Abstract: A method for estimating a cause of coagulation time prolongation includes 1) detecting a coagulation reaction end point Pe in a coagulation reaction curve of a subject blood specimen having a prolonged coagulation time; 2) calculating T(X), wherein T(X) represents a measurement point or time at which the coagulation reaction curve reaches X % of Pe, and X is a variable of greater than 0 and equal to or less than 100; and 3) estimating a cause of coagulation time prolongation of the subject blood specimen based on a form of T(X).

Abstract: Provided is a blood coagulation reaction analysis method. The method includes measuring a blood coagulation reaction of a subject specimen and acquiring first data for calculating a blood coagulation time of the subject specimen and second data for estimating a blood coagulation abnormality factor of the subject specimen, wherein the acquiring of the second data includes: obtaining a first derivative V(i) of a coagulation reaction curve R(i); and determining a point pk where V(i) assumes Xk before reaching a maximum value of V(i), Vmax, and a point qk where V(i) assumes Xk after reaching Vmax.

Abstract: A method for detecting a blood coagulation reaction, comprising: 1) measuring a blood coagulation reaction of a subject blood specimen and acquiring a first derivative V(i) of a coagulation reaction up to a latest measurement point; 2) calculating areas under the curve (AUCs) before the peak and after the peak, wherein a top of the peak of V(i) is cVmax(k) which is a maximum value of V(i); and 3) detecting cVmax(k) as Vmax which is a true maximum value of V(i) when the pre-peak AUC and the post-peak AUC are both equal to or higher than a first threshold AUCth1 and a period L during which the pre-peak AUC and the post-peak AUC have continued to be a constant value reaches a predetermined length.

Abstract: Provided is a blood analysis method including: acquiring coagulation reaction data on a blood specimen; calculating a parameter related to a centroid point from a differential curve of the coagulation reaction data; and evaluating coagulation properties of the blood specimen using the parameter related to the centroid point.

Abstract: Provided is a blood coagulation time measurement method. In the method, reaction X(i) is acquired through smoothing and zero-point adjustment of a measured value P(i) for coagulation reaction of a blood specimen, and then an integration ratio Z(i) of the reaction X(i) is acquired. These values are used to calculate an index for coagulation time Tc calculation, and it is determined whether or not the index satisfies the criteria. The procedure is sequentially repeated until an index that satisfies the criteria is obtained.

Abstract: Provided is a method for accurately measuring coagulation time of blood specimens showing various coagulation reactions. The method for measuring blood coagulation time includes acquiring coagulation reaction P(i) of a subject specimen and reaction velocity V(i); calculating a calculation start point Te by using the ratio of the V(i) to maximum reaction velocity as an index; and calculating time Tc giving P(Tc)=P(Te)×N % (0<N<100) and determining the Tc as the blood coagulation time.

Abstract: Provided is a method for accurately measuring coagulation time of blood samples showing various coagulation reactions. The method for measuring blood coagulation time includes measuring coagulation reaction of a sample prepared by mixing a subject specimen and a coagulation time measurement reagent; calculating weighted average time of a calculation target area of a waveform related to coagulation velocity from the resulting measurement data; and determining the weighted average time as blood coagulation time.

Abstract: An APTT prolongation factor estimation system includes one or more facilities each including an analyzer which measures a blood coagulation reaction of a subject blood specimen, a database which stores data on a blood coagulation reaction and APTT prolongation factor of blood specimens, and a computer which estimates an APTT prolongation factor of the subject blood specimen based on the data on the blood coagulation reaction from the analyzer and the data stored in the database. The facilities each further includes a data transmission unit which transmits, to the computer, the data on the blood coagulation reaction of the subject blood specimen obtained by the analyzer, and a data reception unit which receives a result of the estimation of the APTT prolongation factor, which is obtained by the computer, regarding the subject blood specimen measured by each of the analyzers.

Abstract: An automatic analysis apparatus is capable of stirring a reagent without reducing the analysis processing capacity. The automatic analysis apparatus includes a reagent table that is rotatable and that holds reagent vessels, and a plurality of magnets are disposed below the reagent table, with orientations of magnetic poles of the magnets fixed, along a movement path of the reagent vessels moving on a circumference when the reagent table is rotationally driven. The plurality of magnets is disposed such that the fixed orientations of the magnetic poles of the magnets vary along the movement path, and act a magnetic force on a stirring bar in each of the reagent vessels. When the reagent table is rotated and the reagent vessels pass above the magnets, the stirring bar in each of the reagent vessels is rotated or oscillated by the magnetic force received from the magnets, to stir the reagent.

Abstract: A stirring bar capable of reducing a dead space inside a container and efficiently using a contained liquid. A stirring bar introduced into a reagent bottle having an opening mouth portion and rotated by a magnetic force transmitted from the outside of the reagent bottle so as to stir a reagent in the reagent bottle, including: a magnet having a predetermined shape; and a main body including a magnetic member therein, in which the main body is provided with a through-hole which has an opening area corresponding to an opened area and is able to receive a nozzle in the opening area, and in which the stirring bar in a rotation state is able to receive the nozzle in a circular center area narrower than the opening area and having a diameter of an opening width of a center portion of the opening area.

Abstract: Provided is a method by which a titer of a coagulation factor inhibitor can be measured simply and in a short time. The present invention relates to a method for measuring a titer of a coagulation factor inhibitor. The method includes: preparing a mixed specimen containing a subject blood specimen and a normal blood specimen; heating the mixed specimen and acquiring a coagulation reaction curve for the heated mixed specimen; acquiring a coagulation reaction curve for the mixed specimen that has not been heated; calculating a parameter related to the coagulation reaction curve of the mixed specimen that has not been heated as a first parameter; calculating a parameter related to the coagulation reaction curve of the heated mixed specimen as a second parameter; and calculating a titer of a coagulation factor inhibitor in the subject blood specimen on the basis of the ratio or the difference between the first parameter and the second parameter.

Abstract: An automatic analysis apparatus includes a rack identification information reading unit for reading rack identification information assigned to a specimen rack, a CTS drive unit for executing a piercing operation of piercing the stopper of the specimen vessel having the stopper at a specimen suction position by a piercer and sucking a specimen in the specimen vessel having the stopper by a specimen suction nozzle passing through a hole of the stopper formed by the piercer, a piercing condition setting unit for setting a piercing operation condition by the piercer for the specimen vessel having the stopper loaded in the specimen rack based on the rack identification information read by the rack identification information reading unit, and a control unit for controlling an operation of the CTS drive unit based on a set piercing operation condition.

Abstract: Independent automatic analysis apparatuses include controllers for controlling an operation of each unit of the apparatus, reagent-related information input/output units for inputting and outputting reagent-related information I related to a reagent installed in a reagent supply portion including a reagent in use, reagent vessel detection units for detecting that a reagent vessel is taken in and/or taken out of the automatic analysis apparatus, and reagent-related information reading units for reading reagent-related information from the reagent and/or reagent vessel in use detected to be taken in by the reagent vessel detection unit. The controllers compare the reagent-related information read by the reagent-related information reading unit with the reagent-related information input to the reagent-related information input/output units, and control an operation of the reagent supply portion based on a comparison result thereof.

Abstract: An automatic authentication method includes an identification code reading step of reading an identification code assigned to an article from an apparatus side. The method includes a password part generation reproduction step of reproducing a procedure for generating a second password part according to a predetermined random character creation rule based on characters included in an identification information part and a first password part of the read identification code. The method includes a password collation step of collating the second password part generated by the reproduction with a second password part of the identification code of the article read by the identification code reading step. The method includes authentication steps of authenticating the article as a genuine product when the collated second password parts match each other.

Abstract: To provide a method for analyzing coagulation characteristics of a blood specimen. To provide a method for analyzing a blood specimen, including: acquiring a waveform related to a coagulation rate or coagulation acceleration of a sample obtained by mixing a subject blood specimen with a reagent for measuring coagulation time; extracting multiple parameters characterizing the waveform related to a coagulation rate or a coagulation acceleration; and determining an activity level or activity abnormality of a coagulation factor in the subject blood specimen on the basis of the multiple parameters.

Abstract: Excellent analysis of a coagulation characteristic of a blood sample is implemented. A method for analyzing a coagulation characteristic of a blood specimen according to the present invention includes: acquiring data for a coagulation reaction curve indicating a coagulation reaction amount of a mixed solution containing a blood sample and a reagent with respect to reaction time; calculating data for a differential curve obtained by differentiating the coagulation reaction curve; calculating information related to a center-of-gravity point of the differential curve; and evaluating the coagulation characteristic of the blood sample using the information related to the center-of-gravity point.

Abstract: An autosampler includes an installation part allowing a plurality of racks to be installed therein, a transfer part capable of holding one rack installed in the installation part and moving back and forth in a first movement direction along an installation direction, and a rack transport path used to move the rack held by the transfer part back and forth in a second movement direction intersecting the first movement direction are included. The transfer part is moved forward in the first movement direction to transfer the rack present in the installation part to a side of the rack transport path, and the transfer part is moved backward in the first movement direction to send the rack present in the rack transport path back to a side of the installation part.

Abstract: An autosampler includes an installation part for racks to be installed therein, an installation part movement mechanism which moves the installation part back and forth in an installation part transport direction and successively transfers the racks to a transport position, and a rack movement mechanism which moves the racks at the transport position forward in a rack transport direction to send out the racks, and moves the racks backward to send the racks back to the installation part after specimens are sampled from the specimen containers held in the racks. Information about inspection item content is accumulated using the installation part, and an accumulation result is compared with the amount of measurement resources, so that sampling is started after it is determined that the measurement resources are not insufficient.

Abstract: Provided is a sampling mechanism capable of performing sampling through proper perforation with respect to a plug body. A perforating body has a first piercer inserted into a cap and penetrating the cap with a tip closed and a second piercer formed in a tubular shape, disposed outside the first piercer, approaching the cap together with the first piercer by causing the first piercer to protrude downward, reaching the cap after the first piercer reaches the cap, and penetrating the cap by being inserted into the cap. A probe is passed through the second piercer remaining after retraction of the first piercer.

Abstract: A stirring bar capable of reducing a dead space inside a container and efficiently using a contained liquid. A stirring bar introduced into a reagent bottle having an opening mouth portion and rotated by a magnetic force transmitted from the outside of the reagent bottle so as to stir a reagent in the reagent bottle, including: a magnet having a predetermined shape; and a main body including a magnetic member therein, in which the main body is provided with a through-hole which has an opening area corresponding to an opened area and is able to receive a nozzle in the opening area, and in which the stirring bar in a rotation state is able to receive the nozzle in a circular center area narrower than the opening area and having a diameter of an opening width of a center portion of the opening area.