Abstract: The present invention provides a composite granulated product that is optimal for allowing a tablet, preferably an orally disintegrating tablet (OD tablet) to be excellent in disintegrability and have proper hardness. The composite granulated product includes a sugar or a sugar alcohol, a swelling binder, a disintegrating agent, and a highly absorbent excipient.

Abstract: The present invention provides a composite granulated product that is optimal for allowing a tablet, preferably an orally disintegrating tablet (OD tablet) to be excellent in disintegrability and have proper hardness. The composite granulated product includes a sugar or a sugar alcohol, a swelling binder, a disintegrating agent, and a highly absorbent excipient.

Abstract: The present invention provides a novel base material for a dry solid dispersion, a solid dispersion containing the base material, and a composition containing the dispersion; the solid dispersion of the present invention, which contains a poorly soluble component with improved dissolvability, can be obtained by mixing a polyvinyl alcohol-based copolymer, as a base material for the dry solid dispersion, with a poorly soluble component, and then heating it.

Abstract: The present invention provides a novel base material for a dry solid dispersion, a solid dispersion containing the base material, and a composition containing the dispersion; the solid dispersion of the present invention, which contains a poorly soluble component with improved dissolvability, can be obtained by mixing a polyvinyl alcohol-based copolymer, as a base material for the dry solid dispersion, with a poorly soluble component, and then heating it.

Abstract: An object of the present invention is to provide a dry coating process that can produce a dry-coated preparation in a large amount. A large amount of dry-coated preparation can be produced more efficiently, than by prior-art processes, by a process in which a material containing core particles and a dry binder (lauric acid, myristic acid, or the like) is kneaded in a twin-screw kneader to produce dry binder particles in which the surfaces of the core particles are dry-coated with the dry binder. Further, a dry coating particle production process in which a material containing core particles, a dry binder, and a coating powder is kneaded in a twin-screw kneader can also produce a large amount of dry-coated preparation more efficiently than prior-art processes.

Abstract: A solid dispersion and a method of producing a solid dispersion of a sparingly water-soluble drug characterized by mixing the sparingly water-soluble drug and a water-soluble polymer at a temperature where neither the water-soluble drug nor water-soluble polymer is melted.

Abstract: This invention relates to .alpha.-crystals of cefazolin sodium with a water content in the range of 13.0 to 15.8%, useful as an antibiotic of improved thermal and light stability.

Abstract: The invention relates to a sustained release tablet which comprises easily disintegrable granules containing(a) a drug,(b) a disintegrating agent selected from the group consisting of starch derivatives, gums, cellulose derivatives and ion-exchange resins, and(c) a water soluble polymer selected from the group consisting of cellulose derivatives, synthetic water soluble polymers and polysaccharides, the surfaces of which granules are treated solely with a wax selected from the group consisting of plant or animal wax, hydrogenated oils and paraffin.

Abstract: The invention relates to a pharmaceutical oral capsule preparation filled with a substantially anhydrous mixture which is in solid or semi-solid form comprising:(a) a drug or a drug treated by a conventional manner, each of which is in solid form, and(b) a drug carrier which is a semi-solid mixture comprising a selected aqueous polymer and a selected liquid oil, the ratio of aqueous polymer to liquid oil by weight being 2:1 to 1:40.