Patents by Inventor Toshiki Kawabe

Toshiki Kawabe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9017536
    Abstract: An object of the present invention is to provide a method for measuring hemoglobin that enables short-time, high-accuracy measurement of hemoglobin, in particular stable hemoglobin A1c, which is used as a diagnostic indicator of diabetes mellitus, and an electrophoresis apparatus that is suitably used in this measurement method. The present invention provides a method for measuring hemoglobins using electrophoresis, which includes: using a migration path having an inner surface coated with a cationic substance to be immobilized on the inner surface or a migration path having an inner surface made of a cationic material; and using a buffer solution containing a water-soluble polymer having an anionic group as an electrophoresis buffer solution.
    Type: Grant
    Filed: December 26, 2007
    Date of Patent: April 28, 2015
    Assignee: Sekisui Chemical Co., Ltd.
    Inventors: Kazuyuki Oishi, Izumi Omoto, Eriko Kusaka, Toshiki Kawabe
  • Patent number: 8257567
    Abstract: An object of the present invention is to provide a method for measuring hemoglobin using electrophoresis, in particular a method for measuring hemoglobin that enables high accuracy measurement of stable hemoglobin A1c and a method for simultaneously measuring stable hemoglobin A1c and abnormal hemoglobins. The present invention provides a method for measuring hemoglobin using electrophoresis, which comprises: immobilizing an ionic polymer on an inner surface of a migration path; and using a buffer solution containing a sulfated polysaccharide.
    Type: Grant
    Filed: October 12, 2007
    Date of Patent: September 4, 2012
    Assignee: Sekisui Chemical Co., Ltd.
    Inventors: Kazuyuki Oishi, Izumi Omoto, Toshiki Kawabe, Eriko Kusaka
  • Publication number: 20100282607
    Abstract: An object of the present invention is to provide a method for measuring hemoglobin using electrophoresis, in particular a method for measuring hemoglobin that enables high accuracy measurement of stable hemoglobin A1c and a method for simultaneously measuring stable hemoglobin A1c and abnormal hemoglobins. The present invention provides a method for measuring hemoglobin using electrophoresis, which comprises: immobilizing an ionic polymer on an inner surface of a migration path; and using a buffer solution containing a sulfated polysaccharide.
    Type: Application
    Filed: October 12, 2007
    Publication date: November 11, 2010
    Inventors: Kazuyuki Oishi, Izumi Omoto, Toshiki Kawabe, Eriko Kusaka
  • Publication number: 20100006436
    Abstract: An object of the present invention is to provide a method for measuring hemoglobin that enables short-time, high-accuracy measurement of hemoglobin, in particular stable hemoglobin A1c, which is used as a diagnostic indicator of diabetes mellitus, and an electrophoresis apparatus that is suitably used in this measurement method. The present invention provides a method for measuring hemoglobins using electrophoresis, which includes: using a migration path having an inner surface coated with a cationic substance to be immobilized on the inner surface or a migration path having an inner surface made of a cationic material; and using a buffer solution containing a water-soluble polymer having an anionic group as an electrophoresis buffer solution.
    Type: Application
    Filed: December 26, 2007
    Publication date: January 14, 2010
    Inventors: Kazuyuki Oishi, Izumi Omoto, Eriko Kusaka, Toshiki Kawabe
  • Publication number: 20030176609
    Abstract: This invention provides a hydrophobic substance adsorbent capable of adsorbing hydrophobic substances, in particular hormonally active agents, polycyclic aromatic hydrocarbons or volatile organic compounds, with high efficiency, allowing them to be desorbed with ease and, furthermore, preventing these substances from being eluted.
    Type: Application
    Filed: November 6, 2002
    Publication date: September 18, 2003
    Inventors: Kazuyuki Oishi, Toshiki Kawabe
  • Patent number: 6488857
    Abstract: A method for separating hemoglobin A2 from a hemoglobin mixture according to a cation exchange liquid chromatography characterized that at least two types of eluents are used including an eluent (hereinafter referred to as “eluent A”) for elution of faster hemoglobins than hemoglobin A0 and an eluent (hereinafter referred to as “eluent B”) for elution of hemoglobin A0 and slower hemoglobins than hemoglobin A0, and that the eluent A has a pH of 4.0-6.0 and the eluent B is maintained at a pH of at least 0.5 higher than that of the eluent A.
    Type: Grant
    Filed: April 18, 2001
    Date of Patent: December 3, 2002
    Assignee: Sekisui Chemical Co., Ltd.
    Inventors: Kazuhiko Shimada, Yuji Setoguchi, Kazuyuki Oishi, Toshiki Kawabe
  • Patent number: 6428704
    Abstract: A method for determining hemoglobins is provided which is suitable for determination of stable hemoglobin A1c. A method for determining hemoglobins by cation exchange liquid chromatography wherein an eluent is used containing a chaotropic ion and further an inorganic acid, an organic acid and/or any salt thereof having a buffer capacity in the 4.0-6.8 pH range.
    Type: Grant
    Filed: February 7, 2001
    Date of Patent: August 6, 2002
    Assignee: Sekisui Chemical Co., Ltd.
    Inventors: Yuji Setoguchi, Kazuyuki Oishi, Kazuhiko Shimada, Toshiki Kawabe, Takayuki Oka
  • Patent number: 5453379
    Abstract: An eliminating agent used for the measurement of the amount of glycosylated hemoglobins in a blood sample is provided. The eliminating agent comprises condensed phosphoric acids and/or the salts thereof as the main ingredient, wherein the agent eliminates labile glycosylated hemoglobin A.sub.1c into non-glycosylated hemoglobin and glucose. There is also provided a reagent comprising the eliminating agent and a hemolysis agent, which is used for the measurement of the amount of glycosylated hemoglobins; and an eluent comprising the eliminating agent, which is used for the separation of glycosylated hemoglobins in blood samples by ion-exchange chromatography to measure the amount of the glycosylated hemoglobins. A method for measuring the amount of glycosylated hemoglobin A.sub.1c in a blood sample involves the use of the eliminating agent, the reagent comprising the eliminating agent and the hemolysis agent, and/or the eluent.
    Type: Grant
    Filed: September 3, 1991
    Date of Patent: September 26, 1995
    Assignee: Sekisui Kagaku Kogyo Kabushiki Kaisha
    Inventors: Kazutoshi Yamazaki, Masahiro Takechi, Toshiki Kawabe, Masayuki Yokoi
  • Patent number: 5292818
    Abstract: According to the present invention, a production method of a carrier appropriate for cation exchange liquid chromatography and a method for determining glycosylated hemoglobins using the carrier obtained by the production method are provided.The production method of the carrier comprises the steps of providing hydrophobic particles to which a polymerization initiator is adhered; and adding a polymerizable monomer having a carboxyl group to an aqueous dispersion in which the hydrophobic crosslinked polymer particles are dispersed and polymerizing the monomer on surfaces of the hydrophobic crosslinked polymer particles, thereby obtaining polymer particles the surfaces of which are coated with polymer layers having carboxyl groups.
    Type: Grant
    Filed: July 20, 1982
    Date of Patent: March 8, 1994
    Assignee: Sekisui Kagaku Kogyo Kabushiki Kaisha
    Inventors: Kazuyuki Oishi, Kazutoshi Yamazaki, Toshiki Kawabe, Masahiro Takechi, Makoto Takahara
  • Patent number: 5292663
    Abstract: An eliminating agent used for the measurement of the amount of glycosylated hemoglobins in a blood sample is provided. The eliminating agent comprises condensed phosphoric acids and/or the salts thereof as the main ingredient, wherein the agent eliminates labile glycosylated hemoglobin A.sub.1c into non-glycosylated hemoglobin and glucose. There is also provided a reagent comprising the eliminating agent and a hemolysis agent, which is used for the measurement of the amount of glycosylated hemoglobins; and an eluent comprising the eliminating agent, which is used for the separation of glycosylated hemoglobins in blood samples by ion-exchange chromatography to measure the amount of the glycosylated hemoglobins. A method for measuring the amount of glycosylated hemoglobin A.sub.1c in a blood sample involves the use of the eliminating agent, the reagent comprising the eliminating agent and the hemolysis agent, and/or the eluent.
    Type: Grant
    Filed: May 3, 1993
    Date of Patent: March 8, 1994
    Assignee: Sekisui Kagaku Kogyo Kabushiki Kaisha
    Inventors: Kazutoshi Yamazaki, Masahiro Takechi, Toshiki Kawabe, Masayuki Yokoi
  • Patent number: D860473
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: September 17, 2019
    Assignee: SEKISUI MEDICAL CO., LTD.
    Inventors: Toshiki Kawabe, Akiko Matsumoto, Hiroshi Takahashi
  • Patent number: D860474
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: September 17, 2019
    Assignee: SEKISUI MEDICAL CO., LTD.
    Inventors: Toshiki Kawabe, Akiko Matsumoto, Hiroshi Takahashi