Patents by Inventor Toshiki Kawabe

Toshiki Kawabe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240027476
    Abstract: Provided is a blood coagulation reaction analysis method. The method includes measuring a blood coagulation reaction of a subject specimen and acquiring first data for calculating a blood coagulation time of the subject specimen and second data for estimating a blood coagulation abnormality factor of the subject specimen, wherein the acquiring of the second data includes: obtaining a first derivative V(i) of a coagulation reaction curve R(i); and determining a point pk where V(i) assumes Xk before reaching a maximum value of V(i), Vmax, and a point qk where V(i) assumes Xk after reaching Vmax.
    Type: Application
    Filed: September 8, 2021
    Publication date: January 25, 2024
    Applicant: SEKISUI MEDICAL CO., LTD.
    Inventors: Toshiki KAWABE, Yukio ODA
  • Publication number: 20230393156
    Abstract: A method for detecting a blood coagulation reaction, comprising: 1) measuring a blood coagulation reaction of a subject blood specimen and acquiring a first derivative V(i) of a coagulation reaction up to a latest measurement point; 2) calculating areas under the curve (AUCs) before the peak and after the peak, wherein a top of the peak of V(i) is cVmax(k) which is a maximum value of V(i); and 3) detecting cVmax(k) as Vmax which is a true maximum value of V(i) when the pre-peak AUC and the post-peak AUC are both equal to or higher than a first threshold AUCth1 and a period L during which the pre-peak AUC and the post-peak AUC have continued to be a constant value reaches a predetermined length.
    Type: Application
    Filed: October 29, 2021
    Publication date: December 7, 2023
    Applicant: SEKISUI MEDICAL CO., LTD.
    Inventors: Toshiki KAWABE, Kengo ONISHI
  • Publication number: 20230341371
    Abstract: Provided is a blood analysis method including: acquiring coagulation reaction data on a blood specimen; calculating a parameter related to a centroid point from a differential curve of the coagulation reaction data; and evaluating coagulation properties of the blood specimen using the parameter related to the centroid point.
    Type: Application
    Filed: July 15, 2021
    Publication date: October 26, 2023
    Applicant: SEKISUI MEDICAL CO., LTD.
    Inventors: Toshiki KAWABE, Yukio ODA
  • Publication number: 20230341423
    Abstract: Provided is a blood coagulation time measurement method. In the method, reaction X(i) is acquired through smoothing and zero-point adjustment of a measured value P(i) for coagulation reaction of a blood specimen, and then an integration ratio Z(i) of the reaction X(i) is acquired. These values are used to calculate an index for coagulation time Tc calculation, and it is determined whether or not the index satisfies the criteria. The procedure is sequentially repeated until an index that satisfies the criteria is obtained.
    Type: Application
    Filed: December 25, 2020
    Publication date: October 26, 2023
    Applicant: SEKISUI MEDICAL CO., LTD.
    Inventor: Toshiki KAWABE
  • Publication number: 20230213497
    Abstract: Provided is a method for accurately measuring coagulation time of blood specimens showing various coagulation reactions. The method for measuring blood coagulation time includes acquiring coagulation reaction P(i) of a subject specimen and reaction velocity V(i); calculating a calculation start point Te by using the ratio of the V(i) to maximum reaction velocity as an index; and calculating time Tc giving P(Tc)=P(Te)√óN % (0<N<100) and determining the Tc as the blood coagulation time.
    Type: Application
    Filed: April 7, 2021
    Publication date: July 6, 2023
    Applicant: SEKISUI MEDICAL CO., LTD.
    Inventor: Toshiki KAWABE
  • Publication number: 20230152335
    Abstract: Provided is a method for accurately measuring coagulation time of blood samples showing various coagulation reactions. The method for measuring blood coagulation time includes measuring coagulation reaction of a sample prepared by mixing a subject specimen and a coagulation time measurement reagent; calculating weighted average time of a calculation target area of a waveform related to coagulation velocity from the resulting measurement data; and determining the weighted average time as blood coagulation time.
    Type: Application
    Filed: March 5, 2021
    Publication date: May 18, 2023
    Applicant: SEKISUI MEDICAL CO., LTD.
    Inventor: Toshiki KAWABE
  • Publication number: 20220373565
    Abstract: An APTT prolongation factor estimation system includes one or more facilities each including an analyzer which measures a blood coagulation reaction of a subject blood specimen, a database which stores data on a blood coagulation reaction and APTT prolongation factor of blood specimens, and a computer which estimates an APTT prolongation factor of the subject blood specimen based on the data on the blood coagulation reaction from the analyzer and the data stored in the database. The facilities each further includes a data transmission unit which transmits, to the computer, the data on the blood coagulation reaction of the subject blood specimen obtained by the analyzer, and a data reception unit which receives a result of the estimation of the APTT prolongation factor, which is obtained by the computer, regarding the subject blood specimen measured by each of the analyzers.
    Type: Application
    Filed: June 19, 2020
    Publication date: November 24, 2022
    Applicants: SEKISUI MEDICAL CO., LTD., PUBLIC UNIVERSITY CORPORATION NARA MEDICAL UNIVERSITY
    Inventors: Toshiki KAWABE, Yukio ODA, Midori SHIMA, Keiji NOGAMI, Kenichi OGIWARA, Naruto SHIMONISHI
  • Publication number: 20220349911
    Abstract: An automatic analysis apparatus is capable of stirring a reagent without reducing the analysis processing capacity. The automatic analysis apparatus includes a reagent table that is rotatable and that holds reagent vessels, and a plurality of magnets are disposed below the reagent table, with orientations of magnetic poles of the magnets fixed, along a movement path of the reagent vessels moving on a circumference when the reagent table is rotationally driven. The plurality of magnets is disposed such that the fixed orientations of the magnetic poles of the magnets vary along the movement path, and act a magnetic force on a stirring bar in each of the reagent vessels. When the reagent table is rotated and the reagent vessels pass above the magnets, the stirring bar in each of the reagent vessels is rotated or oscillated by the magnetic force received from the magnets, to stir the reagent.
    Type: Application
    Filed: July 7, 2022
    Publication date: November 3, 2022
    Inventors: Toshiki KAWABE, Tomohisa NISHIO, Hirotoshi MATSUSHITA, Shota TAKIMORI, Toyomi YAMAGUCHI
  • Patent number: 11471843
    Abstract: A stirring bar capable of reducing a dead space inside a container and efficiently using a contained liquid. A stirring bar introduced into a reagent bottle having an opening mouth portion and rotated by a magnetic force transmitted from the outside of the reagent bottle so as to stir a reagent in the reagent bottle, including: a magnet having a predetermined shape; and a main body including a magnetic member therein, in which the main body is provided with a through-hole which has an opening area corresponding to an opened area and is able to receive a nozzle in the opening area, and in which the stirring bar in a rotation state is able to receive the nozzle in a circular center area narrower than the opening area and having a diameter of an opening width of a center portion of the opening area.
    Type: Grant
    Filed: June 25, 2020
    Date of Patent: October 18, 2022
    Assignee: SEKISUI MEDICAL CO., LTD.
    Inventor: Toshiki Kawabe
  • Publication number: 20220326262
    Abstract: Provided is a method by which a titer of a coagulation factor inhibitor can be measured simply and in a short time. The present invention relates to a method for measuring a titer of a coagulation factor inhibitor. The method includes: preparing a mixed specimen containing a subject blood specimen and a normal blood specimen; heating the mixed specimen and acquiring a coagulation reaction curve for the heated mixed specimen; acquiring a coagulation reaction curve for the mixed specimen that has not been heated; calculating a parameter related to the coagulation reaction curve of the mixed specimen that has not been heated as a first parameter; calculating a parameter related to the coagulation reaction curve of the heated mixed specimen as a second parameter; and calculating a titer of a coagulation factor inhibitor in the subject blood specimen on the basis of the ratio or the difference between the first parameter and the second parameter.
    Type: Application
    Filed: April 23, 2020
    Publication date: October 13, 2022
    Applicants: SEKISUI MEDICAL CO., LTD., PUBLIC UNIVERSITY CORPORATION NARA MEDICAL UNIVERSITY
    Inventors: Toshiki KAWABE, Yukio ODA, Mari EMMI, Midori SHIMA, Keiji NOGAMI, Kenichi OGIWARA, Naruto SHIMONISHI
  • Publication number: 20220221478
    Abstract: Independent automatic analysis apparatuses include controllers for controlling an operation of each unit of the apparatus, reagent-related information input/output units for inputting and outputting reagent-related information I related to a reagent installed in a reagent supply portion including a reagent in use, reagent vessel detection units for detecting that a reagent vessel is taken in and/or taken out of the automatic analysis apparatus, and reagent-related information reading units for reading reagent-related information from the reagent and/or reagent vessel in use detected to be taken in by the reagent vessel detection unit. The controllers compare the reagent-related information read by the reagent-related information reading unit with the reagent-related information input to the reagent-related information input/output units, and control an operation of the reagent supply portion based on a comparison result thereof.
    Type: Application
    Filed: March 30, 2022
    Publication date: July 14, 2022
    Inventors: Toshiki KAWABE, Kosuke OGASAWARA, Yumi IIJIMA
  • Publication number: 20220222685
    Abstract: An automatic authentication method includes an identification code reading step of reading an identification code assigned to an article from an apparatus side. The method includes a password part generation reproduction step of reproducing a procedure for generating a second password part according to a predetermined random character creation rule based on characters included in an identification information part and a first password part of the read identification code. The method includes a password collation step of collating the second password part generated by the reproduction with a second password part of the identification code of the article read by the identification code reading step. The method includes authentication steps of authenticating the article as a genuine product when the collated second password parts match each other.
    Type: Application
    Filed: March 29, 2022
    Publication date: July 14, 2022
    Inventor: Toshiki KAWABE
  • Publication number: 20220221479
    Abstract: An automatic analysis apparatus includes a rack identification information reading unit for reading rack identification information assigned to a specimen rack, a CTS drive unit for executing a piercing operation of piercing the stopper of the specimen vessel having the stopper at a specimen suction position by a piercer and sucking a specimen in the specimen vessel having the stopper by a specimen suction nozzle passing through a hole of the stopper formed by the piercer, a piercing condition setting unit for setting a piercing operation condition by the piercer for the specimen vessel having the stopper loaded in the specimen rack based on the rack identification information read by the rack identification information reading unit, and a control unit for controlling an operation of the CTS drive unit based on a set piercing operation condition.
    Type: Application
    Filed: March 30, 2022
    Publication date: July 14, 2022
    Inventors: Toshiki KAWABE, Kosuke OGASAWARA, Yumi IIJIMA, Masaaki IWASAKI
  • Publication number: 20220146537
    Abstract: To provide a method for analyzing coagulation characteristics of a blood specimen. To provide a method for analyzing a blood specimen, including: acquiring a waveform related to a coagulation rate or coagulation acceleration of a sample obtained by mixing a subject blood specimen with a reagent for measuring coagulation time; extracting multiple parameters characterizing the waveform related to a coagulation rate or a coagulation acceleration; and determining an activity level or activity abnormality of a coagulation factor in the subject blood specimen on the basis of the multiple parameters.
    Type: Application
    Filed: January 31, 2020
    Publication date: May 12, 2022
    Applicants: SEKISUI MEDICAL CO., LTD., PUBLIC UNIVERSITY CORPORATION NARA MEDICAL UNIVERSITY
    Inventors: Toshiki KAWABE, Yukio ODA, Midori SHIMA, Keiji NOGAMI, Kenichi OGIWARA
  • Publication number: 20210333295
    Abstract: Excellent analysis of a coagulation characteristic of a blood sample is implemented. A method for analyzing a coagulation characteristic of a blood specimen according to the present invention includes: acquiring data for a coagulation reaction curve indicating a coagulation reaction amount of a mixed solution containing a blood sample and a reagent with respect to reaction time; calculating data for a differential curve obtained by differentiating the coagulation reaction curve; calculating information related to a center-of-gravity point of the differential curve; and evaluating the coagulation characteristic of the blood sample using the information related to the center-of-gravity point.
    Type: Application
    Filed: November 15, 2019
    Publication date: October 28, 2021
    Applicant: SEKISUI MEDICAL CO., LTD.
    Inventors: Toshiki KAWABE, Yukio ODA
  • Publication number: 20210255210
    Abstract: An autosampler includes an installation part allowing a plurality of racks to be installed therein, a transfer part capable of holding one rack installed in the installation part and moving back and forth in a first movement direction along an installation direction, and a rack transport path used to move the rack held by the transfer part back and forth in a second movement direction intersecting the first movement direction are included. The transfer part is moved forward in the first movement direction to transfer the rack present in the installation part to a side of the rack transport path, and the transfer part is moved backward in the first movement direction to send the rack present in the rack transport path back to a side of the installation part.
    Type: Application
    Filed: April 22, 2021
    Publication date: August 19, 2021
    Inventor: Toshiki KAWABE
  • Publication number: 20210239724
    Abstract: An autosampler includes an installation part for racks to be installed therein, an installation part movement mechanism which moves the installation part back and forth in an installation part transport direction and successively transfers the racks to a transport position, and a rack movement mechanism which moves the racks at the transport position forward in a rack transport direction to send out the racks, and moves the racks backward to send the racks back to the installation part after specimens are sampled from the specimen containers held in the racks. Information about inspection item content is accumulated using the installation part, and an accumulation result is compared with the amount of measurement resources, so that sampling is started after it is determined that the measurement resources are not insufficient.
    Type: Application
    Filed: April 22, 2021
    Publication date: August 5, 2021
    Inventor: Toshiki KAWABE
  • Publication number: 20210033635
    Abstract: Provided is a sampling mechanism capable of performing sampling through proper perforation with respect to a plug body. A perforating body has a first piercer inserted into a cap and penetrating the cap with a tip closed and a second piercer formed in a tubular shape, disposed outside the first piercer, approaching the cap together with the first piercer by causing the first piercer to protrude downward, reaching the cap after the first piercer reaches the cap, and penetrating the cap by being inserted into the cap. A probe is passed through the second piercer remaining after retraction of the first piercer.
    Type: Application
    Filed: October 19, 2020
    Publication date: February 4, 2021
    Inventor: Toshiki KAWABE
  • Publication number: 20200324259
    Abstract: A stirring bar capable of reducing a dead space inside a container and efficiently using a contained liquid. A stirring bar introduced into a reagent bottle having an opening mouth portion and rotated by a magnetic force transmitted from the outside of the reagent bottle so as to stir a reagent in the reagent bottle, including: a magnet having a predetermined shape; and a main body including a magnetic member therein, in which the main body is provided with a through-hole which has an opening area corresponding to an opened area and is able to receive a nozzle in the opening area, and in which the stirring bar in a rotation state is able to receive the nozzle in a circular center area narrower than the opening area and having a diameter of an opening width of a center portion of the opening area.
    Type: Application
    Filed: June 25, 2020
    Publication date: October 15, 2020
    Inventor: Toshiki KAWABE
  • Patent number: D860473
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: September 17, 2019
    Assignee: SEKISUI MEDICAL CO., LTD.
    Inventors: Toshiki Kawabe, Akiko Matsumoto, Hiroshi Takahashi