Patents by Inventor Toshimi Shimizu
Toshimi Shimizu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9018156Abstract: Provided is an organic nanotube having a hydrophobized inner surface, formed by molecules including an asymmetric bipolar lipid molecule represented by the following General Formula (1) and a derivative thereof represented by the following General Formula (2), wherein the organic nanotube has a hydrophilized outer surface and a hydrophobized inner surface of a hollow cylinder and is formed by binary self-assembly, the organic nanotube encapsulates a hydrophobic guest in the hollow cylinder, has a function of refolding a denatured protein, and has a function of sustainably-releasing a hydrophobic drug according to the change in hydrophobicity of the inner surface of the tube or external stimulus, In Formulas (1) and (2), wherein the same symbols have the same meanings, G is a 1-glucopyranosyl group or 2-glucopyranosyl group, and n is an integer of 12 to 22.Type: GrantFiled: March 30, 2012Date of Patent: April 28, 2015Assignee: National Institute of Advanced Industrial Science and TechnologyInventors: Naohiro Kameta, Wuxiao Ding, Mitsutoshi Masuda, Hiroyuki Minamikawa, Momoyo Wada, Toshimi Shimizu
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Publication number: 20140147476Abstract: Provided is an organic nanotube having a hydrophobized inner surface, formed by molecules including an asymmetric bipolar lipid molecule represented by the following General Formula (1) and a derivative thereof represented by the following General Formula (2), wherein the organic nanotube has a hydrophilized outer surface and a hydrophobized inner surface of a hollow cylinder and is formed by binary self-assembly, the organic nanotube encapsulates a hydrophobic guest in the hollow cylinder, has a function of refolding a denatured protein, and has a function of sustainably-releasing a hydrophobic drug according to the change in hydrophobicity of the inner surface of the tube or external stimulus, In Formulas (1) and (2), wherein the same symbols have the same meanings, G is a 1-glucopyranosyl group or 2-glucopyranosyl group, and n is an integer of 12 to 22.Type: ApplicationFiled: March 30, 2012Publication date: May 29, 2014Applicant: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGYInventors: Noahiro Kameta, Wuxiao Ding, Mitsutoshi Masuda, Hiroyuki Minamikawa, Momoyo Wada, Toshimi Shimizu
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Patent number: 8652269Abstract: Disclosed herein are a flux and a soldering paste based on the flux. The flux is free from a change in viscosity with age, “skinned surface,” and “rough and crumbling,” and is excellent in printability and solderability. The flux contains, as elements, a resin, a thixo agent, an activator, a solvent and glucopyranosylamine type nanotube. The soldering paste further contains a solder powder. Preferably, the solder powder is free from lead.Type: GrantFiled: September 25, 2009Date of Patent: February 18, 2014Assignee: Nihon Superior Co., Ltd.Inventors: Tetsuro Nishimura, Mitsuhiro Kawahara, Masuml Asakawa, Toshimi Shimizu
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Patent number: 8551916Abstract: The present invention provides a method for obtaining O/W emulsions by emulsifying various to-be-emulsified material without the use of any organic solvent, and drying and making into powder the O/W emulsion. The invention relates to a method for producing an O/W emulsion including after preliminarily dispersing a to-be-emulsified material and an interfacially active organic compound in water, heating the preliminary dispersion to a temperature equal to or higher than the melting point of the to-be-emulsified material and equal to or higher than the phase transition temperature of a self-assembled product of the interfacially active organic compound in the absence of an organic solvent, and performing emulsification under a pressure.Type: GrantFiled: February 25, 2009Date of Patent: October 8, 2013Assignees: Hodogaya Chemical Co., Ltd., National Institute of Advanced Insustrial Science and TechnologyInventors: Masumi Asakawa, Masaki Kogiso, Toshimi Shimizu, Atsushi Kisuno
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Publication number: 20110220247Abstract: Disclosed herein are a flux and a soldering paste based on the flux. The flux is free from a change in viscosity with age, “skinned surface,” and “rough and crumbling,” and is excellent in printability and solderability. The flux contains, as elements, a resin, a thixo agent, an activator, a solvent and glucopyranosylamine type nanotube. The soldering paste further contains a solder powder. Preferably, the solder powder is free from lead.Type: ApplicationFiled: September 25, 2009Publication date: September 15, 2011Applicants: NIHON SUPERIOR CO., LTD., NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGYInventors: Tetsuro Nishimura, Mitsuhiro Kawahara, Masumi Asakawa, Toshimi Shimizu
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Publication number: 20110052702Abstract: An object of the present invention is to provide a method and apparatus capable of continuously producing organic nanotubes, wherein an organic nanotube material dispersion solution consisting of an organic nanotube material and an organic solvent is pressurized and caused to pass through a very narrow orifice.Type: ApplicationFiled: January 21, 2009Publication date: March 3, 2011Applicant: National Institute of Advanced Industrial Science and TechnologyInventors: Masumi Asakawa, Masaki Kogiso, Toshimi Shimizu
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Publication number: 20110003695Abstract: The present invention provides a method for obtaining O/W emulsions by emulsifying various to-be-emulsified material without the use of any organic solvent, and drying and making into powder the O/W emulsion. The invention relates to a method for producing an O/W emulsion including after preliminarily dispersing a to-be-emulsified material and an interfacially active organic compound in water, heating the preliminary dispersion to a temperature equal to or higher than the melting point of the to-be-emulsified material and equal to or higher than the phase transition temperature of a self-assembled product of the interfacially active organic compound in the absence of an organic solvent, and performing emulsification under a pressure.Type: ApplicationFiled: February 25, 2009Publication date: January 6, 2011Applicants: HODOGAYA CHEMICAL CO., LTD., NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGYInventors: Masumi Asakawa, Masaki Kogiso, Toshimi Shimizu, Atsushi Kisuno
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Patent number: 7713545Abstract: Presents novel hollow fiber shaped organic nanotubes that can be easily produced in a short time span and also have a broad range of utility. An N-glycoside type glycolipid represented by the general formula (1) shown below. G-NHCO—R??(1) (In the formula, G represents a saccharide radical other than a hemiacetal hydroxyl group bonded to the anomer carbon atom of the saccharide, and R represents an unsaturated hydrocarbon group containing ten to 39 carbon atoms.) This molecule self-aggregates and forms hollow fiber shaped organic nanotubes in water when this N-glycoside type glycolipid is dissolved, allowed to cool gradually and allowed to stand undisturbed at room temperature. The average external diameter of the nanotubes is from 70 nm to 500 nm and the average internal diameter (average diameter of the cavity) is from 40 nm to 300 nm.Type: GrantFiled: December 25, 2003Date of Patent: May 11, 2010Assignees: Japan Science and Technology Agency, National Institute of Advanced Industrial Science and TechnologyInventors: Shoko Kamiya, Toshimi Shimizu, Jong Hwa Jung
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Publication number: 20090211907Abstract: The invention provides a novel packing composition for separation and/or analysis which permits easy capillary replacement; a process for the production of the packing composition; a method for filling a capillary with the packing composition; and electrophoretic methods (such as capillary electrophoresis) with the same. The invention relates to a packing composition for electrophoretic separation and/or analysis which contains a long self-assembly produced by dissolving a low-molecular-weight amphiphilic compound having a hydrophobic moiety and a hydrophilic moiety in water under heating and then cooling the resulting solution; a process for the production of the packing composition; a method of separation and/or analysis with the composition; and so on.Type: ApplicationFiled: February 24, 2006Publication date: August 27, 2009Applicants: Japan Science and Technology Agency, National Institute of Advanced Industrial Science and TechnologyInventors: Mitsutoshi Masuda, Kazuko Matsumoto, Rika Iwaura, Yoshinori Yamaguchi, Toshimi Shimizu
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Publication number: 20090202641Abstract: Disclosed is a method of synthesizing a water-free nanotube capable of efficiently encapsulating a functional substance therein, in large quantities.Type: ApplicationFiled: June 11, 2007Publication date: August 13, 2009Applicant: National Institute of Advanced Industrial Science and TechnologyInventors: Masumi Asakawa, Masaki Kogiso, Shouko Kamiya, Toshimi Shimizu
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Publication number: 20070292338Abstract: To provide nano-tubes consisting of transition metal oxide and a production method thereof. The nano-tubes consisting of a transition metal oxide with an average diameter of about 10 to 1,000 nm and an average length of about 1 to 100 ?m can be obtained by coexisting a peptide lipid represented by the general formula RCO(NHCH2CO)mOH, wherein R represents a hydrocarbon group with six to eighteen carbon atoms and m represents an integer one to three, and a transition metal ion in water and sintering at 300 to 600° C. the fibrous substance formed.Type: ApplicationFiled: September 12, 2005Publication date: December 20, 2007Inventors: Masaki Kogiso, Toshimi Shimizu
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Patent number: 7202228Abstract: A gelatinizer is provided having a component which promises to have biological compatibility, which can easily be mass-produced by a simple method, and which can solidify a large amount of water or aqueous solution when only a very small weight of it is used. This invention is a hydrogelatinizer represented by the general formula: R-An where A, which may be identical or different, are respectively nucleotides, n is 2 or 3, and R is a hydrocarbon chain (when n is 2, R is bivalent, and when n is 3, R is trivalent), said hydrocarbon being bonded to a phosphoric acid part of said nucleotides.Type: GrantFiled: March 15, 2002Date of Patent: April 10, 2007Assignees: Japan Science and Technology Agency, National Institute of Advance Industrial Science and TechnologyInventors: Toshimi Shimizu, Rika Iwamura, Mitsutoshi Masuda
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Patent number: 7196178Abstract: A gelatinizer having gel-forming capability in both organic solvents and water, is provided. The hydrogelatinizer is represented by: (where, A is a sugar residue, and R is an alkyl group).Type: GrantFiled: March 15, 2002Date of Patent: March 27, 2007Assignees: Japan Science and Technology Agency, National Institute of Advancco Industrial Science and TechnologyInventors: Jong Hwa Jung, George John, Toshimi Shimizu
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Patent number: 7172747Abstract: Spiral shaped fibers were utilized to prepare completely novel metal oxide nanotubes comprising solely metal oxides. The metal oxide nanotubes comprise solely a hollow cylinder shaped metal oxide which may contain hydroxyl groups constituting a double helix and having hole diameter distributions containing two peak hole diameters ranging from 1 to 2 nm and from 3 to 7 nm. The tubes may be obtained by forming spiral shaped fibers from a solution of compound 1 and compound 2 and using the fibers as a template for making the nanotubes. The hydrogen adsorption and storage capacity of the metal oxide nanotubes are extremely good.Type: GrantFiled: March 26, 2003Date of Patent: February 6, 2007Assignees: Japan Science and Technology Agency, National Institute of Advanced Industrial Science and TechnologyInventors: Toshimi Shimizu, John Hwa Jung
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Publication number: 20060160248Abstract: Presents novel hollow fiber shaped organic nanotubes that can be easily produced in a short time span and also have a broad range of utility. An N-glycoside type glycolipid represented by the general formula (1) shown below. G-NHCO—R??(1) (In the formula, G represents a saccharide radical other than a hemiacetal hydroxyl group bonded to the anomer carbon atom of the saccharide, and R represents an unsaturated hydrocarbon group containing ten to 39 carbon atoms.) This molecule self-aggregates and forms hollow fiber shaped organic nanotubes in water when this N-glycoside type glycolipid is dissolved, allowed to cool gradually and allowed to stand undisturbed at room temperature. The average external diameter of the nanotubes is from 70 nm to 500 nm and the average internal diameter (average diameter of the cavity) is from 40 nm to 300 nm.Type: ApplicationFiled: December 25, 2003Publication date: July 20, 2006Inventors: Shoko Kamiya, Toshimi Shimizu, Jong Jung
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Publication number: 20060140847Abstract: The objective is to easily introduce a desired functional substance into organic nanotubes under milder conditions such as ambient temperature and ambient pressure. The method comprises the steps of allowing a surface active organic compound comprising hydrophobic hydrocarbon groups and hydrophilic groups to self aggregate in liquid phase to form organic nanotubes having an internal cavity size of at least 5 nm (step 1), freeze drying the organic nanotubes (step 2), dissolving or dispersing a desired functional substance in a solvent (step 3) and dispersing said freeze dried organic nanotubes in the solvent or the dispersion at or below the gel-liquid crystal phase transition temperature of said surface active organic compound (step 4). The organic nanotubes formed can be used in a variety of applications depending on the properties of the functional substance.Type: ApplicationFiled: February 12, 2004Publication date: June 29, 2006Inventors: Bo Yang, Toshimi Shimizu, Shoko Kamiya
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Publication number: 20060057220Abstract: The present invention relates to a fine spherical particle having uniform molecular orientation having uniform molecular orientation, which is useful in fine chemical fields or electronic and information fields, such as a functional material and a medical material, using membrane formation of a bicephalic compound; a spherical microcapsule encapsulating a hydrophilic core substance; and a process for producing the same. The fine spherical particle can be produced by immersing a substrate having hydrophilicity in an aqueous solution of a salt of the compound represented by the following formula (1) to precipitate the fine particle under an acidic atmosphere. wherein R represents a hydrogen atom or an alkyl group having 1 to 5 carbon atoms; n is an integer of 8 to 20; and m is an integer of 1 to 3.Type: ApplicationFiled: October 2, 2003Publication date: March 16, 2006Inventors: Yoko Matsuzawa, Mutsuyoshi Matsumoto, Masaki Kogiso, Toshimi Shimizu
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Patent number: 6897326Abstract: The present invention is a stable, nanometer scale micro-tubular aggregated material of an asymmetric double-headed lipid represented by the general formula R—NHCO—(CH2)n—COOH??(I) (in the formula, R represents an aldopyranose radical from which the terminal reducing hydroxyl group is excluded and n is from six to twenty). The external diameter of the micro-tubular aggregated material is 10-300 nm, and the length is 0.3-10 ?m. The micro-tubular aggregated material can be manufactured by dispersing the asymmetric double-headed lipid described above in water at pH of two to eight, next heating to 80-100° C. to dissolve it and then gradually cooling the aqueous solution obtained.Type: GrantFiled: February 1, 2002Date of Patent: May 24, 2005Assignee: Japan Science and Technology CorporationInventors: Mitsutoshi Masuda, Toshimi Shimizu
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Publication number: 20050077496Abstract: Spiral shaped fibers were utilized to prepare completely novel metal oxide nanotubes comprising solely metal oxides. The metal oxide nanotubes comprise solely a hollow cylinder shaped metal oxide which may contain hydroxyl groups constituting a double helix and having hole diameter distributions containing two peak hole diameters ranging from 1 to 2 nm and from 3 to 7 nm. The tubes may be obtained by forming spiral shaped fibers from a solution of compound 1 and compound 2 and using the fibers as a template for making the nanotubes. The hydrogen adsorption and storage capacity of the metal oxide nanotubes are extremely good.Type: ApplicationFiled: March 26, 2003Publication date: April 14, 2005Inventors: Toshimi Shimizu, John Jung
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Publication number: 20050065304Abstract: Disclosed is a monomer represented by the following general formula (Ia): wherein M represents a transition metal coordinatable with the four nitrogen atoms and two additional ligands, P represents a group having, at a terminus thereof through a hydrocarbyl group, a nitrogen atom coordinatable with a metal, said hydrocarbyl group being selected from aliphatic hydrocarbon groups and aromatic hydrocarbon groups, Q represents a hydrocarbyl group selected from aliphatic hydrocarbon groups and aromatic hydrocarbon groups, R represents a hydrocarbyl group selected from aliphatic hydrocarbon groups and aromatic hydrocarbon groups and X represents an arbitrary anion atom. The monomer can give a polymer via metal coordination interaction and hydrogen bonding.Type: ApplicationFiled: March 20, 2002Publication date: March 24, 2005Inventors: Masumi Asakawa, Hiroko Yamanishi, Toshimi Shimizu