Patents by Inventor Toshinari Sakurai

Toshinari Sakurai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10872411
    Abstract: A diagnostic imaging assistance apparatus according to the present invention performs a process of inputting images of a tissue and a cell, a process of extracting feature amounts of a wide view and a narrow view from a target image to be processed, a process of classifying whether the target images having different views are normal or abnormal from the feature amounts, and a process of classifying a lesion likelihood using a classification result.
    Type: Grant
    Filed: October 26, 2017
    Date of Patent: December 22, 2020
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Hideharu Hattori, Kenko Uchida, Sadamitsu Aso, Toshinari Sakurai, Yasuki Kakishita
  • Patent number: 10858621
    Abstract: The present invention addresses the problem of providing: a cell dispersion measurement mechanism whereby it becomes possible to fully disperse cells regardless of the experiences of operators skilled in cell culture and it also becomes possible to determine the number or concentration of cells accurately; a cell culture apparatus equipped with the cell dispersion measurement mechanism; and a cell dispersion measurement method. The problem can be solved by circulating a cell suspension in a flow path to disperse cell masses contained in the cell suspension, and then determining over time the number or concentration of cells and/or the degree of dispersion of cells in the cell suspension that is flowing in the circulation flow path.
    Type: Grant
    Filed: July 8, 2015
    Date of Patent: December 8, 2020
    Assignee: Hitachi High-Tech Corporation
    Inventors: Masako Kawarai, Akihiro Shimase, Sadamitsu Aso, Toshinari Sakurai, Eiichiro Takada, Kazumichi Imai
  • Patent number: 10846849
    Abstract: The present invention provides a method and an apparatus for analyzing a cell state, cell death in particular, in an interior of a spheroid non-invasively and quantitatively when the spheroid is cultured. More specifically, the present invention provides a method and an apparatus for analyzing a cell state by implementing optical imaging of a spheroid by using an optical instrument characterized by a high resolution and analyzing the internal structure of the spheroid.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: November 24, 2020
    Assignee: Hitachi High-Tech Corporation
    Inventors: Naoko Senda, Toshinari Sakurai
  • Patent number: 10815524
    Abstract: The purpose of the invention is to provide a nucleic acid analyzer that sets and executes temperature regulation, said temperature regulation matching the characteristics of analyzing items and the configuration of the analyzer, by a simple operation while preventing deterioration in analytical performance caused by partial overheating of a liquid reaction mixture to thereby improve temperature change speed and shorten analysis time. To achieve the above purpose, provided is a method wherein, in the case of performing overshooting: as a first processing, the temperature is continuously elevated until reaching a target overshoot temperature; as a second processing, after reaching the aforesaid temperature, the overshoot target temperature is maintained for a preset period of time; and, as a third processing, the temperature is continuously lowered until reaching a target temperature of the liquid reaction mixture.
    Type: Grant
    Filed: February 23, 2015
    Date of Patent: October 27, 2020
    Assignee: Hitachi High-Tech Corporation
    Inventors: Manami Nammoku, Terumi Tamura, Kohshi Maeda, Daisuke Morishima, Toshinari Sakurai, Wataru Sato
  • Patent number: 10804033
    Abstract: The object of the present invention is to provide a dielectric ceramic composition having good properties, particularly good IR property and high temperature accelerated lifetime. The dielectric ceramic composition of the present invention has a main component made of a perovskite type compound expressed by a compositional formula of (Ba1-x-ySrxCay)m(Ti1-zZrz)O3 (note that, m, x, y, and z of the above compositional formula all represent molar ratios, and each satisfies 0.9?m?1.1, 0?x?0.5, 0?y?0.3, 0?(x+y)?0.6, and 0.03?z?0.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: October 13, 2020
    Assignee: TDK CORPORATION
    Inventors: Dan Sakurai, Toshihiko Kaneko, Nobuto Morigasaki, Toshinari Takahashi, Yasuhiro Ito
  • Patent number: 10768189
    Abstract: When a sample of biological origin in an aqueous solution is used as the measurement medium in analysis using an electrochemical process, and a voltage of +1.2 V or greater (with saturated silver-silver chloride electrode potential as a reference) is applied, there are instances in which bubbles are observed to be produced within the flow cell, due to an electrolysis reaction deriving from the measurement buffer. There is a possibility that bubbles produced on the electrode will cover the electrode surface, reducing the effective surface area of the electrode. Also, the distribution of magnetic particles captured on the electrode will be disturbed by the gas produced thereby, lowering the reproducibility of the results of the analysis. Deaeration of the measurement medium prior to introduction of the measurement medium into the detector minimizes the effects of bubble production in degrading the analytical capability makes it possible to carry out highly sensitive electrochemical analysis.
    Type: Grant
    Filed: January 9, 2015
    Date of Patent: September 8, 2020
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Kenta Imai, Yoshinori Negishi, Toshinari Sakurai, Kyoko Imai
  • Publication number: 20200151877
    Abstract: An image diagnosis assisting apparatus according to the present invention executes: processing of inputting an image of a tissue or cell; processing of extracting a feature amount of a tissue or cell from a processing target image; processing of extracting a feature amount of a tissue or cell from an image having a component different from that of the target image; and processing of determining presence or absence of a lesion and lesion probability for each of the target images by using a plurality of the feature amounts.
    Type: Application
    Filed: February 26, 2018
    Publication date: May 14, 2020
    Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
    Inventors: Hideharu HATTORI, Yasuki KAKISHITA, Kenko UCHIDA, Sadamitsu ASO, Toshinari SAKURAI
  • Patent number: 10614957
    Abstract: A dielectric ceramic composition having good properties, particularly good IR property and high temperature accelerated lifetime, even under high electric field intensity. A dielectric ceramic composition having a main component made of a perovskite type compound expressed by a compositional formula of (Ba1-x-ySrxCay)m(Ti1-zZrz)O3 (note that, m, x, y, and z of the above compositional formula all represent molar ratios, and each satisfies 0.9<m<1.1, 0<x<0.5, 0<y<0.3, 0<(x+y)<0.6, and 0.03<z<0.3), and a first sub component made of an oxide of a rare earth element R (note that, R is at least one selected from the group consisting of Sc, Y, La, Ce, Pr, Nd, Pm, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, and Lu), wherein the dielectric ceramic composition includes dielectric particles and a particle boundary.
    Type: Grant
    Filed: January 17, 2019
    Date of Patent: April 7, 2020
    Assignee: TDK CORPORATION
    Inventors: Dan Sakurai, Toshihiko Kaneko, Nobuto Morigasaki, Toshinari Takahashi, Yasuhiro Ito
  • Publication number: 20190329240
    Abstract: A conventional solution exchanging method in a next-generation sequencer needs a reagent amount four or more times greater than an in-flow cell flow passage volume in order to efficiently promote a chemical reaction by replacing a reagent A in the flow cell with a new reagent B. Thus, the reagent consumption amount increases, and the cost is high. Meanwhile, an analysis apparatus according to the present invention is provided with: a flow cell used for analyzing samples; a sample container for containing a sample; a reagent container for containing a reagent; and a pressure generation mechanism for feeding the sample and the reagent to the flow cell through the flow passage, and also has an atmospheric opening in the flow passage of the flow cell on the upstream side.
    Type: Application
    Filed: February 17, 2016
    Publication date: October 31, 2019
    Inventors: Hirokazu KATO, Tatsuya YAMASHITA, Junji ISHIZUKA, Tomohiro SHOJI, Toshinari SAKURAI
  • Patent number: 10456767
    Abstract: A cytometric mechanism includes: a flow path through which a cell suspension is made to flow; a liquid drive unit for sending the cell suspension which is in the flow path; and a computation unit for irradiating, with irradiation light from a light source, a cell suspension flowing through a flow cell, and for finding a cell survival rate in the cell suspension on the basis of a resulting forward scattered light intensity and transmittance and/or side scattered light intensity. The invention is provided with a calibration curve database for storing, in advance, respective calibration curves indicative of a relationship between viable cell concentration and forward scattered light intensity, a relationship between dead cell concentration and the transmittance, and a relationship between a cell survival rate and the side scattered light intensity.
    Type: Grant
    Filed: October 22, 2014
    Date of Patent: October 29, 2019
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Masako Kawarai, Toshinari Sakurai, Akihiro Shimase, Hiroyuki Koshi
  • Publication number: 20190244349
    Abstract: The present invention provides a method and an apparatus for analyzing a cell state, cell death in particular, in an interior of a spheroid non-invasively and quantitatively when the spheroid is cultured. More specifically, the present invention provides a method and an apparatus for analyzing a cell state by implementing optical imaging of a spheroid by using an optical instrument characterized by a high resolution and analyzing the internal structure of the spheroid.
    Type: Application
    Filed: June 16, 2016
    Publication date: August 8, 2019
    Applicant: Hitachi High-Technologies Corporation
    Inventors: Naoko SENDA, Toshinari SAKURAI
  • Publication number: 20190237255
    Abstract: A dielectric ceramic composition having good properties, particularly good IR property and high temperature accelerated lifetime, even under high electric field intensity. A dielectric ceramic composition having a main component made of a perovskite type compound expressed by a compositional formula of (Ba1-x-ySrxCay)m(Ti1-zZrz)O3 (note that, m, x, y, and z of the above compositional formula all represent molar ratios, and each satisfies 0.9<m<1.1, 0<x<0.5, 0<y<0.3, 0<(x+y)<0.6, and 0.03<z<0.3), and a first sub component made of an oxide of a rare earth element R (note that, R is at least one selected from the group consisting of Sc, Y, La, Ce, Pr, Nd, Pm, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, and Lu), wherein the dielectric ceramic composition includes dielectric particles and a particle boundary.
    Type: Application
    Filed: January 17, 2019
    Publication date: August 1, 2019
    Applicant: TDK CORPORATION
    Inventors: Dan SAKURAI, Toshihiko KANEKO, Nobuto MORIGASAKI, Toshinari TAKAHASHI, Yasuhiro ITO
  • Publication number: 20190237254
    Abstract: The object of the present invention is to provide a dielectric ceramic composition having good properties, particularly good IR property and high temperature accelerated lifetime. The dielectric ceramic composition of the present invention has a main component made of a perovskite type compound expressed by a compositional formula of (Ba1-x-ySrxCay)m(Ti1-zZrz)O3 (note that, m, x, y, and z of the above compositional formula all represent molar ratios, and each satisfies 0.9?m?1.1, 0?x?0.5, 0?y?0.3, 0?(x+y)?0.6, and 0.03?z?0.
    Type: Application
    Filed: December 21, 2018
    Publication date: August 1, 2019
    Applicant: TDK CORPORATION
    Inventors: Dan SAKURAI, Toshihiko KANEKO, Nobuto MORIGASAKI, Toshinari TAKAHASHI, Yasuhiro ITO
  • Publication number: 20190237264
    Abstract: The object of the present invention is to provide the multilayer ceramic capacitor having no deterioration of dielectric properties even in case an inhibitor of an internal electrode layer is pushed out to a dielectric layer when sintering. The multilayer ceramic capacitor 1 including a capacitor element body 10 comprising a dielectric layer 2 and an internal electrode layer 3 stacked in an alternating manner, wherein when Za represents Zr concentration of an dielectric particle in a center part 6 of the dielectric layer 2 and Zb represents Zr concentration of a dielectric particle near the internal electrode layer, 0<(Za/Zb)<1 is satisfied.
    Type: Application
    Filed: January 17, 2019
    Publication date: August 1, 2019
    Applicant: TDK CORPORATION
    Inventors: Dan SAKURAI, Toshihiko KANEKO, Nobuto MORIGASAKI, Toshinari TAKAHASHI, Yasuhiro ITO
  • Publication number: 20190236779
    Abstract: A diagnostic imaging assistance apparatus according to the present invention performs a process of inputting images of a tissue and a cell, a process of extracting feature amounts of a wide view and a narrow view from a target image to be processed, a process of classifying whether the target images having different views are normal or abnormal from the feature amounts, and a process of classifying a lesion likelihood using a classification result.
    Type: Application
    Filed: October 26, 2017
    Publication date: August 1, 2019
    Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
    Inventors: Hideharu HATTORI, Kenko UCHIDA, Sadamitsu ASO, Toshinari SAKURAI, Yasuki KAKISHITA
  • Publication number: 20190172206
    Abstract: Reaction values indicating based on which areas in an input image a plurality of identification results representing the states of cells or tissues are judged are calculated, and differences between a plurality of reaction values are obtained to thereby calculate the degree to which cells or tissues in an area of interest likely are in each state. Thereby, each state of cells or tissues can be visualized at an accurate position in an area of interest; therefore, diagnostic assistance to pathologist becomes possible.
    Type: Application
    Filed: August 28, 2017
    Publication date: June 6, 2019
    Inventors: Yasuki KAKISHITA, Hideharu HATTORI, Kenko UCHIDA, Sadamitsu ASO, Toshinari SAKURAI
  • Publication number: 20190153377
    Abstract: A sterile connector has a first connector including a first housing provided with a first flow channel; a first pipeline connected to the first flow channel; first and second openings, the first opening being positioned inward from the second opening; and a first sealing member covering the second opening. Also, a second connector includes a second housing provided with a second flow channel; a third opening; and a second sealing member covering the third opening. The first and second connectors are detachable from each other. The first sealing member seals a space between the inner circumferential surface of the first housing and the outer circumferential surface of the second housing, while the second sealing member seals a space between the inner circumferential surface of the second housing and the outer circumferential surface of the first pipeline so that the first flow channel communicates with the second flow channel.
    Type: Application
    Filed: November 7, 2014
    Publication date: May 23, 2019
    Inventors: Akihiro SHIMASE, Eiichiro TAKADA, Kazumichi IMAI, Toshinari SAKURAI
  • Publication number: 20190136176
    Abstract: There is a need for fabrication of a three-dimensional structure for forming a regenerated tissue/regenerated organ having a desired size, shape, or structure by adjusting culture conditions with high precision and without causing contamination or damage to cells. Provided are: a device for acquiring a fabrication condition of a three-dimensional structure to be fabricated on the basis of externally inputted information relating to the three-dimensional structure, generating a magnetic field in a culture container for cells on the basis of the acquired fabrication condition, supplying magnetized cells to the culture container in which the magnetic field is generated, and culturing the supplied cells; and a method using the device.
    Type: Application
    Filed: March 1, 2017
    Publication date: May 9, 2019
    Inventors: Ryosuke KAWACHI, Toshinari SAKURAI
  • Patent number: 10138456
    Abstract: A device which automatically performs a step in which expanded and cultured cells are diluted to a desired cell concentration and re-inoculated using a cell-concentration adjustment device having an inlet for taking in a cell suspension; an outlet for discharging a diluted cell suspension; and a flow path which is provided between the inlet and the outlet and is capable of holding a cell suspension, the flow path being provided with: a liquid delivery pump for causing a cell suspension inside to flow; a cell-concentration measurement instrument for collecting data related to a cell concentration per unit amount of the cell suspension; and a dilution-liquid container for holding a dilution liquid which is supplied to the flow path to dilute the cell suspension.
    Type: Grant
    Filed: July 8, 2015
    Date of Patent: November 27, 2018
    Assignee: HITACHI HIGH-TECHNOLOGIES CORPORATION
    Inventors: Akihiro Shimase, Kazumichi Imai, Sadamitsu Aso, Eiichiro Takada, Masako Kawarai, Toshinari Sakurai
  • Publication number: 20180258377
    Abstract: Provided are a flow passage module which can achieve complete liquid substitution in a circulating flow passage with a simple structure, and a cell culture apparatus using said flow passage module. A flow passage module comprises: a flexible branching section which is provided with a first branching flow passage connected with an inflow passage for a fluid, a second branching flow passage connected with an outflow passage, a third branching flow passage connected with an entry-side end part of a circulating flow passage, and a fourth branching flow passage connected with an exit-side end part of the circulating flow passage, and which enables the branching flow passages to be communicated with each other; and a communication state switching part which has opening/closing members for closing and opening the desired branching flow passage from among the plurality of branching flow passages.
    Type: Application
    Filed: September 28, 2015
    Publication date: September 13, 2018
    Inventors: Akihiro SHIMASE, Toshinari SAKURAI