Patents by Inventor Toshikazu Tsuji
Toshikazu Tsuji has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11649311Abstract: There is provided a method for introducing a temperature-sensitive probe comprising a copolymer, which comprises a thermoresponsive unit and a fluorescent unit, into a cell, and the method using the copolymer further comprising a cationic unit as the temperature-sensitive probe, and the method comprising the step of mixing the copolymer with the cell in a solvent. The copolymer can be preferably used as a fluorescence temperature sensor which measures intracellular temperature since the copolymer has a cationic group and thus enters into a cell without using a special method.Type: GrantFiled: December 13, 2018Date of Patent: May 16, 2023Assignees: KIRIN HOLDINGS KABUSHIKI KAISHA, THE UNIVERSITY OF TOKYOInventors: Toshikazu Tsuji, Kumiko Ikado, Seiichi Uchiyama, Kyoko Kawamoto
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Publication number: 20220396644Abstract: Disclosed is a compound having a chemical structure (Xf? is a counter anion selected from the group consisting of Cl?, NO3?, Br?, I?, CH3SO3? and OH?) of the following general formula (I). By using this compound as a polymerization initiator, the amount of the aggregation formed in emulsion polymerization can be reduced.Type: ApplicationFiled: November 19, 2020Publication date: December 15, 2022Applicant: KIRIN HOLDINGS KABUSHIKI KAISHAInventors: Toshikazu TSUJI, Takashi YAMAZAKI, Akiko OGAWA
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Patent number: 11452697Abstract: An intracellular delivery vehicle of which surface is covered by a positive charge, an intracellular delivery complex in which a component or compound desired is loaded in the intracellular delivery vehicle, a temperature-sensitive probe comprising the intracellular delivery complex, and a method for measuring the intracellular temperature by the temperature-sensitive probe are disclosed. The intracellular delivery vehicle is useful on account of its capability of easily delivering the component or compound desired inside the cell without inhibiting cell proliferation.Type: GrantFiled: June 12, 2020Date of Patent: September 27, 2022Assignees: KIRIN HOLDINGS KABUSHIKI KAISHA, THE UNIVERSITY OF TOKYO, TOHOKU UNIVERSITYInventors: Toshikazu Tsuji, Kumiko Ikado, Sayuri Yamada, Seiichi Uchiyama, Kyoko Kawamoto, Hidetoshi Tokuyama, Kentaro Okano
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Patent number: 11199537Abstract: There is provided a method for introducing a temperature-sensitive probe comprising a copolymer, which comprises a thermoresponsive unit and a fluorescent unit, into a cell, and the method using the copolymer further comprising a cationic unit as the temperature-sensitive probe, and the method comprising the step of mixing the copolymer with the cell in a solvent. The copolymer can be preferably used as a fluorescence temperature sensor which measures intracellular temperature since the copolymer has a cationic group and thus enters into a cell without using a special method.Type: GrantFiled: December 13, 2018Date of Patent: December 14, 2021Assignees: KIRIN HOLDINGS KABUSHIKI KAISHA, THE UNIVERSITY OF TOKYOInventors: Toshikazu Tsuji, Kumiko Ikado, Seiichi Uchiyama, Kyoko Kawamoto
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Publication number: 20210363323Abstract: Disclosed is an additive for imparting antimicrobial properties to a resin. The additive comprises a string polymer, at least one terminal of which has a positive charge, wherein the string polymer is a polymer containing structural units derived from a cationic polymerization initiator and a monomer containing a carbon-carbon double bond. By using this additive, it becomes possible to obtain an antibacterial resin molded body which can be prepared simply and inexpensively and which has high stability and safety.Type: ApplicationFiled: April 25, 2019Publication date: November 25, 2021Applicant: KIRIN HOLDINGS KABUSHIKI KAISHAInventors: Toshikazu TSUJI, Hideki KOIZUMI, Akiko JITSUHIRO, Yuki KONOEDA, Atsushi HOTTA, Tomoki MAEDA
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Publication number: 20200309782Abstract: An intracellular delivery vehicle of which surface is covered by a positive charge, an intracellular delivery complex in which a component or compound desired is loaded in the intracellular delivery vehicle, a temperature-sensitive probe comprising the intracellular delivery complex, and a method for measuring the intracellular temperature by the temperature-sensitive probe are disclosed. The intracellular delivery vehicle is useful on account of its capability of easily delivering the component or compound desired inside the cell without inhibiting cell proliferation.Type: ApplicationFiled: June 12, 2020Publication date: October 1, 2020Applicants: KIRIN HOLDINGS KABUSHIKI KAISHA, THE UNIVERSITY OF TOKYO, TOHOKU UNIVERSITYInventors: Toshikazu Tsuji, Kumiko Ikado, Sayuri Yamada, Seiichi Uchiyama, Kyoko Kawamoto, Hidetoshi Tokuyama, Kentaro Okano
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Patent number: 10712346Abstract: An intracellular delivery vehicle of which surface is covered by a positive charge, an intracellular delivery complex in which a component or compound desired is loaded in the intracellular delivery vehicle, a temperature-sensitive probe comprising the intracellular delivery complex, and a method for measuring the intracellular temperature by the temperature-sensitive probe are disclosed. The intracellular delivery vehicle is useful on account of its capability of easily delivering the component or compound desired inside the cell without inhibiting cell proliferation.Type: GrantFiled: September 6, 2016Date of Patent: July 14, 2020Assignees: KIRIN HOLDINGS KABUSHIKI KAISHA, THE UNIVERSITY OF TOKYO, TOHOKU UNIVERSITYInventors: Toshikazu Tsuji, Kumiko Ikado, Sayuri Yamada, Seiichi Uchiyama, Kyoko Kawamoto, Hidetoshi Tokuyama, Kentaro Okano
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Publication number: 20190137503Abstract: An intracellular delivery vehicle of which surface is covered by a positive charge, an intracellular delivery complex in which a component or compound desired is loaded in the intracellular delivery vehicle, a temperature-sensitive probe comprising the intracellular delivery complex, and a method for measuring the intracellular temperature by the temperature-sensitive probe are disclosed. The intracellular delivery vehicle is useful on account of its capability of easily delivering the component or compound desired inside the cell without inhibiting cell proliferation.Type: ApplicationFiled: September 6, 2016Publication date: May 9, 2019Applicants: KIRIN KABUSHIKI KAISHA, THE UNIVERSITY OF TOKYO, TOHOKU UNIVERSITYInventors: Toshikazu TSUJI, Kumiko IKADO, Sayuri YAMADA, Seiichi UCHIYAMA, Kyoko KAWAMOTO, Hidetoshi TOKUYAMA, Kentaro OKANO
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Publication number: 20190128874Abstract: There is provided a method for introducing a temperature-sensitive probe comprising a copolymer, which comprises a thermoresponsive unit and a fluorescent unit, into a cell, and the method using the copolymer further comprising a cationic unit as the temperature-sensitive probe, and the method comprising the step of mixing the copolymer with the cell in a solvent. The copolymer can be preferably used as a fluorescence temperature sensor which measures intracellular temperature since the copolymer has a cationic group and thus enters into a cell without using a special method.Type: ApplicationFiled: December 13, 2018Publication date: May 2, 2019Applicants: KIRIN HOLDINGS KABUSHIKI KAISHA, THE UNIVERSITY OF TOKYOInventors: Toshikazu TSUJI, Kumiko IKADO, Seiichi UCHIYAMA, Kyoko KAWAMOTO
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Publication number: 20190113505Abstract: There is provided a method for introducing a temperature-sensitive probe comprising a copolymer, which comprises a thermoresponsive unit and a fluorescent unit, into a cell, and the method using the copolymer further comprising a cationic unit as the temperature-sensitive probe, and the method comprising the step of mixing the copolymer with the cell in a solvent. The copolymer can be preferably used as a fluorescence temperature sensor which measures intracellular temperature since the copolymer has a cationic group and thus enters into a cell without using a special method.Type: ApplicationFiled: December 13, 2018Publication date: April 18, 2019Applicants: KIRIN HOLDINGS KABUSHIKI KAISHA, THE UNIVERSITY OF TOKYOInventors: Toshikazu TSUJI, Kumiko IKADO, Seiichi UCHIYAMA, Kyoko KAWAMOTO
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Patent number: 10191035Abstract: There is provided a method for introducing a temperature-sensitive probe comprising a copolymer, which comprises a thermoresponsive unit and a fluorescent unit, into a cell, and the method using the copolymer further comprising a cationic unit as the temperature-sensitive probe, and the method comprising the step of mixing the copolymer with the cell in a solvent. The copolymer can be preferably used as a fluorescence temperature sensor which measures intracellular temperature since the copolymer has a cationic group and thus enters into a cell without using a special method.Type: GrantFiled: May 20, 2014Date of Patent: January 29, 2019Assignees: KIRIN HOLDINGS KABUSHIKI KAISHA, THE UNIVERSITY OF TOKYOInventors: Toshikazu Tsuji, Kumiko Ikado, Seiichi Uchiyama, Kyoko Kawamoto
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Publication number: 20140342390Abstract: There is provided a method for introducing a temperature-sensitive probe comprising a copolymer, which comprises a thermoresponsive unit and a fluorescent unit, into a cell, and the method using the copolymer further comprising a cationic unit as the temperature-sensitive probe, and the method comprising the step of mixing the copolymer with the cell in a solvent. The copolymer can be preferably used as a fluorescence temperature sensor which measures intracellular temperature since the copolymer has a cationic group and thus enters into a cell without using a special method.Type: ApplicationFiled: May 20, 2014Publication date: November 20, 2014Applicants: THE UNIVERSITY OF TOKYO, KIRIN HOLDINGS KABUSHIKI KAISHAInventors: Toshikazu TSUJI, Kumiko IKADO, Seiichi UCHIYAMA, Kyoko KAWAMOTO
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Patent number: 4270510Abstract: An ignition system for an internal combustion engine having a transistor switch means connected across a primary winding of an ignition coil wherein a base current input terminal of the transistor switch means is connected through a coil to an igniting exciter coil to supply a base current through the coil to the base current input terminal thereby decreasing a power loss at the interruption of a primary current flowing through an ignition coil and operating a transistor in a low power loss region, so that a high voltage may be induced across a secondary winding of an ignition coil.Type: GrantFiled: July 20, 1979Date of Patent: June 2, 1981Assignee: Kokusan Denki Co., Ltd.Inventors: Hirotoshi Nanjo, Toshikazu Tsuji