Patents by Inventor Toshihiro Ishiguro
Toshihiro Ishiguro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20050170047Abstract: The present invention relates to nutritionally enriched maple syrup, which is enriched in vitamins, and more particularly to nutritionally enriched maple syrup which contains vitamin C in an amount of 50 mg or more based on 100 ml of maple syrup obtained by thermally concentrating a maple sap. The present invention also includes maple syrup enriched in vitamins such as vitamin E and vitamin B1 and other nutrients. According to the present invention, the nutritional value and quality of maple syrup, particularly maple syrup obtained by thermal concentration, can be improved and the range of its use for other foods can be widened. Nutrient enrichment can be carried out by an efficient method suited for industrial scale production. Moreover, the nutritionally enriched maple syrup of the present invention exhibits a well-balanced flavor, and thus it can be widely added to various foods.Type: ApplicationFiled: February 21, 2003Publication date: August 4, 2005Applicants: MIC CO., LTD., L.B. MAPLE TREAT INC.Inventors: Yoshiko Watanabe, Luc Bergeron, Toshihiro Ishiguro
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Patent number: 5840881Abstract: A composition is disclosed comprising a water-insoluble or slightly water-soluble compound and a branched cyclodextrin-carboxylic acid. The branched cyclodextrin-carboxylic acid significantly increases the water-solubility of the compound. Also disclosed is a method of enhancing water-solubility of the compound.Type: GrantFiled: May 8, 1995Date of Patent: November 24, 1998Assignee: Takeda Chemical Industries, Ltd.Inventors: Yoshiaki Uda, Takako Yamauchi, Yasushi Nakagawa, Toshihiro Ishiguro, Masahide Oka, Takamasa Yamaguchi, Ikuo Nogami
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Patent number: 5635611Abstract: A process for producing a saccharide carboxylic acid or a salt thereof characterized in that a microorganism belonging to the genus Pseudogluconobacter and capable of oxidizing a hydroxymethyl group and/or hemiacetal hydroxyl-associated carbon atom to a carboxyl group, or an artifact derived from the microorganism, is permitted to act on a hydroxymethyl and/or hemiacetal hydroxyl-containing saccharide or saccharide derivative to produce and accumulate the corresponding carboxylic acid and the carboxylic acid so accumulated is harvested and novel saccharide carboxylic acids produced by the above production method, and by the process, from a broad range of saccharides, saccharic acids having carboxyl groups derived from hydroxymethyl and/or hemiacetal OH groups can be produced with high selectivity and in good yield, the resultant saccharide acids are resistant to enzymatic degradation and have improved water solubility, among other characteristics.Type: GrantFiled: April 10, 1995Date of Patent: June 3, 1997Assignee: Takeda Chemical Industries, Ltd.Inventors: Toshihiro Ishiguro, Masahide Oka, Takamasa Yamaguchi, Ikuo Nogami
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Patent number: 5635610Abstract: A process for producing a saccharide carboxylic acid or a salt thereof characterized in that a microorganism belonging to the genus Pseudogluconobacter and capable of oxidizing a hydroxymethyl group and/or hemiacetal hydroxyl-associated carbon atom to a carboxyl group, or an artifact derived from the microorganism, is permitted to act on a hydroxymethyl and/or hemiacetal hydroxyl-containing saccharide or saccharide derivative to produce and accumulate the corresponding carboxylic acid and the carboxylic acid so accumulated is harvested and novel saccharide carboxylic acids produced by the above production method, and by the process, from a broad range of saccharides, saccharic acids having carboxyl groups derived from hydroxymethyl and/or hemiacetal OH groups can be produced with high selectivity and in good yield, the resultant saccharide acids are resistant to enzymatic degradation and have improved water solubility, among other characteristics.Type: GrantFiled: April 10, 1995Date of Patent: June 3, 1997Assignee: Takeda Chemical Industries, Ltd.Inventors: Toshihiro Ishiguro, Masahide Oka, Takamasa Yamaguchi, Ikuo Nogami
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Patent number: 5629411Abstract: A process for producing a saccharide carboxylic acid or a salt thereof characterized in that a microorganism belonging to the genus Pseudogluconobacter and capable of oxidizing a hydroxymethyl group and/or hemiacetal hydroxyl-associated carbon atom to a carboxyl group, or an artifact derived from the microorganism, is permitted to act on a hydroxymethyl and/or hemiacetal hydroxyl-containing saccharide or saccharide derivative to produce and accumulate the corresponding carboxylic acid and the carboxylic acid so accumulated is harvested and novel saccharide carboxylic acids produced by the above production method, and by the process, from a broad range of saccharides, saccharic acids having carboxyl groups derived from hydroxymethyl and/or hemiacetal OH groups can be produced with high selectivity and in good yield, the resultant saccharide acids are resistant to enzymatic degradation and have improved water solubility, among other characteristics.Type: GrantFiled: April 10, 1995Date of Patent: May 13, 1997Assignee: Takeda Chemical Industries, Ltd.Inventors: Toshihiro Ishiguro, Masahide Oka, Takamasa Yamaguchi, Ikuo Nogami
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Patent number: 5434061Abstract: A process for producing a saccharide carboxylic acid or a salt thereof characterized in that a microorganism belonging to the genus Pseudogluconobacter and capable of oxidizing a hydroxymethyl group and/or hemiacetal hydroxyl-associated carbon atom to a carboxyl group, or an artifact derived from the microorganism, is permitted to act on a hydroxymethyl and/or hemiacetal hydroxyl-containing saccharide or saccharide derivative to produce and accumulate the corresponding carboxylic acid and the carboxylic acid so accumulated is harvested and novel saccharide carboxylic acids produced by the above production method, and by the process, from a broad range of saccharides, saccharic acids having carboxyl groups derived from hydroxymethyl and/or hemiacetal OH groups can be produced with high selectivity and in good yield, the resultant saccharide acids are resistant to enzymatic degradation and have improved water solubility, among other characteristics.Type: GrantFiled: November 15, 1993Date of Patent: July 18, 1995Assignee: Takeda Chemical Industries, Ltd.Inventors: Toshihiro Ishiguro, Masahide Oka, Takamasa Yamaguchi, Ikuo Nogami
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Patent number: 4302463Abstract: Novel 1-azaxanthone-3-carboxylic acid derivatives, which are shown by the following formula (I) ##STR1## wherein R is hydrogen, alkyl, alkoxy or halogen; R.sub.1 and R.sub.2 are the same or different and each is hydrogen, alkyl or alkenyl; and m is 1 or 2; and their physiologically acceptable salts, are usable as effective medicines for preventing and/or treating allergic diseases. The compound of the formula (I) can be produced by reacting a compound of the formula: ##STR2## wherein R and m have the same meaning as defined above; R.sub.3 is carboxyl or group which is convertible into carboxyl through hydrolysis; X is alkyl phosphate radical or halogen, with a compound of the formula: ##STR3## wherein R.sub.1 and R.sub.2 have the same meaning as defined above, or its salt, and conducting hydrolysis, if necessary.Type: GrantFiled: September 10, 1980Date of Patent: November 24, 1981Assignee: Takeda Chemical Industries, Ltd.Inventors: Toshihiro Ishiguro, Kiyoshi Ukawa, Akira Nohara
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Patent number: 4267332Abstract: Novel 3-(tetrazol-5-yl)-1-azaxanthone and its derivatives, which are shown by the following formula ##STR1## wherein R.sub.1 is hydrogen, amino or hydroxyl; R.sub.2 is alkyl, alkoxy, halogen, nitro, carboxyl, hydroxyl, butadienylene (--CH.dbd.CH--CH.dbd.CH--) which forms a benzene ring with any adjacent carbon atoms or amino group which may be unsubstituted or substituted by at least one alkyl; and m is 0, 1 or 2; and their physiologically acceptable salts, are usable as effective medicines for preventing and/or treating allergic diseases.Type: GrantFiled: September 18, 1978Date of Patent: May 12, 1981Assignee: Takeda Chemical Industries, Ltd.Inventors: Akira Nohara, Toshihiro Ishiguro, Kiyoshi Ukawa
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Patent number: 4153794Abstract: Novel N-benzylpiperazine derivatives of the general formula ##STR1## wherein R.sup.1 and R.sup.2 are same or different and each stands for a hydrogen atom or an acyl group; R.sup.3 stands for a hydrogen atom, a carbamoyl group, an acyl group which is unsubstituted or substituted by mercapto or morpholino, or an alkyl group which is unsubstituted or substituted by hydroxy, aryl or aminocarbonyl represented by the formula ##STR2## wherein each of R.sup.4 and R.sup.5 is a hydrogen atom, a lower alkyl group having 1 to 3 carbon atoms or a cyclohexyl group, or R.sup.4 and R.sup.5 form a morpholino or piperidino ring together with the nitrogen atom adjacent thereto, and X stands for a halogen atom, and pharmaceutically acceptable acid addition salts thereof. These compounds and salts thereof have respiratory tract fluid secretion stimulatory properties and are useful as medicines such as respiratory tract fluid secretion stimulators.Type: GrantFiled: March 1, 1978Date of Patent: May 8, 1979Assignee: Takeda Chemical Industries, Ltd.Inventors: Toshihiro Ishiguro, Yasushi Sanno
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Patent number: 4091220Abstract: Novel N-benzylpiperazine derivatives of the general formula ##STR1## wherein R.sup.1 and R.sup.2 are same or different and each stands for a hydrogen atom or an acyl group; R.sup.3 stands for a hydrogen atom; a carbamoyl group, an acyl group which is unsubstituted or substituted by mercapto or morpholino, or an alkyl group which is unsubstituted or substituted by hydroxy, aryl or aminocarbonyl represented by the formula ##STR2## wherein each of R.sup.4 and R.sup.5 is a hydrogen atom, a lower alkyl group having 1 to 3 carbon atoms or a cyclohexyl group, or R.sup.4 and R.sup.5 form a morpholino or piperidino ring together with the nitrogen atom adjacent thereto, and X stands for a halogen atom, and pharmaceutically acceptable acid addition salts thereof. These compounds and salts thereof have respiratory tract fluid secretion stimulatory properties and are useful as medicines such as respiratory track fluid secretion stimulators.Type: GrantFiled: May 3, 1977Date of Patent: May 23, 1978Assignee: Takeda Chemical Industries, Ltd.Inventors: Toshihiro Ishiguro, Yasushi Sanno
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Patent number: 4085116Abstract: The present invention relates to novel chromone derivatives having effective antiallergic action with low toxicity, which are shown by the following formula (I) ##STR1## wherein R is hydrogen or lower alkyl and A is ##STR2## (R' is hydrogen or lower alkyl) or ##STR3## and their physiologically acceptable salts.Type: GrantFiled: March 24, 1976Date of Patent: April 18, 1978Assignee: Takeda Chemical Industries, Ltd.Inventors: Akira Nohara, Toshihiro Ishiguro, Yasushi Sanno
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Patent number: 4029656Abstract: Novel cephalosporanic acid derivatives which are active against both Gram positive and Gram negative pathogenic bacteria, particularly Pseudomonas, and which have .alpha.-sulfoacylamino group at 7-position. A few examples of the compounds are 7-(.alpha.-sulfophenylacetamido)-cephalosporanic acid, 7-(.alpha.-sulfopropionamido)-cephalosporanic acid, 7-(.alpha.-sulfocapronamido)-cephalosporanic acid. They are prepared by condensing 7-aminocephalosporanic acid or salts thereof with .alpha.-sulfocarboxylic acid or functional derivatives thereof in the presence of a solvent at -2.degree. - 10.degree. C.Type: GrantFiled: August 4, 1976Date of Patent: June 14, 1977Assignee: Takeda Chemical Industries, Ltd.Inventors: Toshihiro Ishiguro, Takeshi Fugono, Hiroaki Nomura
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Patent number: 3992370Abstract: 1,1-Dichloro-1a, 10b-dihydrodibenzo(b,f)cycloprop(d)azepine-6(1H)-carboxaldehyde is produced in good yield through a reaction between a compound of the general formula ##SPC1##Wherein R stands for hydrogen or formyl group and chloroform. Thus obtained product can be used as a valuable intermediate for synthesizing medicines and is further convertible to known drugs, e.g. 6-(3-dimethylamino)propyl)-1, 1a, 6, 10b-tetrahydrodibenzo(b,f)cycloprop(d)azepine.Type: GrantFiled: January 23, 1974Date of Patent: November 16, 1976Assignee: Takeda Chemical Industries, Ltd.Inventors: Kenya Kawashima, Takahiro Saraie, Yasuhiko Kawano, Toshihiro Ishiguro
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Patent number: 3988327Abstract: Novel cephalosporanic acid derivatives which are active against both Gram positive and Gram negative pathogenic bacteria, particularly Pseudomonas, and which have an .alpha.-sulfoacylamino group at 7-position. A few examples of the compounds are 7-(.alpha.-sulfophenylacetamido)-cephalosporanic acid, 7-(.alpha.-sulfopropionamido)-cephalosporanic acid, 7-(.alpha.-sulfocapronamido)-cephalosporanic acid. They are prepared by condensing 7-aminocephalosporanic acid or salts thereof with .alpha.-sulfocarboxylic acid or functional derivatives thereof in the presence of a solvent at -2.degree. - 10.degree. C.Type: GrantFiled: February 5, 1975Date of Patent: October 26, 1976Assignee: Takeda Chemical Industries, Ltd.Inventors: Toshihiro Ishiguro, Takeshi Fugono, Hiroaki Nomura