Patents by Inventor Toshimitsu Takiguchi

Toshimitsu Takiguchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Production of staurosporine derivative using acid isomerization
    Patent number: 6197955
    Abstract: A staurosporine derivative with anti-cancer activity and anti-bacterial activity is produced by acidifying a solution containing staurosporine to isomerize staurosporine to its desired derivative, whereby the derivative is recovered from the acidified solution.
    Type: Grant
    Filed: December 20, 1999
    Date of Patent: March 6, 2001
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Satoru Nagamura, Hidenori Aoki, Mitsutaka Kino, Toshimitsu Takiguchi
  • Process for producing staurosporine derivatives
    Patent number: 5344926
    Abstract: Disclosed is a process for producing a staurosporine derivative represented by Formula (I): Q is defined as in specification: ##STR1## The staurosporine derivative (I-1) possesses selective protein kinase C-inhibitory and cell growth-inhibiting activities, and platelet-increasing activity.
    Type: Grant
    Filed: June 22, 1993
    Date of Patent: September 6, 1994
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Chikara Murakata, Toshimitsu Takiguchi, Shigeo Katsumata, Akira Mihara, Keiichi Takahashi, Hiromitsu Saito, Shiro Akinaga, Masami Okabe, Yutaka Saito
  • Epoxycyclohexenone amides with antibacterial activity
    Patent number: 5106868
    Abstract: Compounds UCF1 and derivatives thereof exhibit anti-bacterial and anti-tumor activities and may be used for the preparation of anti-bacterial and anti-tumor agents.Compounds UCF1 may be produced by fermentation of a microorganism of the genus Streptomyces capable of producing compounds UCF1, preferably Streptomyces sp. UOF1 (FERM BP-2844) and recovering the desired compounds from the cultured broth.The compounds UCF1 have the formula ##STR1## wherein R represents either ##STR2## The compounds may be oxidized to obtain derivatives of formula ##STR3## which exhibit similar pharmacological activities.
    Type: Grant
    Filed: May 7, 1991
    Date of Patent: April 21, 1992
    Assignee: Kyowa Hakko Kogyo Kabushiki Kaisha
    Inventors: Hirofumi Nakano, Mitsunobu Hara, Yutaka Saito, Yoji Ikuina, Toshimitsu Takiguchi, Masami Okabe