Abstract: Provided is a two-pack curable adhesive less likely to cause an appearance defect due to air bubbles or the dissolution of a printing layer. A two-pack curable adhesive, containing: a polyisocyanate composition (A) containing a urethane prepolymer (A1), which is a reaction product of polyester polyol (a1), polyether polyol (a2), and a polyisocyanate compound (a3); and a polyol composition (B) containing polyester polyol (B1), in which polyhydric alcohol (a1-2) used in the synthesis of the polyester polyol (a1) and polyhydric alcohol (b1-2) used in the synthesis of the polyester polyol (B1) contain 80% by mass or more of diethylene glycol, respectively, and the compound amount of the polyester polyol (a1) is 50% by mass or more and 90% by mass or less with respect to the total amount of the polyester polyol (a1) and the polyether polyol (a2).

Abstract: A turbine blade includes: a platform; an airfoil portion extending from the platform in a blade height direction and having a pressure surface and a suction surface extending between a leading edge and a trailing edge; a blade root portion disposed on opposite side of the airfoil portion across the platform in the blade height direction and having a bearing surface; and a shank disposed between the platform and the blade root portion. The shank has: a first lateral surface having a first recess portion and disposed on a pressure surface side and along an extension direction of the blade root portion; and a second lateral surface having a second recess portion and disposed on a suction surface side and along the extension direction of the blade root portion.

Abstract: A turbine blade includes: a platform; an airfoil portion extending from the platform in a blade height direction and having a pressure surface and a suction surface extending between a leading edge and a trailing edge; a blade root portion disposed on opposite side of the airfoil portion across the platform in the blade height direction and having a bearing surface; and a shank disposed between the platform and the blade root portion. The shank has: a first lateral surface having a first recess portion and disposed on a pressure surface side and along an extension direction of the blade root portion; and a second lateral surface having a second recess portion and disposed on a suction surface side and along the extension direction of the blade root portion.

Abstract: A housing structure for a rotary machine includes a main body and a heat transfer member. The heat transfer member includes a material having higher thermal conductivity than that of the main body. In addition, the heat transfer member is sandwiched between a first surface and a second surface of the main body while receiving a compressive load from the first surface and the second surface, thereby alleviating temperature distribution that may occur in the main body and reducing thermal deformation.

Abstract: An exhaust-side journal bearing for supporting a gas turbine rotor is disposed inside a bearing box. The bearing box is supported by a strut which extends inward from an exhaust casing, and a seal ring having an annular inner peripheral end is disposed on the bearing box. Executed during a maintenance work are: a bearing adjustment step of displacing a bearing surface of the journal bearing relative to the bearing box in a perpendicular direction perpendicular to the axial direction; and a seal ring adjustment step of displacing the inner peripheral end of the seal ring relative to the bearing box in accordance with the direction of displacement and the amount of displacement of the bearing surface.

Abstract: The present invention provides a method for safely producing a large amount of chloroformate compound with high yield. The chloroformate compound can be produced by mixing and reacting a solution of triphosgene, an amine and an alcohol compound in a flow reactor. The chloroformate compound can also be produced by mixing and reacting a solution of triphosgene with a solution comprising an amine and an alcohol compound in a flow reactor. The amine is preferably tributylamine, and preferably used in an amount of 0.8 to 3 equivalents relative to an amount of the alcohol compound.

Abstract: A tri-carbobenzoxy-arginine represented by the following formula (2): is produced by carbobenzoxylating the arginine or arginine derivative (1) represented by the following formula (1), or a salt thereof: by adding carbobenzoxy chloride and a base in a water/organic solvent bilayer system to an arginine or arginine derivative (1) represented by the formula (1), or a salt thereof.

Abstract: An exhaust-side journal bearing for supporting a gas turbine rotor is disposed inside a bearing box. The bearing box is supported by a strut which extends inward from an exhaust casing, and a seal ring having an annular inner peripheral end is disposed on the bearing box. Executed during a maintenance work are: a bearing adjustment step of displacing a bearing surface of the journal bearing relative to the bearing box in a perpendicular direction perpendicular to the axial direction; and a seal ring adjustment step of displacing the inner peripheral end of the seal ring relative to the bearing box in accordance with the direction of displacement and the amount of displacement of the bearing surface.

Abstract: A tri-carbobenzoxy-arginine represented by the following formula (2): is produced by carbobenzoxylating the arginine or arginine derivative (1) represented by the following formula (1), or a salt thereof: by adding carbobenzoxy chloride and a base in a water/organic solvent bilayer system to an arginine or arginine derivative (1) represented by the formula (1), or a salt thereof.

Abstract: The present invention relates to a flavor composition or fragrance composition which can satisfy diversified requirements for flavored products, as well as to a flavor-improving agent which can improve the quality and release of aroma of a beverage or food. More particularly, the present invention relates to a flavor composition or fragrance composition which comprises an optically active S-alkyl 2-methylbutanethioate as an active ingredient, a flavor- or fragrance-added product, a flavor-improving agent which comprises an optically active S-alkyl 2-methylbutanethioate as an active ingredient, and a beverage or food having an improved flavor. The optically active S-alkyl 2-methylbutanethioate includes S-alkyl(R)-2-methylbutanethioate and S-alkyl(S)-2-methylbutanethioate.

Abstract: The present invention provides a process for producing a 3-aralkyloxypyrrolidine derivative which is important for production of pharmaceutical products and the like. In the present invention, a N-protected-3-hydroxypyrrolidine is converted into a N-protected-3-aralkyloxypyrrolidine by allowing an aralkyl halide to act in the presence of a base and at least one of a metal halide and a phase-transfer catalyst followed by deprotecting a N-protecting group to convert it to a 3-aralkyloxypyrrolidine derivative and subsequently treating the derivative in a solvent containing a polar solvent, thereby obtaining the 3-aralkyloxypyrrolidine derivative as a crystal. According to the present invention, a 3-aralkyloxypyrrolidine derivative of high purity can be produced conveniently and efficiently on an industrial scale.

Abstract: Provided is a process for production of a ?-amino-?-hydroxy carboxamide derivative that is important in production of drugs or the like. In the presence of a predetermined solvent, a ?-(N-protected)amino-?-hydroxycarboxylic acid is reacted with an amine to conversion to a ?-(N-protected)amino-?-hydroxy carboxamide derivative; then the derivative is deprotected for conversion to a ?-amino-?-hydroxy carboxamide derivative; and the derivative is crystallized using a protic solvent to obtain a crystal. The high-purity ?-amino-?-hydroxy carboxamide derivative can be stably produced on an industrial scale by the process.

Abstract: The present invention relates to a novel method for the preparation of diol intermediates having the formula (II) and/or the opposite enantiomer of an acylated diol having the formula (IV) useful for the preparation of escitalopram involving selective enzymatic acylation or deacylation.

Abstract: The present invention provides a novel flavor improving agent capable of sufficiently enhancing or alleviating the flavor sensed in oral cavity; for example, enhancing and improving the thickness in taste or the like to provide depth and profoundness to the flavor, and also improving the sense of volume or the sharpness of aftertaste. The present invention also provides a food/drink, a pharmaceutical product and an oral care product having a good taste which can fulfill the recent high-level demand for taste.

Abstract: The present invention provides a process for producing a 3-aralkyloxypyrrolidine derivative which is important for production of pharmaceutical products and the like. In the present invention, a N-protected-3-hydroxypyrrolidine is converted into a N-protected-3-aralkyloxypyrrolidine by allowing an aralkyl halide to act in the presence of a base and at least one of a metal halide and a phase-transfer catalyst followed by deprotecting a N-protecting group to convert it to a 3-aralkyloxypyrrolidine derivative and subsequently treating the derivative in a solvent containing a polar solvent, thereby obtaining the 3-aralkyloxypyrrolidine derivative as a crystal. According to the present invention, a 3-aralkyloxypyrrolidine derivative of high purity can be produced conveniently and efficiently on an industrial scale.

Abstract: The present invention relates to a flavor composition or fragrance composition which can satisfy diversified requirements for flavored products, as well as to a flavor-improving agent which can improve the quality and release of aroma of a beverage or food. More particularly, the present invention relates to a flavor composition or fragrance composition which comprises an optically active S-alkyl 2-methylbutanethioate as an active ingredient, a flavor- or fragrance-added product, a flavor-improving agent which comprises an optically active S-alkyl 2-methylbutanethioate as an active ingredient, and a beverage or food having an improved flavor. The optically active S-alkyl 2-methylbutanethioate includes S-alkyl(R)-2-methylbutanethioate and S-alkyl(S)-2-methylbutanethioate.

Abstract: The present invention provides a process for producing a 3-aralkyloxypyrrolidine derivative which is important for production of pharmaceutical products and the like. In the present invention, a N-protected-3-hydroxypyrrolidine is converted into a N-protected-3-aralkyloxypyrrolidine by allowing an aralkyl halide to act in the presence of a base and at least one of a metal halide and a phase-transfer catalyst followed by deprotecting a N-protecting group to convert it to a 3-aralkyloxypyrrolidine derivative and subsequently treating the derivative in a solvent containing a polar solvent, thereby obtaining the 3-aralkyloxypyrrolidine derivative as a crystal. According to the present invention, a 3-aralkyloxypyrrolidine derivative of high purity can be produced conveniently and efficiently on an industrial scale.

Abstract: The present invention relates to a novel method for the preparation of diol intermediates having the formula (II) and/or the opposite enantiomer of an acylated diol having the formula (IV) useful for the preparation of escitalopram involving selective enzymatic acylation or deacylation.

Abstract: The present invention provides a novel flavor improving agent capable of sufficiently enhancing or alleviating the flavor sensed in oral cavity; for example, enhancing and improving the thickness in taste or the like to provide depth and profoundness to the flavor, and also improving the sense of volume or the sharpness of aftertaste. The present invention also provides a food/drink, a pharmaceutical product and an oral care product having a good taste which can fulfill the recent high-level demand for taste.

Abstract: Provided is a process for production of a ?-amino-?-hydroxy carboxamide derivative that is important in production of drugs or the like. In the presence of a predetermined solvent, a ?-(N-protected)amino-?-hydroxycarboxylic acid is reacted with an amine to conversion to a ?-(N-protected)amino-?-hydroxy carboxamide derivative; then the derivative is deprotected for conversion to a ?-amino-?-hydroxy carboxamide derivative; and the derivative is crystallized using a protic solvent to obtain a crystal. The high-purity ?-amino-?-hydroxy carboxamide derivative can be stably produced on an industrial scale by the process.