Patents by Inventor Toshikazu Takeshita

Toshikazu Takeshita has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human IL-2 receptor .gamma.-chain molecule antibody
    Patent number: 5889160
    Abstract: The present invention relates to an IL-2 receptor .gamma. chain molecule, a DNA-sequence encoding the IL-2 receptor .gamma. chain molecule, a vector possessing said DNA-sequence, a cell transformed with said vector, a method for the production of an IL-2 receptor .gamma. chain molecule by culturing of said cell, an immune response regulatory agent comprising an IL-2 receptor .gamma. chain molecule and an antibody to an IL-2 receptor .gamma. chain molecule.
    Type: Grant
    Filed: July 30, 1997
    Date of Patent: March 30, 1999
    Assignees: Ajinomoto Co., Inc., Kazuo Sugamura
    Inventors: Kazuo Sugamura, Toshikazu Takeshita, Hironobu Asao, Masataka Nakamura, Toshiro Shimamura, Manabu Suzuki, Junji Hamuro
  • .gamma.-chain humaninterleukin-2 receptor polypeptide and method of making
    Patent number: 5856140
    Abstract: A polypeptide which specifically binds to the .gamma.-chain of the human interleukin-2 receptor and selectively inhibits the binding of the .gamma.-chain of human interleukin-2 receptor to the .beta.-chain of the same is provided. The polypeptide has an activity of blocking the human interleukin-2 response. Also provided are an immunosuppressant containing the polypeptide, a DNA gene coding for the polypeptide, a recombinant DNA having the gene, a transformant having the recombinant DNA, and a method for producing the intended polypeptide by incubating the transformant. The novel polypeptide can be used independently, or with substances capable of inhibiting the binding of interleukin-2 to the interleukin-2 receptor, as a medicine for preventing the rejection of grafts after transplantation and also for curing inflammatory diseases such as allergic diseases and autoimmune diseases.
    Type: Grant
    Filed: April 24, 1996
    Date of Patent: January 5, 1999
    Assignees: Ajinomoto Co., Inc., Kazuo Sugamura
    Inventors: Toshiro Shimamura, Junji Hamuro, Harumi Nakazawa, Yuka Kanayama, Kazuo Sugamura, Toshikazu Takeshita
  • Human IL-2 receptor .gamma. chain molecule
    Patent number: 5705608
    Abstract: The present invention relates to an IL-2 receptor .gamma. chain molecule, a DNA-sequence encoding the IL-2 receptor .gamma. chain molecule, a vector possessing said DNA-sequence, a cell transformed with said vector, a method for the production of an IL-2 receptor .gamma. chain molecule by culturing of said cell, an immune response regulatory agent comprising an Il-2 receptor .gamma. chain molecule and an antibody to an IL-2 receptor .gamma. chain molecule.Both the Il-2 receptor .gamma. chain molecule and the antibody to the IL-2 receptor .gamma. chain molecule are very useful immune response regulatory agents.
    Type: Grant
    Filed: February 6, 1996
    Date of Patent: January 6, 1998
    Assignees: Ajinomoto Co., Inc., Kazuo Sugamura
    Inventors: Kazuo Sugamura, Toshikazu Takeshita, Hironobu Asao, Masataka Nakamura, Toshiro Shimamura, Manabu Suzuki, Junji Hamuro
  • Monoclonal antibodies which bind the gamma chain of human interleukin-2 receptor
    Patent number: 5582826
    Abstract: A polypeptide which specifically binds to the .gamma.-chain of the human interleukin-2 receptor and selectively inhibits the binding of the .gamma.-chain of human interleukin-2 receptor to the .beta.-chain of the same is provided. The polypeptide has an activity of blocking the human interleukin-2 response. Also provided are an immunosuppressant containing the polypeptide, a DNA gene coding for the polypeptide, a recombinant DNA having the gene, a transformant having the recombinant DNA, and a method for producing the intended polypeptide by incubating the transformant. The novel polypeptide can be used independently, or with substances capable of inhibiting the binding of interleukin-2 to the interleukin-2 receptor, as a medicine for preventing the rejection of grafts after transplantation and also for curing inflammatory diseases such as allergic diseases and autoimmune diseases.
    Type: Grant
    Filed: April 21, 1994
    Date of Patent: December 10, 1996
    Assignees: Ajinomoto Co., Inc., Kazuo Sugamura
    Inventors: Toshiro Shimamura, Junji Hamuro, Harumi Nakazawa, Yuka Kanayama, Kazuo Sugamura, Toshikazu Takeshita
  • Human IL-2 receptor .gamma. chain molecule
    Patent number: 5510259
    Abstract: The present invention relates to an IL-2 receptor .gamma. chain molecule, a DNA-sequence encoding the IL-2 receptor .gamma. chain molecule, a vector possessing said DNA-sequence, a cell transformed with said vector, a method for the production of an IL-2 receptor .gamma. chain molecule by culturing of said cell, an immune response regulatory agent comprising an Il-2 receptor .gamma. chain molecule and an antibody to an IL-2 receptor .gamma. chain molecule.Both the Il-2 receptor .gamma. chain molecule and the antibody to the IL-2 receptor .gamma. chain molecule are very useful immune response regulatory agents.
    Type: Grant
    Filed: April 22, 1993
    Date of Patent: April 23, 1996
    Assignees: Ajinomoto Co., Inc., Kazuo Sugamura
    Inventors: Kazuo Sugamura, Toshikazu Takeshita, Hironobu Asao, Masataka Nakamura, Toshiro Shimamura, Manabu Suzuki, Junji Hamuro