Patents by Inventor Toshikatsu Sakai
Toshikatsu Sakai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9310342Abstract: A liquid chromatography apparatus is provided with a sample preparation unit, a column that separates components of a sample, an eluent supplier that includes a feeder for supplying eluents to the column, a flow path directional valve capable of introducing fixed amounts of the sample and the eluents to the column, an analyzer for analyzing a test solution composed of the sample components separated by the column and one of the eluents, and a controller, wherein the eluent supplier supplies the eluents to the flow path directional valve in an unmixed state. As a result of employing this configuration, analysis time is shortened and eluent consumption is reduced.Type: GrantFiled: October 6, 2009Date of Patent: April 12, 2016Assignees: ARKRAY, Inc., Sekisui Medical Co., Ltd.Inventors: Toshikatsu Sakai, Akira Sezaki, Takeshi Takagi, Takuya Yotani, Makoto Takahara, Takayuki Oka
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Publication number: 20150377846Abstract: Provided is a method of measuring at least one kind of hemoglobin, selected from abnormal hemoglobin, or hemoglobin that is a marker for thalassemia, the method comprising: performing high-performance liquid chromatography, using: an eluent L that contains a phosphoric acid monohydrogen dialkali metal salt (component 1) and a phosphoric acid dihydrogen monoalkali metal salt (component 2) as components, and that has a content of component 1 of from 0.08% by mass to 0.50% by mass with respect to a total mass of the eluent L, a content of component 2 of from 0.04% by mass to 1.2% by mass with respect to a total mass of the eluent L, and a ratio of component 2/component 1 of from 0.4 to 10.Type: ApplicationFiled: June 25, 2015Publication date: December 31, 2015Inventors: Kazuki Ishikawa, Toshikatsu Sakai
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Patent number: 8939018Abstract: An analyzing device includes a feeder connected to a container in which a sample is contained for sucking the sample from the container and feeding the sample, and a controller for performing control for feeding from the feeder to a measurer. In measuring the sample, the controller performs control so that results of a plurality of times of measurement are obtained with respect to the single container in which the sample is contained, without changing the container. This arrangement allows quick accuracy check.Type: GrantFiled: October 2, 2009Date of Patent: January 27, 2015Assignee: ARKRAY, Inc.Inventors: Toshikatsu Sakai, Akira Sezaki, Takeshi Takagi
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Patent number: 8361390Abstract: The present invention relates to a liquid chromatography apparatus X, which is provided with a deaerator 4. The liquid chromatography apparatus X is further provided with a dissolved oxygen density adjusting means for maintaining a density of dissolved oxygen in an eluting solution to be supplied to a column 60 constant. Preferably, the dissolved oxygen density adjusting means is configured so as to adjust the density of the dissolved oxygen in the eluting solution by adjusting a degree of decompression in a decompression space of the deaerator 4 based on a measurement result by temperature measurement means 40A, 40B, and 40C for measuring the temperature of the eluting solution.Type: GrantFiled: February 8, 2007Date of Patent: January 29, 2013Assignee: Arkray, Inc.Inventors: Koji Sugiyama, Toshikatsu Sakai, Yoshikiyo Hongo, Akira Sezaki, Takanori Kamada
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Patent number: 8268625Abstract: When the concentration of glycated hemoglobin is measured, a plurality of wavelengths are selected as measurement wavelengths from the wavelength range of 400 to 450 nm. Preferably, by use of a liquid chromatography, at least the light of different peak wavelengths in the wavelength range of 415 to 430 nm are continuously or intermittently received to obtain a three dimensional chromatogram having as variables the wavelength, the elution time and the amount of detection. The concentration of glycated hemoglobin is calculated based on this three dimensional chromatogram.Type: GrantFiled: March 23, 2007Date of Patent: September 18, 2012Assignee: Arkray, Inc.Inventors: Koji Sugiyama, Toshikatsu Sakai
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Publication number: 20120017706Abstract: A method for displaying a chromatogram as a combination of HbA1c region where HbA1c elutes and HbA0 region where HbA0 and one or more variant Hb's elute, the method includes steps of: determining, based on priority levels of HbA0 and one or more variant Hb's, display form of the HbA0 region so that a peak of a component with higher priority level among HbA0 and one or more variant Hb's whose peaks are to be displayed in the HbA0 region is displayed more preferentially; and displaying the HbA0 region in the determined display form and the HbA1c region, concurrently.Type: ApplicationFiled: July 25, 2011Publication date: January 26, 2012Applicant: ARKRAY, Inc.Inventors: Suguru YOSHIDA, Yoshihiro NOMURA, Toshikatsu SAKAI, Takeshi TAKAGI
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Publication number: 20120015388Abstract: The ionic strength of a diluent for preparing an analytical sample is set to be 0.06 to 0.16. The analytical sample prepared by using the diluent having the ionic strength within this range can be subjected to both for analyzing a first object in a test sample by electrode method and for analyzing a second object in the test sample by liquid chromatography method, and high-precision measurement can be attained. The analytical sample is especially useful for preparing a sample for measurement used both for measuring glucose concentration in a blood sample by enzyme electrode method and for measuring glycohemoglobin concentration in the blood sample by liquid chromatography method.Type: ApplicationFiled: June 22, 2011Publication date: January 19, 2012Applicants: SEKISUI MEDICAL CO., LTD., ARKRAY, Inc.Inventors: Takeshi Takagi, Toshikatsu Sakai, Chiaki Miyamoto, Takefumi Asami, Tatsuo Kamata, Takuya Yotani, Takayuki Oka
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Patent number: 8021887Abstract: The present invention relates to a method and an apparatus that measure the concentration of glycated hemoglobin by an optical technique. A wavelength in which the molecular extinction coefficient of oxyhemoglobin agrees or substantially agrees with the molecular extinction coefficient of deoxyhemoglobin is adopted as a measurement wavelength. Preferably, the measurement wavelength is set at from 417 to 421 nm. In the present invention, the concentration of glycated hemoglobin is measured by making use of column chromatography and of using a sample prepared from red blood cells in blood.Type: GrantFiled: March 23, 2007Date of Patent: September 20, 2011Assignee: Arkray, Inc.Inventors: Koji Sugiyama, Toshikatsu Sakai
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Publication number: 20110185797Abstract: An analyzing device includes a feeder connected to a container in which a sample is contained for sucking the sample from the container and feeding the sample, and a controller for performing control for feeding from the feeder to a measurer. In measuring the sample, the controller performs control so that results of a plurality of times of measurement are obtained with respect to the single container in which the sample is contained, without changing the container. This arrangement allows quick accuracy check.Type: ApplicationFiled: October 2, 2009Publication date: August 4, 2011Applicant: ARKRAY, INC.Inventors: Toshikatsu Sakai, Akira Sezaki, Takeshi Takagi
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Publication number: 20110186511Abstract: A liquid chromatography apparatus is provided with a sample preparation unit, a column that separates components of a sample, an eluent supplier that includes a feeder for supplying eluents to the column, a flow path directional valve capable of introducing fixed amounts of the sample and the eluents to the column, an analyzer for analyzing a test solution composed of the sample components separated by the column and one of the eluents, and a controller, wherein the eluent supplier supplies the eluents to the flow path directional valve in an unmixed state. As a result of employing this configuration, analysis time is shortened and eluent consumption is reduced.Type: ApplicationFiled: October 6, 2009Publication date: August 4, 2011Applicants: ARKRAY, INC., SEKISUI MEDICAL CO., LTD.Inventors: Toshikatsu Sakai, Akira Sezaki, Takeshi Takagi, Takuya Yotani, Makoto Takahara, Takayuki Oka
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Publication number: 20100291691Abstract: When the concentration of glycated hemoglobin is measured, a plurality of wavelengths are selected as measurement wavelengths from the wavelength range of 400 to 450 nm. Preferably, by use of a liquid chromatography, at least the light of different peak wavelengths in the wavelength range of 415 to 430 nm are continuously or intermittently received to obtain a three dimensional chromatogram having as variables the wavelength, the elution time and the amount of detection. The concentration of glycated hemoglobin is calculated based on this three dimensional chromatogram.Type: ApplicationFiled: March 23, 2007Publication date: November 18, 2010Applicant: ARKRAY, INC.Inventors: Koji Sugiyama, Toshikatsu Sakai
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Publication number: 20090317912Abstract: The present invention relates to a method and an apparatus that measure the concentration of glycated hemoglobin by an optical technique. A wavelength in which the molecular extinction coefficient of oxyhemoglobin agrees or substantially agrees with the molecular extinction coefficient of deoxyhemoglobin is adopted as a measurement wavelength. Preferably, the measurement wavelength is set at from 417 to 421 nm. In the present invention, the concentration of glycated hemoglobin is measured by making use of column chromatography and of using a sample prepared from red blood cells in blood.Type: ApplicationFiled: March 23, 2007Publication date: December 24, 2009Applicant: ARKRAY, INC.Inventors: Koji Sugiyama, Toshikatsu Sakai
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Publication number: 20090275119Abstract: The present invention relates to a liquid chromatography apparatus X, which is provided with a deaerator 4. The liquid chromatography apparatus X is further provided with a dissolved oxygen density adjusting means for maintaining a density of dissolved oxygen in an eluting solution to be supplied to a column 60 constant. Preferably, the dissolved oxygen density adjusting means is configured so as to adjust the density of the dissolved oxygen in the eluting solution by adjusting a degree of decompression in a decompression space of the deaerator 4 based on a measurement result by temperature measurement means 40A, 40B, and 40C for measuring the temperature of the eluting solution.Type: ApplicationFiled: February 8, 2007Publication date: November 5, 2009Applicant: ARKRAY, INC.Inventors: Koji Sugiyama, Toshikatsu Sakai, Yoshikiyo Hongo, Akira Sezaki, Takanori Kamada
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Patent number: 6033867Abstract: The present invention relates to a fructosyl amino acid oxidase that is obtainable from a culture of a strain of the genus Aspergillus. This strain grows in a selective medium containing at least either of fructosyl lysine and fructosyl-N.sup..alpha. -Z-lysine and is capable of producing a fructosyl amino acid oxidase.Type: GrantFiled: July 29, 1998Date of Patent: March 7, 2000Assignee: Kyoto Daiichi Kagaku Co., Ltd.Inventors: Nobuo Kato, Yasuyoshi Sakai, Yoshiki Tani, Hiroshi Fukuya, Masayuki Yagi, Toshikatsu Sakai, Kaori Ishimaru, Satoshi Cyousa
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Patent number: 5712138Abstract: A novel fructosyl amino acid oxidase derived from genus Fusarium, which is active on both of fructosyl lysine and fructosyl valine, a process for producing the enzyme, an assay of an amadori compound using the enzyme, a reagent or a kit containing the enzyme is provided.Type: GrantFiled: September 29, 1995Date of Patent: January 27, 1998Assignee: Kyoto Daiichi Kagaku Co., Ltd.Inventors: Nobuo Kato, Yasuyoshi Sakai, Yoshiki Tani, Toshikatsu Sakai, Kaori Ishimaru