Abstract: To allow an implantable device including an electronic circuit to be implanted in the head in a more preferable manner in terms of appearance and safely. This implantable device is used for a brain-machine interface or the like. A casing of an implantable device configured to be implanted in a human head has an outer convexity surface matching an external shape of a resected skull related to at least a craniotomy site of the artificial bone designed in accordance with a skull shape of each person in order to fill the craniotomy site. That is, the outer convexity surface of the artificial bone is provided with two functions: the original function of filling the craniotomy site as the artificial bone and a function of serving as the casing of the implantable device.

Abstract: The present invention relates to combination therapy for cancer with a WT1 peptide vaccine and temozolomide.

Abstract: To allow an implantable device including an electronic circuit to be implanted in the head in a more preferable manner in terms of appearance and safely. This implantable device is used for a brain-machine interface or the like. A casing of an implantable device configured to be implanted in a human head has an outer convexity surface matching an external shape of a resected skull related to at least a craniotomy site of the artificial bone designed in accordance with a skull shape of each person in order to fill the craniotomy site. That is, the outer convexity surface of the artificial bone is provided with two functions: the original function of filling the craniotomy site as the artificial bone and a function of serving as the casing of the implantable device.

Abstract: The present invention relates to combination therapy for cancer with a WT1 peptide vaccine and temozolomide.

Abstract: To allow an implantable device including an electronic circuit to be implanted in the head in a more preferable manner in terms of appearance and safely. This implantable device is used for a brain-machine interface or the like. A casing 16 of an implantable device 4 configured to be implanted in a human head has an outer convexity surface 30 matching an external shape of a resected skull 27 related to at least a craniotomy site 26 of the artificial bone 28 designed in accordance with a skull shape of each person in order to fill the craniotomy site 26. That is, the outer convexity surface 30 of the artificial bone 28 is provided with two functions: the original function of filling the craniotomy site 26 as the artificial bone 28 and a function of serving as the casing 16 of the implantable device 4.

Abstract: A machine control device includes: first decoders for estimating, from brain signal information, which one of body movements a user performs or images, based on learning using pairs of movements performed by the user and brain signal information, the body movements going toward one of first to nth body postures; second decoders for estimating from the brain signal information, an correct rate on the body movement estimation, based on learning using pairs of correct rates of the estimation of body movements and the brain signal information; and electric prosthetic arm control section for controlling an electric prosthetic arm to change stepwise its posture between first to nth postures via at least one intermediate posture therebetween, the first to nth postures corresponding to the first to nth body postures. The first decoders perform the estimation only when the estimated correct rate exceeds a threshold.

Abstract: A machine control device includes: first decoders for estimating, from brain signal information, which one of body movements a user performs or images, based on learning using pairs of movements performed by the user and brain signal information, the body movements going toward one of first to nth body postures; second decoders for estimating from the brain signal information, an correct rate on the body movement estimation, based on learning using pairs of correct rates of the estimation of body movements and the brain signal information; and electric prosthetic arm control section for controlling an electric prosthetic arm to change stepwise its posture between first to nth postures via at least one intermediate posture therebetween, the first to nth postures corresponding to the first to nth body postures. The first decoders perform the estimation only when the estimated correct rate exceeds a threshold.

Abstract: An interface device in accordance with the present claimed invention is an interface device 4 that intervenes between a measuring means 2 that measures brain activities of a subject H and an object 31 to be controlled, and that comprises a reference signal storing part D1 that stores a brain activity signal measured at a time when the subject H conducts predetermined thinking different from direct thinking in order to control the object 31 to be controlled in a desired mode as a reference signal, a discriminating part 41 that compares the brain activity signal measured by the measuring means 2 with the reference signal and discriminates whether or not the thinking of the subject H is the predetermined thinking, and a controlling part 42 that controls the object 31 to be controlled in the desired mode when the discriminating part 41 discriminates that the thinking of the subject H is the predetermined thinking.

Abstract: With use of three-dimensional data of a brain shape, a mold for forming a sheet-shaped structure having a three-dimensional shape of the gyrus or sulcus surface, or the interhemispheric fissure or interlobar fissure surface is formed. With use of the mold, a sheet-shaped silicone structure 2 having a three-dimensional shape of the gyrus or sulcus surface, or the interhemispheric fissure or interlobar fissure surface is formed. An electrode 3 is arranged on at least one side of the silicone structure 2. With this configuration, an intracranial electrode 1 in which the electrode 3 is arranged on the sheet-shaped silicone structure 2 having the three-dimensional shape of the gyrus or sulcus surface, or the interhemispheric fissure or interlobar fissure surface can be produced.

Abstract: With use of three-dimensional data of a brain shape, a mold for forming a sheet-shaped structure having a three-dimensional shape of the gyrus or sulcus surface, or the interhemispheric fissure or interlobar fissure surface is formed. With use of the mold, a sheet-shaped silicone structure 2 having a three-dimensional shape of the gyrus or sulcus surface, or the interhemispheric fissure or interlobar fissure surface is formed. An electrode 3 is arranged on at least one side of the silicone structure 2. With this configuration, an intracranial electrode 1 in which the electrode 3 is arranged on the sheet-shaped silicone structure 2 having the three-dimensional shape of the gyrus or sulcus surface, or the interhemispheric fissure or interlobar fissure surface can be produced.

Abstract: The present invention provides introduction of NF-?B decoy oligodeoxynucleotide into rat cranial nerve through a carotid artery during global brain ischemia. Polymerase chain reaction demonstrated that one hour after global brain ischemia, transfected NF-?B decoy oligodeoxynucleotide effectively suppressed expression of tumor necrosis factor ?, interleukin 1? and intracellular adhesion molecule 1 messenger RNAs. Terminal deoxynucleotidyl transferase-mediated deoxyuridine nick-end labeling staining and immunohistochemistry using microtubule-associated protein 2 demonstrated that transfected NF-?B decoy oligodeoxynucleotide significantly attenuated neuronal damage seven days after global brain ischemia. Therapeutic transfection of NF-?B decoy oligodeoxynucleotide during brain ischemia may be effective for attenuation of neuronal damage, suggesting a strategy for protecting the cerebrum from global ischemia.

Abstract: The present invention provides introduction of NF-?B decoy oligodeoxynucleotide into rat cranial nerve through a carotid artery during global brain ischemia. Polymerase chain reaction demonstrated that one hour after global brain ischemia, transfected NF-?B decoy oligodeoxynucleotide effectively suppressed expression of tumor necrosis factor ?, interleukin 1? and intracellular adhesion molecule 1 messenger RNAs. Terminal deoxynucleotidyl transferase-mediated deoxyuridine nick-end labeling staining and immunohistochemistry using microtubule-associated protein 2 demonstrated that transfected NF-?B decoy oligodeoxynucleotide significantly attenuated neuronal damage seven days after global brain ischemia. Therapeutic transfection of NF-?B decoy oligodeoxynucleotide during brain ischemia may be effective for attenuation of neuronal damage, suggesting a strategy for protecting the cerebrum from global ischemia.

Abstract: An interface device in accordance with the present claimed invention is an interface device 4 that intervenes between a measuring means 2 that measures brain activities of a subject H and an object 31 to be controlled, and that comprises a reference signal storing part D1 that stores a brain activity signal measured at a time when the subject H conducts predetermined thinking different from direct thinking in order to control the object 31 to be controlled in a desired mode as a reference signal, a discriminating part 41 that compares the brain activity signal measured by the measuring means 2 with the reference signal and discriminates whether or not the thinking of the subject H is the predetermined thinking, and a controlling part 42 that controls the object 31 to be controlled in the desired mode when the discriminating part 41 discriminates that the thinking of the subject H is the predetermined thinking.

Abstract: Equipment for intracerebral administration of preparations is composed of a preparation-administering device (1) holding a preparation (2), and a plunger (4) removably arranged in the preparation-administering device adapted to push the preparation held therein toward one end of the preparation-administering device. The intracerebral preparation-administration equipment is inserted into a preparation-introducing guide (5) previously implanted in the head of a patient to introduce the preparation into its guide hole (26). The preparation is then guided to a site of administration through a flexible guide tube (23) communicated with the guide hole of the preparation-introducing guide. The equipment for intracerebral administration of preparations may be composed of a tubular preparation-retaining member (30) having a preparation contained therein, and a holder (32) for holding the tubular preparation-retaining member along with a push rod (31) inserted thereinto as an integral part thereof.