Patents by Inventor Toshikazu Minamisawa

Toshikazu Minamisawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for sulfating glycosaminoglycan
    Patent number: 10259889
    Abstract: An object of the present invention is provide a method for sulfating a glycosaminoglycan in a solution of a non-organic solvent. In the present invention, sulfation reaction of a glycosaminoglycan is performed with a sulfating agent in a strongly basic solution of a non-organic solvent. In the present invention, pH of the strongly basic solution is preferably set to be 11.5 or higher. According to the present invention, for example, a glycosaminoglycan having heparin-like anticoagulant activity can be produced from N-acetylheparosan through one-pot procedure. In one embodiment, a sulfated glycosaminoglycan produced by the method of the present invention has a unique disaccharide composition and is expected to be a novel useful material.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: April 16, 2019
    Assignee: SEIKAGAKU CORPORATION
    Inventors: Toshikazu Minamisawa, Nagamasa Asami, Hiroshi Fujita, Kiyoshi Suzuki
  • METHOD FOR SULFATING GLYCOSAMINOGLYCAN
    Publication number: 20180086853
    Abstract: An object of the present invention is provide a method for sulfating a glycosaminoglycan in a solution of a non-organic solvent. In the present invention, sulfation reaction of a glycosaminoglycan is performed with a sulfating agent in a strongly basic solution of a non-organic solvent. In the present invention, pH of the strongly basic solution is preferably set to be 11.5 or higher. According to the present invention, for example, a glycosaminoglycan having heparin-like anticoagulant activity can be produced from N-acetylheparosan through one-pot procedure. In one embodiment, a sulfated glycosaminoglycan produced by the method of the present invention has a unique disaccharide composition and is expected to be a novel useful material.
    Type: Application
    Filed: March 31, 2016
    Publication date: March 29, 2018
    Applicant: SEIKAGAKU CORPORATION
    Inventors: Toshikazu MINAMISAWA, Nagamasa ASAMI, Hiroshi FUJITA, Kiyoshi SUZUKI
  • Compositions and methods for bacterial and genetically modified microorganism production of chondroitin
    Patent number: 9175293
    Abstract: The invention relates to the field of recombinant DNA technology for the production of chondroitin, including the production of chondroitin sulfate via a combination of recombinant bacterial fermentation and post-fermentation sulfation.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: November 3, 2015
    Assignee: Seikagaku Corporation
    Inventors: Daniel H. Doherty, Craig A. Weaver, Kentaro Miyamoto, Toshikazu Minamisawa
  • COMPOSITIONS AND METHODS FOR BACTERIAL PRODUCTION OF CHONDROITIN
    Publication number: 20140296505
    Abstract: The invention relates to the field of recombinant DNA technology for the production of chondroitin, including the production of chondroitin sulfate via a combination of recombinant bacterial fermentation and post-fermentation sulfation.
    Type: Application
    Filed: February 20, 2014
    Publication date: October 2, 2014
    Applicants: Seikagaku Corporation, DSM IP ASSETS B.V.
    Inventors: Daniel H. DOHERTY, Craig A. WEAVER, Kentaro MIYAMOTO, Toshikazu MINAMISAWA
  • Compositions and methods for bacterial production of chondroitin
    Patent number: 8697398
    Abstract: The invention relates to the field of recombinant DNA technology for the production of chondroitin, including the production of chondroitin sulfate via a combination of recombinant bacterial fermentation and post-fermentation sulfation.
    Type: Grant
    Filed: March 1, 2011
    Date of Patent: April 15, 2014
    Assignees: DSM IP Assets B.V., Seikagaku Corporation
    Inventors: Daniel H. Doherty, Craig A. Weaver, Kentaro Miyamoto, Toshikazu Minamisawa
  • Compositions and Methods for Bacterial Production of Chondroitin
    Publication number: 20110244520
    Abstract: The invention relates to the field of recombinant DNA technology for the production of chondroitin, including the production of chondroitin sulfate via a combination of recombinant bacterial fermentation and post-fermentation sulfation.
    Type: Application
    Filed: March 1, 2011
    Publication date: October 6, 2011
    Inventors: Daniel H. Doherty, Craig A. Weaver, Kentaro Miyamoto, Toshikazu Minamisawa
  • Galectin-glycosaminoglycan complex and method for controlling galectin activity
    Patent number: 7687609
    Abstract: A complex consisting of galectin-3 and chondroitin oligosaccharide and methods for seperating and detecting the chondroitin oligosaccharide in a sample using the immobilized complex.
    Type: Grant
    Filed: May 21, 2007
    Date of Patent: March 30, 2010
    Assignees: National Institute of Advanced Industrial Science and Technology, Seikagaku Corporation
    Inventors: Toshikazu Minamisawa, Kiyoshi Suzuki, Jun Hirabayashi
  • GALECTIN-GLYCOSAMINOGLYCAN COMPLEX AND METHOD FOR CONTROLLING GALECTIN ACTIVITY
    Publication number: 20070269833
    Abstract: A galectin-glycosaminoglycan complex and a method for controlling galectin activity.
    Type: Application
    Filed: May 21, 2007
    Publication date: November 22, 2007
    Applicants: SEIKAGAKU CORPORATION, NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Toshikazu Minamisawa, Kiyoshi Suzuki, Jun Hirabayashi
  • IL-12 production inhibitor
    Patent number: 6436911
    Abstract: An IL-12 production inhibitor which comprises, as an active ingredient, a keratan sulfate oligosaccharide or a derivative thereof, for example, a keratan sulfate oligosaccharide comprising at least one repeating unit of either one of the disaccharides represented by the following formulas: Gal (6s)-GlcNAc (6s) and Gal (6s)-GlcNAc wherein Gal represents a galactose residue, GlcNAc represents an N-acetylglucosamine residue, 6s indicates that 6-0-sulfate ester is formed at a Hydroxyl group at the 6-position, and - represents a glycosidic linkage.
    Type: Grant
    Filed: July 21, 2000
    Date of Patent: August 20, 2002
    Assignee: Seikagaku Corporation
    Inventors: Akira Asari, Hitoshi Kurihara, Heping Xu, Satoshi Miyauchi, Toshikazu Minamisawa