Patents by Inventor Toshio Ichiba

Toshio Ichiba has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Production of isochroman compounds by culturing Penicillium
    Patent number: 6440709
    Abstract: This invention relates to the isochroman compound of formula (I) and its pharmaceutically acceptable salts, which are useful as an amyloid aggregation inhibitor and for treating Alzheimer's disease. This invention also relates to processes for producing the isochroman compound, which comprises cultivating Penicillium simplicissimum FERM BP-6357 and then isolating the isochroman compound from the fermentation broth. The present invention also relates to a pharmaceutical composition comprising the isochroman compound.
    Type: Grant
    Filed: August 30, 2000
    Date of Patent: August 27, 2002
    Assignee: Pfizer Inc.
    Inventors: Hideo Hirai, Toshio Ichiba, Hiroko Tonai
  • Isochroman compounds and their production process
    Patent number: 6177458
    Abstract: This invention relates to the isochroman compound of formula (I) and its pharmaceutically acceptable salts, which are useful as an amyloid aggregation inhibitor and for treating Alzheimer's disease. This invention also relates to processes for producing the isochroman compound, which comprises cultivating Penicillium simplicissimum FERM BP-6357 and then isolating the isochroman compound from the fermentation broth. The present invention also relates to a pharmaceutical composition comprising the isochroman compound.
    Type: Grant
    Filed: December 21, 1999
    Date of Patent: January 23, 2001
    Assignee: Pfizer Inc
    Inventors: Hideo Hirai, Toshio Ichiba, Hiroko Tonai
  • Epidioxymanadic acids A and B
    Patent number: 5514705
    Abstract: The present invention is directed to two novel compounds isolated from a Pacific sponge, Plakortis (Homosclerophorida, Plakinidae) which are designated herein as epidioxymanadic acids A and B. These two compounds have been obtained by a bioassay-guided (i.e., antibiotic activity) isolation procedure, involving solvent partition and chromatography on Sephadex LH-20, cyano, and C-18 columns, from extracts of sponge.
    Type: Grant
    Filed: September 7, 1994
    Date of Patent: May 7, 1996
    Assignee: PharmaMar, S.A.
    Inventors: Toshio Ichiba, Paul J. Scheuer, Dolores G. Gravalos
  • Antitumor alkaloids
    Patent number: 4895852
    Abstract: This invention relates to antitumor alkaloid compositions, a process of producing the compositions and a method for inhibiting tumors utilizing the compositions. More particularly, the compositions are antitumor alkaloids which are derived from marine organisms, i.e., the marine sponge Xestospongia, sp.
    Type: Grant
    Filed: November 24, 1987
    Date of Patent: January 23, 1990
    Assignee: Harbor Branch Oceanographic Institution, Inc.
    Inventors: Tatsuo Higa, Ryuichi Sakai, Toshio Ichiba