Patents by Inventor Toshikazu Yagi

Toshikazu Yagi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10329267
    Abstract: The invention addresses the problem of providing a method for producing 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione that is suited to industrial production. The invention provides a method for producing 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione by reacting 3-bromo-3-buten-2-one and 2-hydroxy-1,4-naphthoquinone in the presence of a solvent, then obtaining crystals of 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione by adding an alcohol-based solvent and/or water to the reaction system, and treating the crystals by using a specific adsorbent in the presence of a solvent.
    Type: Grant
    Filed: July 15, 2016
    Date of Patent: June 25, 2019
    Assignee: SUMITOMO DAINIPPON PHARMA CO., LTD.
    Inventors: Toshikazu Yagi, Satoshi Suzuki, Hiroto Tatamidani, Kazuki Hashimoto
  • Publication number: 20180201597
    Abstract: The invention addresses the problem of providing a method for producing 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione that is suited to industrial production. The invention provides a method for producing 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione by reacting 3-bromo-3-buten-2-one and 2-hydroxy-1,4-naphthoquinone in the presence of a solvent, then obtaining crystals of 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione by adding an alcohol-based solvent and/or water to the reaction system, and treating the crystals by using a specific adsorbent in the presence of a solvent.
    Type: Application
    Filed: July 15, 2016
    Publication date: July 19, 2018
    Applicant: Sumitomo Dainippon Pharma Co., Ltd.
    Inventors: Toshikazu YAGI, Satoshi SUZUKI, Hiroto TATAMIDANI, Kazuki HASHIMOTO
  • Patent number: 8598370
    Abstract: The present invention provides a process for producing Droxidopa or a pharmaceutically acceptable salt thereof comprising a step of reacting threo-N-phthaloyl-3-(3,4-dihydroxyphenyl)-L-serine represented by the formula (1) with methylamine, whereby a process for producing threo-3-(3,4-dihydroxyphenyl)-L-serine (common name: Droxidopa), which is useful as an agent for treatment of peripheral orthostatic hypotension or an agent for treatment of Parkinson's disease, with high production efficiency and without requiring troublesome operations.
    Type: Grant
    Filed: June 29, 2010
    Date of Patent: December 3, 2013
    Assignee: Dainippon Sumitomo Pharma Co., Ltd.
    Inventors: Toshikazu Yagi, Koji Koyama, Masanori Itoh
  • Publication number: 20120095256
    Abstract: The present invention provides a process for producing Droxidopa or a pharmaceutically acceptable salt thereof comprising a step of reacting threo-N-phthaloyl-3-(3,4-dihydroxyphenyl)-L-serine represented by the formula (1) with methylamine, whereby a process for producing threo-3-(3,4-dihydroxyphenyl)-L-serine (common name: Droxidopa), which is useful as an agent for treatment of peripheral orthostatic hypotension or an agent for treatment of Parkinson's disease, with high production efficiency and without requiring troublesome operations.
    Type: Application
    Filed: June 29, 2010
    Publication date: April 19, 2012
    Applicant: DAINIPPON SUMITOMO PHARMA CO.,LTD.
    Inventors: Toshikazu Yagi, Koji Koyama, Masanori Itoh
  • Patent number: 7828194
    Abstract: Plate members 17 are respectively rested on first and second tables IA and IB relatively movable toward and away from each other. The plate members 17 are caused to abut against reference positioning members 16a and 16b of reference positioning devices protruded ahead of and over opposing ends 1? of the tables IA and IB so that opposing ends of the plate members 17 are positioned in protrusion ahead of the opposing ends 1? of the tables IA and IB, and the plate members 17 are positioned laterally. Then, the positioned plate members 17 are locked on the tables IA and IB. After the reference positioning devices are retracted, the tables IA and IB are relatively moved toward each other to cause the opposing ends of the plate members 17 to abut together for formation of weld line X.
    Type: Grant
    Filed: March 4, 2010
    Date of Patent: November 9, 2010
    Assignee: IHI Corporation
    Inventors: Kenji Iimura, Tomoo Mizuno, Katsura Oowaki, Hirotaka Kanazawa, Chikamasa Iwamoto, Toshikazu Yagi, Hirotaka Shirai
  • Patent number: 7784666
    Abstract: Plate members 17 are respectively rested on first and second tables 1A and 1B relatively movable toward and away from each other. The plate members 17 are caused to abut against reference positioning members 16a and 16b of reference positioning devices protruded ahead of and over opposing ends 1? of the tables 1A and 1B so that opposing ends of the plate members 17 are positioned ahead of the opposing ends 1? of the tables 1A and 1B, and the plate members 17 are positioned laterally. Then, the positioned plate members 17 are locked on the tables 1A and 1B. After the reference positioning devices are retracted, the tables 1A and 1B are relatively moved toward each other to cause the opposing ends of the plate members 17 to abut together for formation of weld line X.
    Type: Grant
    Filed: June 6, 2005
    Date of Patent: August 31, 2010
    Assignee: IHI Corporation
    Inventors: Kenji Iimura, Tomoo Mizuno, Katsura Oowaki, Hirotaka Kanazawa, Chikamasa Iwamoto, Toshikazu Yagi, Hirotaka Shirai
  • Publication number: 20100187292
    Abstract: It is made possible to position plate members to be butt-welded for formation of weld line in a small amount of time so as to enhance working capacity of butt welding. Plate members 17 are respectively rested on first and second tables 1A and 1B relatively movable toward and away from each other. The plate members 17 are caused to abut against reference positioning members 16a and 16b of reference positioning devices protruded ahead of and over opposing ends 1? of the tables 1A and 1B so that opposing ends of the plate members 17 are positioned in protrusion ahead of the opposing ends 1? of the tables 1A and 1B, and the plate members 17 are positioned laterally. Then, the positioned plate members 17 are locked on the tables 1A and 1B. After the reference positioning devices are retracted, the tables 1A and 1B are relatively moved toward each other to cause the opposing ends of the plate members 17 to abut together for formation of weld line X.
    Type: Application
    Filed: March 4, 2010
    Publication date: July 29, 2010
    Applicant: IHI Corporation
    Inventors: Kenji IIMURA, Tomoo Mizuno, Katsura Oowaki, Hirotaka Kanazawa, Chikamasa Iwamoto, Toshikazu Yagi, Hirotaka Shirai
  • Publication number: 20080265007
    Abstract: It is made possible to position plate members to be butt-welded for formation of weld line in a small amount of time so as to enhance working capacity of butt welding. Plate members 17 are respectively rested on first and second tables 1A and 1B relatively movable toward and away from each other. The plate members 17 are caused to abut against reference positioning members 16a and 16b of reference positioning devices protruded ahead of and over opposing ends 1? of the tables 1A and 1B so that opposing ends of the plate members 17 are positioned in protrusion ahead of the opposing ends 1? of the tables 1A and 1B, and the plate members 17 are positioned laterally. Then, the positioned plate members 17 are locked on the tables 1A and 1B. After the reference positioning devices are retracted, the tables 1A and 1B are relatively moved toward each other to cause the opposing ends of the plate members 17 to abut together for formation of weld line X.
    Type: Application
    Filed: June 6, 2005
    Publication date: October 30, 2008
    Applicant: IHI Corporation
    Inventors: Kenji Iimura, Tomoo Mizuno, Katsura Oowaki, Hirotaka Kanazawa, Chikamasa Iwamoto, Toshikazu Yagi, Hirotaka Shirai
  • Patent number: 7425427
    Abstract: A method for preparing corneocytes specimen, which comprises stripping off corneocytes from the surface of a skin using an adhesive material, staining the corneocytes in a solution of stain in solvent containing a water-miscible organic solvent, and mounting the stained corneocytes into an oil and fat constituent and/or composition that is liquid at 1 atm, 25° C.
    Type: Grant
    Filed: May 18, 2004
    Date of Patent: September 16, 2008
    Assignee: Pola Chemical Industries Inc.
    Inventors: Yoshikazu Hirai, Kenya Hirayama, Nobuo Kashibuchi, Sonoko Kawasaki, Hiroaki Imai, Yoko Zemba, Takanori Takahashi, Seiichi Takaya, Chikako Kamata, Toshikazu Yagi, Jiro Yabusaki
  • Patent number: 7421105
    Abstract: A method for preparing corneocites specimen, which comprises stripping off corneocites from the surface of a skin using an adhesive material, staining the corneocites in a solution of stain in solvent containing a water-miscible organic solvent, and mounting the stained corneocites into an oil and fat constituent and/or composition that is liquid at 1 atm, 25° C.
    Type: Grant
    Filed: May 18, 2004
    Date of Patent: September 2, 2008
    Assignee: Pola Chemical Industries Inc.
    Inventors: Yoshikazu Hirai, Kenya Hirayama, Nobuo Kashibuchi, Sonoko Kawasaki, Hiroaki Imai, Yoko Zemba, Takanori Takahashi, Seiichi Takaya, Chikako Kamata, Toshikazu Yagi, Jiro Yabusaki
  • Publication number: 20040224381
    Abstract: A method for preparing corneocites specimen, which comprises stripping off corneocites from the surface of a skin using an adhesive material, staining the corneocites in a solution of stain in solvent containing a water-miscible organic solvent, and mounting the stained corneocites into an oil and fat constituent and/or composition that is liquid at 1 atm, 25° C.
    Type: Application
    Filed: May 18, 2004
    Publication date: November 11, 2004
    Inventors: Yoshikazu Hirai, Kenya Hirayama, Nobuo Kashibuchi, Sonoko Kawasaki, Hiroaki Imai, Yoko Zemba, Takanori Takahashi, Seiichi Takaya, Chikako Kamata, Toshikazu Yagi, Jiro Yabusaki
  • Publication number: 20040214336
    Abstract: A method for preparing corneocites specimen, which comprises stripping off corneocites from the surface of a skin using an adhesive material, staining the corneocites in a solution of stain in solvent containing a water-miscible organic solvent, and mounting the stained corneocites into an oil and fat constituent and/or composition that is liquid at 1 atm, 25° C.
    Type: Application
    Filed: May 18, 2004
    Publication date: October 28, 2004
    Inventors: Yoshikazu Hirai, Kenya Hirayama, Nobuo Kashibuchi, Sonoko Kawasaki, Hiroaki Imai, Yoko Zemba, Takanori Takahashi, Seiichi Takaya, Chikako Kamata, Toshikazu Yagi, Jiro Yabusaki
  • Publication number: 20030087333
    Abstract: A method for preparing corneocites specimen, which comprises stripping off corneocites from the surface of a skin using an adhesive material, staining the corneocites in a solution of stain in solvent containing a water-miscible organic solvent, and mounting the stained corneocites into an oil and fat constituent and/or composition that is liquid at 1 atm, 25° C.
    Type: Application
    Filed: April 15, 2002
    Publication date: May 8, 2003
    Inventors: Yoshikazu Hirai, Kenya Hirayama, Nobuo Kashibuchi, Sonoko Kawasaki, Hiroaki Imai, Yoko Zemba, Takanori Takahashi, Seiichi Takaya, Chikako Kamata, Toshikazu Yagi, Jiro Yabusaki
  • Patent number: 6348617
    Abstract: The present invention is directed to a method for purifying pyruvic acid compounds, which method comprises reacting a pyruvic acid compound of general formula (I): wherein R1 is an optionally substituted lower alkyl group, a lower alkenyl group, a lower alkynyl group, a cycloalkyl group, an aryl group, or a heterocyclic group, and R2 is a lower alkyl group, with a bisulfite of general formula (II): MHSO3  (II) wherein M is NH4 or an alkali metal, to give a bisulfite adduct of the pyruvic acid compound and then decomposing the adduct with an acid. According to the present invention, pyruvic acid compounds can be purified by simple and easy procedures without using purification techniques such as distillation or column chromatography, and the above method is advantageous as a process for the production on an industrial scale.
    Type: Grant
    Filed: June 21, 1999
    Date of Patent: February 19, 2002
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Hideki Ushio, Motoo Hazama, Toshikazu Yagi, Akihiko Nakamura, Masahiko Mizuno
  • Patent number: 5573989
    Abstract: A process for producing an olefin oxide comprising oxidizing a corresponding lower olefin with molecular oxygen in the gas phase in the presence of a crystalline metallosilicate having supported thereon at least one salt selected from the group consisting of alkali metal salts of nitric acid, alkaline earth metal salts of nitric acid, silver salts of nitric acid and silver salts of nitrous acid. Said process can produce an olefin oxide at a high selectivity.
    Type: Grant
    Filed: August 5, 1994
    Date of Patent: November 12, 1996
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Keisuke Sugita, Toshikazu Yagi
  • Patent number: 5525741
    Abstract: A process for producing an olefin oxide comprising oxidizing a corresponding lower olefin with molecular oxygen in the gas phase in the presence of a crystalline metallosilicate having supported thereon at least one salt selected from the group consisting of alkali metal salts of nitric acid, alkaline earth metal salts of nitric acid, silver salts of nitric acid and silver salts of nitrous acid. Said process can produce an olefin oxide at a high selectivity.
    Type: Grant
    Filed: April 24, 1995
    Date of Patent: June 11, 1996
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Keisuke Sugita, Toshikazu Yagi
  • Patent number: D329355
    Type: Grant
    Filed: February 14, 1991
    Date of Patent: September 15, 1992
    Assignee: Jex Co., Ltd.
    Inventor: Toshikazu Yagi
  • Patent number: D341892
    Type: Grant
    Filed: February 14, 1991
    Date of Patent: November 30, 1993
    Assignee: Jex Co., Ltd.
    Inventor: Toshikazu Yagi