Patents by Inventor Toshio Atsumi
Toshio Atsumi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5081139Abstract: An N-substituted triazole compound of the formula: ##STR1## wherein Ph is a phenyl group or a phenyl group substituted with one or two halogen atoms, R.sup.1 is a C.sub.1 -C.sub.3 alkyl group, R.sup.2 is a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group, R.sup.3 is a C.sub.1 -C.sub.8 alkyl group, a C.sub.4 -C.sub.8 cycloalkylalkyl group or a C.sub.3 -C.sub.6 cycloalkyl group and n is 0, 1 or 2, or an acid addition salt thereof, which is useful as an antifungal agent.Type: GrantFiled: October 2, 1985Date of Patent: January 14, 1992Assignee: Sumitomo Pharmaceuticals Company, LimitedInventors: Ikutaro Saji, Yoshihiro Tanaka, Katsuaki Ichise, Tomoharu Tanio, Takao Okuda, Toshio Atsumi
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Patent number: 4849434Abstract: A novel 2-pyridylthiazolidin-4-one derivative represented by the general formula ##STR1## wherein Ar denotes an aryl group unsubstituted or substituted with a halogen atom or with a lower alkoxy group; X denotes a straight-chain or branched-chain lower alkylene group or a single bond; R denotes a hydrogen atom, lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, acyloxy, di(lower alkyl) amino, hydroxyl or aryl group, or denotes an aryl group substituted with a lower alkoxy group; and Py denotes a pyridyl group, and the acid addition salt thereof, which have an excellent platelet activating factor antagonsm.Type: GrantFiled: July 17, 1987Date of Patent: July 18, 1989Assignees: Sumitomo Pharmaceuticals Company, Limited, Sumitomo Chemical Company, LimitedInventors: Masao Enomoto, Masami Muraoka, Keiichi Ono, Atsuyuki Kojima, Toshio Atsumi, Yoshihiro Komuro, Yuzuru Sanemitsu, Masato Mizutani
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Patent number: 4728729Abstract: A novel cyanoimidazole nucleoside and derivative thereof, particularly 4-cyanoimidazolium-5-olate nucleoside and acyl derivatives thereof, and pharmaceutically acceptable salts thereof which are useful as antitumor agents and immunosuppressants, are prepared by dehydrating carboxamide derivatives of the formula: ##STR1## wherein R is an acyl group, and then, if desired, deacylating.Type: GrantFiled: March 8, 1985Date of Patent: March 1, 1988Assignee: Sumitomo Pharmaceuticals Co., Ltd.Inventors: Yuzo Tarumi, Toshio Atsumi, Masaru Fukui
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Patent number: 4464531Abstract: There are provided compounds of the formula: ##STR1## wherein either R.sub.1 or R.sub.2 is a hydrogen atom, a hydroxy group, an acyloxy group, a phthalimido group or an acetamido group and the other is a hydrogen atom; either R.sub.3 or R.sub.4 is a hydroxy group or an acyloxy group and the other is a hydrogen atom; either R.sub.5 or R.sub.6 is a hydroxy group or an acyloxy group and the other is a hydrogen atom; either R.sub.7 or R.sub.8 is a hydrogen atom, a methyl group, a hydroxymethyl group, an acyloxymethyl group, an alkoxycarbonyl group, a group of the formula: ##STR2## (wherein X.sub.1 and X.sub.2 are a hydrogen atom or a lower alkyl group), or a carboxyl group and the other is a hydrogen atom; either R.sub.11 or R.sub.12 is a hydrogen atom, a hydroxy group or an acyloxy group and the other is a hydrogen atom; either R.sub.13 or R.sub.14 is a hydroxy group or an acyloxy group and the other is a hydrogen atom; either R.sub.15 or R.sub.Type: GrantFiled: April 7, 1982Date of Patent: August 7, 1984Assignee: Sumitomo Chemical Company, LimitedInventors: Toshio Atsumi, Yuzo Tarumi, Tetsutaro Sanjiki, Yoshiaki Takebayashi, Noboru Yoshida
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Patent number: 4410696Abstract: There are provided compounds of the formula: ##STR1## wherein R is a mono-substituted benzoyl group wherein the substituent is a phenyl group, an alkanoyl group, a formyl group, a halogeno-alkyl group, an aralkyloxy group, a phenoxy group, an alkoxycarbonyl group, an aralkyloxycarbonyl group, an alkanoyloxy group, a benzoyl group, a carboxyl group, a hydroxy group, a group of the formula: ##STR2## (wherein X.sub.1 and X.sub.2 are a hydrogen atom or a lower alkyl group), an aralkyloxycarbonylamino group, a lower alkoxycarbonylamino group, a carboxyamino group or a carbamoyl group; a cinnamoyl group which may be substituted at the .alpha.Type: GrantFiled: September 24, 1981Date of Patent: October 18, 1983Assignee: Sumitomo Chemical Company, LimitedInventors: Toshio Atsumi, Tetsutaro Sanjiki, Takao Kiyohara
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Patent number: 4332806Abstract: There are provided compounds of the formula: ##STR1## wherein R is an adamantoyl group substituted with a lower alkyl group, a lower alkoxy group, a hydroxy group, a lower alkanoyloxy group, an aroyloxy group, a halogen atom, an acetamido group, a nitro group, an azide group, a trifluoromethyl group or a phenyl group which may be substituted with a nitro group, a halogen atom, a lower alkyl group or a lower alkoxy group and a process producing them. These compounds are useful as antitumor agents and immunosuppressants.Type: GrantFiled: November 12, 1980Date of Patent: June 1, 1982Assignee: Sumitomo Chemical Company, LimitedInventors: Toshio Atsumi, Yoshiaki Takebayashi, Takao Kiyohara
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Patent number: 4318925Abstract: A new class of 4-homoisotwistane derivatives of the formula, ##STR1## wherein R.sub.1 is a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group, and R.sub.2 is an alkyl group, a phenyl group which may be either unsubstituted or substituted with a C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy, nitro group or a halogen atom (hereinafter referred to as "an optionally substituted phenyl group"), a group of the formula, --A--OH in which A is a C.sub.1 -C.sub.3 alkylene group; a group of the formula, --A--B in which A is as defined as above and B is a halogen atom, or a group of the formula, ##STR2## in which A is as defined above and R.sub.3 and R.sub.4 are independently a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group or R.sub.3 and R.sub.4 may, when taken together with the adjacent nitrogen atom to which R.sub.3 and R.sub.Type: GrantFiled: March 20, 1980Date of Patent: March 9, 1982Assignees: Sumitomo Chemical Co., Ltd., Kao Soap Co., Ltd.Inventors: Toshio Atsumi, Yoshiaki Takebayashi, Masaru Fukui, Hisao Yamamoto
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Patent number: 4317825Abstract: There are provided compounds of the formula: ##STR1## wherein R is a heteroaroyl group containing a nitrogen, sulfur or oxygen atom which may be substituted with a lower alkyl group, an aralkyl group, an acyl group or a halogen atom; or a cycloalkanoyl group which may be substituted with a lower alkyl group, a lower alkenyl group, a halogen atom, a halogeno-lower alkenyl group, a phenyl group, a halogenophenyl group, a lower alkoxyphenyl group, a lower alkylphenyl group, a formyl group, a hydroxy group, an amino group, a carboxyl group, an aminomethyl group or an oxo group, its non toxic salt and a process for producing them. These compounds are useful as antitumor agents and immunosuppressants.Type: GrantFiled: August 5, 1980Date of Patent: March 2, 1982Assignee: Sumitomo Chemical Company, LimitedInventors: Toshio Atsumi, Tetsutaro Sanjiki, Takao Kiyohara
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Patent number: 4283422Abstract: Novel 3-amino-4-homoisotwistane derivatives of the formula, ##STR1## wherein R.sub.1 is a hydrogen atom, a C.sub.1 -C.sub.4 alkyl group or a C.sub.3 -C.sub.5 alkenyl group, and R.sub.2 is a C.sub.1 -C.sub.4 alkyl group or a C.sub.3 -C.sub.5 alkenyl group, or non-toxic pharmaceutically acceptable salts thereof, which are very valuable as medicines for the treatment of virus-caused diseases and as antiviral agents for animals and useful for the treatment of parkinsonean disease.Type: GrantFiled: February 12, 1980Date of Patent: August 11, 1981Assignees: Sumitomo Chemical Company, Limited, Kao Soap Company, LimitedInventors: Toshio Atsumi, Yoshiaki Takebayashi, Hideki Okajima
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Patent number: 4260774Abstract: There are provided compounds of the formula: ##STR1## wherein R is an adamantyl group, or a phenyl group unsubstituted or substituted with a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a halogen atom, a nitro group, a cyano group, a methylenedioxy group or an acetamido group, useful as anti-transplanted-tumor agents and immunosuppressants.Type: GrantFiled: June 25, 1979Date of Patent: April 7, 1981Assignee: Sumitomo Chemical Company, LimitedInventors: Toshio Atsumi, Yoshiaki Takebayashi, Yuzo Tarumi, Hisao Yamamoto
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Patent number: 4218457Abstract: Compounds of the formula, ##STR1## wherein R is C.sub.2 -C.sub.17 alkyl group, C.sub.3 -C.sub.7 cycloalkyl group, 1-adamantyl group, pyridyl group, pyridine N-oxide, diphenylmethyl group, benzyl group which may or may not be substituted with nitro group, halogen atom, C.sub.1 -C.sub.3 alkyl group or C.sub.1 -C.sub.3 alkoxy group, or phenyl group which may or may not be substituted with nitro group, halogen atom, hydroxy group, C.sub.1 -C.sub.3 alkyl group, C.sub.1 -C.sub.3 alkoxy group, carboxy group, C.sub.2 -C.sub.4 alkoxycarbonyl group, phenoxycarbonyl group, carbamoyl group, N-phenylcarbamoyl group, N-adamantylcarbamoyl group, benzoylamino group, trifluoromethyl group, C.sub.2 -C.sub.4 alkanoyloxy group, 1-adamantoyloxy group or benzoyloxy group and salts thereof have an anticancer activity and an immunostimulating activity.Type: GrantFiled: September 6, 1978Date of Patent: August 19, 1980Assignee: Sumitomo Chemical Company, LimitedInventors: Toshio Atsumi, Yuzo Tarumi, Noboru Yoshida
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Patent number: 4209525Abstract: Imidazole derivatives represented by the formula: ##STR1## wherein Y is a hydroxy group, a lower alkoxy group or an amino group, and their non-toxic, pharmaceutically acceptable salts, which have a potent immunostimulating activity and are useful for the immunostimulatory therapy of various diseases, and their preparation and use.Type: GrantFiled: December 19, 1978Date of Patent: June 24, 1980Assignee: Sumitomo Chemical Company, LimitedInventors: Toshio Atsumi, Yuzo Tarumi, Takao Kiyohara
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Patent number: 4140788Abstract: N-Substituted imidazolecarboxamide compounds represented by the formula; ##STR1## wherein R.sub.1 is hydrogen atom, lower alkyl, lower alkenyl, aralkyl, R.sub.2 is hydrogen atom, lower alkyl, lower alkenyl, aralkyl, 1-adamantyl, R.sub.3 is hydrogen atom, lower alkyl, aralkyl; with the proviso that one of R.sub.1, R.sub.2 or R.sub.3 is not hydrogen when the other two are hydrogen, are produced by reacting aminomalonamide derivative with orthoformate derivative in high yields. The compounds (I) exhibit anti-tumor activity against experimental tumors such as Sarcoma 180 in mice.Type: GrantFiled: November 7, 1977Date of Patent: February 20, 1979Assignee: Sumitomo Chemical Company, LimitedInventors: Toshio Atsumi, Yuzo Tarumi, Norboru Yoshida
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Patent number: 3962446Abstract: An analgesic composition comprising an analgesically effective amount of at least one 6,7-benzomorphan derivative of the formula: ##SPC1##Wherein R is a hydrogen atom, a hydroxyl group, a C.sup.1 - C.sup.3 alkoxy group or a C.sup.1 - C.sup.8 alkanoyloxy group; R.sub.1 is a hydrogen atom, a C.sup.1 - C.sup.5 alkyl group, a phenyl group, a halophenyl group, an alkylphenyl group wherein the alkyl moiety has 1 to 3 carbon atoms, an alkoxyphenyl group wherein the alkoxy moiety has 1 to 3 carbon atoms, a trifluoromethylphenyl group, an alkylthiophenyl group wherein the alkylthio moiety has 1 to 3 carbon atoms or a group of the formula (C.sub.m H.sub.2m.sub.-p.sub.+1) - (R.sub.9).sub.p wherein m is an integer of 1 - 6, p is an integer of 1 - 2 and R.sub.9 is a C.sup.1 - C.sup.3 alkoxy group; R.sub. 2 is a hydrogen atom or a C.sup.1 - C.sup.3 alkyl group; R.sub.3 is a hydrogen atom, a C.sup.1 - C.sup.3 alkyl group, a phenyl group or an alkoxyphenyl group wherein the alkoxy moiety has 1 to 3 carbon atoms; R.sub.Type: GrantFiled: November 13, 1974Date of Patent: June 8, 1976Assignee: Sumitomo Chemical Company, LimitedInventors: Toshio Atsumi, Kenji Kobayashi, Yoshiaki Takebayashi, Hisao Yamamoto
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Patent number: 3953441Abstract: A novel process for preparing 2-benzoylalkylbenzomorphan derivatives and salts thereof, represented by the formula ##SPC1##Wherein n, R, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as defined in the specification. The process comprises reacting a pyridinium derivative of the formula, ##SPC2##Wherein X is a halogen atom and Y' is an ethylenedioxy group; with a Grignard reagent of the formula, ##SPC3##Wherein R' is a hydrogen atom or a C.sub.1 -C.sub.3 alkoxy group and Z is a halogen atom, to yield a 1,2-dihydropyridine derivative of the formula; ##SPC4##And then reducing the said 1,2-dihydropyridine derivative to give a 1,2,5,6-tetrahydropyridine derivative of the formula, ##SPC5##Wherein Y is an oxygen atom or an ethylenedioxy group, and further cyclizing the obtained 1,2,5,6-tetrahydropyridine derivative.Type: GrantFiled: June 7, 1971Date of Patent: April 27, 1976Assignee: Sumitomo Chemical Company, LimitedInventors: Toshio Atsumi, Kenji Kobayashi, Yoshiaki Takebayashi, Hisao Yamamoto
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Patent number: 3951984Abstract: A 3-benzazocine compound of the formula: ##SPC1##Wherein R.sub.1, R.sub.3, R.sub.4, R.sub.5 and R.sub.8 are each hydrogen or lower alkyl, R.sub.2 is hydrogen, lower alkyl or phenyl and R.sub.6 and R.sub.7 are each lower alkyl, and its pharmaceutically acceptable acid addition salts, which are useful as analgesics and can be produced by reacting a tetrahydropyridine compound of the formula: ##SPC2##Wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are each as defined above or its salt with a Lewis acid.Type: GrantFiled: December 18, 1973Date of Patent: April 20, 1976Assignee: Sumitomo Chemical Company, LimitedInventors: Michio Kimura, Takeshi Nakajima, Toshio Atsumi, Kenji Kobayashi, Yoshiaki Takebayashi, Shigeho Inaba, Hisao Yamamoto
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Patent number: 3950346Abstract: 2-Ketoethyl-6,7-benzomorphan derivatives of the formula: ##SPC1##And their pharmaceutically acceptable non-toxic salts, which are useful as non-addictive analgesics and pain-relieving agents and can be prepared by reacting the corresponding 6,7-benzomorphan derivative of the formula: ##SPC2##With a vinyl carbonyl compound of the formula: ##EQU1## [wherein R' is a hydrogen atom or a group of the formula: --OR" (wherein R" is a hydrogen atom, an alkanoyl group, an alkyl group, an aralkyl group, an alkoxycarbonylmethyl group or a tetrahydropyranyl group), R.sub.1 is a hydrogen atom, an alkyl group or a substituted or unsubstituted aryl group, R.sub.2 is a hydrogen atom or an alkyl group and A is an alkyl group, an alkoxy group, a substituted or unsubstituted aryl group or a substituted or unsubstituted amino group].Type: GrantFiled: May 3, 1973Date of Patent: April 13, 1976Assignee: Sumitomo Chemical Company, LimitedInventors: Toshio Atsumi, Kenji Kobayashi, Yoshiaki Takebayashi, Hisao Yamamoto