Patents by Inventor Toshikazu Shiba

Toshikazu Shiba has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9138387
    Abstract: The object of the present invention is to provide an oral composition, which can remove tooth stain effectively. The object of the present invention is also to provide an oral composition, which scarcely damages teeth and gums and can be easily applied. An oral composition for removing tooth stain, which comprises 3.5 to 30% by weight of peroxide and 5 to 20% by weight of phosphate polymer (in particular, ultraphosphate having an average chain length of phosphoric acid polymerization of 10 to 30).
    Type: Grant
    Filed: August 10, 2014
    Date of Patent: September 22, 2015
    Assignee: Regenetiss, Inc.
    Inventors: Toshikazu Shiba, Yumi Kawazoe, Shinichi Kato
  • Patent number: 8992894
    Abstract: An oral stain remover which can remove a stain or a dental plaque effectively without a need of brushing the surface of teeth with a toothbrush or the like, and an oral composition containing the stain remover. An oral stain remover contains a salt of ultraphosphoric acid, and an oral composition contains the oral stain remover.
    Type: Grant
    Filed: June 14, 2007
    Date of Patent: March 31, 2015
    Assignees: Mandom Corporation, REGENETISS Inc.
    Inventors: Toshikazu Shiba, Atsushi Saitou, Kazuyoshi Okada, Yoshio Tsujino
  • Publication number: 20140349253
    Abstract: The object of the present invention is to provide an oral composition, which can remove tooth stain effectively. The object of the present invention is also to provide an oral composition, which scarcely damages teeth and gums and can be easily applied. An oral composition for removing tooth stain, which comprises 3.5 to 30% by weight of peroxide and 5 to 20% by weight of phosphate polymer (in particular, ultraphosphate having an average chain length of phosphoric acid polymerization of 10 to 30).
    Type: Application
    Filed: August 10, 2014
    Publication date: November 27, 2014
    Inventors: Toshikazu SHIBA, Yumi KAWAZOE, Shinichi Kato
  • Publication number: 20140113244
    Abstract: A tooth whitening composition with a high level of whitening effectiveness over the entire tooth whitening composition application includes colloidal platinum as a platinum catalyst in a peroxide-containing oral composition. Whitening effectiveness can be enhanced by application of a tooth whitening composition containing colloidal platinum to the teeth surface followed by photo-irradiation of the application site.
    Type: Application
    Filed: September 26, 2012
    Publication date: April 24, 2014
    Applicant: REGENETISS, INC.
    Inventors: Toshikazu Shiba, Yumi Kawazoe, Shinichi Katou
  • Publication number: 20130189200
    Abstract: [Problem] The object of the present invention is to provide an oral composition, which can remove tooth stain effectively. The object of the present invention is also to provide an oral composition, which scarcely damages teeth and gums and can be easily applied. [Method of solution] An oral composition for removing tooth stain, which comprises 3.5 to 30% by weight of peroxide and 5 to 20% by weight of phosphate polymer (in particular, ultraphosphate having an average chain length of phosphoric acid polymerization of 10 to 30).
    Type: Application
    Filed: September 22, 2011
    Publication date: July 25, 2013
    Applicant: REGENETISS, INC.
    Inventors: Toshikazu Shiba, Yumi Kawazoe, Shinichi Kato
  • Patent number: 8461299
    Abstract: Disclosed are: a peptide capable of binding to an immunoglobulin; a fusion protein of the peptide; nucleic acids encoding the peptide and the fusion protein, respectively; production methods for the peptide and the fusion protein, respectively; a composition and a means for binding an immunoglobulin; a pharmaceutical composition for the treatment or prevention of a disease induced by the binding between C1q and an immunoglobulin, which comprises a peptide capable of binding to the immunoglobulin or a fusion protein of the peptide; and others.
    Type: Grant
    Filed: August 20, 2008
    Date of Patent: June 11, 2013
    Assignees: MMT Co., Ltd.
    Inventors: Takahiro Ochi, Toshikazu Shiba, Osamu Masaki
  • Patent number: 7923205
    Abstract: It is an objective of the present invention to provide a method capable of protecting personal information. A method for protecting personal information that can be obtained by analyzing a biological sample is provided, wherein the method comprises adding to the biological sample a component obstructing the analysis of another component that provides personal information to be protected. Thus, the analysis of personal information such as genomic information without the person's consent can be technically prevented. In addition, the present invention provides a technique for not only simply protecting personal information, but also for analyzing the once protected personal information as needed.
    Type: Grant
    Filed: August 24, 2001
    Date of Patent: April 12, 2011
    Inventors: Toshikazu Shiba, Azuma Ohuchi
  • Publication number: 20100167348
    Abstract: Disclosed are: a peptide capable of binding to an immunoglobulin; a fusion protein of the peptide; nucleic acids encoding the peptide and the fusion protein, respectively; production methods for the peptide and the fusion protein, respectively; a composition and a means for binding an immunoglobulin; a pharmaceutical composition for the treatment or prevention of a disease induced by the binding between C1q and an immunoglobulin, which comprises a peptide capable of binding to the immunoglobulin or a fusion protein of the peptide; and others.
    Type: Application
    Filed: August 20, 2008
    Publication date: July 1, 2010
    Applicants: Takahiro Ochi, Tegene Tiss Inc., MMT CO, Ltd
    Inventors: Takahiro Ochi, Toshikazu Shiba, Osamu Masaki
  • Publication number: 20100040686
    Abstract: The present invention provides a biomaterial which releases slowly a biologically active substance acting only on bone cell regeneration, in order to compensate for bone or alveolar bone lost due to surgery, accident or the like. Specifically, the invention relates to a biomaterial containing an osteogenic factor adsorbed on a porous material selected from hydroxyapatite, calcium phosphate, ?-TCP (tricalcium phosphate [?-Ca3(PO4)2]), coral, calcium carbonate, titanium oxide, alumina, zirconia, silicon nitride, and ceramics. This osteogenic factor is preferably polyphosphoric acid or a pharmacologically acceptable salt thereof, or else bone morphogenetic protein (BMP).
    Type: Application
    Filed: October 25, 2007
    Publication date: February 18, 2010
    Inventors: Osamu Masaki, Toshikazu Shiba, Ryuichi Morishita, Koichi Imura, Yusumasa Akagawa
  • Publication number: 20090280072
    Abstract: An oral stain remover which can remove a stain or a dental plaque effectively without a need of brushing the surface of teeth with a toothbrush or the like, and an oral composition containing the stain remover. An oral stain remover contains a salt of ultraphosphoric acid, and an oral composition contains the oral stain remover.
    Type: Application
    Filed: June 14, 2007
    Publication date: November 12, 2009
    Applicant: MANDOM CORPORATION
    Inventors: Toshikazu Shiba, Atsushi Saitou, Kazuyoshi Okada, Yoshio Tsujino
  • Publication number: 20080108111
    Abstract: This invention relates to a novel polyphosphate: AMP phosphotransferase (PAP), a gene coding this PAP, and their use.
    Type: Application
    Filed: October 19, 2007
    Publication date: May 8, 2008
    Applicant: YAMASA CORPORATION
    Inventors: Toshikazu SHIBA, Toshitada Noguchi
  • Patent number: 7329522
    Abstract: This invention relates to a novel polyphosphate: AMP phosphotransferase (PAP), a gene coding this PAP, and their use. The PAP has the following properties: (A) action: catalyzing of the following two reactions: NMP+PolyP(n)?NDP+PolyP(n-1) dNMP+POlyP(n)?dNDP+PolyP(n-1) (wherein NMP represents nucleoside monophosphate, NDP represents nucleoside diphosphate, dNMP represents deoxynucleoside monophosphate, dNDP represents deoxynucleoside diphosphate, n represents degree of polymerization of the polyphosphate which is an integer of up to 100); (B) substrate specificity: specific to AMP, GMP, IMP, dAMP, and dGMP, also acting with CMP, UMP, dCMP, and TMP; (C) molecular weight: about 55 to 56 Kd (kilodalton); and (D) specific activity: at least 70 units per 1 mg of enzyme protein.
    Type: Grant
    Filed: May 28, 2003
    Date of Patent: February 12, 2008
    Assignee: Yamasa Corporation
    Inventors: Toshikazu Shiba, Toshitada Noguchi
  • Publication number: 20060177517
    Abstract: An object of the present invention is to provide an anti-inflammatory agent and an anti-inflammatory medical material, which have a good anti-inflammatory effect and high safety. The present invention relates to an anti-inflammatory agent and an anti-inflammatory medical material, which contain as an active ingredient a polyphosphoric acid that is particularly 1 type of liner phosphoric acid represented by a general formula Hn+2(PnO3n+1) (wherein n denotes an integer between 3 and 800) or a mixture of 2 or more types of such linear phosphoric acid.
    Type: Application
    Filed: February 25, 2004
    Publication date: August 10, 2006
    Inventors: Toshikazu Shiba, Toshie Shiba, Mimoru Yamaoka, Takashi Uematsu, Yoshiharu Takahashi, Hitoshi Tanaka, Takao Kogo, Masanobu Shindo
  • Publication number: 20060088918
    Abstract: This invention relates to a novel polyphosphate: AMP phosphotransferase (PAP), a gene coding this PAP, and their use.
    Type: Application
    Filed: May 28, 2003
    Publication date: April 27, 2006
    Inventors: Toshikazu Shiba, Toshitada Noguchi
  • Publication number: 20040063111
    Abstract: It is an objective of the present invention to provide a method capable of protecting personal information.
    Type: Application
    Filed: July 22, 2003
    Publication date: April 1, 2004
    Inventors: Toshikazu Shiba, Azuma Ohuchi
  • Publication number: 20040002444
    Abstract: A polyphosphate-collagen complex, comprising at least one polyphosphate bound to collagen, a process for preparing the complex, and a method for promoting tissue regeneration using the complex.
    Type: Application
    Filed: April 8, 2003
    Publication date: January 1, 2004
    Applicants: Toshikazu SHIBA, SHIBARIE RESEARCH INSTITUTE
    Inventors: Toshikazu Shiba, Toshie Shiba, Minoru Yamaoka, Takashi Uematsu, Yoshiharu Takahashi, Hitoshi Tanaka
  • Patent number: 6406711
    Abstract: A bone regeneration material uses polyphosphoric acid and/or a polyphosphate together with a biocompatible material, a filler for cosmetic surgery, or a bone morphogenetic protein, to expedite new bone formation and shorten healing time or restoration in the treatment of bone fractures or damage.
    Type: Grant
    Filed: June 30, 1999
    Date of Patent: June 18, 2002
    Inventors: Jin-Yong Lee, Hong-Yeoul Kim, Toshikazu Shiba
  • Patent number: 6333193
    Abstract: Provided are a cell growth accelerator containing a polyphosphoric acid and a cell growth method in which cells are grown by adding the cell growth accelerator to a medium for cells of animals and plants or by using a glass or plastic cell cultivator containing or coated with the cell growth accelerator. When substances are produced in vitro using culture cells, the cell culture and the cell growth acceleration are conducted at low cost safely and efficiently by adding the cell growth accelerator containing the polyphosphoric acid to the medium for cells of animals and plants or by using the cell cultivator containing or coated with the cell growth accelerator.
    Type: Grant
    Filed: August 27, 1999
    Date of Patent: December 25, 2001
    Assignee: Nipro Corporation
    Inventor: Toshikazu Shiba
  • Patent number: 6214590
    Abstract: There is provided a gene for 2-aminothiazoline-4-carboxylate (ATC) racemase, a recombinant DNA comprising the gene or DNA fragment thereof, a transformant or transductant comprising the recombinant DNA, and a process for preparing the 2-aminothiazoline-4-carboxylate racemase using the transformant or transductant. According to the invention, the ATC racemase may be efficiently produced by microorganisms such as E. coli and Pseudomonas and L-cysteine and L-cystine may be efficiently synthesized using the enzyme.
    Type: Grant
    Filed: August 31, 1999
    Date of Patent: April 10, 2001
    Inventor: Toshikazu Shiba
  • Patent number: 6022713
    Abstract: The present invention relates to a process for producing nucleoside 5'-triphosphates (NTP) from nucleoside 5'-diphosphates (NDP) other than adenosine 5'-diphosphate (ADP), characterized by using a polyphosphate kinase as an enzyme and polyphosphate as the phosphate donor; and application of this process to various glycosylation reactions.This process makes it possible to conveniently and economically synthesize NTP from NDP enzymatically. Also, it becomes possible thereby to economically recycle and synthesize sugar nucleotides and synthesize, for example, oligosaccharides associating therewith without resort to expensive phosphoenol pyruvate, ATP, etc. in the reactions for reproducing or converting NDP into NTP in the systems for enzymatically synthesizing oligosaccharides by combining, for example, with the synthesis of sugar nucleotides.
    Type: Grant
    Filed: July 15, 1998
    Date of Patent: February 8, 2000
    Assignee: Yamasa Corporation
    Inventors: Toshitada Noguchi, Toshikazu Shiba