Patents by Inventor Toshimi Kanai
Toshimi Kanai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230218612Abstract: The present invention provides a nitrogen-containing heterocyclic compound or a pharmaceutically acceptable salt thereof having an inhibitory effect on the production of kynurenine, represented by formula (I): (wherein R6 and R7 may be the same or different and each represent a hydrogen atom or the like, R8, R9, R10, and R11 may be the same or different and each represent a hydrogen atom or the like, R1 represents lower alkyl which may be substituted with cycloalkyl, or the like, and R3 represents optionally substituted aryl or an optionally substituted heterocyclic group).Type: ApplicationFiled: March 8, 2023Publication date: July 13, 2023Applicant: Kyowa Kirin Co., Ltd.Inventors: Yuichi FUKUDA, Toshimi KANAI, Yoshisuke NAKASATO, Keisuke KIMPARA
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Publication number: 20230159554Abstract: A compound having anticancer activity, or a pharmaceutically acceptable salt thereof is provided. Used is a compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof: (wherein, L1 and L2 are the same or different and each represents a group represented by one formula selected from the group consisting of formulas (A) to (F), and S represents a group represented by one formula selected from the group consisting of formulas (S1) to (S18)).Type: ApplicationFiled: January 25, 2023Publication date: May 25, 2023Applicant: KYOWA KIRIN CO., LTD.Inventors: Kenji UCHIDA, Ryohei KAWAI, Keisuke YAMAMOTO, Toshimi KANAI, Hideo IKOTA, Takashi IMAEDA, Kei YOSHIDA
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Patent number: 11629152Abstract: A compound having anticancer activity, or a pharmaceutically acceptable salt thereof is provided. Used is a compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof: (wherein, L1 and L2 are the same or different and each represents a group represented by one formula selected from the group consisting of formulas (A) to (F), and S represents a group represented by one formula selected from the group consisting of formulas (S1) to (S18)).Type: GrantFiled: March 29, 2019Date of Patent: April 18, 2023Assignee: KYOWA KIRIN CO., LTD.Inventors: Kenji Uchida, Ryohei Kawai, Keisuke Yamamoto, Toshimi Kanai, Hideo Ikota, Takashi Imaeda, Kei Yoshida
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Patent number: 11591344Abstract: A compound having anticancer activity, or a pharmaceutically acceptable salt thereof is provided. Used is a compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof: (wherein, L1 and L2 are the same or different and each represents a group represented by one formula selected from the group consisting of formulas (A) to (F), and S represents a group represented by one formula selected from the group consisting of formulas (S1) to (S18)).Type: GrantFiled: March 29, 2019Date of Patent: February 28, 2023Assignee: KYOWA KIRIN CO., LTD.Inventors: Kenji Uchida, Ryohei Kawai, Keisuke Yamamoto, Toshimi Kanai, Hideo Ikota, Takashi Imaeda, Kei Yoshida
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Publication number: 20220378923Abstract: The present invention provides a BET (protein) degrader, specifically a BET degrader containing a compound represented by formula (I) or a pharmaceutically acceptable salt thereof: wherein L1 and L2 are the same or different and each represents a small molecular ligand for BET protein, and S represents a group represented by a formula selected from the group consisting of formulas (S1) to (S18).Type: ApplicationFiled: September 30, 2020Publication date: December 1, 2022Applicant: KYOWA KIRIN CO., LTD.Inventors: Keisuke YAMAMOTO, Toshimi KANAI, Kei YOSHIDA, Takashi IMAEDA, Masahiro ESAKI
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Publication number: 20210024540Abstract: A compound having anticancer activity, or a pharmaceutically acceptable salt thereof is provided. Used is a compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof: (wherein, L1 and L2 are the same or different and each represents a group represented by one formula selected from the group consisting of formulas (A) to (F), and S represents a group represented by one formula selected from the group consisting of formulas (S1) to (S18)).Type: ApplicationFiled: March 29, 2019Publication date: January 28, 2021Applicant: KYOWA KIRIN CO., LTD.Inventors: Kenji UCHIDA, Ryohei KAWAI, Keisuke YAMAMOTO, Toshimi KANAI, Hideo IKOTA, Takashi IMAEDA, Kei YOSHIDA
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Publication number: 20200179376Abstract: The present invention provides a nitrogen-containing heterocyclic compound or a pharmaceutically acceptable salt thereof having an inhibitory effect on the production of kynurenine, represented by formula (I): (wherein R6 and R7 may be the same or different and each represent a hydrogen atom or the like, R8, R9, R10, and R11 may be the same or different and each represent a hydrogen atom or the like, R1 represents lower alkyl which may be substituted with cycloalkyl, or the like, and R3 represents optionally substituted aryl or an optionally substituted heterocyclic group).Type: ApplicationFiled: December 4, 2019Publication date: June 11, 2020Applicant: Kyowa Kirin Co., Ltd.Inventors: Yuichi Fukuda, Toshimi Kanai, Yoshisuke Nakasato, Keisuke Kimpara
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Patent number: 10548891Abstract: The present invention provides a nitrogen-containing heterocyclic compound or a pharmaceutically acceptable salt thereof having an inhibitory effect on the production of kynurenine, represented by formula (I): (wherein R6 and R7 may be the same or different and each represent a hydrogen atom or the like, R8, R9, R10, and R11 may be the same or different and each represent a hydrogen atom or the like, R1 represents lower alkyl which may be substituted with cycloalkyl, or the like, and R3 represents optionally substituted aryl or an optionally substituted heterocyclic group).Type: GrantFiled: August 17, 2015Date of Patent: February 4, 2020Assignee: KYOWA HAKKO KIRIN CO., LTD.Inventors: Yuichi Fukuda, Toshimi Kanai, Yoshisuke Nakasato, Keisuke Kimpara
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Patent number: 9701689Abstract: The present invention provides a heterocyclic compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof, in which XA, R1, YA, R2, R3A, and R4A are as defined herein. The compound of formula (I) inhibits a C-C chemokine receptor type 10 (CCR10) receptor and is useful as a prophylactic and/or therapeutic agent for skin diseases.Type: GrantFiled: November 29, 2013Date of Patent: July 11, 2017Assignee: Kyowa Hakko Kirin Co., Ltd.Inventors: Kenji Uchida, Toshimi Kanai, Masakazu Homma, Seiji Aratake, Tatsuya Ishimori
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Publication number: 20150352106Abstract: The present invention provides a nitrogen-containing heterocyclic compound or a pharmaceutically acceptable salt thereof having an inhibitory effect on the production of kynurenine, represented by formula (I): (wherein R6 and R7 may be the same or different and each represent a hydrogen atom or the like, R8, R9, R10, and R11 may be the same or different and each represent a hydrogen atom or the like, R1 represents lower alkyl which may be substituted with cycloalkyl, or the like, and R3 represents optionally substituted aryl or an optionally substituted heterocyclic group).Type: ApplicationFiled: August 17, 2015Publication date: December 10, 2015Inventors: Yuichi FUKUDA, Toshimi Kanai, Yoshisuke Nakasato, Keisuke Kimpara
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Publication number: 20150299214Abstract: The present invention provides a heterocyclic compound represented by the following formula (I), wherein XA represents CH and the like, R1 represents cycloalkyl optionally having substituent(s) and the like, L represents a bond and the like, YA represents —NH— and the like, R2 represents a hydrogen atom and the like, R3A represents the following formula (R3A-1) (wherein, R3 represents hydroxy and the like) and the like, and R4A represents the following formula (R4A-1) (wherein, R4 and R5 are the same or different and each represents a hydrogen atom and the like) and the like, or a pharmaceutically acceptable salt thereof, which is useful as a prophylactic and/or therapeutic agent for skin diseases and the like, and the like.Type: ApplicationFiled: November 29, 2013Publication date: October 22, 2015Applicant: KYOWA HAKKO KIRIN CO., LTD.Inventors: Kenji UCHIDA, Toshimi KANAI, Masakazu HOMMA, Seiji ARATAKE, Tatsuya ISHIMORI
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Patent number: 9150569Abstract: The present invention provides a nitrogen-containing heterocyclic compound or a pharmaceutically acceptable salt thereof having an inhibitory effect on the production of kynurenine, represented by formula (I): (wherein R6 and R7 may be the same or different and each represent a hydrogen atom or the like, R8, R9, R10, and R11 may be the same or different and each represent a hydrogen atom or the like, R1 represents lower alkyl which may be substituted with cycloalkyl, or the like, and R3 represents optionally substituted aryl or an optionally substituted heterocyclic group).Type: GrantFiled: May 9, 2011Date of Patent: October 6, 2015Assignee: KYOWA HAKKO KIRIN CO., LTD.Inventors: Yuichi Fukuda, Toshimi Kanai
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Patent number: 9067923Abstract: A nitrogen-containing heterocyclic compound represented by formula (I-A): (wherein R1A represents lower alkyl which may be substituted with lower alkoxy, R3A represents lower alkyl substituted with fluorine atom(s), and R4A represents an optionally substituted aromatic heterocyclic group) or the like, or a pharmaceutically acceptable salt thereof; and the like, are provided.Type: GrantFiled: November 9, 2012Date of Patent: June 30, 2015Assignee: KYOWA HAKKO KIRIN CO., LTD.Inventors: Toshimi Kanai, Kenji Uchida, Masakazu Honma, Yuichi Fukuda
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Publication number: 20140309231Abstract: A nitrogen-containing heterocyclic compound represented by formula (I-A): (wherein R1A represents lower alkyl which may be substituted with lower alkoxy, R3A represents lower alkyl substituted with fluorine atom(s), and R4A represents an optionally substituted aromatic heterocyclic group) or the like, or a pharmaceutically acceptable salt thereof; and the like, are provided.Type: ApplicationFiled: November 9, 2012Publication date: October 16, 2014Applicant: Kyowa Hakko Kirin Co., Ltd.Inventors: Toshimi Kanai, Kenji Uchida, Masakazu Honma, Yuichi Fukuda
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Publication number: 20130065905Abstract: The present invention provides a nitrogen-containing heterocyclic compound or a pharmaceutically acceptable salt thereof having an inhibitory effect on the production of kynurenine, represented by formula (I): (wherein R6 and R7 may be the same or different and each represent a hydrogen atom or the like, R8, R9, R19, and R11 may be the same or different and each represent a hydrogen atom or the like, R1 represents lower alkyl which may be substituted with cycloalkyl, or the like, and R3 represents optionally substituted aryl or an optionally substituted heterocyclic group).Type: ApplicationFiled: May 9, 2011Publication date: March 14, 2013Applicant: Kyowa Hakko Kirin Co., Ltd.Inventors: Yuichi Fukuda, Toshimi Kanai, Yoshisuke Nakasato, Keisuke Kimpara