Patents by Inventor Toshinobu Nishimura

Toshinobu Nishimura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USE OF POLYVINYL ALCOHOL FOR CELL CULTURE OF IMMUNE CELLS
    Publication number: 20230030773
    Abstract: Serum albumin-free media comprising polyvinyl alcohol (PVA) and methods of culturing immune cells in such media are disclosed. The PVA is used as a replacement for fetal bovine serum, bovine serum albumin, and recombinant serum albumin in media. Advantages of using PVA include that it is a chemically-defined reagent that is available at high-purity with minimal batch-to-batch variability.
    Type: Application
    Filed: December 15, 2020
    Publication date: February 2, 2023
    Inventors: Adam C. Wilkinson, Hiromitsu Nakauchi, Yamazaki Satoshi, Kyle M. Loh, Toshinobu Nishimura
  • Compositions and Methods for Generating Gamma-Delta T Cells from Induced Pluripotent Stem Cells
    Publication number: 20220333073
    Abstract: Provided are methods for generating ?? T cells from induced pluripotent stem cells. Also provided are genetically engineered iPSCs, ?? T cells, CAR-?? T cells, and methods of using the same.
    Type: Application
    Filed: April 4, 2022
    Publication date: October 20, 2022
    Inventors: Mark Wallet, Toshinobu Nishimura, Mark Mendonca, Andriana Lebid, Brenda Salantes, Katherine Santostefano, Michael Francis Naso, Buddha Gurung, Zengrong Zhu, Barry Morse, Luis Borges, Christina Del Casale, Marilda Beqiri, Lucas Thompson
  • Compositions and Methods for Generating Alpha-Beta T Cells from Induced Pluripotent Stem Cells
    Publication number: 20220333074
    Abstract: Provided are method for generating ?? T cells from induced pluripotent stem cells. Also provided are genetically engineered iPSCs, ?? T cells, CAR-?? T cells, and methods of using the same.
    Type: Application
    Filed: April 4, 2022
    Publication date: October 20, 2022
    Inventors: Mark Wallet, Katherine Santostefano, Brenda Salantes, Mark Mendonca, Toshinobu Nishimura, Michael Francis Naso, Buddha Gurung, Zengrong Zhu, Barry Morse, Luis Borges, Jill Marinari Carton
  • METHOD FOR RECONSTRUCTING IMMUNE FUNCTION USING PLURIPOTENT STEM CELLS
    Publication number: 20210032595
    Abstract: According to the present invention, there are provided a method for producing a human T cell, which comprises the steps of inducing an iPS cell from a human T cell, and differentiating the iPS cell into a T cell; a pharmaceutical composition comprising the T cell produced by the method; and a method for cell-based immunotherapy using the method.
    Type: Application
    Filed: August 12, 2020
    Publication date: February 4, 2021
    Inventors: Hiromitsu NAKAUCHI, Shin KANEKO, Toshinobu NISHIMURA
  • Method for reconstructing immune function using pluripotent stem cells
    Patent number: 10787642
    Abstract: According to the present invention, there are provided a method for producing a human T cell, which comprises the steps of inducing an iPS cell from a human T cell, and differentiating the iPS cell into a T cell; a pharmaceutical composition comprising the T cell produced by the method; and a method for cell-based immunotherapy using the method.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: September 29, 2020
    Assignee: The University of Tokyo
    Inventors: Hiromitsu Nakauchi, Shin Kaneko, Toshinobu Nishimura
  • METHOD FOR RECONSTRUCTING IMMUNE FUNCTION USING PLURIPOTENT STEM CELLS
    Publication number: 20170009206
    Abstract: According to the present invention, there are provided a method for producing a human T cell, which comprises the steps of inducing an iPS cell from a human T cell, and differentiating the iPS cell into a T cell; a pharmaceutical composition comprising the T cell produced by the method; and a method for cell-based immunotherapy using the method.
    Type: Application
    Filed: October 30, 2015
    Publication date: January 12, 2017
    Inventors: Hiromitsu NAKAUCHI, Shin KANEKO, Toshinobu NISHIMURA
  • Method for reconstructing immune function using pluripotent stem cells
    Patent number: 9206394
    Abstract: According to the present invention, there are provided a method for producing a human T cell, which comprises the steps of inducing an iPS cell from a human T cell, and differentiating the iPS cell into a T cell; a pharmaceutical composition comprising the T cell produced by the method; and a method for cell-based immunotherapy using the method.
    Type: Grant
    Filed: August 2, 2012
    Date of Patent: December 8, 2015
    Assignee: THE UNIVERSITY OF TOKYO
    Inventors: Hiromitsu Nakauchi, Shin Kaneko, Toshinobu Nishimura
  • METHOD FOR RECONSTRUCTING IMMUNE FUNCTION USING PLURIPOTENT STEM CELLS
    Publication number: 20130078226
    Abstract: According to the present invention, there are provided a method for producing a human T cell, which comprises the steps of inducing an iPS cell from a human T cell, and differentiating the iPS cell into a T cell; a pharmaceutical composition comprising the T cell produced by the method; and a method for cell-based immunotherapy using the method.
    Type: Application
    Filed: August 2, 2012
    Publication date: March 28, 2013
    Applicant: The University of Tokyo
    Inventors: Hiromitsu NAKAUCHI, Shin Kaneko, Toshinobu Nishimura