Patents by Inventor Toshimi Shimizu

Toshimi Shimizu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9018156
    Abstract: Provided is an organic nanotube having a hydrophobized inner surface, formed by molecules including an asymmetric bipolar lipid molecule represented by the following General Formula (1) and a derivative thereof represented by the following General Formula (2), wherein the organic nanotube has a hydrophilized outer surface and a hydrophobized inner surface of a hollow cylinder and is formed by binary self-assembly, the organic nanotube encapsulates a hydrophobic guest in the hollow cylinder, has a function of refolding a denatured protein, and has a function of sustainably-releasing a hydrophobic drug according to the change in hydrophobicity of the inner surface of the tube or external stimulus, In Formulas (1) and (2), wherein the same symbols have the same meanings, G is a 1-glucopyranosyl group or 2-glucopyranosyl group, and n is an integer of 12 to 22.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: April 28, 2015
    Assignee: National Institute of Advanced Industrial Science and Technology
    Inventors: Naohiro Kameta, Wuxiao Ding, Mitsutoshi Masuda, Hiroyuki Minamikawa, Momoyo Wada, Toshimi Shimizu
  • Publication number: 20140147476
    Abstract: Provided is an organic nanotube having a hydrophobized inner surface, formed by molecules including an asymmetric bipolar lipid molecule represented by the following General Formula (1) and a derivative thereof represented by the following General Formula (2), wherein the organic nanotube has a hydrophilized outer surface and a hydrophobized inner surface of a hollow cylinder and is formed by binary self-assembly, the organic nanotube encapsulates a hydrophobic guest in the hollow cylinder, has a function of refolding a denatured protein, and has a function of sustainably-releasing a hydrophobic drug according to the change in hydrophobicity of the inner surface of the tube or external stimulus, In Formulas (1) and (2), wherein the same symbols have the same meanings, G is a 1-glucopyranosyl group or 2-glucopyranosyl group, and n is an integer of 12 to 22.
    Type: Application
    Filed: March 30, 2012
    Publication date: May 29, 2014
    Applicant: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Noahiro Kameta, Wuxiao Ding, Mitsutoshi Masuda, Hiroyuki Minamikawa, Momoyo Wada, Toshimi Shimizu
  • Patent number: 8652269
    Abstract: Disclosed herein are a flux and a soldering paste based on the flux. The flux is free from a change in viscosity with age, “skinned surface,” and “rough and crumbling,” and is excellent in printability and solderability. The flux contains, as elements, a resin, a thixo agent, an activator, a solvent and glucopyranosylamine type nanotube. The soldering paste further contains a solder powder. Preferably, the solder powder is free from lead.
    Type: Grant
    Filed: September 25, 2009
    Date of Patent: February 18, 2014
    Assignee: Nihon Superior Co., Ltd.
    Inventors: Tetsuro Nishimura, Mitsuhiro Kawahara, Masuml Asakawa, Toshimi Shimizu
  • Patent number: 8551916
    Abstract: The present invention provides a method for obtaining O/W emulsions by emulsifying various to-be-emulsified material without the use of any organic solvent, and drying and making into powder the O/W emulsion. The invention relates to a method for producing an O/W emulsion including after preliminarily dispersing a to-be-emulsified material and an interfacially active organic compound in water, heating the preliminary dispersion to a temperature equal to or higher than the melting point of the to-be-emulsified material and equal to or higher than the phase transition temperature of a self-assembled product of the interfacially active organic compound in the absence of an organic solvent, and performing emulsification under a pressure.
    Type: Grant
    Filed: February 25, 2009
    Date of Patent: October 8, 2013
    Assignees: Hodogaya Chemical Co., Ltd., National Institute of Advanced Insustrial Science and Technology
    Inventors: Masumi Asakawa, Masaki Kogiso, Toshimi Shimizu, Atsushi Kisuno
  • Publication number: 20110220247
    Abstract: Disclosed herein are a flux and a soldering paste based on the flux. The flux is free from a change in viscosity with age, “skinned surface,” and “rough and crumbling,” and is excellent in printability and solderability. The flux contains, as elements, a resin, a thixo agent, an activator, a solvent and glucopyranosylamine type nanotube. The soldering paste further contains a solder powder. Preferably, the solder powder is free from lead.
    Type: Application
    Filed: September 25, 2009
    Publication date: September 15, 2011
    Applicants: NIHON SUPERIOR CO., LTD., NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Tetsuro Nishimura, Mitsuhiro Kawahara, Masumi Asakawa, Toshimi Shimizu
  • Publication number: 20110052702
    Abstract: An object of the present invention is to provide a method and apparatus capable of continuously producing organic nanotubes, wherein an organic nanotube material dispersion solution consisting of an organic nanotube material and an organic solvent is pressurized and caused to pass through a very narrow orifice.
    Type: Application
    Filed: January 21, 2009
    Publication date: March 3, 2011
    Applicant: National Institute of Advanced Industrial Science and Technology
    Inventors: Masumi Asakawa, Masaki Kogiso, Toshimi Shimizu
  • Publication number: 20110003695
    Abstract: The present invention provides a method for obtaining O/W emulsions by emulsifying various to-be-emulsified material without the use of any organic solvent, and drying and making into powder the O/W emulsion. The invention relates to a method for producing an O/W emulsion including after preliminarily dispersing a to-be-emulsified material and an interfacially active organic compound in water, heating the preliminary dispersion to a temperature equal to or higher than the melting point of the to-be-emulsified material and equal to or higher than the phase transition temperature of a self-assembled product of the interfacially active organic compound in the absence of an organic solvent, and performing emulsification under a pressure.
    Type: Application
    Filed: February 25, 2009
    Publication date: January 6, 2011
    Applicants: HODOGAYA CHEMICAL CO., LTD., NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Masumi Asakawa, Masaki Kogiso, Toshimi Shimizu, Atsushi Kisuno
  • Patent number: 7713545
    Abstract: Presents novel hollow fiber shaped organic nanotubes that can be easily produced in a short time span and also have a broad range of utility. An N-glycoside type glycolipid represented by the general formula (1) shown below. G-NHCO—R??(1) (In the formula, G represents a saccharide radical other than a hemiacetal hydroxyl group bonded to the anomer carbon atom of the saccharide, and R represents an unsaturated hydrocarbon group containing ten to 39 carbon atoms.) This molecule self-aggregates and forms hollow fiber shaped organic nanotubes in water when this N-glycoside type glycolipid is dissolved, allowed to cool gradually and allowed to stand undisturbed at room temperature. The average external diameter of the nanotubes is from 70 nm to 500 nm and the average internal diameter (average diameter of the cavity) is from 40 nm to 300 nm.
    Type: Grant
    Filed: December 25, 2003
    Date of Patent: May 11, 2010
    Assignees: Japan Science and Technology Agency, National Institute of Advanced Industrial Science and Technology
    Inventors: Shoko Kamiya, Toshimi Shimizu, Jong Hwa Jung
  • Publication number: 20090211907
    Abstract: The invention provides a novel packing composition for separation and/or analysis which permits easy capillary replacement; a process for the production of the packing composition; a method for filling a capillary with the packing composition; and electrophoretic methods (such as capillary electrophoresis) with the same. The invention relates to a packing composition for electrophoretic separation and/or analysis which contains a long self-assembly produced by dissolving a low-molecular-weight amphiphilic compound having a hydrophobic moiety and a hydrophilic moiety in water under heating and then cooling the resulting solution; a process for the production of the packing composition; a method of separation and/or analysis with the composition; and so on.
    Type: Application
    Filed: February 24, 2006
    Publication date: August 27, 2009
    Applicants: Japan Science and Technology Agency, National Institute of Advanced Industrial Science and Technology
    Inventors: Mitsutoshi Masuda, Kazuko Matsumoto, Rika Iwaura, Yoshinori Yamaguchi, Toshimi Shimizu
  • Publication number: 20090202641
    Abstract: Disclosed is a method of synthesizing a water-free nanotube capable of efficiently encapsulating a functional substance therein, in large quantities.
    Type: Application
    Filed: June 11, 2007
    Publication date: August 13, 2009
    Applicant: National Institute of Advanced Industrial Science and Technology
    Inventors: Masumi Asakawa, Masaki Kogiso, Shouko Kamiya, Toshimi Shimizu
  • Publication number: 20070292338
    Abstract: To provide nano-tubes consisting of transition metal oxide and a production method thereof. The nano-tubes consisting of a transition metal oxide with an average diameter of about 10 to 1,000 nm and an average length of about 1 to 100 ?m can be obtained by coexisting a peptide lipid represented by the general formula RCO(NHCH2CO)mOH, wherein R represents a hydrocarbon group with six to eighteen carbon atoms and m represents an integer one to three, and a transition metal ion in water and sintering at 300 to 600° C. the fibrous substance formed.
    Type: Application
    Filed: September 12, 2005
    Publication date: December 20, 2007
    Inventors: Masaki Kogiso, Toshimi Shimizu
  • Patent number: 7202228
    Abstract: A gelatinizer is provided having a component which promises to have biological compatibility, which can easily be mass-produced by a simple method, and which can solidify a large amount of water or aqueous solution when only a very small weight of it is used. This invention is a hydrogelatinizer represented by the general formula: R-An where A, which may be identical or different, are respectively nucleotides, n is 2 or 3, and R is a hydrocarbon chain (when n is 2, R is bivalent, and when n is 3, R is trivalent), said hydrocarbon being bonded to a phosphoric acid part of said nucleotides.
    Type: Grant
    Filed: March 15, 2002
    Date of Patent: April 10, 2007
    Assignees: Japan Science and Technology Agency, National Institute of Advance Industrial Science and Technology
    Inventors: Toshimi Shimizu, Rika Iwamura, Mitsutoshi Masuda
  • Patent number: 7196178
    Abstract: A gelatinizer having gel-forming capability in both organic solvents and water, is provided. The hydrogelatinizer is represented by: (where, A is a sugar residue, and R is an alkyl group).
    Type: Grant
    Filed: March 15, 2002
    Date of Patent: March 27, 2007
    Assignees: Japan Science and Technology Agency, National Institute of Advancco Industrial Science and Technology
    Inventors: Jong Hwa Jung, George John, Toshimi Shimizu
  • Patent number: 7172747
    Abstract: Spiral shaped fibers were utilized to prepare completely novel metal oxide nanotubes comprising solely metal oxides. The metal oxide nanotubes comprise solely a hollow cylinder shaped metal oxide which may contain hydroxyl groups constituting a double helix and having hole diameter distributions containing two peak hole diameters ranging from 1 to 2 nm and from 3 to 7 nm. The tubes may be obtained by forming spiral shaped fibers from a solution of compound 1 and compound 2 and using the fibers as a template for making the nanotubes. The hydrogen adsorption and storage capacity of the metal oxide nanotubes are extremely good.
    Type: Grant
    Filed: March 26, 2003
    Date of Patent: February 6, 2007
    Assignees: Japan Science and Technology Agency, National Institute of Advanced Industrial Science and Technology
    Inventors: Toshimi Shimizu, John Hwa Jung
  • Publication number: 20060160248
    Abstract: Presents novel hollow fiber shaped organic nanotubes that can be easily produced in a short time span and also have a broad range of utility. An N-glycoside type glycolipid represented by the general formula (1) shown below. G-NHCO—R??(1) (In the formula, G represents a saccharide radical other than a hemiacetal hydroxyl group bonded to the anomer carbon atom of the saccharide, and R represents an unsaturated hydrocarbon group containing ten to 39 carbon atoms.) This molecule self-aggregates and forms hollow fiber shaped organic nanotubes in water when this N-glycoside type glycolipid is dissolved, allowed to cool gradually and allowed to stand undisturbed at room temperature. The average external diameter of the nanotubes is from 70 nm to 500 nm and the average internal diameter (average diameter of the cavity) is from 40 nm to 300 nm.
    Type: Application
    Filed: December 25, 2003
    Publication date: July 20, 2006
    Inventors: Shoko Kamiya, Toshimi Shimizu, Jong Jung
  • Publication number: 20060140847
    Abstract: The objective is to easily introduce a desired functional substance into organic nanotubes under milder conditions such as ambient temperature and ambient pressure. The method comprises the steps of allowing a surface active organic compound comprising hydrophobic hydrocarbon groups and hydrophilic groups to self aggregate in liquid phase to form organic nanotubes having an internal cavity size of at least 5 nm (step 1), freeze drying the organic nanotubes (step 2), dissolving or dispersing a desired functional substance in a solvent (step 3) and dispersing said freeze dried organic nanotubes in the solvent or the dispersion at or below the gel-liquid crystal phase transition temperature of said surface active organic compound (step 4). The organic nanotubes formed can be used in a variety of applications depending on the properties of the functional substance.
    Type: Application
    Filed: February 12, 2004
    Publication date: June 29, 2006
    Inventors: Bo Yang, Toshimi Shimizu, Shoko Kamiya
  • Publication number: 20060057220
    Abstract: The present invention relates to a fine spherical particle having uniform molecular orientation having uniform molecular orientation, which is useful in fine chemical fields or electronic and information fields, such as a functional material and a medical material, using membrane formation of a bicephalic compound; a spherical microcapsule encapsulating a hydrophilic core substance; and a process for producing the same. The fine spherical particle can be produced by immersing a substrate having hydrophilicity in an aqueous solution of a salt of the compound represented by the following formula (1) to precipitate the fine particle under an acidic atmosphere. wherein R represents a hydrogen atom or an alkyl group having 1 to 5 carbon atoms; n is an integer of 8 to 20; and m is an integer of 1 to 3.
    Type: Application
    Filed: October 2, 2003
    Publication date: March 16, 2006
    Inventors: Yoko Matsuzawa, Mutsuyoshi Matsumoto, Masaki Kogiso, Toshimi Shimizu
  • Patent number: 6897326
    Abstract: The present invention is a stable, nanometer scale micro-tubular aggregated material of an asymmetric double-headed lipid represented by the general formula R—NHCO—(CH2)n—COOH??(I) (in the formula, R represents an aldopyranose radical from which the terminal reducing hydroxyl group is excluded and n is from six to twenty). The external diameter of the micro-tubular aggregated material is 10-300 nm, and the length is 0.3-10 ?m. The micro-tubular aggregated material can be manufactured by dispersing the asymmetric double-headed lipid described above in water at pH of two to eight, next heating to 80-100° C. to dissolve it and then gradually cooling the aqueous solution obtained.
    Type: Grant
    Filed: February 1, 2002
    Date of Patent: May 24, 2005
    Assignee: Japan Science and Technology Corporation
    Inventors: Mitsutoshi Masuda, Toshimi Shimizu
  • Publication number: 20050077496
    Abstract: Spiral shaped fibers were utilized to prepare completely novel metal oxide nanotubes comprising solely metal oxides. The metal oxide nanotubes comprise solely a hollow cylinder shaped metal oxide which may contain hydroxyl groups constituting a double helix and having hole diameter distributions containing two peak hole diameters ranging from 1 to 2 nm and from 3 to 7 nm. The tubes may be obtained by forming spiral shaped fibers from a solution of compound 1 and compound 2 and using the fibers as a template for making the nanotubes. The hydrogen adsorption and storage capacity of the metal oxide nanotubes are extremely good.
    Type: Application
    Filed: March 26, 2003
    Publication date: April 14, 2005
    Inventors: Toshimi Shimizu, John Jung
  • Publication number: 20050065304
    Abstract: Disclosed is a monomer represented by the following general formula (Ia): wherein M represents a transition metal coordinatable with the four nitrogen atoms and two additional ligands, P represents a group having, at a terminus thereof through a hydrocarbyl group, a nitrogen atom coordinatable with a metal, said hydrocarbyl group being selected from aliphatic hydrocarbon groups and aromatic hydrocarbon groups, Q represents a hydrocarbyl group selected from aliphatic hydrocarbon groups and aromatic hydrocarbon groups, R represents a hydrocarbyl group selected from aliphatic hydrocarbon groups and aromatic hydrocarbon groups and X represents an arbitrary anion atom. The monomer can give a polymer via metal coordination interaction and hydrogen bonding.
    Type: Application
    Filed: March 20, 2002
    Publication date: March 24, 2005
    Inventors: Masumi Asakawa, Hiroko Yamanishi, Toshimi Shimizu