Patents by Inventor Toshio Ariyasu
Toshio Ariyasu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230134948Abstract: A staining method includes staining a biological sample with a coumarin fluorescent dye to provide a fluorescent-stained sample, and bringing the fluorescent-stained sample into contact with osmium tetroxide, further embedding the sample in an epoxy resin, and subsequently slicing the sample to provide a section sample including the fluorescent-stained sample.Type: ApplicationFiled: April 1, 2021Publication date: May 4, 2023Inventors: Hiroshi INAGAKI, Hiroshi Takase, Hajime Kusano, Hiroshi Nagaike, Toshio Ariyasu
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Patent number: 11453694Abstract: The present invention aims to provide a novel glycosyl hesperetin, which is significantly reduced in miscellaneous tastes characteristic of conventional products containing glycosyl hesperetin, and a method for producing the same and uses thereof; and the objects are solved by providing a glycosyl hesperetin which comprises glycosyl hesperetin in an amount of 90% or more by mass but less than 100% by mass, on a dry solid basis, but it does not substantially contain furfural, and a method for producing the same and uses thereof.Type: GrantFiled: May 20, 2020Date of Patent: September 27, 2022Assignee: HAYASHIBARA CO. LTD.Inventors: Mitsuyuki Kambe, Koichi Nishi, Akira Kawashima, Akiko Yasuda, Hitoshi Mitsuzumi, Toshio Ariyasu
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Patent number: 11337910Abstract: An object of the present invention is to provide a particulate composition containing crystalline ?,?-trehalose dihydrate, having an advantageous emulsifying ability. The above object is solved by providing a particulate composition comprising crystalline ?,?-trehalose dihydrate, which consists of particles containing ?,?-trehalose and maltose and/or maltotriose, wherein said particulate composition contains ?,?-trehalose in an amount of 70% by weight or higher but 90% by weight or lower, on a dry solid basis; and maltose and/or maltotriose in a total amount of 3% by weight or higher, on a dry solid basis; and has a degree of crystallinity for crystalline ?,?-trehalose dihydrate of 25% or higher but less than 90%, when calculated based on its powder X-ray diffraction profile.Type: GrantFiled: January 19, 2017Date of Patent: May 24, 2022Assignee: HAYASHIBARA CO., LTD.Inventors: Masaki Kono, Masahiro Fujimoto, Yutaka Akagi, Akiko Miyake, Toshio Ariyasu
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Publication number: 20220031690Abstract: The present invention addresses the problem of providing an orally-administrable anti-neurodegenerative disease agent having an action of accelerating neurocyte growth and an action of promoting neurite-outgrowth, and having excellent transfer properties to central nervous tissues. The problem is solved by providing an anti-neurodegenerative disease agent containing a compound represented by General formula 4 as an active ingredient, and having an action of accelerating neurocyte growth, an action of promoting neurite-outgrowth, and an action of scavenging reactive oxygen species. In General formula 4, R10 and R11 represent the same or different alkyl group having 2-8 carbon atoms, and the alkyl group may be either a straight chain or a branched chain. n represents an integer of 0 or 1, and X4? represents a suitable counter anion that is pharmaceutically acceptable.Type: ApplicationFiled: September 24, 2019Publication date: February 3, 2022Inventors: Hitomi OHTA, Satomi MIYATA, Takashi MORIMOTO, Akira HARASHIMA, Toshio ARIYASU
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Publication number: 20210161791Abstract: An object of the present invention is to provide a particulate composition containing crystalline ?,?-trehalose dihydrate, having an advantageous emulsifying ability. The above object is solved by providing a particulate composition comprising crystalline ?,?-trehalose dihydrate, which consists of particles containing ?,?-trehalose and maltose and/or maltotriose, wherein said particulate composition contains ?,?-trehalose in an amount of 70% by weight or higher but 90% by weight or lower, on a dry solid basis; and maltose and/or maltotriose in a total amount of 3% by weight or higher, on a dry solid basis; and has a degree of crystallinity for crystalline ?,?-trehalose dihydrate of 25% or higher but less than 90%, when calculated based on its powder X-ray diffraction profile.Type: ApplicationFiled: January 19, 2017Publication date: June 3, 2021Inventors: Masaki KONO, Masahiro FUJIMOTO, Yutaka AKAGI, Akiko MIYAKE, Toshio ARIYASU
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Publication number: 20200283466Abstract: The present invention aims to provide a novel glycosyl hesperetin, which is significantly reduced in miscellaneous tastes characteristic of conventional products containing glycosyl hesperetin, and a method for producing the same and uses thereof; and the objects are solved by providing a glycosyl hesperetin which comprises glycosyl hesperetin in an amount of 90% or more by mass but less than 100% by mass, on a dry solid basis, but it does not substantially contain furfural, and a method for producing the same and uses thereof.Type: ApplicationFiled: May 20, 2020Publication date: September 10, 2020Inventors: Mitsuyuki KAMBE, Koichi NISHI, Akira KAWASHIMA, Akiko YASUDA, Hitoshi MITSUZUMI, Toshio ARIYASU
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Patent number: 10703773Abstract: The present invention aims to provide a novel glycosyl hesperetin, which is significantly reduced in miscellaneous tastes characteristic of conventional products containing glycosyl hesperetin, and a method for producing the same and uses thereof; and the objects are solved by providing a glycosyl hesperetin which comprises glycosyl hesperetin in an amount of 90% or more by mass but less than 100% by mass, on a dry solid basis, but it does not substantially contain furfural, and a method for producing the same and uses thereof.Type: GrantFiled: March 3, 2015Date of Patent: July 7, 2020Assignee: HAYASHIBARA CO. LTD.Inventors: Mitsuyuki Kambe, Koichi Nishi, Akira Kawashima, Akiko Yasuda, Hitoshi Mitsuzumi, Toshio Ariyasu
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Patent number: 10568827Abstract: [Object] The present invention has an object to provide an external dermal agent for reducing skin yellowness already generated in the skin. [Means to Attain the Object] The above object is solved by providing an external dermal agent for reducing skin yellowness already generated in the skin, which contains hesperetin and/or glycosyl hesperetin as an effective ingredient(s).Type: GrantFiled: September 1, 2016Date of Patent: February 25, 2020Assignee: HAYASHIBARA CO., LTD.Inventors: Masaki Miyake, Motoyuki Suzuki, Tatsuya Ishihara, Toshio Ariyasu
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Publication number: 20180243195Abstract: [Object] The present invention has an object to provide an external dermal agent for reducing skin yellowness already generated in the skin. [Means to Attain the Object] The above object is solved by providing an external dermal agent for reducing skin yellowness already generated in the skin, which contains hesperetin and/or glycosyl hesperetin as an effective ingredient(s).Type: ApplicationFiled: September 1, 2016Publication date: August 30, 2018Inventors: Masaki MIYAKE, Motoyuki SUZUKI, Tatsuya ISHIHARA, Toshio ARIYASU
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Publication number: 20170081354Abstract: The present invention aims to provide a novel glycosyl hesperetin, which is significantly reduced in miscellaneous tastes characteristic of conventional products containing glycosyl hesperetin, and a method for producing the same and uses thereof; and the objects are solved by providing a glycosyl hesperetin which comprises glycosyl hesperetin in an amount of 90% or more by mass but less than 100% by mass, on a dry solid basis, but it does not substantially contain furfural, and a method for producing the same and uses thereof.Type: ApplicationFiled: March 3, 2015Publication date: March 23, 2017Inventors: Mitsuyuki KAMBE, Koichi NISHI, Akira KAWASHIMA, Akiko YASUDA, Hitoshi MITSUZUMI, Toshio ARIYASU
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Patent number: 8357782Abstract: The present invention has the first object to provide a monoclonal antibody specific to interferon ? subtype ?8 (IFN?8) and its mutant proteins, the second object to provide a hybridoma capable of producing the monoclonal antibody, the third object to provide a method for detecting the IFN?8 and its mutant proteins by the monoclonal antibody, the fourth object to provide a method for purifying the IFN?8 and its mutant proteins by the monoclonal antibody, and the fifth object to provide a therapeutic agent for treating diseases whose onsets or exacerbation are related with IFN?8.Type: GrantFiled: March 16, 2009Date of Patent: January 22, 2013Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Shigeharu Fukuda, Chie Ushio, Harumi Ariyasu, Tohru Kayano, Toshio Ariyasu, Tsunetaka Ohta
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Publication number: 20110091968Abstract: The present invention has the first object to provide a monoclonal antibody specific to interferon ? subtype ?8 (IFN?8) and its mutant proteins, the second object to provide a hybridoma capable of producing the monoclonal antibody, the third object to provide a method for detecting the IFN?8 and its mutant proteins by the monoclonal antibody, the fourth object to provide a method for purifying the IFN?8 and its mutant proteins by the monoclonal antibody, and the fifth object to provide a therapeutic agent for treating diseases whose onsets or exacerbation are related with IFN?8.Type: ApplicationFiled: March 16, 2009Publication date: April 21, 2011Inventors: Shigeharu Fukuda, Chie Ushio, Harumi Ariyasu, Tohru Kayano, Toshio Ariyasu, Tsunetaka Ohta
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Patent number: 7098026Abstract: Disclosed are a novel hedgehog protein, i.e., a Desert hedgehog protein of human origin including mature and precursor forms, a DNA encoding the protein, a monoclonal antibody recognizing the protein, a process for producing the protein, and a method for detecting the protein. The hedgehog protein is useful in establishment of hybridomas which produce antibodies recognizing the protein, and the monoclonal antibody is useful in detection and purification of the protein. The hedgehog protein, DNA, and monoclonal antibody of this invention have efficacy in elucidation of hereditary morphological abnormalities in humans to establish their treatments and diagnoses.Type: GrantFiled: July 14, 2000Date of Patent: August 29, 2006Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Toshio Ariyasu, Shuji Nakamura, Kunzo Orita
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Patent number: 7015308Abstract: Disclosed are a novel hedgehog protein, i.e., a Desert hedgehog protein of human origin including mature and precursor forms, a DNA encoding the protein, a monoclonal antibody recognizing the protein, a process for producing the protein, and a method for detecting the protein. The hedgehog protein is useful in establishment of hybridomas which produce antibodies recognizing the protein, and the monoclonal antibody is useful in detection and purification of the protein. The hedgehog protein, DNA, and monoclonal antibody of this invention have efficacy in elucidation of hereditary morphological abnormalities in humans to establish their treatments and diagnoses.Type: GrantFiled: April 22, 1998Date of Patent: March 21, 2006Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Toshio Ariyasu, Shuji Nakamura, Kunzo Orita
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Publication number: 20050054585Abstract: A process for producing a polyether polymer by polymerizing a monomer having an oxirane group in the presence of a Lewis base having no active hydrogen such as, for example, a nitrile compound, a cyclic ether compound or an ester compound; and a polyether polymer produced by this process. Thus, a polyether polymer having a minimized amount of undesirable crosslinked product can be produced without reduction of polymerization activity.Type: ApplicationFiled: October 11, 2002Publication date: March 10, 2005Inventors: Toshio Ariyasu, Toshiharu Hanaya, Shigeyuki Arai, Masao Ikeda, Masashi Kurimoto
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Publication number: 20050048508Abstract: Disclosed are a mammalian trehalose receptor which comprises a protein comprising any of the amino acid sequences of SEQ ID NOs: 1, 2, 3 and 5; or a protein comprising any of the amino acid sequences of SEQ ID NOs: 1, 4 and 5; and a method for detecting trehalose using an animal cell in which the trehalose receptor has been expressed.Type: ApplicationFiled: September 17, 2003Publication date: March 3, 2005Applicant: KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJOInventors: Toshio Ariyasu, Shuji Matsumoto, Fumiyo Kyono, Toshiharu Hanaya, Shigeyuki Arai, Masao Ikeda, Masashi Kurimoto
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Publication number: 20030059838Abstract: Disclosed are a novel hedgehog protein, i.e., a Desert hedgehog protein of human origin including mature and precursor forms, a DNA encoding the protein, a monoclonal antibody recognizing the protein, a process for producing the protein, and a method for detecting the protein. The hedgehog protein is useful in establishment of hybridomas which produce antibodies recognizing the protein, and the monoclonal antibody is useful in detection and purification of the protein. The hedgehog protein, DNA, and monoclonal antibody of this invention have efficacy in elucidation of hereditary morphological abnormalities in humans to establish their treatments and diagnoses.Type: ApplicationFiled: May 17, 2002Publication date: March 27, 2003Applicant: KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJOInventors: Toshio Ariyasu, Shuji Nakamura, Kunzo Orita