Abstract: A heat-sensitive transfer medium comprises a base material and superposingly formed thereon a release layer, an intermediate layer and an ink layer in this order. The ink layer contains a colorant, a first resin capable of curing upon reaction with a curing agent, a curing agent that causes the resin to cure, and a second resin capable of inhibiting the reaction of the first resin with the curing agent, and the release layer is formed in a coating weight of from 0.005 g/m.sup.2 to 0.4 g/m.sup.2. This heat-sensitive transfer medium enables sharp color printing and also can form transferred patterns having a superior rub resistance.

Abstract: Novel polypeptides having a modified amino acid sequence of human interleukin 1.alpha. polypeptides in which a certain amino acid residue(s) in said amino acid sequence is(are) exchanged for other amino acid residue(s). Said polypeptides having no capacity of induction of production of prostaglandin E.sub.2 while maintaining other biological activities of human interleukin 1 such as activation of lymphocyte and being expected to be useful as a medicament.