Patents by Inventor Toshikazu Tsuji

Toshikazu Tsuji has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11891494
    Abstract: Disclosed is an additive for imparting antimicrobial properties to a resin. The additive comprises a string polymer, at least one terminal of which has a positive charge, wherein the string polymer is a polymer containing structural units derived from a cationic polymerization initiator and a monomer containing a carbon-carbon double bond. By using this additive, it becomes possible to obtain an antibacterial resin molded body which can be prepared simply and inexpensively and which has high stability and safety.
    Type: Grant
    Filed: April 25, 2019
    Date of Patent: February 6, 2024
    Assignee: KIRIN HOLDINGS KABUSHIKI KAISHA
    Inventors: Toshikazu Tsuji, Hideki Koizumi, Akiko Jitsuhiro, Yuki Konoeda, Atsushi Hotta, Tomoki Maeda
  • Patent number: 11649311
    Abstract: There is provided a method for introducing a temperature-sensitive probe comprising a copolymer, which comprises a thermoresponsive unit and a fluorescent unit, into a cell, and the method using the copolymer further comprising a cationic unit as the temperature-sensitive probe, and the method comprising the step of mixing the copolymer with the cell in a solvent. The copolymer can be preferably used as a fluorescence temperature sensor which measures intracellular temperature since the copolymer has a cationic group and thus enters into a cell without using a special method.
    Type: Grant
    Filed: December 13, 2018
    Date of Patent: May 16, 2023
    Assignees: KIRIN HOLDINGS KABUSHIKI KAISHA, THE UNIVERSITY OF TOKYO
    Inventors: Toshikazu Tsuji, Kumiko Ikado, Seiichi Uchiyama, Kyoko Kawamoto
  • Publication number: 20220396644
    Abstract: Disclosed is a compound having a chemical structure (Xf? is a counter anion selected from the group consisting of Cl?, NO3?, Br?, I?, CH3SO3? and OH?) of the following general formula (I). By using this compound as a polymerization initiator, the amount of the aggregation formed in emulsion polymerization can be reduced.
    Type: Application
    Filed: November 19, 2020
    Publication date: December 15, 2022
    Applicant: KIRIN HOLDINGS KABUSHIKI KAISHA
    Inventors: Toshikazu TSUJI, Takashi YAMAZAKI, Akiko OGAWA
  • Patent number: 11452697
    Abstract: An intracellular delivery vehicle of which surface is covered by a positive charge, an intracellular delivery complex in which a component or compound desired is loaded in the intracellular delivery vehicle, a temperature-sensitive probe comprising the intracellular delivery complex, and a method for measuring the intracellular temperature by the temperature-sensitive probe are disclosed. The intracellular delivery vehicle is useful on account of its capability of easily delivering the component or compound desired inside the cell without inhibiting cell proliferation.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: September 27, 2022
    Assignees: KIRIN HOLDINGS KABUSHIKI KAISHA, THE UNIVERSITY OF TOKYO, TOHOKU UNIVERSITY
    Inventors: Toshikazu Tsuji, Kumiko Ikado, Sayuri Yamada, Seiichi Uchiyama, Kyoko Kawamoto, Hidetoshi Tokuyama, Kentaro Okano
  • Patent number: 11199537
    Abstract: There is provided a method for introducing a temperature-sensitive probe comprising a copolymer, which comprises a thermoresponsive unit and a fluorescent unit, into a cell, and the method using the copolymer further comprising a cationic unit as the temperature-sensitive probe, and the method comprising the step of mixing the copolymer with the cell in a solvent. The copolymer can be preferably used as a fluorescence temperature sensor which measures intracellular temperature since the copolymer has a cationic group and thus enters into a cell without using a special method.
    Type: Grant
    Filed: December 13, 2018
    Date of Patent: December 14, 2021
    Assignees: KIRIN HOLDINGS KABUSHIKI KAISHA, THE UNIVERSITY OF TOKYO
    Inventors: Toshikazu Tsuji, Kumiko Ikado, Seiichi Uchiyama, Kyoko Kawamoto
  • Publication number: 20210363323
    Abstract: Disclosed is an additive for imparting antimicrobial properties to a resin. The additive comprises a string polymer, at least one terminal of which has a positive charge, wherein the string polymer is a polymer containing structural units derived from a cationic polymerization initiator and a monomer containing a carbon-carbon double bond. By using this additive, it becomes possible to obtain an antibacterial resin molded body which can be prepared simply and inexpensively and which has high stability and safety.
    Type: Application
    Filed: April 25, 2019
    Publication date: November 25, 2021
    Applicant: KIRIN HOLDINGS KABUSHIKI KAISHA
    Inventors: Toshikazu TSUJI, Hideki KOIZUMI, Akiko JITSUHIRO, Yuki KONOEDA, Atsushi HOTTA, Tomoki MAEDA
  • Publication number: 20200309782
    Abstract: An intracellular delivery vehicle of which surface is covered by a positive charge, an intracellular delivery complex in which a component or compound desired is loaded in the intracellular delivery vehicle, a temperature-sensitive probe comprising the intracellular delivery complex, and a method for measuring the intracellular temperature by the temperature-sensitive probe are disclosed. The intracellular delivery vehicle is useful on account of its capability of easily delivering the component or compound desired inside the cell without inhibiting cell proliferation.
    Type: Application
    Filed: June 12, 2020
    Publication date: October 1, 2020
    Applicants: KIRIN HOLDINGS KABUSHIKI KAISHA, THE UNIVERSITY OF TOKYO, TOHOKU UNIVERSITY
    Inventors: Toshikazu Tsuji, Kumiko Ikado, Sayuri Yamada, Seiichi Uchiyama, Kyoko Kawamoto, Hidetoshi Tokuyama, Kentaro Okano
  • Patent number: 10712346
    Abstract: An intracellular delivery vehicle of which surface is covered by a positive charge, an intracellular delivery complex in which a component or compound desired is loaded in the intracellular delivery vehicle, a temperature-sensitive probe comprising the intracellular delivery complex, and a method for measuring the intracellular temperature by the temperature-sensitive probe are disclosed. The intracellular delivery vehicle is useful on account of its capability of easily delivering the component or compound desired inside the cell without inhibiting cell proliferation.
    Type: Grant
    Filed: September 6, 2016
    Date of Patent: July 14, 2020
    Assignees: KIRIN HOLDINGS KABUSHIKI KAISHA, THE UNIVERSITY OF TOKYO, TOHOKU UNIVERSITY
    Inventors: Toshikazu Tsuji, Kumiko Ikado, Sayuri Yamada, Seiichi Uchiyama, Kyoko Kawamoto, Hidetoshi Tokuyama, Kentaro Okano
  • Publication number: 20190137503
    Abstract: An intracellular delivery vehicle of which surface is covered by a positive charge, an intracellular delivery complex in which a component or compound desired is loaded in the intracellular delivery vehicle, a temperature-sensitive probe comprising the intracellular delivery complex, and a method for measuring the intracellular temperature by the temperature-sensitive probe are disclosed. The intracellular delivery vehicle is useful on account of its capability of easily delivering the component or compound desired inside the cell without inhibiting cell proliferation.
    Type: Application
    Filed: September 6, 2016
    Publication date: May 9, 2019
    Applicants: KIRIN KABUSHIKI KAISHA, THE UNIVERSITY OF TOKYO, TOHOKU UNIVERSITY
    Inventors: Toshikazu TSUJI, Kumiko IKADO, Sayuri YAMADA, Seiichi UCHIYAMA, Kyoko KAWAMOTO, Hidetoshi TOKUYAMA, Kentaro OKANO
  • Publication number: 20190128874
    Abstract: There is provided a method for introducing a temperature-sensitive probe comprising a copolymer, which comprises a thermoresponsive unit and a fluorescent unit, into a cell, and the method using the copolymer further comprising a cationic unit as the temperature-sensitive probe, and the method comprising the step of mixing the copolymer with the cell in a solvent. The copolymer can be preferably used as a fluorescence temperature sensor which measures intracellular temperature since the copolymer has a cationic group and thus enters into a cell without using a special method.
    Type: Application
    Filed: December 13, 2018
    Publication date: May 2, 2019
    Applicants: KIRIN HOLDINGS KABUSHIKI KAISHA, THE UNIVERSITY OF TOKYO
    Inventors: Toshikazu TSUJI, Kumiko IKADO, Seiichi UCHIYAMA, Kyoko KAWAMOTO
  • Publication number: 20190113505
    Abstract: There is provided a method for introducing a temperature-sensitive probe comprising a copolymer, which comprises a thermoresponsive unit and a fluorescent unit, into a cell, and the method using the copolymer further comprising a cationic unit as the temperature-sensitive probe, and the method comprising the step of mixing the copolymer with the cell in a solvent. The copolymer can be preferably used as a fluorescence temperature sensor which measures intracellular temperature since the copolymer has a cationic group and thus enters into a cell without using a special method.
    Type: Application
    Filed: December 13, 2018
    Publication date: April 18, 2019
    Applicants: KIRIN HOLDINGS KABUSHIKI KAISHA, THE UNIVERSITY OF TOKYO
    Inventors: Toshikazu TSUJI, Kumiko IKADO, Seiichi UCHIYAMA, Kyoko KAWAMOTO
  • Patent number: 10191035
    Abstract: There is provided a method for introducing a temperature-sensitive probe comprising a copolymer, which comprises a thermoresponsive unit and a fluorescent unit, into a cell, and the method using the copolymer further comprising a cationic unit as the temperature-sensitive probe, and the method comprising the step of mixing the copolymer with the cell in a solvent. The copolymer can be preferably used as a fluorescence temperature sensor which measures intracellular temperature since the copolymer has a cationic group and thus enters into a cell without using a special method.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: January 29, 2019
    Assignees: KIRIN HOLDINGS KABUSHIKI KAISHA, THE UNIVERSITY OF TOKYO
    Inventors: Toshikazu Tsuji, Kumiko Ikado, Seiichi Uchiyama, Kyoko Kawamoto
  • Publication number: 20140342390
    Abstract: There is provided a method for introducing a temperature-sensitive probe comprising a copolymer, which comprises a thermoresponsive unit and a fluorescent unit, into a cell, and the method using the copolymer further comprising a cationic unit as the temperature-sensitive probe, and the method comprising the step of mixing the copolymer with the cell in a solvent. The copolymer can be preferably used as a fluorescence temperature sensor which measures intracellular temperature since the copolymer has a cationic group and thus enters into a cell without using a special method.
    Type: Application
    Filed: May 20, 2014
    Publication date: November 20, 2014
    Applicants: THE UNIVERSITY OF TOKYO, KIRIN HOLDINGS KABUSHIKI KAISHA
    Inventors: Toshikazu TSUJI, Kumiko IKADO, Seiichi UCHIYAMA, Kyoko KAWAMOTO
  • Patent number: 4270510
    Abstract: An ignition system for an internal combustion engine having a transistor switch means connected across a primary winding of an ignition coil wherein a base current input terminal of the transistor switch means is connected through a coil to an igniting exciter coil to supply a base current through the coil to the base current input terminal thereby decreasing a power loss at the interruption of a primary current flowing through an ignition coil and operating a transistor in a low power loss region, so that a high voltage may be induced across a secondary winding of an ignition coil.
    Type: Grant
    Filed: July 20, 1979
    Date of Patent: June 2, 1981
    Assignee: Kokusan Denki Co., Ltd.
    Inventors: Hirotoshi Nanjo, Toshikazu Tsuji