Patents by Inventor Toshikazu Ishihara

Toshikazu Ishihara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210285057
    Abstract: An indicator may have improved accuracy for predicting an effect of a medicinal therapy on breast cancer. The method may estimate a breast cancer cell existence ratio and other methods, the method including: (1) analyzing methylation level of (1a) a cytosine residue in a CG portion of nucleotides at positions 1,000 to 1,001 in a nucleotide sequence of SEQ ID NO: 1, (1b) a cytosine residue in a CG portion of nucleotides at positions 1,000 to 1,001 in a nucleotide sequence of SEQ ID NO: 2, (1c) a cytosine residue in a CG portion of nucleotides at positions 1,001 to 1,002 in a nucleotide sequence of SEQ ID NO: 3, or (1d) a combination of the cytosine residues, in a sample derived from a human subject; and (2) estimating the breast cancer cell existence ratio in the sample, based on the methylation level analyzed at (1).
    Type: Application
    Filed: September 11, 2019
    Publication date: September 16, 2021
    Applicants: NATIONAL CANCER CENTER, H.U. Group Research Institute G.K.
    Inventors: Hiroki ISHIHARA, Toshikazu USHIJIMA
  • Patent number: 8393172
    Abstract: An heat pump drying machine has a normal dry mode (e.g., compression ratio is equal to or greater than 3) for operating a compressor at a predetermined dry operation frequency and an energy saving dry mode (e.g., compression ratio is equal to or greater than 2.3 and is less than 3) for operating the compressor at an energy saving operation frequency that is lower than the dry operation frequency. A control device is provided to control an operation frequency of the compressor 5so that the two dry operation modes are switched to each other. The control device can execute the control for increasing the operation frequency of the compressor to the dry operation frequency during the operation of the energy saving dry mode.
    Type: Grant
    Filed: September 29, 2009
    Date of Patent: March 12, 2013
    Assignee: Sanyo Electric Co., Ltd.
    Inventors: Keiji Sato, Haruhisa Yamasaki, Eiji Fukuda, Yoshiaki Noguchi, Tetsuya Masuda, Hiroyuki Kuribara, Satoshi Imai, Toshikazu Ishihara
  • Publication number: 20100077787
    Abstract: An heat pump drying machine has a normal dry mode (e.g., compression ratio is equal to or greater than 3) for operating a compressor at a predetermined dry operation frequency and an energy saving dry mode (e.g., compression ratio is equal to or greater than 2.3 and is less than 3) for operating the compressor at an energy saving operation frequency that is lower than the dry operation frequency. A control device is provided to control an operation frequency of the compressor 5 so that the two dry operation modes are switched to each other. The control device can execute the control for increasing the operation frequency of the compressor to the dry operation frequency during the operation of the energy saving dry mode.
    Type: Application
    Filed: September 29, 2009
    Publication date: April 1, 2010
    Applicant: SANYO ELECTRIC CO., LTD.
    Inventors: Tetsuya Masuda, Hiroyuki Kuribara, Satoshi Imai, Toshikazu Ishihara, Keiji Sato, Haruhisa Yamasaki, Eiji Fukuda, Yoshiaki Noguchi
  • Patent number: 7631510
    Abstract: A multi-stage refrigeration system is provided. The refrigeration system includes a first compression element which produces a first compressed refrigerant stream. A mixer combines the first compressed refrigerant stream with an auxiliary refrigerant stream. A second compression element is coupled to the mixer and produces a second compressed refrigerant stream. A first heat exchanger receives the second compressed refrigerant stream and generates a cooled stream. A stream splitter receives the cooled stream and provides first and second output streams. A first expansion valve receives the first output stream and controls the flow of the first output stream and a second expansion valve receives the second output stream and controls the flow of the second output stream. A second heat exchanger generates the auxiliary refrigerant stream provided to the mixer.
    Type: Grant
    Filed: February 28, 2005
    Date of Patent: December 15, 2009
    Assignees: Thermal Analysis Partners, LLC., Sanyo Electric Co., Ltd.
    Inventors: Reinhard Radermacher, Toshikazu Ishihara, Hans Huff, Yunho Hwang, Masahisa Otake, Hiroshi Mukaiyama, Osamu Kuwabara, Ichiro Kamimura
  • Publication number: 20080236190
    Abstract: There is disclosed an apparatus including a freezing unit in which the freezing unit can be operated without any trouble even when a main body rotates. A liquid crystal display projector (an apparatus) including a freezing unit having a refrigerant circuit constituted of a compressor, a radiator, a capillary tube (a pressure reducing unit), an evaporator and the like includes a rotator as a posture adjustment unit for adjusting the main body to a basic posture to maintain at least a lubricating performance of the compressor in accordance with a posture change of the main body. The rotator rotates to adjust the basic posture of the whole freezing unit, and a rotary shaft of this rotator is arranged in parallel with an optical axis of a light source on the same plane.
    Type: Application
    Filed: March 28, 2008
    Publication date: October 2, 2008
    Inventors: Masaki Tsuchiya, Toshikazu Ishihara, Takahiro Nakamura
  • Patent number: 7104079
    Abstract: A heat pump apparatus that having a refrigerating cycle including a compressor, a gas cooler, a pressure reducing device and an evaporator and is designed so that water can be heated by the gas cooler. A refrigerant such as CO2 or the like working in a supercritical area is filled and used at a high-pressure side in the refrigerating cycle and a radiator is equipped between the exit of the gas cooler and the pressure reducing device. The refrigerant temperature at the exit of the radiator is kept at a substantially fixed temperature irrespective of the temperature of hot water to the gas cooler.
    Type: Grant
    Filed: July 2, 2002
    Date of Patent: September 12, 2006
    Assignee: Sanyo Electric Co., Ltd.
    Inventors: Osamu Kuwabara, Hiroshi Mukaiyama, Masahiro Kobayashi, Ichiro Kamimura, Hirokazu Izaki, Toshikazu Ishihara
  • Publication number: 20060191288
    Abstract: A multi-stage refrigeration system is provided. The refrigeration system includes a first compression element which produces a first compressed refrigerant stream. A mixer combines the first compressed refrigerant stream with an auxiliary refrigerant stream. A second compression element is coupled to the mixer and produces a second compressed refrigerant stream. A first heat exchanger receives the second compressed refrigerant stream and generates a cooled stream. A stream splitter receives the cooled stream and provides first and second output streams. A first expansion valve receives the first output stream and controls the flow of the first output stream and a second expansion valve receives the second output stream and controls the flow of the second output stream. A second heat exchanger generates the auxiliary refrigerant stream provided to the mixer.
    Type: Application
    Filed: February 28, 2005
    Publication date: August 31, 2006
    Inventors: Reinhard Radermacher, Toshikazu Ishihara, Hans Huff, Yunho Hwang, Masahisa Otake, Hiroshi Mukaiyama, Osamu Kuwabara, Ichiro Kamimura
  • Patent number: 6889512
    Abstract: The present invention concerns an on-vehicle air-conditioner, resolving problems of the prior art, and allowing to perform cooling, heating, dehumidification or others efficiently even for vehicles of low waste heat, such as hybrid cars taking electricity and gasoline as energy source, idle stop coping cars or battery cars taking only electricity as energy source, or other vehicles, by cooling by loading a refrigeration circuit, using for example CO2 refrigerant, and provided with an electrically driven two-stage compression system compressor, and at the same time, installing a refrigerant heat exchanger for cooling the refrigerant, compressed in the first stage in a way to exchange heat with the car interior air, and using conveniently also for heating together with the heat of the cooling water for cooling the engine.
    Type: Grant
    Filed: February 12, 2002
    Date of Patent: May 10, 2005
    Assignee: Sanyo Electric Co., Ltd.
    Inventors: Toshiyuki Ebara, Hiroshi Mukaiyama, Osamu Kuwabara, Toshikazu Ishihara
  • Publication number: 20040020230
    Abstract: In a heat pump apparatus that having a refrigerating cycle including a compressor 1, a gas cooler 3, a pressure reducing device 5 and an evaporator 7 and is designed so that water can be heated by the gas cooler, refrigerant such as CO2 or the like working in a supercritical area is filled and used at a high-pressure side in the refrigerating cycle and a radiator 21 is equipped between the exit of the gas cooler and the pressure reducing device. The refrigerant temperature at the exit of the radiator is kept to a substantially fixed temperature irrespective of the temperature of hot water to the gas cooler.
    Type: Application
    Filed: February 25, 2003
    Publication date: February 5, 2004
    Inventors: Osamu Kuwabara, Hiroshi Mukaiyama, Masahiro Kobayashi, Ichiro Kamimura, Hirokazu Izaki, Toshikazu Ishihara
  • Publication number: 20040007006
    Abstract: The present invention concerns an on-vehicle air-conditioner, resolving problems of the prior art, and allowing to perform cooling, heating, dehumidification or others efficiently even for vehicles of low waste heat, such as hybrid cars taking electricity and gasoline as energy source, idle stop coping cars or battery cars taking only electricity as energy source, or other vehicles, by cooling by loading a refrigeration circuit, using for example CO2 refrigerant, and provided with an electrically driven two-stage compression system compressor, and at the same time, installing a refrigerant heat exchanger for cooling the refrigerant, compressed in the first stage in a way to exchange heat with the car interior air, and using conveniently also for heating together with the heat of the cooling water for cooling the engine.
    Type: Application
    Filed: November 25, 2002
    Publication date: January 15, 2004
    Inventors: Toshiyuki Ebara, Hiroshi Mukaiyama, Osamu Kuwabara, Toshikazu Ishihara
  • Patent number: 5400599
    Abstract: Gas displacement volumes of a high temperature chamber and a middle temperature chamber in a high temperature portion of a hot gas machine are different. Alternatively, a gas displacement volume of a low temperature chamber and a middle temperature chamber in a low temperature portion are different.
    Type: Grant
    Filed: December 8, 1992
    Date of Patent: March 28, 1995
    Assignee: Sanyo Electric Co., Ltd.
    Inventors: Hiroshi Sekiya, Masahisa Otake, Junji Matsue, Ryouichi Katohno, Toshikazu Ishihara, Izumi Okamoto, Yoshiaki Kurosawa, Mitsuhiko Ishino
  • Patent number: 4495560
    Abstract: A fluctuating drive system comprises: random generating means for generating a randomly varying physical quantity; control means for controlling the randomly varying physical quantity; amplifying means for amplifying the controlled physical quantity; and driving means for driving an energy generating means in accordance with the amplified physical quantity, thereby to generate the randomly varying energy from the energy generating means. With this system, the environment or stimulus is positively fluctuated at random with l/f characteristics or the like.
    Type: Grant
    Filed: July 7, 1981
    Date of Patent: January 22, 1985
    Assignee: Kabushiki Kaisha Toyota Chuo Kenkyusho
    Inventors: Gunji Sugimoto, Hideo Arakawa, Toshikazu Ishihara, Masahiro Sugiura, Katsuhiko Takahashi
  • Patent number: 4484135
    Abstract: A hematocrit measuring instrument of the type which determines hematocrit of blood from the electrical resistivity of the blood is provided with a blood resistivity measurement device, an ultrafilter for filtering a part of the plasma from the blood, a filtrate resistivity measurement device for measuring the resistivity of the filtrate from the ultrafilter and an arithmetic circuit for calculating the hematocrit of the blood from the resistivities of the blood and the filtrate. The hematocrit measuring instrument is connected into a circulatory path for the blood outside of the patient's body and continuously measures the hematocrit of the blood from the resistivity of the blood and the resistivity of the filtrate from the ultrafilter.
    Type: Grant
    Filed: August 10, 1982
    Date of Patent: November 20, 1984
    Assignee: Kabushiki Kaisha Toyota Chuo Kenkyusho
    Inventors: Toshikazu Ishihara, Hazime Inagaki
  • Patent number: 4471786
    Abstract: A telemetering intracranial pressure transducer comprises an airtight casing member housing a pressure-electric transducer for detecting an intracranial pressure, a pressure-receiving layer disposed in contact with the pressure-electric transducer and in pressed engagement with the dura under the skull, and a transmitting circuit for transmitting an output signal indicative of the intracranial pressure through a transmitting antenna. The transmitting circuit includes a telemetering transmission circuit, a microbattery and a switch for switching on and off the microbattery. The transducer thus constructed is entirely embedded below the head, dispensing with external wires or a receiving coil on the head, and detects an intracranial pressure safely and accurately without confining or disturbing the activities of a testee.
    Type: Grant
    Filed: April 20, 1982
    Date of Patent: September 18, 1984
    Assignee: Kabushiki Kaisha Toyota Chuo Kenkyusho
    Inventors: Hazime Inagaki, Toshikazu Ishihara, Tomoyuki Kitano
  • Patent number: 4469593
    Abstract: A blood purification apparatus includes an extracorporeal circulation system, a blood purifier provided in the system for purifying blood by dialysis or filtration through a semipermeable membrane, a circulation blood volume measuring instrument for measuring changes in a circulating blood volume within a patient's body, a control section comprising a memory for storing a program for a pattern of changes in the circulating blood volume during blood purification, the program being matched to the condition of a patient, and a regulator connected to the extracorporeal circulation system and the control section, for controlling the circulating blood volume, the regulator being controlled by the control section on the basis of the circulating blood volume measured during blood purification and the programmed amount. In this apparatus, optimum blood purification is carried out while maintaining the circulating blood volume at a prescribed level.
    Type: Grant
    Filed: March 9, 1983
    Date of Patent: September 4, 1984
    Assignees: Kabushiki Kaisha Toyota Chuo Kenkyusho, Kenji Maeda
    Inventors: Toshikazu Ishihara, Tomoyuki Kitano, Kenji Maeda, Toru Shinzato