Patents by Inventor Toshimichi Aota

Toshimichi Aota has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10429363
    Abstract: In order to achieve high sensitivity without an increase in device complexity or cost, a far-ultraviolet absorbance detection device for liquid chromatography is provided with: an optical system including a light source that emits light including far-ultraviolet light, a diffraction grating for dispersing the light emitted from the light source, a flow cell through which a liquid is passed, a slit for selecting a predetermined wavelength of +1 order light diffracted by the diffraction grating and causing the light to enter the flow cell, a first photodetector for detecting the light transmitted by the flow cell, and a second photodetector for detecting light other than the +1 order light diffracted by the diffraction grating; a mechanism for evacuating or substituting the optical system with nitrogen gas; and a computation unit that calculates absorbance from an output signal from the first photodetector and an output signal from the second photodetector. The second photodetector is fixedly disposed.
    Type: Grant
    Filed: February 4, 2016
    Date of Patent: October 1, 2019
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Yuichi Uchiho, Masao Kamahori, Toshimichi Aota
  • Patent number: 10281439
    Abstract: In the present invention, differences in liquid feed properties between liquid chromatographic devices are determined, a liquid feed time table that takes these differences into account is acquired by way of system changes, and flow control is performed by a pump. Furthermore, the liquid feed time table after the system changes is divided into a plurality of intervals, and instructions are sent to the pump after approximate calculations are performed. Thus, by efficiently performing system change processes, the same measurement results can be obtained in a plurality of different liquid chromatograph devices, regardless of the differences in liquid feed properties.
    Type: Grant
    Filed: November 11, 2013
    Date of Patent: May 7, 2019
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Toshimichi Aota, Satoshi Mitsuyama, Masahito Ito, Chihiro Yoshioka, Takaaki Suzuki
  • Patent number: 9581573
    Abstract: A liquid chromatograph includes a liquid chromatograph unit that has a pump sending an eluent to a detector and a control unit that controls the liquid to be sent by the pump based on a predetermined time table. The control unit stores an elution response of the liquid chromatograph unit which is obtained when a predetermined command value is input and another elution response which is obtained when the same command value is input to another liquid chromatograph. The time table is converted in the control unit based on the elution response and the other elution response to obtain respective elution profiles. In this manner, even when a measuring method related to another liquid chromatograph is used, it is possible to provide a liquid chromatograph capable of obtaining measurement results which are the same as those obtained when the measuring method is used in the other liquid chromatograph.
    Type: Grant
    Filed: November 11, 2013
    Date of Patent: February 28, 2017
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Toshimichi Aota, Masahito Ito, Chihiro Yoshioka, Takaaki Suzuki, Peter Grosshans
  • Publication number: 20160258913
    Abstract: In order to achieve high sensitivity without an increase in device complexity or cost, a far-ultraviolet absorbance detection device for liquid chromatography is provided with: an optical system including a light source that emits light including far-ultraviolet light, a diffraction grating for dispersing the light emitted from the light source, a flow cell through which a liquid is passed, a slit for selecting a predetermined wavelength of +1 order light diffracted by the diffraction grating and causing the light to enter the flow cell, a first photodetector for detecting the light transmitted by the flow cell, and a second photodetector for detecting light other than the +1 order light diffracted by the diffraction grating; a mechanism for evacuating or substituting the optical system with nitrogen gas; and a computation unit that calculates absorbance from an output signal from the first photodetector and an output signal from the second photodetector. The second photodetector is fixedly disposed.
    Type: Application
    Filed: February 4, 2016
    Publication date: September 8, 2016
    Inventors: Yuichi UCHIHO, Masao KAMAHORI, Toshimichi AOTA
  • Publication number: 20160216239
    Abstract: In the present invention, differences in liquid feed properties between liquid chromatographic devices are determined, a liquid feed time table that takes these differences into account is acquired by way of system changes, and flow control is performed by a pump. Furthermore, the liquid feed time table after the system changes is divided into a plurality of intervals, and instructions are sent to the pump after approximate calculations are performed. Thus, by efficiently performing system change processes, the same measurement results can be obtained in a plurality of different liquid chromatograph devices, regardless of the differences in liquid feed properties.
    Type: Application
    Filed: November 11, 2013
    Publication date: July 28, 2016
    Inventors: Toshimichi AOTA, Satoshi MITSUYAMA, Masahito ITO, Chihiro YOSHIOKA, Takaaki SUZUKI
  • Publication number: 20150293064
    Abstract: A liquid chromatograph includes a liquid chromatograph unit that has a pump sending an eluent to a detector and a control unit that controls the liquid to be sent by the pump based on a predetermined time table. The control unit stores an elution response of the liquid chromatograph unit which is obtained when a predetermined command value is input and another elution response which is obtained when the same command value is input to another liquid chromatograph. The time table is converted in the control unit based on the elution response and the other elution response to obtain respective elution profiles. In this manner, even when a measuring method related to another liquid chromatograph is used, it is possible to provide a liquid chromatograph capable of obtaining measurement results which are the same as those obtained when the measuring method is used in the other liquid chromatograph.
    Type: Application
    Filed: November 11, 2013
    Publication date: October 15, 2015
    Inventors: Toshimichi Aota, Masahito Ito, Chihiro Yoshioka, Takaaki Suzuki, Peter Grosshans