Abstract: The present invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, m and n are as defined in the specification, with an inhibitory effect of PD-L1 expression and an inhibitory effect of reduced production of IL-2 and a medicament useful for the treatment of a disease associated with the reduced immune function caused by the formation of PD-1/PD-L1 binding.

Abstract: The present invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, m and n are as defined in the specification, with an inhibitory effect of PD-L1 expression and an inhibitory effect of reduced production of IL-2 and a medicament useful for the treatment of a disease associated with the reduced immune function caused by the formation of PD-1/PD-L1 binding.

Abstract: The present invention provides a useful medicament for the treatment and/or prophylaxis of a disease associated with the enhancement of OPN production including cancer, which comprises a compound of formula: wherein R1, R2, R3, R4, R5, R6, R7, m, n, p, X, and Y are as defined in the specification, a pharmaceutically acceptable salt thereof.

Abstract: The present invention provides a medicament useful for treatment and/or prevention of cancer, a vaccine adjuvant, and an inhibitor of immune checkpoint comprising a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein Bonds a-d, Ring A, R1, R1?, R2, R2?, R3-R8, and n are as defined in the present specification.

Abstract: The present invention provides a medicament useful for treatment and/or prevention of cancer, a vaccine adjuvant, and an inhibitor of immune checkpoint comprising a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein Bonds a-d, Ring A, R1, R1?, R2, R2?, R3-R8, and n are as defined in the present specification.

Abstract: The present invention provides a useful medicament for the treatment and/or prophylaxis of a disease associated with the enhancement of OPN production including cancer, which comprises a compound of formula: wherein R1, R2, R3, R4, R5, R6, R7, m, n, p, X, and Y are as defined in the specification, a pharmaceutically acceptable salt thereof.

Abstract: A fuel tank plumbing structure includes a first pipe; a second pipe coaxially connected to the first pipe; a flexible locking piece having a protruding end displaced in a radial direction of one of the first pipe or the second pipe; a locking portion formed in another of the first pipe or the second pipe to engage the locking piece; and a lock member annularly formed and fitted externally onto the one of the first pipe or the second pipe, and including an escape groove portion and a control wall portion arranged adjacent to the escape groove. The lock member is displaced in an axis line direction of the one of the first pipe or the second pipe between a first position wherein the locking piece is displaced toward the escape groove portion, and a second position wherein the locking piece abuts against the control wall portion.

Abstract: Disclosed herein is an osteopontin production inhibitor capable of preventing a disease resulting from increased production of osteopontin. The osteopontin production inhibitor contains a dictyopyrone derivative or a dihydrodictyopyrone derivative as an active ingredient. The dictyopyrone derivative is preferably a compound represented by Chemical Formula 1 or 2, and the dihydrodictyopyrone derivative is preferably a compound represented by Chemical Formula 3 or 4.

Abstract: Disclosed herein is an osteopontin production inhibitor capable of preventing a disease resulting from increased production of osteopontin. The osteopontin production inhibitor contains a dictyopyrone derivative or a dihydrodictyopyrone derivative as an active ingredient. The dictyopyrone derivative is preferably a compound represented by Chemical Formula 1 or 2, and the dihydrodictyopyrone derivative is preferably a compound represented by Chemical Formula 3 or 4.

Abstract: A connector to connect a fluid path to a fuel tank includes a main portion made of a synthetic resin through which a gas produced from fuel hardly passes, and a shell formed outside the main portion and made of a synthetic resin through which the gas passes easier than the main portion and which can be melt-bonded to the outer surface of a fuel tank. The main portion includes a flange part in the outer periphery. The shell has a wall section for a melt-bonding portion which extends around from the top surface side of the flange part and covers the bottom side of the flange part. The undersurface of the flange part is provided with an inclination having the peripheral edge side of the flange part upside thereof.

Abstract: A connector to connect a fluid path to a fuel tank includes a main portion made of a synthetic resin through which a gas produced from fuel hardly passes, and a shell formed outside the main portion and made of a synthetic resin through which the gas passes easier than the main portion and which can be melt-bonded to the outer surface of a fuel tank. The main portion includes a flange part in the outer periphery. The shell has a wall section for a melt-bonding portion which extends around from the top surface side of the flange part and covers the bottom side of the flange part. The undersurface of the flange part is provided with an inclination having the peripheral edge side of the flange part upside thereof.

Abstract: A fuel tank plumbing structure adapted to be inserted into a through-hole formed in a wall portion of a fuel tank, includes a first pipe adapted to be attached to the fuel tank; a second pipe coaxially connected to the first pipe; a flexible locking piece protruding in one of either the first or second pipe; a locking portion formed in the other of the first or second pipe, and locking the locking piece; and a lock member to be displaceable between a predetermined first and second position. While the lock member is separated from the locking piece in the first position to allow an engagement and a disengagement of the locking piece and the locking portion, the lock member abuts against the locking piece in the second position to prevent the disengagement of the locking piece from the locking portion.

Abstract: A connector includes an outer melt-bonding projection 2 integrally formed with a projecting end 10a of a flange 10 of a base member 1, and an inner melt-bonding member 3 having an upper side 30 unified to a lower surface 10g of the flange 10 of the base member 1 and configured to have an outer lateral side 31 unified to an inner lateral side 20 of the outer melt-bonding projection 2. The outer melt-bonding projection 2 is formed of a first synthetic resin, which is melt-bondable to an outer layer Ta of a fuel tank T, the base member 1 is formed of a second synthetic resin difficult to pass a gas produced from fuel therethrough and adaptable to the first synthetic resin, and the inner melt-bonding member 3 is formed of the first synthetic resin.

Abstract: A connector includes an outer melt-bonding projection 2 integrally formed with a projecting end 10a of a flange 10 of a base member 1, and an inner melt-bonding member 3 having an upper side 30 unified to a lower surface 10g of the flange 10 of the base member 1 and configured to have an outer lateral side 31 unified to an inner lateral side 20 of the outer melt-bonding projection 2. The outer melt-bonding projection 2 is formed of a first synthetic resin, which is melt-bondable to an outer layer Ta of a fuel tank T, the base member 1 is formed of a second synthetic resin difficult to pass a gas produced from fuel therethrough and adaptable to the first synthetic resin, and the inner melt-bonding member 3 is formed of the first synthetic resin.

Abstract: A fuel supply pipe device for a fuel tank of a vehicle includes a fuel supply pipe connected to the fuel tank, and a filler pipe connected to the fuel supply pipe. A hose intrusion preventing member is situated inside the fuel supply pipe. The hose intrusion preventing member includes plural obstructing plates extending parallel to each other following an axial line of the fuel supply pipe, and an annular member attached to the obstructing plates. A metal pipe member is disposed inside the fuel supply pipe adjacent to the hose intrusion preventing member to locate the hose intrusion preventing member inside the fuel supply pipe.

Abstract: Treatment agents are provided for cell seedlings. Each treatment agent comprises water, a dispersant, and activated carbon finely dispersed with the dispersant in the water. Potted seedlings can be treated by dipping them in the treatment agent and/or by irrigating them with the treatment agent. In this manner, cell seedlings can be pre-treated before planting. The thus-planted seedlings may be irrigated with the treatment agent.

Abstract: A heat exchanger used in a screw air compressor has a low temperature chamber through which low temperature fluid flows and a high temperature chamber through which high temperature fluid flows. The low temperature chamber and the high temperature chamber are separated by a partition plate. The high temperature chambers and the low temperature chambers are alternately arranged in layers, so that the low temperature chambers are disposed at both ends in a layered direction. Additionally, the flowing direction of the low temperature fluid in the low temperature chambers and the flowing direction of the high temperature fluid in the high temperature chambers are substantially orthogonal to each other.

Abstract: A fuel supply pipe device for a fuel tank of a vehicle includes a fuel supply pipe connected to the fuel tank, and a filler pipe connected to the fuel supply pipe. A hose intrusion preventing member is situated inside the fuel supply pipe. The hose intrusion preventing member includes plural obstructing plates extending parallel to each other following an axial line of the fuel supply pipe, and an annular member attached to the obstructing plates. A metal pipe member is disposed inside the fuel supply pipe adjacent to the hose intrusion preventing member to locate the hose intrusion preventing member inside the fuel supply pipe.

Abstract: A heat exchanger used in a screw air compressor has a low temperature chamber through which low temperature fluid flows and a high temperature chamber through which high temperature fluid flows. The low temperature chamber and the high temperature chamber are separated by a partition plate. The high temperature chambers and the low temperature chambers are alternately arranged in layers, so that the low temperature chambers are disposed at both ends in a layered direction. Additionally, the flowing direction of the low temperature fluid in the low temperature chambers and the flowing direction of the high temperature fluid in the high temperature chambers are substantially orthogonal to each other.

Abstract: A pressure control valve includes a valve chamber having the first communicating portion connected to a canister and the second communicating portion connected to a fuel tank, the first valve member disposed inside the valve chamber, and the second valve member disposed inside the first valve member. The first valve member includes a valve portion for blocking the second communicating portion, the first communicating hole passing through the valve portion, and the second communicating hole communicating between the first valve member and the valve chamber. The second valve member blocks the second communicating hole. When the fuel tank reaches a certain high pressure state, the first valve member rises to open the second communicating portion. When the fuel tank reaches a certain low pressure state, the second valve member rises to open the second communicating hole.