Abstract: The present disclosure provides, for example, a compound represented by the general formula below or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of the compound or salt: wherein X1, X2, X3 and X4 are each independently —CR2? or N?, R2 is, for example, a halogen atom, R1 is, for example, —S(?O)2—NH—R8, R8 is, for example, a C1-6 alkyl group, R3 is, for example, a hydrogen atom, R5 is, for example, a halogen atom, R6 is, for example, a hydrogen atom, and R4 is, for example, a cyclopropyl group. The compounds, salts or solvates provided by the present disclosure exhibit high RAF/MEK complex-stabilizing activity and can be used for the treatment or prevention of cell proliferative disorders, particularly cancers.

Abstract: A bulk feeder includes a feeder main body, a track member provided vibratably with respect to the feeder main body and formed with a conveyance path through which multiple components are conveyed, an excitation device configured to apply vibration to the track member so that the multiple components are conveyed along the conveyance path, and a vibration sensor configured to detect a vibration value indicating a vibration state of the track member that vibrates by the excitation of the excitation device.

Abstract: The present invention relates to a method for replenishing an electrodeposition coating bath by subjecting to an ultrafiltration, an electro-deposition bath liquid which has been decomposed with time under a pressure of 0.2-3.0 kg/cm.sup.2 changing the direction of the bath liquid during the ultrafiltration step so as to cause the liquid to flow in opposite directions in the ultrafiltering apparatus; recycling the concentrate obtained from the ultrafiltration to the electrodeposition coating bath for the purpose of adjusting the liquid characteristics of the bath and using the thus-obtained filtrate, obtained from the ultrafiltration, the diluent for preparing a replenishing supply liquid.