingo Makino, Tatsuya Okuzumi, Toshihiko Yoshimura, Yuko Satake, Nobuyasu Suzuki, Hiroyuki Izawa, Kazuyuki Sagi, Akira Chiba, Eiji Nakanishi, Masahiro Murata, Takashi Tsuji
  • Patent number: 8168827
    Abstract: Amide derivatives represented by the formula (I): wherein: A is a cycloalkyl group, an aryl group or a heteroaryl group; X is a nitrogen atom or CR17; Y is —NRa-, —(CRbRb?)m-, and the like; m is 0 to 4; and R1 to R17 may be the same or different and each is a hydrogen atom, a halogen atom, a cyano group, a nitro group, a carboxyl group, a formyl group, a hydroxyl group, an ammonium group, an alkyl group optionally having one or more substituents, -ZR18 and the like, Z is —O—, —S(O)p-, —S(O)pO—, —NH—, —NR19-, and the like; or a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof may be applied to pharmaceutical use such as anti-inflammatory and analgesic action and the like.
    Type: Grant
    Filed: June 19, 2009
    Date of Patent: May 1, 2012
    Assignee: Ajinomoto Co., Inc.
    Inventors: Tadakiyo Nakagawa, Tamotsu Suzuki, Kaoru Takenaka, Shinichi Fujita, Youji Yamada, Yoichiro Shima, Tatsuya Okuzumi, Toshihiko Yoshimura, Masanao Yoshida, Masahiro Murata
  • Patent number: 7994353
    Abstract: The present invention provides PPAR (peroxisome proliferator-activated receptor) activity regulators, which can be widely used for improving insulin resistance and preventing/treating various diseases such as diabetes, metabolic syndromes, hyperlipemia, high-blood pressure, vascular disorders, inflammation, hepatitis, fatty liver, liver fibrosis, NASH (non-alcoholic steatohepatitis) and obesity.
    Type: Grant
    Filed: March 5, 2009
    Date of Patent: August 9, 2011
    Assignee: Ajinomoto Co., Inc.
    Inventors: Akiko Oonuki, Toshihiko Yoshimura, Katsumi Maezono, Yayoi Kawato, Hideyuki Tanaka, Naoyuki Fukuchi, Nozomu Ishida
  • Publication number: 20110065918
    Abstract: Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to ?4 integrin. They are used as therapeutic agents for various diseases concerning ?4 integrin.
    Type: Application
    Filed: November 22, 2010
    Publication date: March 17, 2011
    Applicant: Ajinomoto Co., Inc.
    Inventors: Shingo MAKINO, Tatsuya Okuzumi, Toshihiko Yoshimura, Yuko Satake, Nobuyasu Suzuki, Hiroyuki Izawa, Kazuyuki Sagi, Akira Chiba, Eiji Nakanishi, Masahiro Murata, Takashi Tsuji
  • Patent number: 7884204
    Abstract: Phenylalanine derivatives of the following formula, analogues thereof and pharmaceutically acceptable salts thereof have an antagonistic activity to ?4 integrin. They are used as therapeutic agents or preventive agents for various diseases concerning ?4 integrin in which ?4 integrin-depending adhesion process participates in the pathology, such as inflammatory diseases, rheumatoid arthritis, inflammatory bowel diseases, systemic lupus erythematosus, multiple sclerosis, Sjögren's syndrome, asthma, psoriasis, allergy, diabetes, cardiovascular diseases, arterial sclerosis, restenosis, tumor proliferation, tumor metastasis and transplantation rejection. wherein R1 is a methyl group and R2 is a methoxy group.
    Type: Grant
    Filed: June 25, 2007
    Date of Patent: February 8, 2011
    Assignee: Ajinomoto Co., Inc.
    Inventors: Tatsuya Okuzumi, Kazuyuki Sagi, Toshihiko Yoshimura, Yuji Tanaka, Eiji Nakanishi, Miho Ono, Masahiro Murata
  • Patent number: 7879863
    Abstract: The present invention provides a novel compound having a kininogenase-inhibitory action and its pharmaceutical use. The compounds are represented by the formulas (A), (B), (C), (E) and (H): wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: September 29, 2006
    Date of Patent: February 1, 2011
    Assignee: Ajinomoto Co., Inc.
    Inventors: Munetaka Tokumasu, Masayuki Sugiki, Haruko Hirashima, Hideki Matsumoto, Toshihiko Yoshimura, Yasuko Nogi, Mitsuo Takahashi, Manabu Kitazawa, Akiko Oonuki, Naoyuki Fukuchi, Yoichiro Shima
  • Patent number: 7872125
    Abstract: Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to ?4 integrin. They are used as therapeutic agents for various diseases concerning ?4 integrin.
    Type: Grant
    Filed: May 30, 2006
    Date of Patent: January 18, 2011
    Assignee: Ajinomoto Co., Inc.
    Inventors: Shingo Makino, Tatsuya Okuzumi, Toshihiko Yoshimura, Yuko Satake, Nobuyasu Suzuki, Hiroyuki Izawa, Kazuyuki Sagi, Akira Chiba, Eiji Nakanishi, Masahiro Murata, Takashi Tsuji
  • Patent number: 7759388
    Abstract: Specific phenylalanine derivatives or pharmaceutically acceptable salts thereof have an antagonistic effect on the ? 4 integrins and, therefore, are usable as therapeutic agents or preventive agents for diseases in which ? 4 integrin-depending adhesion process participates in the pathology, such as inflammatory diseases, rheumatoid arthritis, inflammatory bowel diseases, systemic lupus erythematosus, multiple sclerosis, Sjögren's syndrome, asthma, psoriasis, allergy, diabetes, cardiovascular diseases, arterial sclerosis, restenosis, tumor proliferation, tumor metastasis and transplantation rejection.
    Type: Grant
    Filed: October 16, 2008
    Date of Patent: July 20, 2010
    Assignee: Ajinomoto Co., Inc.
    Inventors: Nobuyasu Suzuki, Toshihiko Yoshimura, Hiroyuki Izawa, Kazuyuki Sagi, Shingo Makino, Eiji Nakanishi, Masahiro Murata, Takashi Tsuji
  • Patent number: 7732637
    Abstract: The present invention provides an acylamide compound of the following formula (1), prodrugs thereof, or pharmaceutically acceptable salts thereof; and an adiponectin inducer or secretagogue, therapeutic agent of metabolic syndromes, therapeutic agent of hypoadiponectinemia, therapeutic agent of hyperlipemia, preventive/therapeutic agent of diabetes, improving agent of impaired glucose tolerance, improving agent of insulin resistance, enhancing agent of insulin sensitivity, therapeutic agent of hypertension, preventive/therapeutic agent of vascular disorders, an anti-inflammatory agent, therapeutic agent of hepatic inflammation, therapeutic agent of fatty liver, therapeutic agent of hepatic fibrosis, therapeutic agent of liver cirrhosis, preventive/therapeutic agent of non-alcoholic/nonviral steatohepatitis (NASH) or non-alcoholic/nonviral fatty liver disease (NAFLD), or therapeutic agent of obesity, each of which has the above compounds as an active ingredient.
    Type: Grant
    Filed: August 7, 2007
    Date of Patent: June 8, 2010
    Assignee: Ajinomoto Co., Inc.
    Inventors: Katsumi Maezono, Toshihiko Yoshimura, Nozomu Ishida, Naoyuki Fukuchi, Toshihiro Hatanaka, Osamu Ikehara, Yayoi Kawato, Hideyuki Tanaka
  • Patent number: 7728158
    Abstract: The object of the present invention is to provide PPAR (peroxisome proliferator-activated receptor) activity regulators, which can be widely used for improving insulin resistance and preventing/treating various diseases such as diabetes, metabolic syndromes, hyperlipemia, high-blood pressure, vascular disorders, inflammation, hepatitis, fatty liver, liver fibrosis, NASH (non-alcoholic steatohepatitis) and obesity. The present invention provides PPAR activity regulators which comprise an acylamide compound having the specific structure, prodrugs thereof, or pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: May 25, 2007
    Date of Patent: June 1, 2010
    Assignee: Ajinomoto Co., Inc.
    Inventors: Akiko Oonuki, Toshihiko Yoshimura, Katsumi Maezono, Yayoi Kawato, Hideyuki Tanaka, Naoyuki Fukuchi, Nozomu Ishida
  • Publication number: 20100063151
    Abstract: The present invention provides acylamide compounds, prodrugs thereof, or pharmaceutically acceptable salts thereof; and an adiponectin inducer or secretagogue, and therapeutic methods by administering the same.
    Type: Application
    Filed: November 18, 2009
    Publication date: March 11, 2010
    Applicant: Ajinomoto Co., Inc.
    Inventors: Katsumi MAEZONO, Toshihiko YOSHIMURA, Nozomu ISHIDA, Naoyuki FUKUCHI, Toshihiro HATANAKA, Osamu IKEHARA, Yayoi KAWATO, Hideyuki TANAKA
  • Patent number: 7605165
    Abstract: The present invention relates to the following phenylalanine derivatives or analogues thereof having an antagonistic activity to ?4 integrin and therapeutic agents for various diseases concerning ?4 integrin.
    Type: Grant
    Filed: August 20, 2004
    Date of Patent: October 20, 2009
    Assignee: Ajinomoto Co., Inc.
    Inventors: Kazuyuki Sagi, Hiroyuki Izawa, Akira Chiba, Tatsuya Okuzumi, Toshihiko Yoshimura, Yuji Tanaka, Miho Ono, Masahiro Murata
  • Publication number: 20090259061
    Abstract: The object of the present invention is to provide PPAR (peroxisome proliferator-activated receptor) activity regulators, which can be widely used for improving insulin resistance and preventing/treating various diseases such as diabetes, metabolic syndromes, hyperlipemia, high-blood pressure, vascular disorders, inflammation, hepatitis, fatty liver, liver fibrosis, NASH (non-alcoholic steatohepatitis) and obesity. The present invention provides PPAR activity regulators which comprise an acylamide compound having the specific structure, prodrugs thereof, or pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: March 5, 2009
    Publication date: October 15, 2009
    Applicant: AJINOMOTO, CO., INC.
    Inventors: Akiko OONUKI, Toshihiko YOSHIMURA, Katsumi MAEZONO, Yayoi KAWATO, Hideyuki TANAKA, Naoyuki FUKUCHI, Nozomu ISHIDA
  • Publication number: 20090258900
    Abstract: Amide derivatives represented by the formula (I): wherein: A is a cycloalkyl group, an aryl group or a heteroaryl group; X is a nitrogen atom or CR17; Y is —NRa—, —(CRbRb?)m-, and the like; m is 0 to 4; and R1 to R17 may be the same or different and each is a hydrogen atom, a halogen atom, a cyano group, a nitro group, a carboxyl group, a formyl group, a hydroxyl group, an ammonium group, an alkyl group optionally having one or more substituents, -ZR18 and the like, Z is —O—, —S(O)p-, —S(O)pO—, —NH—, —NR19-, and the like; or a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof may be applied to pharmaceutical use such as anti-inflammatory and analgesic action and the like.
    Type: Application
    Filed: June 19, 2009
    Publication date: October 15, 2009
    Applicant: AJINOMOTO CO. INC
    Inventors: Tadakiyo Nakagawa, Tamotsu Suzuki, Kaoru Takenaka, Shinichi Fujita, Youji Yamada, Yoichiro Shima, Tatsuya Okuzumi, Toshihiko Yoshimura, Masanao Yoshida, Masahiro Murata
  • Patent number: 7572815
    Abstract: Amide derivatives represented by the formula (I): wherein: A is a cycloalkyl group, an aryl group or a heteroaryl group; X is a nitrogen atom or CR17; Y is —NRa—, —(CRbRb?)m-, and the like; m is 0 to 4; and R1 to R17 may be the same or different and each is a hydrogen atom, a halogen atom, a cyano group, a nitro group, a carboxyl group, a formyl group, a hydroxyl group, an ammonium group, an alkyl group optionally having one or more substituents, ZR18 and the like, Z is —O—, —S(O)p-, —S(O)pO—, —NH—, —NR19-, and the like; or R1 and R2 may in combination form a ring, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof may be applied to pharmaceutical use such as anti-inflammatory and analgesic action and the like.
    Type: Grant
    Filed: November 18, 2005
    Date of Patent: August 11, 2009
    Assignee: Ajinomoto Co., Inc.
    Inventors: Tadakiyo Nakagawa, Tamotsu Suzuki, Kaoru Takenaka, Shinichi Fujita, Youji Yamada, Yoichiro Shima, Tatsuya Okuzumi, Toshihiko Yoshimura, Masanao Yoshida, Masahiro Murata
  • Publication number: 20090048236
    Abstract: Specific phenylalanine derivatives or pharmaceutically acceptable salts thereof have an antagonistic effect on the ?4 integrins and, therefore, are usable as therapeutic agents or preventive agents for diseases in which ?4 integrin-depending adhesion process participates in the pathology, such as inflammatory diseases, rheumatoid arthritis, inflammatory bowel diseases, systemic lupus erythematosus, multiple sclerosis, Sjögren's syndrome, asthma, psoriasis, allergy, diabetes, cardiovascular diseases, arterial sclerosis, restenosis, tumor proliferation, tumor metastasis and transplantation rejection.
    Type: Application
    Filed: October 16, 2008
    Publication date: February 19, 2009
    Applicant: AJINOMOTO CO. INC
    Inventors: Nobuyasu SUZUKI, Toshihiko Yoshimura, Hiroyuki Izawa, Kazuyuki Sagi, Shingo Makino, Eiji Nakanishi, Masahiro Murata, Takashi Tsuji
  • Patent number: 7452905
    Abstract: Specific phenylalanine derivatives or pharmaceutically acceptable salts thereof have an antagonistic effect on the ? 4 integrins and, therefore, are usable as therapeutic agents or preventive agents for diseases in which ? 4 integrin-depending adhesion process participates in the pathology, such as inflammatory diseases, rheumatoid arthritis, inflammatory bowel diseases, systemic lupus erythematosus, multiple sclerosis, Sjögren's syndrome, asthma, psoriasis, allergy, diabetes, cardiovascular diseases, arterial sclerosis, restenosis, tumor proliferation, tumor metastasis and transplantation rejection.
    Type: Grant
    Filed: March 31, 2003
    Date of Patent: November 18, 2008
    Assignee: Ajinomoto Co., Inc.
    Inventors: Nobuyasu Suzuki, Toshihiko Yoshimura, Eiji Nakanishi, Masahiro Murata, Takashi Tsuji