Abstract: A harvester includes an image compositing unit and a display unit. The image compositing unit generates a composite image showing a vehicle body and the vicinity of the vehicle body based on shot images generated by a front camera 21, a rear camera 22, a first side camera 23, and a second side camera 24 and vehicle body data stored in a storage unit. The display unit displays the composite image generated by the image compositing unit. The front camera 21 is provided on a front part of a driving section 8, the rear camera 22 is provided on a rear cover part 14, the first side camera 23 is provided on an outer side part of the driving section 8 in a left-right direction of the vehicle body, and the second side camera 24 is provided on an outer side part of a threshing device 11.

Abstract: Desired is development of novel CDN derivatives having STING agonist activity; and a therapeutic agents and/or therapeutic methods using the novel CDN derivatives for diseases associated with STING agonist activity. Further desired is development of a therapeutic agents and/or therapeutic methods capable of delivering the novel CDN derivatives specifically to targeted cells and organs for diseases associated with STING agonist activity. The present invention provides novel CDN derivatives having potent STING agonist activity, and antibody-CDN derivative conjugates including the novel CDN derivatives.

Abstract: An endoscope cable includes a plurality of individual cables, and is provided with an entire shield portion including a metal wire group having an electric shield function to surround entirety of the plurality of individual cables, and a cable core wire including a metal wire group in each of the individual cables. The metal wire group in at least one of the entire shield portion and the cable core wires is configured by combining a plurality of types of metal wires having different compositions from each other.

Abstract: An endoscope including a plurality of nozzles that injects a fluid toward an observation window, and an operation unit that operates the injection of the fluid by the nozzles, wherein a plurality of fluid channels that supplies the fluid from the operation unit to the nozzles is provided independently, and each nozzle performs the injection non-simultaneously.

Abstract: An endoscope cable includes a plurality of individual cables, and is provided with an entire shield portion including a metal wire group having an electric shield function to surround entirety of the plurality of individual cables, and a cable core wire including a metal wire group in each of the individual cables. The metal wire group in at least one of the entire shield portion and the cable core wires is configured by combining a plurality of types of metal wires having different compositions from each other.

Abstract: A sealing device capable of suppressing depletion of lubricant is provided. A sliding surface of a side lip 220 at a position away from a distal end of the side lip 220 is provided with a plurality of annular grooves 222 adjacent each other, each of all parts that form annular protrusions 223 between adjacent annular grooves 222 protrudes most at a center in a width direction thereof, with an amount of protrusion gradually decreasing with increasing separation from the center, and both sides of the center in the width direction are symmetric in shape. A tip portion of the sliding surface of the side lip 220 on the distal side of a region, which is provided with the plurality of annular grooves 222, is configured to make a planar contact with an end face of the annular member.

Abstract: A sealing device includes a reinforcing ring having annular shape around an axis line and an elastic body part formed from an elastic body, the elastic body part being attached to the reinforcing ring and having an annular shape around the axis line. The elastic body part includes an annular seal lip and an annular side lip that is provided on an outer side of the seal lip and that extends toward the outer side. In an inner peripheral surface of the side lip on an inner periphery side, at least one circumferential groove which is a groove having an annular shape around the axis line is provided and at least one axial groove which is a groove extending along a direction of the axis line is provided. The circumferential groove and the axial groove are connected with each other.

Abstract: A method for producing a protein is provided. An objective protein is produced by culturing in a culture medium Talaromyces cellulolyticus having an objective protein-producing ability, which has been modified so that the activity of a Pep4 protein is reduced.

Abstract: A harvester capable of autonomous travel in a field includes: a harvesting unit that harvests a crop from the field; a conveyance device that conveys, toward the rear of a harvester body, a whole culm of the harvested crop harvested by the harvesting unit; a detection sensor that detects a drive speed of the conveyance device; and a clog determining unit that determines a clog of the harvested crop in the conveyance device on the basis of the drive speed. The clog determining unit outputs a vehicle stop command that stops the harvester body when the drive speed becomes lower than a pre-set first threshold during the autonomous travel.

Abstract: A sealing device is disposed between a rotational shaft and an inner surface of a housing. The sealing device includes a mounted part mounted on the housing; an annular part extending radially inward from the mounted part; an inner cylindrical part supported by the annular part; a seal lip protruding radially inward from the inner cylindrical part, the seal lip brought into slidable contact with the rotational shaft; and a garter spring wound around the inner cylindrical part to compress the seal lip against the rotational shaft. The distance between the boundary between the inner cylindrical part and the annular part and the lip edge of the seal lip along the axial direction of the rotational shaft is equal to or greater than 4 mm. The garter spring applies a force that is equal to or greater than 22 N to the inner cylindrical part.

Abstract: An endoscope or the like that prevents crosstalk between multiple light-emitting parts is provided. An endoscope includes: an observation window that is disposed at a distal end of an insertion part; a plurality of first light-emitting parts that are disposed around the observation window; a second light-emitting part that is disposed between the first light-emitting parts and emits light at a bandwidth different from a bandwidth of light emitted by the first light-emitting parts; and a light-shielding body that is disposed between one of the first light-emitting parts and the second light-emitting part.

Abstract: Provided are an endoscope capable of preventing a cleaning liquid from remaining on a surface of an observation optical system with a simpler configuration, and a method for manufacturing the endoscope. In the endoscope that includes a convex observation optical system provided at a distal end of an insertion portion and in which a cleaning liquid is ejected from an air and water supply nozzle, a distal end surface surrounding the observation optical system and having an uneven shape is provided.

Abstract: A sealing device includes a reinforcing ring and an elastic body part. The elastic body part includes an annular seal lip, an annular dust lip, and an annular side lip that extends toward an outer side on an outer periphery side of the dust lip. The side lip includes an annular middle portion that increases in diameter as progress toward the outer side and an annular distal end portion that is a portion connected to and on the outer side of the middle portion and that increases in diameter as progress toward the outer side. In the side lip, the distal end portion is bent to an inner periphery side from the middle portion. In the middle portion, at least one groove is formed annularly around an axis x.

Abstract: An endoscope includes: an imaging unit that is incorporated in a distal tip of an insertion tube and images an observed site through an observation window; a plurality of first LEDs juxtaposed outside the imaging unit; and a plurality of second LEDs juxtaposed outside a region where the first LEDs are juxtaposed. The region where the first LEDs are juxtaposed and a region where the second LEDs are juxtaposed are covered with a light distribution lens, light emission of the first LED is output to an angular range smaller than a viewing angle of the imaging unit through the light distribution lens, and light emission of the second LED is output to an angular range smaller than the viewing angle of the imaging unit through the light distribution lens.

Abstract: An extraction apparatus can obtain a first alert and a second alert that are generated, when an anomaly occurs in a control system, in order to provide notification of the anomaly. The extraction apparatus includes: a classification unit configured to generate association information associating the first alert with the second alert; a learning unit configured to learn a generation pattern of the second alert when the anomaly occurs due to a cause other than a cyber-attack based on the association information generated by the classification unit and a generation pattern of the first alert when the anomaly occurs due to a cause other than a cyber-attack; and an extraction unit configured to extract, from among the second alerts, the second alert generated due to a cyber-attack based on the generation pattern of the second alert that is learned by the learning unit and output the extracted second alert.

Abstract: A harvester includes an image compositing unit and a display unit. The image compositing unit generates a composite image showing a vehicle body and the vicinity of the vehicle body based on shot images generated by a front camera 21, a rear camera 22, a first side camera 23, and a second side camera 24 and vehicle body data stored in a storage unit. The display unit displays the composite image generated by the image compositing unit. The front camera 21 is provided on a front part of a driving section 8, the rear camera 22 is provided on a rear cover part 14, the first side camera 23 is provided on an outer side part of the driving section 8 in a left-right direction of the vehicle body, and the second side camera 24 is provided on an outer side part of a threshing device 11.

Abstract: Provided is a working vehicle capable of operation and driving that includes a plurality of image capture devices 4 that capture an image of surroundings of a vehicle body; a direction detection unit 51 that detects an advancement direction of the operation and driving; an image selection unit 52 that acquires, as a detection image, a surrounding area image captured by one image capture device 4 of the plurality of image capture devices 4 capturing a front advancement direction detected by the direction detection unit 51; and a detection unit 53 that analyzes the detection image acquired by the image selection unit 52 and detects an obstacle.

Abstract: A sealing device capable of suppressing depletion of lubricant is provided. A sliding surface of a side lip 220 at a position away from a distal end of the side lip 220 is provided with a plurality of annular grooves 222 adjacent each other, each of all parts that form annular protrusions 223 between adjacent annular grooves 222 protrudes most at a center in a width direction thereof, with an amount of protrusion gradually decreasing with increasing separation from the center, and both sides of the center in the width direction are symmetric in shape. A tip portion of the sliding surface of the side lip 220 on the distal side of a region, which is provided with the plurality of annular grooves 222, is configured to make a planar contact with an end face of the annular member.

Abstract: An endoscope, which is provided with an observation optical system provided at the tip of an insertion portion and a connecting pipe portion for sending a fluid onto the observation optical system side, includes a small diameter portion which has one end opening to which a fluid from the connecting pipe portion flows and has a diameter smaller than the connecting pipe portion, a lid portion which covers the other end opening of the small diameter portion, and a guide wall which is provided inside the lid portion to be separated from an edge of the other end opening in a radial direction of the other end opening and guides the fluid from the small diameter portion to an outlet.

Abstract: A sealing device that can suppress entrance of foreign matter into a place between the end surface of a rotating ring and the end surface of a fixed ring. A sealing device 10 that seals the annular gap between a rotating shaft and a housing having a shaft bore into which the rotating shaft is inserted includes a rotating ring unit 100 provided to the rotating shaft and a fixed ring unit 200 provided to the housing. A plurality of protrusions 140 configured to generate an airflow from the rotating ring 130 side to the fixed ring 230 side when the rotating ring unit 100 rotates are provided on the inner peripheral surface of the rotating ring 130.